Review
Medicine, General & Internal
Erlangga Yusuf, Hannelore I. Bax, Nelianne J. Verkaik, Mireille van Westreenen
Summary: Infections in the ICU are often caused by Gram-negative bacteria, which can become resistant to traditional antibiotics, limiting treatment options. In recent years, FDA has approved new antibiotics with predominant activities against Gram-negative bacteria, providing more choices for treatment in specific circumstances.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Infectious Diseases
Qi Zhang, Shang Chen, Xiaojia Liu, Wenhan Lin, Kui Zhu
Summary: The combination of marine antibiotic equisetin and colistin shows a strong synergistic effect against Gram-negative bacteria, especially multi-drug resistant strains. Colistin promotes the intracellular accumulation of equisetin, leading to quick bacteria killing. Equisetin also restores colistin activity in an infection model, providing an alternative approach to combat Gram-negative pathogens in clinics.
Article
Microbiology
Yuvaneswary Veloo, Syahidiah S. A. Thahir, Sakshaleni Rajendiran, Lim K. Hock, Norazah Ahmad, Vickneshwaran Muthu, Rafiza Shaharudin
Summary: The indiscriminate use of antibiotics in poultry farming has led to the emergence of antibiotic-resistant bacteria in poultry products and the surrounding environment. This study found high rates of multidrug-resistant Gram-negative bacteria in the environment of poultry farms, with some strains exhibiting resistance to multiple antibiotics. The presence of these bacteria poses a significant threat to the effectiveness of available antibiotics in treating infectious diseases. Efforts to regulate antibiotic use and conduct research on One Health issues are necessary to combat and prevent the spread of antibiotic-resistant bacteria.
MICROBIOLOGY SPECTRUM
(2022)
Article
Chemistry, Medicinal
Min Li, Jialin Li, Jingyi Li, Jie Zhang, Yuqing Zhao, Wenying Li, Yunfei Zhang, Jinrong Hu, Xiaolin Xie, Dezhu Zhang, Han Li, Qianqian Zhao, Hong Gao, Chengyuan Liang
Summary: The emergence of drug-resistant strains presents a challenge for traditional antibiotics. In this study, a collection of pleuromutilin aromatic acrylate derivatives were designed and synthesized to explore novel antibacterial drugs. Most of these derivatives displayed excellent antibacterial activity against both Gram-positive and Gram-negative bacteria, with 5g showing the strongest activity and potential as a clinical treatment for drug-resistant bacterial infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Infectious Diseases
Mihret Tilahun
Summary: Antibiotic resistance is a global issue, and this study assessed the prevalence of multidrug-resistant bacteria among surgical patients in northeast Ethiopia. The findings revealed a high prevalence of resistant strains and highlighted the need for enhanced infection prevention and control measures.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Nityanand Jain, Inese Jansone, Tatjana Obidenova, Raimonds Simanis, Janis Meisters, Dagnija Straupmane, Aigars Reinis
Summary: This study conducted a retrospective analysis of microbiological data from a large public hospital in Latvia from 2017 to 2020, investigating antimicrobial resistance trends for 19 gram-negative bacterial genera. It found that carbapenems were most effective against GNBs while some bacteria showed significant increases in resistance rates against certain antibiotics. Despite lower prescription levels of penicillin group antimicrobials compared to the European average, GNBs exhibited high average resistant rates, indicating the role of ESBL+ isolates in resistance rates. Constant vigilance and proper infection control measures are necessary to track emerging trends in AMR in GNBs.
Review
Medicine, Research & Experimental
Matteo Bassetti, Antonio Vena, Daniele Roberto Giacobbe, Nadia Castaldo
Summary: The article discusses the global increase in isolation of multidrug-resistant Gram-negative bacteria and the challenges in providing effective therapy using old antibiotics. It emphasizes the importance of establishing appropriate clinical and therapeutic recommendations for the antibiotic treatment of these pathogens.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Immunology
Sharon Ong'uti, Mary Czech, Elizabeth Robilotti, Marisa Holubar
Summary: Cefiderocol, a novel injectable siderophore cephalosporin, is effective against multidrug-resistant gram-negative bacteria by hijacking the bacterial iron transport system. It has broad-spectrum antibacterial activity, including against carbapenem-resistant and Acinetobacter baumannii strains.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Infectious Diseases
Lorenzo Chiusaroli, Cecilia Liberati, Maria Caseti, Luigi Rulli, Elisa Barbieri, Carlo Giaquinto, Daniele Dona
Summary: The treatment options and outcomes for MDR and XDR Gram-negative bacterial infections in neonates are heterogeneous and limited mainly to older antimicrobials. Newer drugs show promise but are not affordable for many low- and middle-income countries. Therefore, strategies need to be tailored according to the country's epidemiology and resources. More extensive studies are needed to include new antimicrobials and optimize combination strategies for the older ones.
Article
Infectious Diseases
Jose Raul Nieto-Saucedo, Luis Esau Lopez-Jacome, Rafael Franco-Cendejas, Claudia Adriana Colin-Castro, Melissa Hernandez-Duran, Luis Raul Rivera-Garay, Karina Senyase Zamarripa-Martinez, Juan Luis Mosqueda-Gomez
Summary: The prevalence of carbapenem-resistant Gram-negative bacilli (CR-GNB) and the frequency of carbapenemase-encoding genes were evaluated in a tertiary referral center in El Bajio, Mexico. Among 508 Gram-negative bacilli, 37 were carbapenem-resistant (7.3%), and only 15 (40.5%) of them carried carbapenemase-encoding genes.
Article
Medicine, General & Internal
Beata Maczynska, Magdalena Frej-Madrzak, Jolanta Sarowska, Krystyna Woronowicz, Irena Choroszy-Krol, Agnieszka Jama-Kmiecik
Summary: In recent years, the use and overuse of broad-spectrum antimicrobial agents have led to a growing drug resistance among bacteria. This study aimed to analyze the changes in drug resistance of Gram-negative Enterobacterales over five years. The evaluation of these data will help determine changes in susceptibility to antibiotics used in the hospital and propose new therapeutic options for severe infections. The analysis revealed that the number of multi-resistant K. pneumoniae strains has been increasing, possibly due to the widespread use of broad-spectrum antibiotics during the pandemic.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Mei-Chun Lee, Hsun Chang, Fang-Ju Sun, Alice Ying-Jung Wu, Chien -Hung Lu, Chun -Ming Lee
Summary: This study focuses on the association between carbapenem-resistant Enterobacteriales and antimicrobial consumption in Taiwan. The findings reveal an increase in the consumption of piperacillin/tazobactam, fluoroquinolones, meropenem, and doripenem, and a decrease in the consumption of aminoglycosides and imipenem/cilastatin. The prevalence of carbapenem-resistant Klebsiella pneumoniae (CRKP) rose over time and correlated positively with the consumption of certain antibiotics. Both CRKP and carbapenem-resistant Escherichia coli (CREC) prevalence were negatively correlated with aminoglycosides consumption.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Microbiology
Giancarlo Ceccarelli, Francesco Alessandri, Sonia Moretti, Alessandra Borsetti, Maria Teresa Maggiorella, Silvia Fabris, Alessandro Russo, Franco Ruberto, Daniele De Meo, Massimo Ciccozzi, Claudio M. Mastroianni, Mario Venditti, Francesco Pugliese, Gabriella D'Ettorre
Summary: This study assessed the risk factors for CR-GNB colonization and the clinical impact of colonization in severe trauma patients. The results showed a strong association between ICU stay duration, mechanical ventilation duration, previous colonization, and the risk of colonization. Additionally, factors such as higher comorbidity index and longer duration of treatment were associated with infection in colonized patients.
Article
Infectious Diseases
Wei-Chuan Liao, Chau-Hui Wang, Tzu-Hui Sun, Yu-Cheng Su, Chia-Hung Chen, Wen-Teng Chang, Po-Lin Chen, Yow-Ling Shiue
Summary: The encapsulated form of colistin, CCM-CL, showed improved safety and efficacy compared to free colistin in treating drug-resistant Pseudomonas aeruginosa infection. CCM-CL exhibited higher safe doses and drug concentrations, resulting in significantly higher survival rates in a mouse model of neutropenic pneumonia caused by carbapenem-resistant Pseudomonas aeruginosa.
Review
Pharmacology & Pharmacy
Chuanhai Wang, Deqing Yang, Yifan Wang, Wentao Ni
Summary: Cefiderocol is a promising powerful weapon for treating multidrug-resistant (MDR) infections, showing high in vitro and in vivo activity, especially against carbapenem-resistant isolates. Clinical trials have demonstrated its efficacy in treating complicated urinary tract infection and nosocomial pneumonia.
FRONTIERS IN PHARMACOLOGY
(2022)
