期刊
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
卷 54, 期 7, 页码 499-509出版社
WILEY
DOI: 10.1002/ajim.20952
关键词
breast cancer; case-control study; occupation; nurses; textile workers; farmers; agricultural workers; rubber and plastics product makers
资金
- Fondation de France [2004012618, 2007005156]
- Institut National du Cancer (INCa) [2007-1SPC2, 2008-1-CP-4, 2009-1-SHS SP-04]
- Association Pour la Recherche Contre le Cancer (ARC) [2008-1-CP-4]
- Agence Francaise de Securite Sanitaire de l'Environnement et du Travail (AFSSET) [ST-2005-003, ES12008/1/26, VS-2009-21]
- Ligue Contre le Cancer Grand Ouest
Background It has been suggested that certain occupational exposures may play a role in breast cancer etiology. The recognition of high-risk occupations may give clues about potential mammary carcinogens in the work place. Methods We conducted a population-based case-control study in France including 1,230 breast cancer cases and 1,315 population controls with detailed information on lifetime work history. Odds ratios for women ever employed in an occupation or industry were adjusted for well-established risk factors for breast cancer Results Adjusted odds ratios were marginally increased in some white-collar occupations, as well as in textile workers (2.4; 95% CI [0.9-6.0]), rubber and plastics product makers (1.8; 95% CI [0.9-3.5]), and in women employed for more than 10 years as nurses (1.4; 95% CI [0.9-2.1]) and as tailors/dressmakers (1.5; 95% CI [0.9-2.6]). The incidence of breast cancer was increased among women employed in the manufacture of chemicals, of non-metallic mineral products, and decreased among women in agriculture. Conclusions These findings suggest a possible role of occupational exposures in breast cancer including night-shift work, solvents and endocrine disrupting chemicals and require further studies with detailed assessment of occupational exposures. Am. J. Ind. Med. 54:499-509, 2011. (C) 2011 Wiley-Liss, Inc.
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