Review
Pharmacology & Pharmacy
Nathan S. Bryan
Summary: Hypertension is a global health crisis, and the loss of nitric oxide production is the primary contributor to its development. Strategies aimed at preventing the loss of nitric oxide production and restoring nitric oxide production have a significant impact on improving patients' health and controlling blood pressure.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Peter U. Amadi, Emmanuel N. Agomuo, Joy A. Amadi, Adaeze I. Bob-Chile Agada, Uche C. Njoku, Chinedu S. Ogunwa, Prince C. Odika, Justice O. Osuoha, Atieme J. Ogbolosingha, Chiamaka W. Adumekwe, Ifeyinwa N. Chigbu
Summary: This study suggests that using walnut as an adjuvant medication during hypertension treatment can significantly reduce LDLc levels, increase HDLc levels, and is associated with reduced activities of proprotein convertase subtilisin kexin 9 (PCSK9) and apolipoprotein E (APOE).
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Review
Medicine, General & Internal
Keisuke Narita, Satoshi Hoshide, Kazuomi Kario
Summary: Although various guidelines for cardiovascular disease prevention have been established, the optimal drug therapy is often not implemented due to poor medication adherence and clinical inertia. Polypill strategies, which include combination tablets of three or more medications, have been proven to be useful in preventing cardiovascular disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Arun Maharaj, Stephen M. Fischer, Katherine N. Dillon, Yejin Kang, Mauricio A. Martinez, Arturo Figueroa
Summary: This study found that L-CIT supplementation improves endothelial function and aortic blood pressure in hypertensive postmenopausal women through increased availability of L-ARG.
Review
Medicine, General & Internal
Setor K. Kunutsor, Jari A. Laukkanen
Summary: Sauna bathing is a long-standing tradition in Finnish culture and is associated with various health benefits such as reducing the incidence of diseases and improving overall well-being. The positive effects of sauna bathing are attributed to its properties such as blood pressure reduction, anti-inflammatory and antioxidant effects. Frequent sauna bathing may serve as a protective factor and enhance the effects of other healthy lifestyle factors. This review summarizes the epidemiologic and interventional evidence linking the combined effects of Finnish sauna bathing and other risk factors on vascular and nonvascular outcomes.
MAYO CLINIC PROCEEDINGS
(2023)
Article
Peripheral Vascular Disease
Jaejin An, Tiffany Luong, Lei Qian, Rong Wei, Ran Liu, Paul Muntner, Jeffrey Brettler, Marc G. Jaffe, Andrew E. Moran, Kristi Reynolds
Summary: The study found that patients who initiated ACEI-thiazide diuretic combination therapy were more likely to achieve BP goals compared with those who initiated monotherapy.
Article
Transplantation
Christian Ott, Felix Mahfoud, Giuseppe Mancia, Krzysztof Narkiewicz, Luis M. Ruilope, Martin Fahy, Markus P. Schlaich, Michael Bohm, Roland E. Schmieder
Summary: The blood pressure lowering effects of renal denervation (RDN) were compared between hypertensive patients with or without chronic kidney disease (CKD). The results showed that the reduction in 24-hour systolic and diastolic blood pressure was similar in both groups after RDN, but the reduction in office systolic blood pressure was less in patients with CKD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Peripheral Vascular Disease
Ji-Guang Wang, Biff F. Palmer, Katherine Vogel Anderson, Peter Sever
Summary: Hypertension is a major global health issue affecting billions of people. Amlodipine, a calcium channel blocker, has unique characteristics that make it an effective treatment option for hypertension. This review provides an updated overview of the evidence supporting the use of amlodipine and highlights its cardiovascular benefits.
JOURNAL OF CLINICAL HYPERTENSION
(2023)
Article
Nutrition & Dietetics
Giuseppe Grosso, Justyna Godos, Walter Currenti, Agnieszka Micek, Luca Falzone, Massimo Libra, Francesca Giampieri, Tamara Y. Forbes-Hernandez, Jose L. Quiles, Maurizio Battino, Sandro La Vignera, Fabio Galvano
Summary: This review examines the effects of dietary polyphenols on vascular health, blood pressure, and hypertension. Evidence suggests that certain polyphenol-rich foods, such as berries, cocoa, green tea, almonds, pistachios, and soy products, can improve blood pressure levels. However, there are limitations to consider, such as the variability of polyphenol content and absorption in plant-derived foods, as well as differences in dosages between animal and human studies.
Article
Biology
Tomas Jurko, Michal Mestanik, Andrea Mestanikova, Kamil Zelenak, Alexander Jurko
Summary: Endothelial dysfunction is a key pathomechanism in many diseases, including hypertension. This study assessed endothelial function in pediatric hypertensives using peripheral arterial tonometry (PAT), and found that the area under the curve of hyperemic response (AUC) was the only parameter sensitive to the effect of hypertension and significantly correlated with mean ambulatory monitored blood pressure.
Article
Cardiac & Cardiovascular Systems
Akihiro Honda, Nobuhiro Tahara, Atsuko Tahara, Munehisa Bekki, Shoko Maeda-Ogata, Yoichi Sugiyama, Sachiyo Igata, Yuri Nishino, Takanori Matsui, Seiji Kurata, Toshi Abe, Sho-ichi Yamagishi, Yoshihiro Fukumoto
Summary: This study aimed to investigate the mechanisms of anti-hypertensive drugs on improving vascular endothelial function in patients with essential hypertension. The results showed that olmesartan and amlodipine could improve endothelial function in different ways, the former by suppressing vascular inflammation and the latter by reducing blood pressure variability.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Jaewon Oh, Wonho Kim, Gee-Hee Kim, Hack-Lyoung Kim, Sang-Don Park, Kyung Wan Min, Dongkeun Hyun, Jun Hwa Hong, Soo Lim, Jinho Shin
Summary: This study assessed the real-world safety and effectiveness of an SPC containing olmesartan, amlodipine, and hydrochlorothiazide in South Korean patients with hypertension and cardiovascular risk factors. The results showed that the therapy led to a significant reduction in blood pressure and had a high control rate.
ADVANCES IN THERAPY
(2023)
Review
Nutrition & Dietetics
Monica Volino-Souza, Gustavo Vieira de Oliveira, Carlos Adam Conte-Junior, Arturo Figueroa, Thiago Silveira Alvares
Summary: L-arginine is crucial for nitric oxide synthesis and supplementation with its precursor L-citrulline, found in watermelon, can improve vascular function. However, there are differing findings on the effect of watermelon supplementation, possibly due to varying L-citrulline doses. Food technology can be applied to concentrate L-citrulline content and reduce volume for convenient ingestion. Watermelon-derived L-citrulline appears to be an effective supplementation for improving vascular health.
Article
Agriculture, Dairy & Animal Science
Darcy Adin, Clarke Atkins, Oliver Domenig, Catherine Glahn, Teresa Defrancesco, Kathryn Meurs
Summary: This study found that circulating RAAS is activated in systemically hypertensive cats receiving amlodipine. This suggests that the use of concurrent RAAS-suppressant therapy might be indicated in amlodipine-treated SHT cats with chronic kidney disease.