Article
Peripheral Vascular Disease
Ryan J. Pewowaruk, Claudia Korcarz, Yacob Tedla, Gregory Burke, Philip Greenland, Colin Wu, Adam D. Gepner
Summary: By analyzing the data from the Multi-Ethnic Study of Atherosclerosis, it was found that load-dependent stiffness was significantly associated with the incidence of cardiovascular disease (CVD) events, while structural stiffness was not.
Article
Peripheral Vascular Disease
Xue Tian, Yingting Zuo, Shuohua Chen, Yijun Zhang, Xiaoli Zhang, Qin Xu, Shouling Wu, Anxin Wang
Summary: This study investigated the association between different blood pressure and arterial stiffness status with diabetes. The results showed that both hypertension and arterial stiffness were associated with diabetes. Additionally, arterial stiffness had a better predictive ability for diabetes than hypertension.
Article
Clinical Neurology
Tanya N. Turan, Osama O. Zaidat, Gary S. Gronseth, Marc Chimowitz, Antonio Culebras, Anthony J. Furlan, Larry B. Goldstein, Nestor R. Gonzalez, Julius G. Latorre, Steven R. Messe, Thanh N. Nguyen, Rajbeer S. Sangha, Michael J. Schneck, Aneesh B. Singhal, Lawrence R. Wechsler, Alejandro A. Rabinstein, Mary Dolan O'Brien, Heather Silsbee, Jeffrey J. Fletcher
Summary: This study reviewed treatments for reducing the risk of recurrent stroke or death in patients with symptomatic intracranial atherosclerotic arterial stenosis (sICAS). The major recommendations include prescribing aspirin and clopidogrel for long-term prevention of stroke, recommending high-intensity statin therapy, maintaining target blood pressure levels, engaging in regular physical activity, and treating other modifiable vascular risk factors. The study also advises against certain procedures such as angioplasty and stenting for stroke prevention in moderate or severe sICAS patients.
Article
Cardiac & Cardiovascular Systems
Pierre Boutouyrie, Phil Chowienczyk, Jay D. Humphrey, Gary F. Mitchell
Summary: Arterial stiffness is a key marker of risk in hypertension, and can be measured at material or structural levels. Studies have shown that structural stiffness predicts outcomes, with elastic arteries being most sensitive to blood pressure and age. Stiffness is considered an index of vascular aging and affects brain, kidneys, and heart function. Reduction of stiffness through antihypertensive treatments and preventive drugs may have additional benefits beyond lowering blood pressure. Newer anti-inflammatory drugs also have effects on stiffness independent of blood pressure.
CIRCULATION RESEARCH
(2021)
Article
Peripheral Vascular Disease
Enrique Rodilla, Maria Dolores Lopez-Carmona, Xavi Cortes, Lidia Cobos-Palacios, Sergio Canales, Maria Carmen Saez, Samara Campos Escudero, Manuel Rubio-Rivas, Jesus Diez Manglano, Santiago J. Freire Castro, Nuria Vazquez Piqueras, Elisabeth Mateo Sanchis, Paula Maria Pesqueira Fontan, Jeffrey Oskar Magallanes Gamboa, Andres Gonzalez Garcia, Victor Madrid Romero, Lara Tamargo Chamorro, Julio Gonzalez Moraleja, Javier Villanueva Martinez, Amara Gonzalez Noya, Ana Suarez-Lombrana, Anyuli Gracia Gutierrez, Manuel Lorenzo Lopez Reboiro, Jose Manuel Ramos Rincon, Ricardo Gomez Huelgas
Summary: This study analyzed the association between arterial stiffness (AS) and all-cause mortality in COVID-19 patients, finding that AS and systolic blood pressure <120 mm Hg independently predicted in-hospital all-cause mortality after adjusting for other factors.
Article
Peripheral Vascular Disease
Zhe Zhou, Ai-Jun Xing, Jian-Ning Zhang, Wen-Hao Xia, Chen Su, Shi-Yue Xu, Xiao-Yu Zhang, Shuo-Hua Chen, Zhe Huang, Xiao-Xian Qian, Shou-Ling Wu, Jun Tao
Summary: The combination of hypertension and elevated arterial stiffness (AS) is independently associated with a higher risk of clinical outcomes such as stroke, myocardial infarction, and death. Individuals with both hypertension and elevated AS have a much higher risk compared to those with ideal vascular function or hypertension with normal AS. Controlling both hypertension and AS may help reduce the risk of clinical events.
Article
Peripheral Vascular Disease
Philippe Gosse, Romain Boulestreau, Julien Doublet, Stephane Laurent, Antoine Cremer
Summary: Arterial stiffness is a key predictor of cardiovascular events and has two components: one related to the blood pressure at the time of measurement, and the other related to the long-term effects of cardiovascular risk factors, including blood pressure. This study aims to investigate the relationship between QKD(100-60), an index of arterial stiffness, and 24-hour blood pressure in different groups of patients. The results show that QKD(100-60) is independent of 24-hour blood pressure in normal and treated hypertensive patients, but weakly related to it in untreated hypertensive patients with long-term arterial damage caused by high blood pressure.
JOURNAL OF HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Alec Saunders, Gani N. Nuredini, Frances A. Kirkham, Erin Drazich, Eva Bunting, Philip Rankin, Khalid Ali, Michael Okorie, Chakravarthi Rajkumar
Summary: This study reveals a relationship between white-coat hypertension/effect (WCH/E) and markers of cardiovascular risk and cerebrovascular events. Patients with WCH/E have higher arterial stiffness and a higher prevalence of lacunar strokes.
JOURNAL OF HYPERTENSION
(2022)
Review
Cardiac & Cardiovascular Systems
Alicia Saz-Lara, Rosa Maria Bruno, Ivan Cavero-Redondo, Celia Alvarez-Bueno, Blanca Notario-Pacheco, Vicente Martinez-Vizcaino
Summary: This systematic review and meta-analysis found that arterial stiffness, systolic blood pressure, and diastolic blood pressure are associated with incident hypertension. These findings are clinically important for the prevention of arterial hypertension and reducing cardiovascular morbidity and mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Tanja Dragun, Courtney V. Brown, Mikko P. Tulppo, Ante Obad, Zeljko Dujic
Summary: Studies have shown that cannabidiol may reduce blood pressure and arterial stiffness in normotensive individuals, but its effects on those with untreated hypertension are still unclear. This study aimed to investigate the influence of cannabidiol on 24-hour ambulatory blood pressure and arterial stiffness in hypertensive individuals. The results demonstrated that oral cannabidiol significantly lowered arterial stiffness, systolic blood pressure, and mean arterial pressure over 24 hours compared to placebo. However, further research is needed to determine the clinical implications and long-term safety of cannabidiol in treating hypertension.
ADVANCES IN THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Juraj Jug, Didi Delalic, Valerija Bralic Lang, Tomislav Bulum, Ingrid Prkacin
Summary: This study aimed to compare the pulse wave velocity (PWV) values in subjects with prediabetes, non-dipper profile, and arterial hypertension with their values in healthy subjects. The results showed that subjects with prediabetes and non-dipping profiles had significantly higher PWV values. Age, blood pressure, nocturnal indices, and fasting plasma glucose were identified as independent predictors of PWV values. These findings highlight the importance of prediabetes and non-dipping hypertension as factors contributing to increased PWV.
Article
Peripheral Vascular Disease
Kees M. van Hespen, Claire Mackaaij, Ingeborg S. E. Waas, Marloes P. de Bree, Jaco J. M. Zwanenburg, Hugo J. Kuijf, Mat J. A. P. Daemen, Jeroen Hendrikse, Dorien M. A. Hermkens
Summary: This study aimed to quantify arterial remodeling in intracranial arteries of individuals with and without a history of hypertension using MRI and histological analysis. The results showed no significant differences in vessel wall thickness and area between both groups, but arterial wall stiffness was significantly higher in the internal carotid artery of the hypertensive group. Histological analysis revealed differences in arterial wall composition for the internal carotid artery.
Article
Peripheral Vascular Disease
Hirofumi Tomiyama, Takumi Imai, Kazuki Shiina, Yukihito Higashi, Hiroki Nakano, Takamichi Takahashi, Masatsune Fujii, Chisa Matsumoto, Akira Yamashina, Taishiro Chikamori
Summary: This study examines the association of cardiovascular risk factors (CVRFs) with the rate of progression of arterial stiffness based on long-term repeated measurements. Smoking, heavy alcohol intake, hypertension, diabetes, hypertriglyceridemia, and hyperuricemia were found to be independently associated with a fast progression of arterial stiffness, while lower values in certain biomarkers were associated with a slow progression. The findings highlight the importance of early interventions to control CVRFs in maintaining arterial health.
Article
Peripheral Vascular Disease
Athanasia Chainoglou, Kosmas Sarafidis, Katerina Chrysaidou, Evangelia Farmaki, Konstantinos Kollios, Marina Economou, Vasilios Kotsis, Stella Stabouli
Summary: Preterm birth is associated with higher nocturnal blood pressure and increased arterial stiffness in childhood and adolescence. Increased awareness for detection of hypertension and prevention of obesity in childhood could prevent future adverse cardiovascular outcomes in preterm individuals.
JOURNAL OF HYPERTENSION
(2022)
Article
Cardiac & Cardiovascular Systems
Muhammad Ahmer Wali, Valeria Raparelli, Louise Pilote, Stella S. Daskalopoulou
Summary: The study found that abnormal blood pressure variability, especially night non-dipping, is common in normotensive perimenopausal women. Maximum overnight blood pressure is significantly associated with arterial stiffness, which can be used to identify women at higher cardiovascular risk.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Neurosciences
Huawei Lin, Tingting Jin, Lewen Chen, Yaling Dai, Weiwei Jia, Xiaojun He, Minguang Yang, Jianhong Li, Shengxiang Liang, Jinsong Wu, Jia Huang, Lidian Chen, Weilin Liu, Jing Tao
Summary: The study revealed that chronic cerebral ischemia leads to neurochemical metabolic disorders impacting working memory and object recognition memory, with impaired NAA, Glu, mI, and Cho metabolism in different brain regions. Optogenetics modulation of PV neurons in the mPFC can improve these metabolic abnormalities and enhance working memory.
BRAIN RESEARCH BULLETIN
(2021)
Article
Environmental Sciences
Shih-Hua Fang, Chi-Cheng Lu, Hua-Wei Lin, Kuan-Chen Kuo, Chen-Yu Sun, Yi-Ying Chen, Wen-Dien Chang
Summary: This study examines the acute effects of nicotine gum on physiological responses and sports performance in baseball players. The results show that chewing nicotine gum can induce changes in endocrine and sympathetic nerve activity, enhance cognitive function and baseball-hitting performance, but does not increase muscle strength.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Hospitality, Leisure, Sport & Tourism
Huawei Lin, Jiayong Zhang, Yaling Dai, Huanhuan Liu, Xiaojun He, Lewen Chen, Jing Tao, Chaohui Li, Weilin Liu
Summary: This study aims to investigate the role of neurogranin (Ng) in swimming training to improve cognitive impairment caused by chronic cerebral hypoperfusion (CCH). The results showed that swimming training can enhance hippocampal synaptic plasticity by regulating the expression of Ng, thereby ameliorating the spatial memory impairment of vascular cognitive impairment.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2023)
Article
Neurosciences
Weilin Liu, Jianhong Li, Le Li, Yuhao Zhang, Minguang Yang, Shengxiang Liang, Long Li, Yaling Dai, Lewen Chen, Weiwei Jia, Xiaojun He, Huawei Lin, Jing Tao
Summary: Memory generalization is crucial for cognitive flexibility. In Alzheimer's disease, the impairment of generalization leads to deficits in episodic memory, but cognitive training can enhance memory generalization through improving brain function and metabolism.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Weilin Liu, Jianhong Li, Minguang Yang, Xiaohua Ke, Yaling Dai, Huawei Lin, Sinuo Wang, Lidian Chen, Jing Tao
Summary: The degeneration of the cholinergic circuit from the basal forebrain to the hippocampus contributes to memory loss in Alzheimer's disease patients. Activation of the cholinergic circuit using chemical genetics improves learning and memory function in APP/PS1 mice models. Levels of choline in the basal forebrain and N-acetyl aspartate in the hippocampus could serve as biomarkers for early diagnosis of AD.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Cell Biology
Yaling Dai, Yuhao Zhang, Minguang Yang, Huawei Lin, Yulu Liu, Wenshan Xu, Yanyi Ding, Jing Tao, Weilin Liu
Summary: This study demonstrates that electroacupuncture (EA) treatment can improve cognitive function in rats with vascular cognitive impairment (VCI) by enhancing the synaptic transmission efficiency and plasticity of the hippocampal CA3-CA1 circuit.
MEDIATORS OF INFLAMMATION
(2022)
Article
Engineering, Electrical & Electronic
Lei Ge, Huawei Lin, Yuan Ji, Kam-Weng Tam, Yue Zhao
Summary: Self-decoupling coupled-fed patch antennas are designed, which achieve high isolation between elements without additional decoupling structures based on a weak-field region formed by the T-shaped probe feed and the radiating patch. Dual-element antenna array and four-element MIMO linear antenna array are built to validate the decoupling mechanism, obtaining better than 30 dB isolation over the impedance band of 3.3-3.66 GHz and demonstrating the suitability for 5G MIMO applications.
ELECTRONICS LETTERS
(2023)
Review
Neurosciences
Peiyuan Zhuo, Lianhong Huang, Miaoran Lin, Jie Chen, Yaling Dai, Minguang Yang, Huawei Lin, Jingfang Zhu, Jia Huang, Weilin Liu, Jing Tao
Summary: This study found that acupuncture combined with rehabilitation therapy has significant therapeutic effects on poststroke cognitive impairment based on the analysis of 18 randomized controlled trials. These findings suggest that acupuncture combined with rehabilitation therapy may be more effective than rehabilitation therapy alone, and it is worth promoting in the treatment of poststroke cognitive impairment.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Nanoscience & Nanotechnology
Huawei Lin, Qin Su, Ruixi Mao, Qian Cheng, Deliang Zhu, Shun Han, Ming Fang, Wenjun Liu, Peijiang Cao, Youming Lu, Dnyandeo Pawar
Summary: A super-high-performance self-powered ultraviolet photodetector, based on p-GaN/a-Ga2O3 p-n heterojunction, was fabricated by growing nanoscale-thick films of n-type a-Ga2O3 on p-type GaN film using magnetron sputtering at room temperature. This device exhibited a self-powered effect and dual-band UV detection capability, showing exceptional photodetection performance.
ACS APPLIED NANO MATERIALS
(2023)
Article
Biology
Yaling Dai, Sinuo Wang, Minguang Yang, Peiyuan Zhuo, Yanyi Ding, Xiaoling Li, Yajun Cao, Xiaoqin Guo, Huawei Lin, Jing Tao, Lidian Chen, Weilin Liu
Summary: This study found that electroacupuncture treatment has protective effects on vascular cognitive impairment (VCI) by enhancing BOLD signal in the hippocampus and entorhinal cortex. The miR-219a gene plays a crucial role in regulating VCI, and inhibiting miR-219a can improve VCI and enhance learning and memory.
BIOLOGICAL RESEARCH
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Chi-Hou Chio, Roberto Gomez-Garcia, Kam-Weng Tam, HuaWei Lin, Cheng Teng, WenHai Zhang
Summary: The design of a microwave angular-displacement sensor based on group-delay variation is discussed. The sensor utilizes the spectral phase-slope variation of its transfer function by altering the frequency separation. A microstrip prototype of the sensor is manufactured and evaluated for experimental validity, demonstrating high sensitivity and dynamic range.
2022 IEEE MTT-S INTERNATIONAL MICROWAVE WORKSHOP SERIES ON ADVANCED MATERIALS AND PROCESSES FOR RF AND THZ APPLICATIONS, IMWS-AMP
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Huawei Lin, Yin Li, Sai-Wai Wong, Baiyang Liu, Shahid Iqbal, Cheng Teng, Kam Weng Tam
Summary: A new frequency selective surface with a wide passband and wide rejection band, suitable for dual-polarized applications and low profile, is proposed.
2022 IEEE MTT-S INTERNATIONAL MICROWAVE WORKSHOP SERIES ON ADVANCED MATERIALS AND PROCESSES FOR RF AND THZ APPLICATIONS, IMWS-AMP
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Yijun Ye, Huawei Lin, Pedro Cheong, Wai-Wa Choi
Summary: This paper proposes a microstrip-based parasitic element decoupling structure for designing a high-isolation patch antenna array. By adding the decoupling structure, the isolation between the antennas is increased, and the radiation pattern of the antenna is improved.
2022 CROSS STRAIT RADIO SCIENCE & WIRELESS TECHNOLOGY CONFERENCE, CSRSWTC
(2022)
Review
Cell Biology
Wei-Lin Liu, Hua-Wei Lin, Miao-Ran Lin, Yan Yu, Huan-Huan Liu, Ya-Ling Dai, Le-Wen Chen, Wei-Wei Jia, Xiao-Jun He, Xiao-Ling Li, Jing-Fang Zhu, Xie-Hua Xue, Jing Tao, Li-Dian Chen
Summary: Blood exosomes, as noninvasive tools for monitoring brain physiology and disease states, are emerging as potential biomarkers for preclinical and clinical Alzheimer's disease. This study conducted a meta-analysis and systematic review to comprehensively analyze the diagnostic performance of blood exosome biomarkers in preclinical Alzheimer's disease, mild cognitive impairment, and Alzheimer's disease.
NEURAL REGENERATION RESEARCH
(2022)
Review
Cell Biology
Wei-Lin Liu, Hua-Wei Lin, Miao-Ran Lin, Yan Yu, Huan-Huan Liu, Ya-Ling Dai, Le-Wen Chen, Wei-Wei Jia, Xiao-Jun He, Xiao-Ling Li, Jing-Fang Zhu, Xie-Hua Xue, Jing Tao, Li-Dian Chen
Summary: Blood exosomes, extracellular vesicles secreted by living cells, can be used as a noninvasive tool for monitoring brain physiology and diseases. A meta-analysis and systematic review of blood exosome biomarkers in preclinical Alzheimer's disease, mild cognitive impairment, and Alzheimer's disease revealed increased levels of core biomarkers and other molecules related to risk factors. These findings support the development of exosome biomarkers for clinical blood tests for Alzheimer's disease.
NEURAL REGENERATION RESEARCH
(2022)