Article
Peripheral Vascular Disease
Arnaud D. Kaze, Solomon K. Musani, Aurelian Bidulescu, Adolfo Correa, Alain G. Bertoni, Rexford S. Ahima, Sherita H. Golden, Marwah Abdalla, Justin B. Echouffo-Tcheugui
Summary: This study found an association between plasma leptin levels and blood pressure progression in Blacks, suggesting that leptin concentrations may help identify individuals at risk for hypertension and guide prevention and management strategies.
Article
Endocrinology & Metabolism
Martha Hanschkow, Nathalie Boulet, Elena Kempf, Anne Bouloumie, Wieland Kiess, Robert Stein, Antje Korner, Kathrin Landgraf
Summary: MSCA1 and CD36 are associated with obesity-related alterations in children's adipose tissue, with CD36 expression predicting the adipogenic potential of SVF cells.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Yair Pincu, Uri Yoel, Yulia Haim, Nataly Makarenkov, Nitzan Maixner, Ruthy Shaco-Levy, Nava Bashan, Dror Dicker, Assaf Rudich
Summary: Obesity is a heterogeneous condition that affects patients' lives and health in different ways. Most current approaches to treat obesity do not consider individual obesity subtypes or predicted health risks. Adipose tissue is noticeably affected in obesity, and the extent of adipose tissue changes correspond to the severity of obesity-related complications. Assessing adipose tissue disease (OrAD) provides an opportunity for personalized anti-obesity management and predicting future endpoints and treatment response.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Md Shamim Rahman, Heejin Jun
Summary: This review explains the impact of fat types and tissue microenvironment on energy expenditure, focusing on the role and regulation of macrophages in adaptive thermogenic fat.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kathrin Landgraf, Andreas Kuhnapfel, Maria Schlanstein, Ronald Biemann, Berend Isermann, Elena Kempf, Holger Kirsten, Markus Scholz, Antje Korner
Summary: This study found that childhood obesity is associated with dysfunction and early signs of metabolic disease in adipose tissue. By analyzing gene expression profiles in adipose tissue samples from obese children, the researchers identified genes that are associated with obesity and related parameters. They also discovered that EGFL6 gene may play a role in the pathogenesis of metabolic disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Sufen Wang, Yifan Liu, Jiaqi Chen, Yuejing He, Wanrui Ma, Xinguang Liu, Xuerong Sun
Summary: Adipocytes have important roles in regulating nutrition, energy balance, metabolism, hormone secretion, and immune regulation. Different types of adipocytes contribute differently to the body, with white adipocytes storing energy, brown adipocytes generating heat, and beige adipocytes having the potential to produce heat.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Christy M. Gliniak, Line Pedersen, Philipp E. Scherer
Summary: The prevalence of obesity is increasing exponentially worldwide. The lack of effective long-term weight loss treatment options has made the problem even more significant. Research has shown that adipose tissue has a biological memory, which is a crucial determinant of long-term weight maintenance. Maladaptive cellular responses in adipose tissue lead to inflammation and fibrosis, explaining the link between obesity and insulin resistance, type 2 diabetes, cardiovascular disease, and fatty liver disease.
JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Cell Biology
Ursula White
Summary: White adipose tissue (WAT) expansion plays a crucial role in metabolic health, and impaired WAT expansion can lead to metabolic disorders. While increased hyperplasia is considered important for healthy WAT expansion, the role of adipogenesis remains debated. This mini-review will summarize recent developments and highlight the significance of WAT expansion in obesity and disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Medicine, General & Internal
Oscar Osorio-Conles, Josep Vidal, Ana de Hollanda
Summary: Bariatric surgery is the most effective intervention for significant and sustained weight loss in severe obesity, as it can improve white adipose tissue function beyond reducing fat depot sizes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell Biology
Qian Li, Kirsty L. Spalding
Summary: Adipocytes undergo extensive cytoskeletal remodeling to accommodate their dramatic morphological changes. Cell growth-related signaling pathways are activated to meet the increasing cellular needs. Continued expansion of adipocytes can lead to metabolic dysfunction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Hong-Jin Chen, Ting Meng, Ping-Jin Gao, Cheng-Chao Ruan
Summary: BAT, primarily composed of brown adipocytes and stromal vascular fraction, plays a crucial role in regulating cardiovascular health and diseases. It enhances energy expenditure by promoting glucose and lipid metabolism and secreting adipokines in an autocrine and/or paracrine fashion to protect the cardiovascular system.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Physiology
Hongbing Song, Xiaohan Zhang, Jing Wang, Yanling Wu, Taimin Xiong, Jieqiong Shen, Ruiyi Lin, Tianfang Xiao, Weimin Lin
Summary: Adipose tissue is crucial for maintaining energy balance and dysfunctional adipose tissue is linked to obesity-related metabolic diseases. Mitochondria in adipocytes play a key role in energy metabolism and interact with other organelles to regulate metabolic processes and reduce the occurrence of obesity-related diseases.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mascha Koenen, Michael A. Hill, Paul Cohen, James R. Sowers
Summary: Cardiovascular diseases, as the leading cause of death worldwide, are strongly associated with overweight and obesity, which contribute to vascular dysfunction and cardiovascular diseases. The abnormal remodeling of specific adipose tissue depots during obesity plays a critical role in the development of hypertension, endothelial dysfunction, and vascular stiffness, with fat distribution being a key determinant of the risk for cardiovascular diseases.
CIRCULATION RESEARCH
(2021)
Article
Nutrition & Dietetics
Carlos A. Ibanez, Gabriela Lira-Leon, Luis A. A. Reyes-Castro, Guadalupe L. Rodriguez-Gonzalez, Consuelo Lomas-Soria, Alejandra Hernandez-Rojas, Eyerahi Bravo-Flores, Juan Mario Solis-Paredes, Guadalupe Estrada-Gutierrez, Elena Zambrano
Summary: We investigated the effects of maternal obesity on adipocyte size distribution and gene expression in offspring. It was found that retroperitoneal adipose tissue expansion and metabolic dysfunction differed between male and female offspring. The expression of pro-adipogenic genes and insulin signaling were reduced in males, while lipid mobilization-related genes were reduced in females.
Article
Endocrinology & Metabolism
Agne Kulyte, Alisha Aman, Rona J. Strawbridge, Peter Arner, Ingrid A. Dahlman
Summary: Interindividual differences in the generation of new fat cells are associated with body fat and type 2 diabetes risk. This study identified several genetic loci and candidate genes, including SPATS2L, KCTD18, RPL8, HSD17B12, and PEPD, that are potentially important in controlling fat cell numbers, body fat size, and diabetes risk.
Article
Pediatrics
Sachiyo Fukushima, Nobuto Nakanishi, Kazumichi Fujioka, Kenichi Suga, Taku Shirakawa, Kayo Osawa, Kanako Hara, Rie Tsutsumi, Maki Urushihara, Ryuji Nakagawa, Hiroyuki Awano, Jun Oto, Hiroshi Sakaue, Kazumoto Iijima, Masafumi Matsuo
Summary: This study investigated the changes in urinary titin N-fragment levels in infants with postmenstrual age, revealing an exponential decline with postmenstrual age and a significant increase in catabolic state in preterm infants.
PEDIATRIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Kana Beppu, Rie Tsutsumi, Satoshi Ansai, Nana Ochiai, Mai Terakawa, Marie Mori, Masashi Kuroda, Kazuki Horikawa, Takumi Tomoi, Joe Sakamoto, Yasuhiro Kamei, Kiyoshi Naruse, Hiroshi Sakaue
Summary: This study established an engineered strain of medaka that allows direct visualization of taste receptor expression and identified potential therapeutic agents for dysgeusia. The findings provide new insights and tools for the treatment of taste disorders.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Pediatrics
Motoki Katsube, Shigehito Yamada, Natsuko Utsunomiya, Naoki Morimoto
Summary: The face is a small complex three-dimensional structure composed of various bones and essential organs. Geometric morphometrics (GM) uses shape configurations to retain geometric information and help visualize results, making it advantageous in morphometric studies of congenital facial anomalies.
CONGENITAL ANOMALIES
(2022)
Article
Immunology
Hirofumi Tenshin, Jumpei Teramachi, Mohannad Ashtar, Masahiro Hiasa, Yusuke Inoue, Asuka Oda, Kotaro Tanimoto, So Shimizu, Yoshiki Higa, Takeshi Harada, Masahiro Oura, Kimiko Sogabe, Tomoyo Hara, Ryohei Sumitani, Tomoko Maruhashi, Mayu Sebe, Rie Tsutsumi, Hiroshi Sakaue, Itsuro Endo, Toshio Matsumoto, Eiji Tanaka, Masahiro Abe
Summary: LLZ can alleviate inflammation and bone destruction in rheumatoid arthritis by inhibiting the formation and activation of NLRP3 inflammasome and suppressing the production of TNF-alpha and IL-6.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Takahiro Seki, Yunlong Yang, Xiaoting Sun, Sharon Lim, Sisi Xie, Ziheng Guo, Wenjing Xiong, Masashi Kuroda, Hiroshi Sakaue, Kayoko Hosaka, Xu Jing, Masahito Yoshihara, Lili Qu, Xin Li, Yuguo Chen, Yihai Cao
Summary: Exposure to cold conditions inhibits the growth of various types of solid tumors by decreasing blood glucose and impeding glycolysis-based metabolism in cancer cells. Cold exposure also reduces glucose uptake in tumor tissue. These findings provide a new concept and paradigm for cancer therapy using a simple and effective approach.
Article
Multidisciplinary Sciences
Bingzi Dong, Masahiro Hiasa, Yoshiki Higa, Yukiyo Ohnishi, Itsuro Endo, Takeshi Kondo, Yuichi Takashi, Maria Tsoumpra, Risa Kainuma, Shun Sawatsubashi, Hiroshi Kiyonari, Go Shioi, Hiroshi Sakaue, Tomoki Nakashima, Shigeaki Kato, Masahiro Abe, Seiji Fukumoto, Toshio Matsumoto
Summary: In this study, the authors identify interleukin-11 as a mediator of bone-adipose crosstalk during mechanical loading of the bone. They demonstrate that interleukin-11 secreted by the bone controls both osteogenesis and systemic adiposity in response to mechanical loading. The findings provide important insights into the understanding of osteoporosis and metabolic syndromes.
NATURE COMMUNICATIONS
(2022)
Article
Cell & Tissue Engineering
Takashi Nakano, Michiharu Sakamoto, Yasuhiro Katayama, Yoshihiro Shimizu, Masukazu Inoie, Yuanjiaozi Li, Hiroki Yamanaka, Itaru Tsuge, Susumu Saito, Naoki Morimoto
Summary: Autologous cultured epidermis (CE) is an effective approach for treating extensive burns, but its production time is too long. Allogeneic CE can be prepared in advance and used as a wound dressing to promote wound healing. Dried CE, prepared by removing all water and viable cells, accelerates wound healing and may be a new therapeutic strategy. This study evaluated the safety and efficacy of dried CE in wound healing using a miniature swine model.
REGENERATIVE THERAPY
(2023)
Article
Surgery
Shinsuke Akita, Hiraku Kumamaru, Hisashi Motomura, Nobuyuki Mitsukawa, Naoki Morimoto, Minoru Sakuraba
Summary: This study analyzed data from 19,482 free-flap surgeries performed at 407 facilities in Japan and found that free-flap surgeries performed at institutions with a low average annual number of procedures had a higher risk of total necrosis. It is recommended to either aggregate cases into high-volume centers or improve management at low-volume centers.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Letter
Surgery
Itaru Tsuge, Nobuyuki Mitsukawa, Takane Suzuki, Shinsuke Akita, Yoshimichi Imai, Koichi Omori, Naoki Morimoto
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Surgery
Itaru Tsuge, Maria Chiara Munisso, Tomoko Kosaka, Ayako Takaya, Yoshihiro Sowa, Chang Liu, Goshiro Yamamoto, Susumu Saito, Naoki Morimoto
Summary: This study successfully visualized subcutaneous arteries using photoacoustic tomography and compared the results with intraoperative fluorescence angiography, with a matching rate of 71.3-82.1%. The results of this study demonstrate that photoacoustic tomography can aid in selecting perforators for abdominal flap surgery.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Cell & Tissue Engineering
Takashi Nakano, Hiroki Yamanaka, Michiharu Sakamoto, Itaru Tsuge, Yasuhiro Katayama, Susumu Saito, Jiro Ono, Tetsuji Yamaoka, Naoki Morimoto
Summary: This study successfully developed a self-assembled, cell-based dermal substitute derived from human dermal fibroblasts through long-term three-dimensional culture. The scaffold-free cultured dermis exhibited superior properties, such as sufficient tensile strength, high biocompatibility, and efficacy in promoting wound healing when compared to the collagen-based artificial dermis.
TISSUE ENGINEERING PART A
(2023)
Article
Nutrition & Dietetics
Takahiro Kato, Satoshi Kamiya, Soshi Narasaki, Ayako Sumii, Yasuo M. Tsutsumi, Kyoka Machida, Kanako Hara, Yuna Izumi-Mishima, Rie Tsutsumi, Hiroshi Sakaue
Summary: The consumption of partially hydrolyzed guar gum (PHGG) can improve the gut environment, alleviate the negative effects of H1N1 influenza virus infection, by promoting the production of short-chain fatty acids (SCFAs), inhibiting the increase of inflammatory cytokines, and enhancing natural killer cell activity and regulatory T-cell differentiation.
Article
Cell & Tissue Engineering
Qiannan Zhao, Shuichi Ogino, Sunghee Lee, Yuki Kato, Yuanjiaozi Li, Michiharu Sakamoto, Hiroki Yamanaka, Takashi Nakano, Eiichi Sawaragi, Naoki Morimoto
Summary: Poly-L-lactic acid (PLLA) mesh implants combined with collagen sponge (CS) were replaced with autologous adipose tissue for regeneration. The study compared different combinations of external frames (P (LA/CL), PLLA, LMWPLLA) and internal fillings (PGA nanosheets, CS) and found that PLLA served as a promising external frame material while PGA nanosheets were an effective alternative internal filling material for adipose tissue regeneration.
REGENERATIVE THERAPY
(2023)
Article
Cell & Tissue Engineering
Motoki Katsube, Natsuko Utsunomiya, Yasuhiro Katayama, Hiroki Yamanaka, Itaru Tsuge, Yoshihiro Sowa, Michiharu Sakamoto, Naoki Morimoto
Summary: This study demonstrates that the use of bFGF-CGS in primary palatoplasty can significantly reduce the occurrence of post-operative oronasal fistulas.
REGENERATIVE THERAPY
(2023)
Article
Medicine, Research & Experimental
Yuya Ikezumi, Yasushi Matsuura, Teruhiro Morishita, Noriko Ide, Isao Kitada, Takafumi Katayama, Rie Tsutsumi, Hiroshi Sakaue, Yutaka Taketani, Koichi Sairyo, Eiji Takeda
Summary: This study examined the changes in serum 25-hydroxyvitamin D (25(OH)D) levels after daily intake of 1000 IU vitamin D for 3 months, 6 months, and then a cessation of vitamin D intake for 6 months. The results showed a significant increase in serum 25(OH)D levels after 3 months of intake, maintenance of higher levels after 6 months of intake, and a decrease after 6 months of cessation. The study suggests that a daily intake of 1000 IU vitamin D can maintain higher levels of 25(OH)D without causing vitamin D intoxication.
JOURNAL OF MEDICAL INVESTIGATION
(2022)
