Article
Critical Care Medicine
Samuel T. Kuna, David M. Reboussin, Elsa S. Strotmeyer, Richard P. Millman, Gary Zammit, Michael P. Walkup, Thomas A. Wadden, Rena R. Wing, F. Xavier Pi-Sunyer, Adam P. Spira, Gary D. Foster
Summary: Intensive lifestyle intervention for weight loss can lead to reduced severity of obstructive sleep apnea in individuals with type 2 diabetes mellitus, and this improvement can be sustained over a 10-year period. The amount of weight loss is related to the improvement in OSA severity, and ILI may play a significant role in this improvement.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Clinical Neurology
Le Wang, Dong-hui Wei, Jing Zhang, Jie Cao
Summary: The aim of this study was to investigate the distribution of the percentage of cumulative time with oxygen saturation below 90% in total sleep time (T90) in obstructive sleep apnea (OSA) patients with similar severity and evaluate its relationship with hypertension. The study found that OSA patients with similar severity of apnea hypopnea index (AHI) may have different T90 values, especially in severe cases. After adjusting for traditional risk factors, a higher T90 was independently associated with an increased risk of hypertension in patients with severe OSA.
NATURE AND SCIENCE OF SLEEP
(2022)
Article
Psychiatry
Xuan Zhang, Ning Zhang, Yang Yang, Shuo Wang, Ping Yu, Bo-Yuan Guan, Chun-Xue Wang
Summary: This retrospective study explored the characteristics and treatment status of obstructive sleep apnea (OSA) patients with hypertension. The study found that patients in the severe group had higher BMI, higher N1% and lower N2%, average, and minimum blood oxygen. The acceptance of titration therapy among OSA patients with hypertension was low.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Adrian Ujin Yap, Madeleine Wan Yong Tan, Sharon Hui Xuan Tan, Ai Ping Chua
Summary: This study examined the temporal relationships between apnea-hypopnea (AH) and sleep bruxism (SB) events and their correlation with respiratory/sleep indexes in patients with obstructive sleep apnea (OSA) and SB. The majority of AH events were unrelated to SB events. When they were related, SB events often occurred after AH events, indicating a specific form of secondary SB triggered by sleep micro-arousals. SB events were associated with total sleep time, but not with the AH index.
CLINICAL ORAL INVESTIGATIONS
(2023)
Review
Health Care Sciences & Services
Sy Duong-Quy, Hoang Nguyen-Huu, Dinh Hoang-Chau-Bao, Si Tran-Duc, Lien Nguyen-Thi-Hong, Thai Nguyen-Duy, Tram Tang-Thi-Thao, Chandat Phan, Khue Bui-Diem, Quan Vu-Tran-Thien, Thu Nguyen-Ngoc-Phuong, Vinh Nguyen-Nhu, Huong Le-Thi-Minh, Timothy Craig
Summary: Obstructive Sleep Apnea (OSA) is a common disease that is often underestimated and undertreated in all age groups. Personalized diagnosis and treatment approaches are necessary for clinical practice due to morphological differences, clinical phenotype diversity, and variations in diagnosis and treatment of OSA in children and adults. Treatment should be based on individual tolerance to sleep-quality-related parameters, the harmful effects of hypoxia on the cardiovascular system, and patients' comorbidities.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Endocrinology & Metabolism
M. Leentjens, Abdulmohsen Alterki, Mohamed Abu-Farha, P. F. N. Bosschieter, CAL. de Raaff, CEE. de Vries, Eman Al Shawaf, Thangavel Alphonse Thanaraj, Irina Al-Khairi, Preethi Cherian, Arshad Channanath, Sina Kavalakatt, B. A. van Wagensveld, N. de Vries, Jehad Abubaker
Summary: This study found significantly increased levels of ANGPTL7 in both the circulation and adipose tissue of patients with OSA, which were associated with increased inflammation and OSA severity. Bariatric surgery was shown to significantly reduce ANGPTL7 levels and improve OSA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Arie Oksenberg, Timo Leppanen
Summary: Several factors, including gender, age, body mass index, sleep stage, and sleeping position, influence the duration of respiratory events during sleep. Women tend to have shorter events compared to men, while older adults experience longer events. An increase in body mass index decreases the duration of respiratory events. Sleeping position, especially in the supine posture, also affects event duration.
SLEEP MEDICINE REVIEWS
(2023)
Article
Clinical Neurology
Hiwa Mohammadi, Ardalan Aarabi, Mohammad Rezaei, Habibolah Khazaie, Serge Brand
Summary: The study found that individuals with OSAS have significantly lower spindle density in N3 and shorter spindle duration in N2 compared to healthy controls. Furthermore, individuals with mild OSAS showed sleep spindle characteristics more similar to healthy controls, unlike those with moderate and severe OSAS.
FRONTIERS IN NEUROLOGY
(2021)
Article
Health Care Sciences & Services
Christopher Seifen, Johannes Pordzik, Katharina Bahr, Lisa Grosse-Brueggemann, Katharina Ludwig, Berit Hackenberg, Christoph Matthias, Perikles Simon, Haralampos Gouveris
Summary: Evidence suggests that the apnea-hypopnea index (AHI) increases with aging, especially in males. However, the impact of aging on sleep-related metrics, specifically AHI, has been less studied in different gender-specific subpopulations while considering confounding factors such as obstructive sleep apnea-related comorbidities and body mass index (BMI). A retrospective analysis of 186 first-time polysomnographic recordings and medical files was conducted, forming six groups based on age and gender. The older mixed-gender and female cohorts showed significantly higher AHI, apnea-index, and hypopnea-index values. Within the older male cohort, AHI and apnea-index were also significantly higher. No significant differences in BMI were found. The older male cohort had significantly more patients with arterial hypertension, diabetes mellitus, cardiovascular diseases, and chronic mental health disorders. Conversely, the female subpopulation showed no significant differences in these comorbidities. In conclusion, sleep PSG-parameters increased in older subpopulations, possibly due to the accumulation of comorbidities in older males but not in females.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Geetha Kandasamy, Tahani Almeleebia
Summary: This study aimed to assess OSA and the relationship between AHI and polysomnographic characteristics in OSA patients. The results showed a significant prevalence of obesity and high frequency of OSA in men, with polysomnography being the primary method for early detection and treatment of the condition.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Marina Ruxandra Otelea, Mihaela Trenchea, Agripina Rascu, Sabina Antoniu, Corina Zugravu, Stefan Busnatu, Anca Angela Simionescu, Oana Cristina Arghir
Summary: This study aimed to define smoking combined with obstructive sleep apnea (OSA) as a phenotype (SOSA) and demonstrate the detrimental effects of continued smoking on OSA. The findings indicated that smokers had an earlier onset of OSA and more severe daytime sleepiness. Chronic obstructive pulmonary disease (COPD) was more prevalent among smokers, and smoking significantly influenced the severity of OSA.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Jean-Pierre T. F. Ho, Ning Zhou, Jan de Lange
Summary: This retrospective cohort study aimed to analyze the influence of apnea-predominant versus hypopnea-predominant obstructive sleep apnea (OSA) on surgical outcome after maxillomandibular advancement (MMA) and evaluate whether MMA alters the presence of apnea-predominant to hypopnea-predominant OSA more than vice versa. The results showed that hypopnea-predominant OSA patients had higher baseline indices and better surgical outcomes compared to apnea-predominant OSA patients. MMA was found to shift some apnea-predominant patients to hypopnea-predominant OSA, but had a smaller effect on the vice versa shift.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Clinical Neurology
Francesco Di Bello, Luigi Napolitano, Marco Abate, Claudia Colla Ruvoloa, Simone Morra, Gianluigi Califano, Marco Capece, Massimiliano Creta, Cristiano Scandurra, Benedetta Muzii, Claudio Di Nola, Vincenzo Bochicchio, Riccardo Nocini, Vincenzo Abbate, Nelson Mauro Maldonato, Giovanni Dell ' Aversana Orabona, Nicola Longo, Elena Cantone
Summary: Lower urinary tract symptoms, especially nocturia, are a significant public health problem worldwide, particularly in elderly individuals, and are associated with sleep disorders and obstructive sleep apnea syndrome. However, the causes and pathophysiology of nocturia in OSAS patients have not been thoroughly examined. The effect of treatment on managing nocturia in OSAS patients also remains unclear.
SLEEP MEDICINE REVIEWS
(2023)
Article
Clinical Neurology
Chia-Feng Juang, Chih-Yu Wen, Kai-Ming Chang, Yu-Hsuan Chen, Ming-Feng Wu, Wei-Chang Huang
Summary: The study aimed to propose a self-estimation method for predicting obstructive sleep apnea-hypopnea syndrome (OSAHS) using easy-to-obtain physiological features, and the results showed that the explainable fuzzy neural network (EFNN) was the preferred method for predicting moderate-to-severe OSAHS.
Article
Clinical Neurology
Arie Oksenberg, Timo Leppanen
Summary: Research on the duration of respiratory events in obstructive sleep apnea (OSA) has been limited, but recent studies have emphasized the importance of this overlooked parameter. Most studies suggest that longer respiratory events have more severe physiological and clinical consequences, likely due to higher hypoxic burden. However, some qualified studies show that even short respiratory events have deleterious effects on sleep and OSA. Therefore, the duration of respiratory events should be quantified in the diagnosis and assessment of OSA.
SLEEP MEDICINE REVIEWS
(2023)
