期刊
AMERICAN JOURNAL OF HUMAN GENETICS
卷 86, 期 4, 页码 519-525出版社
CELL PRESS
DOI: 10.1016/j.ajhg.2010.02.017
关键词
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资金
- UK Medical Research Council
- Wellcome Trust
- University of Bristol
- MRC [MRC 90600705, MRC G0800582]
- Australian National Health and Medical Research Council (NHMRC) [241944, 339462, 389927, 389875, 389891, 389892, 389938, 443036, 442915, 442981, 496739, 552485, 552498]
- Australian Research Council [A7960034, A79906588, A79801419, DP0212016, DP0343921]
- Netherlands Scientific Organization (NWO) [480-05-003]
- MRC [G0600705, G0800582] Funding Source: UKRI
- Medical Research Council [G9815508, G0600705, G0800582] Funding Source: researchfish
The ratio of the lengths of an individual's second to fourth digit (2D:4D) is commonly used as a noninvasive retrospective biomarker for prenatal androgen exposure. In order to identify the genetic determinants of 20:40, we applied a genome-wide association approach to 1507 11-year-old children from the Avon Longitudinal Study of Parents and Children (ALSPAC) in whom 2D:4D ratio had been measured, as well as a sample of 1382 12- to 16-year-olds from the Brisbane Adolescent Twin Study. A meta-analysis of the two scans identified a single variant in the LIN28B gene that was strongly associated with 2D:4D (rs314277: p = 4.1 x 10(-8)) and was subsequently independently replicated in an additional 3659 children from the ALSPAC cohort (p = 1.53 x 10(-6)). The minor allele of the rs314277 variant has previously been linked to increased height and delayed age at menarche, but in our study it was associated with increased 20:4D in the direction opposite to that of previous reports on the correlation between 2D:4D and age at menarche. Our findings call into question the validity of 2D:4D as a simplistic retrospective biomarker for prenatal testosterone exposure.
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