期刊
AMERICAN JOURNAL OF HUMAN GENETICS
卷 82, 期 3, 页码 748-755出版社
CELL PRESS
DOI: 10.1016/j.ajhg.2007.12.014
关键词
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资金
- NHGRI NIH HHS [T32 HG002536] Funding Source: Medline
- NHLBI NIH HHS [R01 HL070150, P01 HL028481, R01 HL082762] Funding Source: Medline
- NIGMS NIH HHS [R01 GM053275] Funding Source: Medline
- NIMH NIH HHS [R01 MH059490, R37 MH059490] Funding Source: Medline
This paper introduces a likelihood method of estimating ethnic admixture that uses individuals, pedigrees, or a combination of individuals and pedigrees. For each founder of a pedigree, admixture proportions are calculated by conditioning on the pedigree-wide genotypes at all ancestry-informative markers. These estimates are then propagated down the pedigree to the nonfounders by a simple averaging process. The large-sample standard errors of the founders' proportions can be similarly transformed into standard errors for the admixture proportions of the descendants. These standard errors are smaller than the corresponding standard errors when each individual is treated independently. Both hard and soft information on a founder's ancestry can be accommodated in this scheme, which has been implemented in the genetic software package Mendel. The utility of the method is demonstrated on simulated data and a real data example involving Mexican families of mixed Amerindian and Spanish ancestry.
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