Article
Medicine, General & Internal
Deepika R. Laddu, FeiFei Qin, Haley Hedlin, Marcia L. Stefanick, JoAnn E. Manson, Oleg Zaslavsky, Charles Eaton, Lisa Warsinger Martin, Thomas Rohan, Themistocles L. Assimes
Summary: In older women, utilizing DXA measurements of fatness can improve the accuracy of predicting cardiometabolic disease risk, particularly diabetes. Percentage of trunk fat is the most effective adiposity measure, and it demonstrates improved predictive value for diabetes and ASCVD compared to traditional adiposity indices such as WC, BMI, and WHR.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Endocrinology & Metabolism
Aline Alves Lopes, Luciano Albuquerque, Mayara Fontes, Daniella Rego, Francisco Bandeira
Summary: This study aims to evaluate body composition and its relationship with hormonal control in acromegaly, comparing the effectiveness of Bioelectrical impedance analysis (BIA) with dual X-ray absorptiometry (DXA), which is commonly used in current studies. The results show that there were no significant differences in body composition between patients with controlled and active disease. In patients with adequate hormonal control, there was preservation of muscle mass and a lower prevalence of metabolic comorbidities, such as type 2 diabetes (T2D) and high blood pressure (HBP).
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Naeha Sharif, Syed Zulqarnain Gilani, David Suter, Siobhan Reid, Pawel Szulc, Douglas Kimelman, Barret A. Monchka, Mohammad Jafari Jozani, Jonathan M. Hodgson, Marc Sim, Kun Zhu, Nicholas C. Harvey, Douglas P. Kiel, Richard L. Prince, John T. Schousboe, William D. Leslie, Joshua R. Lewis
Summary: This study trained and tested a convolutional neural network (CNN) algorithm for automated scoring of abdominal aortic calcification (AAC-24) and validated its consistency with scores from trained imaging specialists. The results showed that ML-AAC-24 scores were significantly associated with the risk of cardiovascular events in a real-world setting, indicating that this approach could improve the identification of individuals at high risk of cardiovascular disease in clinical settings.
Article
Endocrinology & Metabolism
Fiorella Palmas, Andreea Ciudin, Raul Guerra, Daniel Eiroa, Carina Espinet, Nuria Roson, Rosa Burgos, Rafael Simo
Summary: This study aims to evaluate the accuracy of a new method that combines CT imaging data with automatic software and artificial intelligence to estimate body composition in patients with obesity. The results show that this new method has high accuracy in estimating body composition in obese patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Inge A. L. P. van Beijsterveldt, Manouk van der Steen, Kirsten S. de Fluiter, Sander A. M. J. Spaans, Anita C. S. Hokken-Koelega
Summary: Childhood obesity is a global public health threat, and this study provides sex-specific reference values and charts for body composition and bone mineral density in children aged 2-5 years.
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Hongbo Dong, Yinkun Yan, Junting Liu, Hong Cheng, Xiaoyuan Zhao, Xinying Shan, Guimin Huang, Jie Mi
Summary: This study provided sex-and age-specific body fat reference centiles for Chinese children and adolescents using DXA. Different trends were observed in body fat development and distribution between genders and age groups. The proposed body fat references were lower than the US values but similar to Korean values.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Erika Aparecida Silveira, Larissa Silva Barbosa, Matias Noll, Hudson Azevedo Pinheiro, Cesar de Oliveira
Summary: The study aimed to validate the use of anthropometric equations to estimate body fat percentage in older adults. Results showed differences in predictions among different equations, indicating the need for developing specific equations for older adults.
CLINICAL NUTRITION
(2021)
Article
Geriatrics & Gerontology
Ben Kirk, Ebrahim Bani Hassan, Sharon Brennan-Olsen, Sara Vogrin, Stefanie Bird, Jesse Zanker, Steven Phu, Jarrod D. Meerkin, Steven B. Heymsfield, Gustavo Duque
Summary: This study established reference ranges for LM and FM parameters from Hologic DXA machines in Australia, finding that LM indicators remained stable until age 50 then declined, while FM indicators progressively increased with age in both men and women.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Health Care Sciences & Services
Che-Cheng Chang, Yen-Kung Chen, Hou-Chang Chiu, Jiann-Horng Yeh
Summary: Patients with myasthenia gravis (MG) have a higher prevalence of obesity and decreased muscle mass with aging. The prevalence of sarcopenia and sarcopenic obesity increases with age and disease severity.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Medicine, General & Internal
Leona S. Alizadeh, Thomas J. Vogl, Stephan S. Waldeck, Daniel Overhoff, Tommaso D'Angelo, Simon S. Martin, Ibrahim Yel, Leon D. Gruenewald, Vitali Koch, Florian Fulisch, Christian Booz
Summary: This article discusses the technical principles and clinical applications of dual-energy computed tomography (DECT) in cardiothoracic imaging, with a focus on current developments and techniques. Different vendors have developed distinct hardware and software approaches for generating multi-energy datasets and various DECT applications, which have been clinically investigated in different fields. Recent literature reports have highlighted the benefits of DECT in oncology, trauma and emergency radiology, musculoskeletal imaging, and cardiovascular imaging. State-of-the-art applications such as virtual monoenergetic imaging, material decomposition, perfused blood volume imaging, and virtual non-contrast imaging have the potential to significantly improve cardiothoracic CT image workflows and enhance diagnostic accuracy and patient safety.
Article
Fisheries
Liang Zhao, Shanshan Lian, Qiang Ren, Zhihui Yang, Zhenyi Guo, Jiarun Lou, Xiangfu Kong, Moli Li, Zhenmin Bao, Xiaoli Hu
Summary: This study introduces a rapid and non-destructive method for assessing scallop muscle traits using X-ray technology, which calculates the ratio between adductor muscle area and shell area to evaluate muscle mass and percentage. The technique proves to be efficient and non-invasive for evaluating scallop muscle traits.
Article
Dentistry, Oral Surgery & Medicine
Peijun Zhu, An Li, Qingqing Cai, Yuntao Chen, Yang Liu, Harriet Jager-Wittenaar, Geerten-Has E. Tjakkes, Shulan Xu
Summary: This study aimed to determine the sex differences in the association between DXA-measured body composition and phenotypes with periodontitis. The study found that women with higher BMI, higher body fat mass, and the high adiposity-low muscle phenotype were more likely to develop periodontitis, while no significant associations were found in men.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Nutrition & Dietetics
Maria Consuelo Velazquez-Alva, Maria Esther Irigoyen-Camacho, Marco Antonio Zepeda-Zepeda, Itzam Rangel-Castillo, Isabel Arrieta-Cruz, Luciano Mendoza-Garces, Antonio Castano-Seiquer, Javier Flores-Fraile, Roger Gutierrez-Juarez
Summary: This study found that BIA yielded good results in the estimation of BF% among women with heights over 145 cm. The Woolcott predictive equation based on waist circumference and height ratio showed no significant differences compared to DXA in the paired comparison; however, the large error of estimates observed may limit its application.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Lionne N. Grootjen, Joost P. H. J. Rutges, Layla Damen, Stephany H. Donze, Alicia F. Juriaans, Gerthe F. Kerkhof, Anita C. S. Hokken-Koelega
Summary: This study found that 8 years of GH treatment has no adverse effects on the prevalence and severity of scoliosis in children with PWS until the age of 11. The study also revealed that higher bone mineral density of the lumbar spine was associated with a lower Cobb angle, highlighting the importance of optimizing BMD status in children with PWS.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Kevin J. Scully, Laura T. Jay, Steven Freedman, Gregory S. Sawicki, Ahmet Uluer, Joel S. Finkelstein, Melissa S. Putman
Summary: Measures of body fat and lean mass may better predict important clinical outcomes in patients with cystic fibrosis than body mass index. Diet quality and exercise impact body composition in these patients, with higher physical activity levels associated with greater ALMI and lower body fat. Future studies analyzing the effect of dietary intake and exercise on body composition and clinical outcomes in CF patients are needed.
Article
Public, Environmental & Occupational Health
Jonathan Fix, Macarius M. Donneyong, Stephen R. Rapp, Maryam Sattari, Beverly M. Snively, Jean Wactawski-Wende, Emily W. Gower
Summary: Predictors associated with pneumococcal and seasonal influenza vaccination among older women include race, health insurance, and residential area. The study emphasizes the need to improve access, education, and provider recommendations for vaccination.
PUBLIC HEALTH REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Michael J. LaMonte, Joshua H. Gordon, Patricia Diaz-Moreno, Christopher A. Andrews, Daichi Shimbo, Kathleen M. Hovey, Michael J. Buck, J. Wactawski-Wende
Summary: There is an association between oral microbiota and blood pressure regulation as well as development of hypertension in postmenopausal women, suggesting that specific oral bacteria may be related to the risk of hypertension.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Geriatrics & Gerontology
Bonnie C. Sachs, Sarah A. Gaussoin, Gretchen A. Brenes, Ramon Casanova, Rowan T. Chlebowski, Jiu-Chiuan Chen, Juhua Luo, Stephen R. Rapp, Aladdin H. Shadyab, Sally Shumaker, Jean Wactawski-Wende, Gretchen L. Wells, Kathleen M. Hayden
Summary: The relationship between optimism and cognitive functioning is not fully understood. This study found that less pessimism was associated with a lower risk of mild cognitive impairment (MCI) and dementia, while more optimism did not have a significant relationship with these conditions.
AGING & MENTAL HEALTH
(2023)
Article
Oncology
Kathy Pan, Aaron K. Aragaki, Yvonne Michael, Cynthia A. Thomson, Linda G. Snetselaar, Jean Wactawski-Wende, David O. Garcia, Christina M. Dieli-Conwright, Aladdin H. Shadyab, Nazmus Saquib, Rowan T. Chlebowski
Summary: This study found that women participating in the Women's Health Initiative dietary modification randomized trial had a lower rate of physical inactivity and spent more time in recreational physical activity compared to the control group.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Obstetrics & Gynecology
Edwina H. Yeung, Pauline Mendola, Rajeshwari Sundaram, Tzu-Chun Lin, Miranda M. Broadney, Diane L. Putnick, Sonia L. Robinson, Kristen J. Polinski, Jean Wactawski-Wende, Akhgar Ghassabian, Thomas G. O'Connor, Robert E. Gore -Langton, Judy E. Stern, Erin Bell
Summary: The study aimed to evaluate whether children conceived using assisted reproductive technology (ART) or ovulation induction (OI) have greater cardiometabolic risk compared to children conceived without treatment. The results showed that at 9 years of age, children conceived using ART or OI did not have greater cardiometabolic risk compared to children conceived without treatment.
FERTILITY AND STERILITY
(2022)
Article
Oncology
Tarah J. Ballinger, Zora Djuric, Sagar Sardesai, Kathleen M. Hovey, Chris A. Andrews, Theodore M. Brasky, Jian Ting Zhang, Thomas E. Rohan, Nazmus Saquib, Aladdin H. Shadyab, Michael Simon, Jean Wactawski-Wende, Robert Wallace, Ikuko Kato
Summary: This study found that the use of PPI was inversely associated with the risk of colorectal cancer, while the use of H2RA showed no such association. This relationship is consistent with the preclinical data showing the preventive effect of FASN inhibition on colon cancer.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Alexi Vasbinder, Richard K. Cheng, Susan R. Heckbert, Hilaire Thompson, Oleg Zaslavksy, Rowan T. Chlebowski, Aladdin H. Shadyab, Lisa Johnson, Jean Wactawski-Wende, Gretchen Wells, Rachel Yung, Lisa Warsinger Martin, Electra D. Paskett, Kerryn Reding
Summary: This study aimed to investigate the associations between biomarkers and long-term radiation-induced cardiovascular disease (RICVD) in breast cancer survivors. The results showed that a higher 8-OH-dG ratio was significantly associated with an elevated long-term risk of RICVD, suggesting that oxidative DNA damage may be a potential pathway for RICVD.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Lindsey J. Mattick, Jennifer W. Bea, Kathy M. Hovey, Jean Wactawski-Wende, Jane A. Cauley, Carolyn J. Crandall, Lili Tian, Heather M. Ochs-Balcom
Summary: We investigated the effects of two endogenous hormones on bone health in older women. Higher levels of follicle-stimulating hormone (FSH) were associated with bone disease, particularly in lower levels of estradiol. FSH attenuates the relationship between estradiol and bone density, which may have implications for future clinical interventions on bone loss.
OSTEOPOROSIS INTERNATIONAL
(2023)
Review
Cell Biology
Sabine Kuznia, Anna Zhu, Taisuke Akutsu, Julie E. Buring, Carlos A. Camargo Jr, Nancy R. Cook, Li-Ju Chen, Ting-Yuan David Cheng, Sari Hantunen, I. -Min Lee, JoAnn E. Manson, Rachel E. Neale, Robert Scragg, Aladdin H. Shadyab, Sha Sha, John Sluyter, Tomi-Pekka Tuomainen, Mitsuyoshi Urashima, Jyrki K. Virtanen, Ari Voutilainen, Jean Wactawski-Wende, Mary Waterhouse, Hermann Brenner, Ben Schoettker
Summary: A systematic review and meta-analysis of randomized, placebo-controlled trials (RCTs) and individual patient data (IPD) was conducted to evaluate the effect of vitamin D3 supplementation on cancer mortality in the general population and on prognosis in cancer patients. The main meta-analysis of the 14 RCTs showed a non-significant reduction in cancer mortality by 6%. Subgroup analyses revealed a significant reduction in cancer mortality in trials with daily dosing, while no reduction was seen in trials using a bolus regimen. The IPD meta-analysis confirmed the findings of all trials.
AGEING RESEARCH REVIEWS
(2023)
Article
Public, Environmental & Occupational Health
Aaron Holman-Vittone, Brian Monahan, Erin S. LeBlanc, Simin Liu, Rami Nassir, Nazmus Saquib, Peter F. Schnatz, Aladdin H. Shadyab, Rachel Sinkey, Jean Wactawski-Wende, Robert A. Wild, Lisa Chasan-Taber, JoAnn E. Manson, Cassandra N. Spracklen
Summary: Preterm birth is associated with increased risk of developing type 2 diabetes at an earlier age, but not with overall risk of incident type 2 diabetes. The association between preterm birth and type 2 diabetes may exist during early years but wane over time.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Sandi L. Navarro, G. A. Nagana Gowda, Lisa F. Bettcher, Robert Pepin, Natalie Nguyen, Mathew Ellenberger, Cheng Zheng, Lesley F. Tinker, Ross L. Prentice, Ying Huang, Tao Yang, Fred K. Tabung, Queenie Chan, Ruey Leng Loo, Simin Liu, Jean Wactawski-Wende, Johanna W. Lampe, Marian L. Neuhouser, Daniel Raftery
Summary: Demographic and clinical factors have an influence on the metabolome. A study on 444 post-menopausal women found correlations between serum and urine metabolites and demographic and clinical parameters.
Article
Medicine, General & Internal
Diddier Prada, Carolyn J. Crandall, Allison Kupsco, Marianthi-Anna Kioumourtzoglou, James D. Stewart, Duanping Liao, Jeff D. Yanosky, Andrea Ramirez, Jean Wactawski-Wende, Yike Shen, Gary Miller, Iuliana Ionita-Laza, Eric A. Whitsel, Andrea A. Baccarelli
Summary: Osteoporosis has a major impact on postmenopausal women, and it is influenced by environmental exposures. This study found that criteria air pollutants, such as PM10, NO, NO2, and SO2, were negatively associated with bone mineral density in postmenopausal women. Nitrogen oxides exposure was identified as the leading contributor to bone loss in this population.
Article
Oncology
Ana Babic, Qiao-Li Wang, Alice A. Lee, Chen Yuan, Nader Rifai, Juhua Luo, Fred K. Tabung, Aladdin H. Shadyab, Jean Wactawski-Wende, Nazmus Saquib, Jihye Kim, Peter Kraft, Howard D. Sesso, Julie E. Buring, Edward L. Giovannucci, JoAnn E. Manson, Meir J. Stampfer, Kimmie Ng, Charles S. Fuchs, Brian M. Wolpin
Summary: The study found that high levels of adiponectin in the prediagnostic period were associated with shorter survival among women with pancreatic cancer. Several polymorphisms in ADIPOR1 and LEPR were associated with patient survival.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Surgery
Elizabeth L. Chou, Mary Pettinger, Bernhard Haring, Matthew A. Allison, Matthew W. Mell, Mark A. Hlatky, Jean Wactawski-Wende, Robert A. Wild, Aladdin H. Shadyab, Robert B. Wallace, Linda G. Snetselaar, Tracy E. Madsen, Matthew J. Eagleton, Mark F. Conrad, Simin Liu
Summary: This study finds that premature menopause may be an important risk factor for AAA in women with significant smoking history. There was no significant association between premature menopause and risk of AAA amongst women who have never smoked.
Meeting Abstract
Clinical Neurology
Galit Dunietz, Kerby Shedden, Kara Michels, Ronald Chervin, Xiru Lyu, Joshua Freeman, Ana Baylin, Louise O'Brien, Jean Wactawski-Wende, Enrique Schisterman, Sunni Mumford