Article
Biology
K. Barbara Sahlin, Indira Pla, Jessica de Siqueira Guedes, Krzysztof Pawlowski, Roger Appelqvist, Gyorgy Marko-Varga, Gilberto Barbosa Domont, Fabio Cesar Sousa Nogueira, Aleksander Giwercman, Aniel Sanchez, Johan Malm
Summary: Long term testosterone deficiency has negative effects on metabolism, muscle degradation, and metabolic diseases, while short-term testosterone changes seem to impact amino acid levels, with an association between tyrosine and phenylalanine levels and testosterone changes. The study suggests that fasting amino acid levels can be used to monitor early metabolic changes induced by testosterone fluctuations.
Article
Andrology
Kassim Kourbanhoussen, France-Helene Joncas, Christopher J. D. Wallis, Helene Hovington, Francois Dagenais, Yves Fradet, Chantal Guillemette, Louis Lacombe, Paul Toren
Summary: This study evaluates the association between preoperative FSH levels and long-term cardiovascular and oncologic outcomes in men with prostate cancer. The findings suggest that FSH levels are not significantly associated with oncologic outcomes or predictors of long-term cardiovascular risk in these patients.
ASIAN JOURNAL OF ANDROLOGY
(2022)
Article
Urology & Nephrology
Soum D. Lokeshwar, Premal Patel, Richard J. Fantus, Joshua Halpern, Cecilia Chang, Atil Y. Kargi, Ranjith Ramasamy
Summary: A study found that total testosterone (TT) levels have been declining among adolescent and young adult males over the past two decades. Higher body mass index (BMI) was associated with lower TT levels, a trend that remained significant even among men with normal BMI. Further studies are needed to verify these findings.
EUROPEAN UROLOGY FOCUS
(2021)
Article
Public, Environmental & Occupational Health
Kai Ma, Qiang Dong
Summary: The study aimed to examine the association between sleep quality and benign prostate hyperplasia (BPH) among middle-aged and older men in India. The results showed that worse sleep quality was significantly associated with a higher incidence of BPH among middle-aged and older Indian men. Further prospective studies are needed to clarify this association and explore potential mechanisms.
Article
Geriatrics & Gerontology
Xue Dong, Hong Jiang, Suyun Li, Dongfeng Zhang
Summary: This study found that serum testosterone concentrations were inversely associated with cognitive performance in older men but not in women in the United States.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Urology & Nephrology
Jose M. Flores, Helen L. Bernie, Eduardo Miranda, Bruno Nascimento, Elizabeth Schofield, Nicole Benfante, Sigrid Carlsson, John P. Mulhall
Summary: This study evaluates the relationship between testosterone (T) and prostate-specific antigen (PSA) in patients with prostate cancer (PC). The results suggest a significant association between low T levels and PSA levels below 4 ng/mL and 2 ng/mL, indicating the importance of measuring T levels in the diagnosis and treatment of PC.
JOURNAL OF SEXUAL MEDICINE
(2022)
Article
Biology
Walter Rayford, Alp Tuna Beksac, Jordan Alger, Mohammed Alshalalfa, Mohsen Ahmed, Irtaza Khan, Ugo G. Falagario, Yang Liu, Elai Davicioni, Daniel E. Spratt, Edward M. Schaeffer, Felix Y. Feng, Brandon Mahal, Paul L. Nguyen, Robert B. Den, Mark D. Greenberger, Randy Bradley, Justin M. Watson, Matthew Beamer, Lambros Stamatakis, Darrell J. Carmen, Shivanshu Awasthi, Jonathan Hwang, Rachel Weil, Harri Merisaari, Nihal Mohamed, Leslie A. Deane, Dimple Chakravarty, Kamlesh K. Yadav, Kosj Yamoah, Sujit S. Nair, Ashutosh K. Tewari
Summary: Racial disparities in prostate cancer were investigated in a multi-institutional retrospective analysis of African-American and European-American men who underwent radical prostatectomy. Differences were found in gene expression with African-American men showing higher expression of inflammation genes and lower expression of mismatch repair genes.
COMMUNICATIONS BIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Fatima El Fakiri, Jessica Bouwman-Notenboom, Charles Agyemang
Summary: Although little information is available on the health status and functional limitations of older migrants in Europe, this study found significant ethnic inequalities in functional limitations, particularly in vision, among older migrants in the Netherlands. These results highlight the importance of tailored preventive interventions for older migrants.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2022)
Review
Oncology
Melissa Barlow, Liz Down, Luke Timothy Allan Mounce, Samuel William David Merriel, Jessica Watson, Tanimola Martins, Sarah Elizabeth Rose Bailey
Summary: Black men are twice as likely to be diagnosed with prostate cancer than White men. It is unknown whether PSA levels differ for men of different ethnic groups.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Endocrinology & Metabolism
Miguel Damas-Fuentes, Hatim Boughanem, Maria Molina-Vega, Francisco J. Tinahones, Jose C. Fernandez-Garcia, Manuel Macias-Gonzalez
Summary: This study investigated the relationship between serum vitamin D and testosterone levels in young men with obesity. The results showed that vitamin D deficiency was associated with decreased testosterone levels and increased androstenedione levels, with BMI mediating this relationship. In severely obese participants, vitamin D was associated with total testosterone levels, partially mediated by BMI.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Kazuyoshi Shigehara, Yuki Kato, Kouji Izumi, Atsushi Mizokami
Summary: The decline in testosterone is associated with sarcopenia and frailty, and testosterone replacement therapy has been shown to improve muscle mass and strength.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Andrology
Robert Bozick
Summary: This study examines the relationship between men's testosterone levels and their sexual behaviors, finding that this relationship is contingent upon age, with positive correlation among younger men and negative correlation among older men.
Article
Endocrinology & Metabolism
Fang Huang, Yongchao Li, Yu Cui, Zewu Zhu, Jinbo Chen, Feng Zeng, Yang Li, Zhiyong Chen, Hequn Chen
Summary: The study aimed to evaluate the relationship between serum testosterone levels and kidney stone prevalence in males. The results showed a significant inverse association between serum testosterone levels and the prevalence of kidney stones in men over 40 years of age, but no correlation was seen in the 20-40 age group.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Elizabeth Pan, Justin Shaya, Lisa Madlensky, J. Michael Randall, Frederick E. Millard, Brent Rose, J. Kellogg Parsons, Sarah M. Nielsen, Kathryn E. Hatchell, Edward D. Esplin, Robert L. Nussbaum, Nicole Weise, James Murphy, Maria Elena Martinez, Rana R. Mckay
Summary: This study aimed to investigate the rate of pathogenic/likely pathogenic germline alterations in Hispanic men with prostate cancer. The results showed that the rate of pathogenic/likely pathogenic germline alterations was similar between Hispanic and non-Hispanic white men, while the rate of variants of uncertain significance was significantly higher in Hispanic men.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Oncology
Charlie D. Zhou, Andreas Pettersson, Anna Plym, Svitlana Tyekucheva, Kathryn L. Penney, Howard D. Sesso, Philip W. Kantoff, Lorelei A. Mucci, Konrad H. Stopsack
Summary: Older age at diagnosis is consistently associated with worse clinical outcomes in prostate cancer. However, age-related genes are not consistently associated with risk of metastases and prostate cancer-specific death, suggesting that tumor genomic differences may not be the main explanation for age-related differences in prostate cancer prognosis.
CANCER PREVENTION RESEARCH
(2022)