Article
Oncology
Anne L. Angiolillo, Reuven J. Schore, John A. Kairalla, Meenakshi Devidas, Karen R. Rabin, Patrick Zweidler-McKay, Michael J. Borowitz, Brent Wood, Andrew J. Carroll, Nyla A. Heerema, Mary V. Relling, Johann Hitzler, Ashley R. Lane, Kelly W. Maloney, Cindy Wang, Mylene Bassal, William L. Carroll, Naomi J. Winick, Elizabeth A. Raetz, Mignon L. Loh, Stephen P. Hunger
Summary: The study showed that patients with newly diagnosed NCI standard-risk B-ALL had excellent outcomes with the VCR/DEX12 maintenance treatment regimen, and there was no improvement in outcomes with a higher starting dose of MTX at 40 mg/m(2) compared to 20 mg/m(2). The decreased frequency of vincristine/dexamethasone pulses has been included in frontline COG B-ALL trials to reduce the burden of therapy for patients and their families.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Hematology
Kun-yin Qiu, Jia-yi Wang, Li-bin Huang, Chang-gang Li, Lu-hong Xu, Ri-yang Liu, Hui-qin Chen, Yong-sheng Ruan, Zi-jun Zhen, Chi-kong Li, Jian-pei Fang
Summary: The efficacy and safety of adding vincristine and dexamethasone pulses to maintenance therapy for childhood acute lymphoblastic leukemia (ALL) remain uncertain, according to a randomized, open-label, multicenter, phase III clinical trial conducted in Guangdong Province, China.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Review
Pediatrics
Luke Maese, Rachel E. Rau
Summary: Cure rates for pediatric acute lymphoblastic leukemia (ALL) have significantly improved in the past five decades, largely due to the development and understanding of combination chemotherapy. Asparaginase, a recent addition to ALL chemotherapy, plays a crucial role in therapy by depleting the essential amino acid asparagine. Its unique toxicity profile, including hypersensitivity reactions, and the need for therapeutic drug monitoring have influenced the incorporation of asparaginase into ALL treatment. Despite its long-term use and standard-of-care status, there is still room for further improvement in the utilization of asparaginase therapy.
FRONTIERS IN PEDIATRICS
(2022)
Article
Oncology
Manon Queudeville, Anthony S. Stein, Franco Locatelli, Martin Ebinger, Rupert Handgretinger, Nicola Goekbuget, Lia Gore, Yi Zeng, Priya Gokani, Gerhard Zugmaier, Hagop M. Kantarjian
Summary: The study found that a lower baseline bone marrow blast percentage (bBMB%) is associated with better treatment outcomes in patients with B-cell acute lymphoblastic leukemia (B-ALL) receiving blinatumomab. This suggests that bBMB% <50% is associated with improved efficacy following blinatumomab treatment for B-ALL.
Article
Medicine, General & Internal
P. G. Richardson, S. Trudel, R. Popat, M- Mateos, A. J. Vangsted, K. Ramasamy, J. Martinez-Lopez, H. Quach, R. Z. Orlowski, M. Arnao, S. Lonial, C. Karanes, C. Pawlyn, K. Kim, A. Oriol, J. G. Berdeja, P. Rodriguez Otero, I Casas-Aviles, A. Spirli, J. Poon, S. Li, J. Gong, L. Wong, M. Lamba, D. W. Pierce, M. Amatangelo, T. Peluso, P. Maciag, J. Katz, Michael Pourdehnad, Nizar J. Bahlis
Summary: In this study, patients with relapsed and refractory multiple myeloma received oral mezigdomide in combination with dexamethasone. The combination therapy showed promising efficacy in heavily pretreated patients with multiple myeloma, with treatment-related adverse events consisting mainly of myelotoxic effects.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yifan Zhang, Jingnan An, Yu Shao, Na Yu, Shujing Yue, Huanli Sun, Jubin Zhang, Wenxing Gu, Yifeng Xia, Jinping Zhang, Yang Xu, Zhiyuan Zhong
Summary: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children, and current intensive chemotherapy often leads to severe and lifelong side effects, highlighting the urgent need for more selective and less toxic treatments. DP-VCR, a CD38-directed nanotherapy, demonstrated superior efficacy and safety in treating CD38-positive ALL.
Article
Hematology
Shai Shimony, Yiwen Liu, Yannis K. Valtis, Jonathan D. Paolino, Andrew E. Place, Andrew M. Brunner, Lachelle D. Weeks, Lewis B. Silverman, Lynda M. Vrooman, Donna S. Neuberg, Richard M. Stone, Daniel J. DeAngelo, Marlise R. Luskin
Summary: By retrospectively analyzing 44 patients with relapsed and refractory T-cell acute lymphoblastic leukemia and lymphoma, it was found that nelarabine combination therapy was more effective and associated with improved survival compared to monotherapy. However, combination therapy was associated with more adverse reactions.
Article
Oncology
Max S. Topp, Nicola Goekbuget, Gerhard Zugmaier, Anthony S. Stein, Herve Dombret, Yuqi Chen, Josep-Maria Ribera, Ralf C. Bargou, Heinz-August Horst, Hagop M. Kantarjian
Summary: This study analyzed long-term follow-up data from two clinical trials involving blinatumomab, finding that one-third of patients with relapsed and/or refractory B-cell precursor acute lymphoblastic leukemia achieving a deep response with blinatumomab lived for 3 years or longer. These results suggest that long-term survival is possible after treatment with blinatumomab, with some patients even undergoing stem cell transplantation showing improved survival outcomes.
Article
Oncology
Wendy Stock, Giovanni Martinelli, Matthias Stelljes, Daniel J. DeAngelo, Nicola Goekbuget, Anjali S. Advani, Susan O'Brien, Michaela Liedtke, Akil A. Merchant, Ryan D. Cassaday, Tao Wang, Hui Zhang, Erik Vandendries, Elias Jabbour, David Marks, Hagop M. Kantarjian
Summary: The study demonstrated that InO was more effective than standard intensive chemotherapy for patients with R/R Ph+ ALL, showing higher rates of complete remission and minimal residual disease negativity, as well as improved hematopoietic stem cell transplantation rates. However, there was no significant benefit in overall survival, and the probability of being event-free at 12 months was higher with InO treatment.
Review
Pediatrics
Sima Jeha
Summary: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children, and the T-cell subtype (T-ALL) has historically had worse outcomes than B-cell ALL (B-ALL). However, the prognosis of T-ALL has significantly improved with new treatment options, including nelarabine and targeted therapies. Immunotherapy and cellular therapy regimens are also being investigated for T-cell malignancies.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Oncology
Vinod A. Pullarkat, Norman J. Lacayo, Elias Jabbour, Jeffrey E. Rubnitz, Ashish Bajel, Theodore W. Laetsch, Jessica Leonard, Susan Colace, Seong Lin Khaw, Shaun A. Fleming, Ryan J. Mattison, Robin Norris, Joseph T. Opferman, Kathryn G. Roberts, Yaqi Zhao, Chunxu Qu, Mohamed Badawi, Michelle Schmidt, Bo Tong, John C. Pesko, Yan Sun, Jeremy A. Ross, Deeksha Vishwamitra, Lindsey Rosenwinkel, Su Young Kim, Amanda Jacobson, Charles G. Mullighan, Thomas B. Alexander, Wendy Stock
Summary: In this phase I study, combining venetoclax with low-dose navitoclax and chemotherapy showed good tolerability and promising efficacy in patients with relapsed/refractory acute lymphoblastic leukemia or lymphoblastic lymphoma. Responses were observed in patients across histologic and genomic subtypes, even in those who had failed stem cell transplant therapies.
Article
Oncology
Jia Zhu, Juan Wang, Feifei Sun, Zijun Zhen, Tingting Chen, Suying Lu, Junting Huang, Yizhuo Zhang, Xiaofei Sun
Summary: The combination of vincristine, irinotecan, and temozolomide is an effective salvage regimen for relapsed or refractory neuroblastoma patients, achieving a response rate of 69.6% with manageable toxicities.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Edoardo Pennesi, Naomi Michels, Erica Brivio, Vincent H. J. van der Velden, Yilin Jiang, Adriana Thano, Anneke J. C. Ammerlaan, Judith M. Boer, H. Berna Beverloo, Barbara Sleight, Ying Chen, Britta Vormoor-Buerger, Susana Rives, Bella Bielorai, Claudia Roessig, Arnaud Petit, Carmelo Rizzari, Gernot Engstler, Jan Stary, Francisco J. Bautista Sirvent, Christiane Chen-Santel, Benedicte Bruno, Yves Bertrand, Fanny Rialland, Genevieve Plat, Dirk Reinhardt, Luciana Vinti, Arend Von Stackelberg, Franco Locatelli, Christian M. Zwaan
Summary: Inotuzumab Ozogamicin has shown promising efficacy in relapsed or refractory B cell acute lymphoblastic leukemia, with a high overall response rate and a significant reduction in minimal residual disease. However, the occurrence of sinusoidal obstructive syndrome, especially after HSCT treatment, is a major concern.
Article
Oncology
Talha Badar, Aniko Szabo, Shira Dinner, Michaela Liedtke, Madelyn Burkart, Rory M. Shallis, Ilana R. Yurkiewicz, Eric Kuo, Muhammad Ali Khan, Suresh Balasubramanian, Jay Yang, Mehrdad Hefazi, Nikolai Podoltsev, Anand Patel, Emily Curran, Amy Wang, Shukaib Arslan, Ibrahim Aldoss, Caitlin Siebenaller, Ryan J. Mattison, Mark R. Litzow, Martha Wadleigh, Anjali S. Advani, Ehab Atallah
Summary: A study comparing the efficacy of blinatumomab and InO as first or second NA therapy in patients with relapsed/refractory B-cell acute lymphoblastic leukemia found that the two agents may have comparable efficacy in this setting.
Article
Cell Biology
Anna Ferrari, Delia Cangini, Andrea Ghelli Luserna di Rora, Annalisa Condorelli, Marta Pugliese, Giovanni Schinina, Sebastiano Cosentino, Eugenio Fonzi, Chiara Domizio, Giorgia Simonetti, Salvatore Leotta, Giuseppe Milone, Giovanni Martinelli
Summary: High-risk relapsed/refractory adult Philadelphia-negative (Ph-) B-cell acute lymphoblastic leukemia (B-ALL) is difficult to treat, especially in cases with extramedullary (EM) involvement. Treatment approaches such as blinatumomab, inotuzumab ozogamicin, and CAR-T may have some efficacy in EM patients with relapsed/refractory B-ALL. However, the molecular mechanisms of response or refractoriness are often not well investigated in both medullary and EM sites.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Hematology
Justin M. Watts, Maria R. Baer, Jay Yang, Thomas Prebet, Sangmin Lee, Gary J. Schiller, Shira N. Dinner, Arnaud Pigneux, Pau Montesinos, Eunice S. Wang, Karen P. Seiter, Andrew H. Wei, Stephane De Botton, Montserrat Arnan, Will Donnellan, Anthony P. Schwarer, Christian Recher, Brian A. Jonas, P. Brent Ferrell Jr, Christophe Marzac, Patrick Kelly, Jennifer Sweeney, Sanjeev Forsyth, Sylvie M. Guichard, Julie Brevard, Patrick Henrick, Hesham Mohamed, Jorge E. Cortes
Summary: This study evaluated the safety, pharmacokinetics, pharmacodynamics, and clinical activity of Olutasidenib in patients with acute myeloid leukemia or myelodysplastic syndrome with mutant IDH1. The results showed that Olutasidenib, as monotherapy or in combination with azacitidine, was well tolerated and exhibited meaningful clinical activity. These findings provide a rationale for further evaluation of Olutasidenib in different populations of patients with myeloid malignancies.
LANCET HAEMATOLOGY
(2023)
Article
Urology & Nephrology
Camilo Montero, Nancy Yomayusa, Rodolfo Torres, Jorge Cortes, Carlos Alvarez, Juan Gallo, Guillermo Aldana, Andres Acevedo, Maria Rios, Johana Echeverri, Zuly Yepes, Adriana Silva, Diana Gayon, Jorge Perez, Milciades Ibanez
Summary: This study aimed to evaluate asymptomatic CMV reactivation and CMV disease in kidney transplant recipients with positive CMV serostatus. The results showed that asymptomatic CMV reactivation was higher in patients who received thymoglobulin induction, while the rates of CMV disease were similar between the two treatment groups. The significant difference in asymptomatic CMV reactivation between the two groups did not affect graft function and histology.
Article
Oncology
Michael J. Mauro, Timothy P. Hughes, Dong-Wook Kim, Delphine Rea, Jorge E. Cortes, Andreas Hochhaus, Koji Sasaki, Massimo Breccia, Moshe Talpaz, Oliver Ottmann, Hironobu Minami, Yeow Tee Goh, Daniel J. DeAngelo, Michael C. Heinrich, Valle Gomez-Garcia de Soria, Philipp le Coutre, Francois-Xavier Mahon, Jeroen J. W. M. Janssen, Michael Deininger, Naranie Shanmuganathan, Mark B. Geyer, Silvia Cacciatore, Fotis Polydoros, Nithya Agrawal, Matthias Hoch, Fabian Lang
Summary: Asciminib has been approved for patients with Philadelphia chromosome-positive chronic-phase chronic myeloid leukemia (CML-CP) who have received >= 2 prior tyrosine kinase inhibitors or have the T315I mutation. A phase 1 trial evaluated the safety and efficacy of asciminib monotherapy in 115 CML-CP patients without T315I. After a median exposure of approximately 4 years, most patients remained on asciminib and achieved significant molecular responses.
Article
Hematology
Mycal Casey, Lorriane Odhiambo, Nidhi Aggarwal, Mahran Shoukier, K. M. Islam, Jorge Cortes
Summary: Despite advances in cancer outcomes, there are significant health disparities in the treatment of lymphomas. This study examined the representation of different demographic groups in randomized controlled trials (RCTs) for lymphoma and found significant underrepresentation of black, Hispanic, and female patients. Geographic distribution of trials also limited access for patients in certain areas. Correcting enrollment disparities is crucial to ensure that the results of these trials are applicable to all populations.
Article
Oncology
Fabio Efficace, Francesco Cottone, Betina Yanez, Vamsi Kota, Fausto Castagnetti, Giovanni Caocci, Massimiliano Bonifacio, Andrea Patriarca, Isabella Capodanno, Maria Cristina Miggiano, Mario Tiribelli, Massimo Breccia, Luigia Luciano, Valentina Giai, Alessandra Iurlo, Elisabetta Abruzzese, Carmen Fava, Shira Dinner, Jessica K. Altman, Gianantonio Rosti, Jorge Cortes, Marco Vignetti, David Cella
Summary: Patient-reported symptom monitoring from the beginning of therapy in patients with CML may be critical to improve adherence to therapy and early molecular response rates. The current findings suggest that systematic monitoring of patient-reported symptoms is associated with high adherence rates.
Article
Oncology
Koji Sasaki, Kiyomi Morita, Hagop Kantarjian, Guillermo Garcia-Manero, Elias Jabbour, Farhad Ravandi, Marina Konopleva, Gautam Borthakur, William Wierda, Naval Daver, Koichi Takahashi, Courtney Dinardo, Guillermo Montalban Bravo, Ghayas C. Issa, Sherry A. Pierce, Kelly A. Soltysiak, Martha S. Tingen, Jorge E. Cortes
Summary: This study investigated the impact of geographic disparities on cancer survival. The study found that factors such as age, income, race, and distance to cancer centers were predictive of survival. The results showed significant disparities in cancer care based on geographic locations.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2023)
Article
Virology
Pankaj Ahluwalia, Ashutosh Vashisht, Harmanpreet Singh, Nikhil Shri Sahajpal, Ashis K. Mondal, Kimya Jones, Jaspreet Farmaha, Ryan Bloomquist, Caroline Marie Carlock, Drew Fransoso, Christina Sun, Tyler Day, Comfort Prah, Trinh Vuong, Patty Ray, Danielle Bradshaw, Marisol Miranda Galvis, Sadanand Fulzele, Girindra Raval, Justin Xavier Moore, Jorge Cortes, Jeffrey N. James, Vamsi Kota, Ravindra Kolhe
Summary: This study aimed to investigate the temporal changes in the humoral immune response among healthcare workers in Augusta, GA, USA, and explore any associations with ethno-demographic features. The findings showed a significant decline in neutralizing antibody (NAb) and IgG levels at 8-12 months post-vaccination, with a more pronounced decline in White HCWs. Booster doses were found to increase antibody levels significantly, while participants without booster doses experienced a decline in antibody levels at 12 months post-vaccination.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Hematology
Marisol Miranda-Galvis, Kellen C. Tjioe, E. Andrew Balas, Gagan Agrawal, Jorge E. Cortes
Summary: This article evaluates the impact of social determinants of health on the outcomes of patients with hematologic malignancies. The study found that factors such as education level, health insurance coverage, income level, and marital status significantly affect patients' survival rates. However, there are contradictory reports regarding the effect of distance to treatment centers on treatment outcomes. Additionally, data on transportation, debt, diet, and other factors are lacking.
Review
Hematology
Mahesh Swaminathan, Jorge E. E. Cortes
Summary: Gemtuzumab-ozogamicin (GO) is an ADC approved for the treatment of CD33(+) AML. Despite initial recall due to lack of efficacy and hepatotoxicities, subsequent phase 3 studies showed significant survival benefits with lower and fractionated doses of GO in combination with standard chemotherapy. GO at a dose of 6 mg/m(2) was associated with higher grade > 3 hepatotoxicities and VOD compared to 3 mg/m(2). GO has been reapproved in 2017 and is currently being studied for its role in combination therapies and MRD elimination in CD33(+) AML patients.
THERAPEUTIC ADVANCES IN HEMATOLOGY
(2023)
Meeting Abstract
Hematology
Gemma Shay, Michael W. Deininger, Tim H. Bruemmendorf, Jeffrey H. Lipton, Leif Stenke, Eric Leip, Simon Purcell, Andrea Viqueira, Jorge E. Cortes
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Meeting Abstract
Oncology
Richard F. Schlenk, Pau Montesinos, Antonio Romero-Aguilar, Radovan Vrhovac, Elzbieta Patkowska, Hee-Je Kim, Pavel Zak, Po-Nan Wang, James Hanyok, Li Liu, Yasser Mostafa Kamel, Arnaud Lesegretain, Jorge Cortes, Mikkael A. Sekeres, Herve Dombret, Sergio Amadori, Jianxiang Wang, Alexander E. Perl, Mark J. Levis, Harry P. Erba
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2023)
Meeting Abstract
Oncology
Muhannad Sharara, Kellen Cristine Tjioe, Marisol Miranda Galvis, Gagan Agrawal, Andrew Balas, Jorge Cortes
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2023)
Meeting Abstract
Oncology
Aram Bidikian, Sreyashi Basu, Zhong He, Himachandana Atluri, Jabra Zarka, Michael Andreeff, Koji Sasaki, Elias Jabbour, Jorge E. Cortes, Padmanee Sharma, Ghayas C. Issa
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2023)
Meeting Abstract
Oncology
Joannie Clements, Cristina Ruiz, Andrea Damon, Peter Schuld, Pauline Frank, Cristina Constantinescu, Jorge Cortes
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2023)
Meeting Abstract
Oncology
Jorge Cortes, Michael Deininger, Elza Lomaia, Beatriz Moiraghi, Maria Undurraga Sutton, Carolina Pavlovsky, Charles Chuah, Tomasz Sacha, Jeffrey H. Lipton, James McCloskey, Philippe Rousselot, Gianantonio Rosti, Hugues de Lavallade, Christine Rojas, Anna Turkina, Moshe Talpaz, Michael Mauro, Vickie Lu, Alexander Vorog, Jane Apperley
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2023)
