Reconstructing sickle cell disease: A data-based analysis of the “hyperhemolysis paradigm” for pulmonary hypertension from the perspective of evidence-based medicine

Reproducibility of tricuspid regurgitant jet velocity measurements in children and young adults with sickle cell disease undergoing screening for pulmonary hypertension

(2010) Robert I. Liem et al.   AMERICAN JOURNAL OF HEMATOLOGY

Hypoxic upregulation of arginase II in human lung endothelial cells

(2010) Karina Krotova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia

(2010) Yi Jin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endothelial Dysfunction Enhances Vasoconstriction Due to Scavenging of Nitric Oxide by a Hemoglobin-based Oxygen Carrier

(2010) Binglan Yu et al.   ANESTHESIOLOGY

Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

Endothelial function as a functional expression of cardiovascular risk factors

(2010) Martin K Reriani et al.   Biomarkers in Medicine

Free Heme and the Polymerization of Sickle Cell Hemoglobin

(2010) Veselina V. Uzunova et al.   BIOPHYSICAL JOURNAL

Left ventricular hypertrophy and diastolic dysfunction in children with sickle cell disease are related to asleep and waking oxygen desaturation

(2010) M. C. Johnson et al.   BLOOD

Pulmonary hypertension and nitric oxide depletion in sickle cell disease

(2010) H. F. Bunn et al.   BLOOD

Pulmonary hypertension and NO in sickle cell

(2010) M. T. Gladwin et al.   BLOOD

The critical roles of platelet activation and reduced NO bioavailability in fatal pulmonary arterial hypertension in a murine hemolysis model

(2010) W. Hu et al.   BLOOD

High levels of placenta growth factor in sickle cell disease promote pulmonary hypertension

(2010) N. Sundaram et al.   BLOOD

Effect of eculizumab on haemolysis-associated nitric oxide depletion, dyspnoea, and measures of pulmonary hypertension in patients with paroxysmal nocturnal haemoglobinuria

(2010) Anita Hill et al.   BRITISH JOURNAL OF HAEMATOLOGY

Pulmonary hypertension in sickle cell disease children under 10 years of age

(2010) Raffaella Colombatti et al.   BRITISH JOURNAL OF HAEMATOLOGY

Exercise capacity and haemodynamics in patients with sickle cell disease with pulmonary hypertension treated with bosentan: results of the ASSET studies

(2010) Robyn J. Barst et al.   BRITISH JOURNAL OF HAEMATOLOGY

Pulmonary Hypertension in Hemolytic Disorders

(2010) Roberto F. Machado et al.   CHEST

Endothelium-derived Vasoactive Factors and Hypertension: Possible Roles in Pathogenesis and as Treatment Targets

(2010) Michel Félétou et al.   CURRENT HYPERTENSION REPORTS

Mitochondrial cytochrome redox states and respiration in acute pulmonary oxygen sensing

(2010) N. Sommer et al.   EUROPEAN RESPIRATORY JOURNAL

Updated classification and management of pulmonary hypertension

(2010) H. M Nef et al.   HEART

Six-minute walk test: observed adverse events and oxygen desaturation in a large cohort of patients with chronic lung disease

(2010) S. Jenkins et al.   INTERNAL MEDICINE JOURNAL

Selective Enhancement of Contractions to α1-adrenergic Receptor Activation in the Aorta of Mice With Sickle Cell Disease

(2010) Ramiro Juncos et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension

(2010) Patrick Crosswhite et al.   JOURNAL OF HYPERTENSION

Microvascular Responses to Cardiovascular Risk Factors

(2010) D. NEIL GRANGER et al.   MICROCIRCULATION

The use of sildenafil to treat pulmonary hypertension associated with interstitial lung disease

(2010) Tamera J. CORTE et al.   RESPIROLOGY

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

The six minute walk test accurately estimates mean peak oxygen uptake

(2010) Robert M Ross et al.   BMC Pulmonary Medicine

Prospective Echocardiography Assessment of Pulmonary Hypertension and Its Potential Etiologies in Children With Sickle Cell Disease††Conflicts of interest: Dr. Gordeuk has received grants from BioMarin Pharmaceutical Inc., Novato, California, and Actelion Pharmaceuticals Ltd., Allschwil, Switzerland, and is a consultant for Ikaria Holdings, Clinton, New Jersey.

(2009) Niti Dham et al.   AMERICAN JOURNAL OF CARDIOLOGY

Antisickling property of fetal hemoglobin enhances nitric oxide bioavailability and ameliorates organ oxidative stress in transgenic-knockout sickle mice

(2009) Trisha Dasgupta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Echocardiographic findings in patients with sickle cell disease

(2009) Shahla G. Naoman et al.   ANNALS OF HEMATOLOGY

Toxicological Consequences of Extracellular Hemoglobin: Biochemical and Physiological Perspectives

(2009) Paul W. Buehler et al.   ANTIOXIDANTS & REDOX SIGNALING

Spontaneous Adult-Onset Pulmonary Arterial Hypertension Attributable to Increased Endothelial Oxidative Stress in a Murine Model of Hereditary Hemorrhagic Telangiectasia

(2009) Mourad Toporsian et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammatory cytokines in vascular dysfunction and vascular disease

(2009) Alexander H. Sprague et al.   BIOCHEMICAL PHARMACOLOGY

Band 3 catalyzes sickle hemoglobin polymerization

(2009) Maria A. Rotter et al.   BIOPHYSICAL CHEMISTRY

The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle cell syndromes: results of a 17-year, single-center trial (LaSHS)

(2009) E. Voskaridou et al.   BLOOD

Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell disease

(2009) V. R. Gordeuk et al.   BLOOD

ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension

(2009) et al.   CIRCULATION

Comprehensive Invasive and Noninvasive Approach to the Right Ventricle–Pulmonary Circulation Unit

(2009) Hunter C. Champion et al.   CIRCULATION

Asymmetric dimethylarginine (ADMA) and endothelial dysfunction: implications for atherogenesis

(2009) Maurício Batista Paes Landim et al.   Clinics

Mechanisms of hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem

(2009) Jeremy PT Ward et al.   CURRENT OPINION IN PHARMACOLOGY

Hematologic, biochemical, and cardiopulmonary effects of l-arginine supplementation or phosphodiesterase 5 inhibition in patients with sickle cell disease who are on hydroxyurea therapy

(2009) Jane A. Little et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Circulating erythrocyte-derived microparticles are associated with coagulation activation in sickle cell disease

(2009) E. J. van Beers et al.   HAEMATOLOGICA

Elevated tricuspid regurgitant jet velocity in children and adolescents with sickle cell disease: association with hemolysis and hemoglobin oxygen desaturation

(2009) C. P. Minniti et al.   HAEMATOLOGICA

Sickle Cell Disease Painful Crisis and Steady State Differentiation by Proton Magnetic Resonance

(2009) Adolfo A. Fernández et al.   HEMOGLOBIN

Prevalência da apneia obstrutiva do sono em crianças e adolescentes portadores da anemia falciforme

(2009) Cristina Salles et al.   Jornal Brasileiro de Pneumologia

Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration

(2009) You-Yang Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Diagnosis, Assessment, and Treatment of Non-Pulmonary Arterial Hypertension Pulmonary Hypertension

(2009) Marius M. Hoeper et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Development and Pathology of Pulmonary Hypertension

(2009) Rubin M. Tuder et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cellular and Molecular Basis of Pulmonary Arterial Hypertension

(2009) Nicholas W. Morrell et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Diagnosis and Assessment of Pulmonary Arterial Hypertension

(2009) David B. Badesch et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inflammation, Growth Factors, and Pulmonary Vascular Remodeling

(2009) Paul M. Hassoun et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Updated Clinical Classification of Pulmonary Hypertension

(2009) Gérald Simonneau et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Pulmonary Hypertension: Diagnosis and Management

(2009) Michael D. McGoon et al.   MAYO CLINIC PROCEEDINGS

Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1

(2009) Gregg L. Semenza   PHYSIOLOGY

Angiogenic and Inflammatory Markers of Cardiopulmonary Changes in Children and Adolescents with Sickle Cell Disease

(2009) Xiaomei Niu et al.   PLoS One

Hemoglobin-based oxygen carriers: current status and future directions

(2009) Toby A. Silverman et al.   TRANSFUSION

Mechanisms of nitric oxide synthase uncoupling in endotoxin-induced acute lung injury: Role of asymmetric dimethylarginine

(2009) Shruti Sharma et al.   VASCULAR PHARMACOLOGY

Pulmonary Hypertension and Cor Pulmonale during Severe Acute Chest Syndrome in Sickle Cell Disease

(2008) Armand Mekontso Dessap et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Prevention of the Pulmonary Vasoconstrictor Effects of HBOC-201 in Awake Lambs by Continuously Breathing Nitric Oxide

(2008) Binglan Yu et al.   ANESTHESIOLOGY

Regulation of Endothelial Junctional Permeability

(2008) Emily Vandenbroucke et al.   Annals of the New York Academy of Sciences

Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological Consequences

(2008) Huan-Xiang Zhou et al.   Annual Review of Biophysics

Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease

(2008) A. E. Ashley-Koch et al.   BLOOD

Microvesicles in haemoglobinopathies offer insights into mechanisms of hypercoagulability, haemolysis and the effects of therapy

(2008) Maxwell Westerman et al.   BRITISH JOURNAL OF HAEMATOLOGY

Molecular biology of inflammation and sepsis: A primer*

(2008) Ismail Cinel et al.   CRITICAL CARE MEDICINE

Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms

(2008) N. Sommer et al.   EUROPEAN RESPIRATORY JOURNAL

No association of the hypercoagulable state with sickle cell disease related pulmonary hypertension

(2008) E.J. van Beers et al.   HAEMATOLOGICA

Sickle cell disease-related organ damage occurs irrespective of pain rate: implications for clinical practice

(2008) E. J. van Beers et al.   HAEMATOLOGICA

Coagulation activation and inflammation in sickle cell disease-associated pulmonary hypertension

(2008) K. I. Ataga et al.   HAEMATOLOGICA

Molecular pathogenesis of pulmonary arterial hypertension

(2008) Marlene Rabinovitch   JOURNAL OF CLINICAL INVESTIGATION

Endothelial microparticles: a universal marker of vascular health?

(2008) E Shantsila   JOURNAL OF HUMAN HYPERTENSION

Severity of Obstructive Sleep Apnea in Children With Sickle Cell Disease

(2008) Joseph Kaleyias et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Pulmonary Complications of Sickle Cell Disease

(2008) Mark T. Gladwin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic targets in pulmonary arterial hypertension

(2008) Christopher J. Rhodes et al.   PHARMACOLOGY & THERAPEUTICS

Abnormal autonomic cardiac response to transient hypoxia in sickle cell anemia

(2008) S Sangkatumvong et al.   PHYSIOLOGICAL MEASUREMENT

Chronic Hyper-Hemolysis in Sickle Cell Anemia: Association of Vascular Complications and Mortality with Less Frequent Vasoocclusive Pain

(2008) James G. Taylor et al.   PLoS One

Genetic endothelial systems biology of sickle stroke risk

(2007) L. Chang Milbauer et al.   BLOOD