Article
Medicine, General & Internal
Adeel Ahmad, Diana Mihalca, Ben Stacey, Sayna Samaee, Dipal Mehta, Stephen Hibbs, Tanya Freeman, Basabi Chatterjee, Enamul Ali, Leo Cheng, Dimitris A. Tsitsikas
Summary: This study examined the dental health of sickle cell disease patients and found that a majority of them required dental extractions. More than half of the patients did not have regular dental check-ups. The lack of correlation with disease severity suggests that poor awareness of the importance of dental health may be the main factor contributing to the high prevalence of severe dental disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Multidisciplinary Sciences
Anna Nowogrodzki
Summary: The United States has made progress in reducing child mortality, but adults have been neglected in this regard.
Article
Health Care Sciences & Services
Seethal A. Jacob, Roua Daas, Anna Feliciano, Julia E. LaMotte, Aaron E. Carroll
Summary: This study aims to understand the barriers to care and perceptions of telemedicine among caregivers of pediatric SCD patients in the Midwest. The study reveals common burdens faced by caregivers, barriers and facilitators of SCD care, and caregiver perceptions of the usefulness of telemedicine for SCD care.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Spectroscopy
Rajesh Srinivasan, V. R. Eugene Christo, Radhika Nambannor Kunnath, Prateek Katare, Aravind Venukumar, Nisanth K. M. Nambison, Sai Siva Gorthi
Summary: People with sickle cell disease suffer from a reduced quality of life, and current detection methods are costly and time-consuming. This study proposes a new low-cost method that can rapidly and accurately screen and diagnose sickle cell disease, potentially revolutionizing the field.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Multidisciplinary Sciences
Shannon Phillips, Yumei Chen, Rita Masese, Laurence Noisette, Kasey Jordan, Sara Jacobs, Lewis L. Hsu, Cathy L. Melvin, Marsha Treadwell, Nirmish Shah, Paula Tanabe, Julie Kanter
Summary: This study aimed to identify barriers to sickle cell disease (SCD) care from the perspective of individuals with SCD in a multi-state sample. The results showed that lack of knowledge, inadequate caregiver support, limited provider knowledge, and transportation barriers were major obstacles to optimal SCD care. Strategies tailored towards reducing these barriers are necessary to improve the quality of SCD care.
Article
Medicine, Research & Experimental
Shahida A. Khan, Saeed H. Halawani, Torki Al Zughaibi, Sarah A. Khan
Summary: Inflammation plays a crucial role in the complications of sickle cell disease. This study found a correlation between age and high-sensitivity C-reactive protein (hsCRP) levels, as well as an increase in total homocysteine (tHCY) levels as the disease progresses.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Editorial Material
Multidisciplinary Sciences
Benjamin Plackett
Summary: Sickle-cell disease is prevalent in the Middle East, with 2.6% of the population in some areas affected by this genetic disorder. Adlette Inati, a specialist in clinical haematology at the Lebanese American University, and president of a foundation supporting sickle-cell disease patients in Lebanon, discusses the potential benefits of genetic screening in this region.
Article
Multidisciplinary Sciences
Khadija Al Saif, Fatema Mohamed Abdulla, Anwaar Alrahim, Sara Abduljawad, Zainab Matrook, Jenan Jaafar Abdulla, Fatima Bughamar, Fatema Alasfoor, Rana Taqi, Amna Almarzooq, Jamil Ahmed
Summary: This study examined the challenges faced by caregivers of adolescents with sickle cell disease (SCD) in seeking care, including difficulties accessing healthcare and the impact on their emotional, financial, and social aspects of life.
Article
Genetics & Heredity
Agnes Jonathan, Hilda Tutuba, William Lloyd, Joyce Ndunguru, Julie Makani, Paschal Ruggajo, Irene K. Minja, Emmanuel Balandya
Summary: In Dar es Salaam, Tanzania, healthcare workers have limited knowledge on sickle cell disease (SCD) care and lack critical resources such as diagnostic tests and medication therapy, especially at regional-level hospitals. Efforts are needed to improve healthcare worker knowledge and availability of resources to enhance care for SCD patients and reduce morbidity and mortality in Tanzania.
FRONTIERS IN GENETICS
(2022)
Review
Hematology
Lydia H. Pecker, Deva Sharma, Alecia Nero, Michael J. Paidas, Russell E. Ware, Andra H. James, Kim Smith-Whitley
Summary: There is an urgent need to address the reproductive health of girls and women with sickle cell disease (SCD). Existing literature is mostly descriptive and lacks high-quality interventional studies. An expert panel convened in 2020 identified significant limitations to clinical care and prominent barriers to research and care for women with SCD.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Psychiatry
Cara Nikolajski, Julia O'Brien, Emily Nardo, Eva Szigethy, Charles Jonassaint
Summary: This study aimed to understand the perceptions and preferences of African American individuals with sickle cell disease (SCD) regarding digital cognitive behavioral therapy (CBT) mental health treatment. A series of focus groups were conducted, and several themes emerged, including the importance of connecting with others living with SCD, personalization of app content and coaching, characteristics of coaches, journaling and pain tracking, and considerations for optimal engagement. Enhancing user experience and relevance to patient populations is crucial for improving program engagement and uptake.
JMIR MENTAL HEALTH
(2023)
Article
Medicine, General & Internal
Matthew P. Smeltzer, Kristen E. Howell, Marsha Treadwell, Liliana Preiss, Allison A. King, Jeffrey A. Glassberg, Paula Tanabe, Sherif M. Badawy, Lisa DiMartino, Robert Gibson, Julie Kanter, Lisa M. Klesges, Jane S. Hankins
Summary: Many providers were not familiar with NHLBI's SCD care guidelines, and barriers to providing care for patients with SCD were influenced by providers' specialty, training, and practice setting. Increasing provider knowledge could improve hydroxyurea utilization, pain management, and mental health support.
Article
Multidisciplinary Sciences
April Grady, Anthony Fiori, Dhaval Patel, Jessica Nysenbaum
Summary: Sickle cell disease is a genetic condition that can lead to serious medical complications and decreased quality of life. Medicaid covered a significant portion of hospitalizations and emergency department visits related to the disease in the early 2000s. Data from four states with large populations showed higher mortality rates, rates of disability-related eligibility, and healthcare utilization among Medicaid enrollees with sickle cell disease. With gene therapies on the horizon, it is important for stakeholders to understand the affected populations and address coverage, costs, and outcomes.
Article
Medicine, General & Internal
George Goshua, Cecelia Calhoun, Satoko Ito, Lyndon P. James, Andrea Luviano, Lakshmanan Krishnamurti, Ankur Pandya
Summary: Gene therapy is a potential cure for sickle cell disease. Conventional cost-effectiveness analysis and distributional cost-effectiveness analysis were used to compare the effects of gene therapy and standard care in patients with sickle cell disease.
ANNALS OF INTERNAL MEDICINE
(2023)
Review
Medicine, General & Internal
Emily Limerick, Allistair Abraham
Summary: Sickle cell disease (SCD) affects a significant number of African American children in the United States. Hematopoietic cell transplantation (HCT) is the only curative option, and alternative donor strategies are being explored due to limited availability of HLA-matched sibling HCT. This review examines different conditioning regimens and their outcomes in pediatric SCD patients.
JOURNAL OF CLINICAL MEDICINE
(2022)