Article
Medicine, Research & Experimental
Dunming Xiao, Yue Zhang, Wanxin Chen, Jianwei Xuan, Yingyao Chen
Summary: This study evaluated the cost-effectiveness of linaclotide for patients with IBS-C. The results showed that linaclotide treatment for 1 year can improve patients' QALYs at a lower cost compared to other medications. Therefore, linaclotide is highly cost-effective.
ADVANCES IN THERAPY
(2022)
Review
Medicine, General & Internal
Sarah Patel, Bethany Doerfler, Katerine Boutros, Samson Ng, Machelle Manuel, Elayne DeSimone
Summary: IBS-C and CIC are common disorders of gut-brain interaction, presenting with symptoms such as constipation, abdominal pain, and bloating that significantly impact quality of life. Family medicine practitioners are uniquely qualified to diagnose and manage these conditions.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Review
Pediatrics
Desiree F. Baaleman, Shivani Gupta, Marc A. Benninga, Neetu Bali, Karla H. Vaz, Desale Yacob, Carlo Di Lorenzo, Peter L. Lu
Summary: Linaclotide is well-tolerated and effective in treating functional constipation and IBS-C in adults, but its efficacy and safety in children remain unclear. A retrospective study of children at Nationwide Children's Hospital in Columbus, Ohio found that nearly half of children with FC or IBS-C benefited from linaclotide, but adverse events were relatively common. Further prospective, controlled studies are needed to confirm these findings and identify which patients are most likely to benefit from linaclotide.
Article
Medicine, General & Internal
Juan J. Sebastian Domingo
Summary: Irritable bowel syndrome is a common functional bowel disorder with significant impact on patients' daily lives and society's economy. It is characterized by abdominal pain, bloating, and altered bowel movements, and its etiology and pathophysiological mechanism are still unknown.
Review
Nutrition & Dietetics
Giuseppe Chiarioni, Stefan Lucian Popa, Abdulrahman Ismaiel, Cristina Pop, Dinu Iuliu Dumitrascu, Vlad Dumitru Brata, Traian Adrian Duse, Victor Incze, Teodora Surdea-Blaga, Jose Antonio Uranga
Summary: This systematic review evaluates the efficacy and safety of herbal remedies in the management of IBS-C. The included studies demonstrate some evidence of the beneficial effects of herbal remedies on IBS-C symptoms. However, the heterogeneity of the interventions and outcome measures limits the ability to perform a meta-analysis.
Article
Gastroenterology & Hepatology
Sameer K. Berry, Rani Berry, David Recker, Jeffrey Botbyl, Lucy Pun, William D. Chey
Summary: Digital gut-directed hypnotherapy (GDH) treatment program can improve symptoms of IBS, including abdominal pain and stool problems. There was no significant difference in effectiveness between digital GDH and digital muscle relaxation (MR), but the GDH treatment group had more abdominal pain responders.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Li Hua Peng, Jing Yuan Fang, Ning Dai, Xi Zhong Shen, You Lin Yang, Jing Sun, Yun Sheng Yang
Summary: Linaclotide (290 μg/d) was effective and well-tolerated in Chinese IBS-C patients, with a rapid onset of action.
JOURNAL OF DIGESTIVE DISEASES
(2022)
Article
Medicine, General & Internal
Oana-Bogdana Barboi, Ioan Chirila, Irina Ciortescu, Carmen Anton, Vasile-Liviu Drug
Summary: This study suggests that a specific constipation diet combined with inulin, choline, and silymarin can have significant clinical benefits on IBS patients with constipation, improving bowel movement, abdominal pain, and bloating symptoms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Xue Shang, E. Fen-Fen, Kang-Le Guo, Yan-Fei Li, Hong-Lin Zhao, Yan Wang, Nan Chen, Tao Nian, Chao-Qun Yang, Ke-Hu Yang, Xiu-Xia Li
Summary: This study conducted a systematic review and meta-analysis to evaluate the effectiveness and safety of probiotics in treating constipation-predominant irritable bowel syndrome (IBS-C). The findings suggest that probiotics can improve stool consistency and increase the number of Bifidobacteria and Lactobacilli in feces with good safety. However, the certainty of the evidence is low and more high-quality studies are needed to verify the results.
Article
Gastroenterology & Hepatology
Lin Chang, Brian E. Lacy, Baha Moshiree, Amy Kassebaum, Jessica L. Abel, Jennifer Hanlon, Wilmin Bartolini, Ramesh Boinpally, Wieslaw Bochenek, Susan M. Fox, Madhuja Mallick, Ken Tripp, Nicholas Omniewski, Elizabeth Shea, Niels Borgstein
Summary: Linaclotide significantly improved abdominal symptoms related to constipation-predominant irritable bowel syndrome (IBS-C) compared to placebo, including bloating, discomfort, and pain. The study found that linaclotide had a higher overall change from baseline in abdominal score (AS) and a higher responder rate for abdominal symptoms improvement, with diarrhea being the most common side effect. The use of a novel multi-item AS derived from the Diary for IBS Symptoms-Constipation may be valuable in future clinical studies for IBS-C to measure meaningful improvements beyond traditional endpoints.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Theodora Kalli, Tilemachos Koutouratsas, George Karamanolis, Maria Gazouli
Summary: The study found a significant association between the rs696217 genetic polymorphism and IBS susceptibility, with the GG and GT genotypes as well as the G allele being linked to IBS risk, while the T allele may have a protective effect. There was no correlation between ghrelin gene polymorphisms and different IBS subtypes.
Review
Medicine, General & Internal
Lynne McFarland, Tarkan Karakan, Ali Karatas
Summary: After screening 521 studies, 42 randomized controlled trials were included in this study, with 4 probiotics showing significant reduction in abdominal pain, particularly B. coagulans MTCC5260. Mild-moderate adverse events were reported in 51% of the trials, but none were more associated with the probiotics compared to controls.
Review
Medicine, General & Internal
Michael Camilleri
Summary: This narrative review summarizes the epidemiology, pathophysiology, diagnosis, management, and prognosis of irritable bowel syndrome (IBS), which has a high prevalence in the United States, especially among women and young people. The diagnosis is traditionally based on the positive identification of symptoms related to various syndromes, while treatment methods should be customized based on specific symptoms.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Review
Nutrition & Dietetics
Claudia Di Rosa, Annamaria Altomare, Vittoria Terrigno, Florencia Carbone, Jan Tack, Michele Cicala, Michele Pier Luca Guarino
Summary: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by abdominal pain and altered bowel habits. The exact cause of IBS is not fully understood, but it is believed to involve a combination of factors such as abnormal gut motility, inflammation, increased intestinal permeability, and sensitivity. Diet and gut microbiota have also been identified as important contributors to IBS. This review examines the effects of dietary components, functional foods, prebiotics, probiotics, and symbiotics on symptoms and gut microbiota in individuals with IBS-C.
Review
Economics
T. Joseph Mattingly, Bryan L. Love, Bilal Khokhar
Article
Gastroenterology & Hepatology
Bryan L. Love, Christopher J. Finney, Jill K. J. Gaidos
Summary: This study identified risk factors for severe pneumococcal disease in IBD patients, including having Crohn's disease, more comorbidities, and exposure to combination immunosuppression. Vaccination with pneumococcal vaccines, especially the combination of PCV13 and PPSV23, significantly reduced the risk of severe pneumococcal disease.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Pharmacology & Pharmacy
Eric E. Chinaeke, Bryan L. Love, Joe Magagnoli, Ismaeel Yunusa, Gene Reeder
Summary: This study demonstrates that the use of statins is associated with a decrease in 30-day ICU mortality, ICU LOS, and 30-day in-hospital mortality among patients with sepsis.
Letter
Medicine, General & Internal
Ismaeel Yunusa, Bryan L. Love, Chao Cai, Tessa Hastings, Claiborne E. Reeder, Elizabeth W. Blake, Cynthia Phillips
Summary: This cross-sectional study compares the number of insulin prescriptions filled before and during the COVID-19 pandemic to understand the influencing factors.
Article
Public, Environmental & Occupational Health
Chao Cai, Bryan L. Love, Ismaeel Yunusa, Claiborne E. Reeder
Summary: Standard survival models may bias the estimation of medication persistence if there is a high rate of long-term persistent patients. In this study, a mixture cure model was introduced to improve the estimation of medication persistence.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2022)
Article
Health Care Sciences & Services
Chelsea L. Richard, Bryan L. Love, Nansi Boghossian, James Hardin, Suzanne McDermott
Summary: This study examines the difference in opioid prescribing during pregnancy by disability status among Medicaid beneficiaries in South Carolina. The findings indicate that women with disabilities, particularly those with physical, inflammatory, and psychiatric disabilities, are prescribed more opioids and at higher dosages during pregnancy compared to women without disabilities.
DISABILITY AND HEALTH JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Ismaeel Yunusa, Bryan L. Love
Summary: This study evaluated the economic and clinical implications of using vonoprazan-based and rifabutin-based regimens compared to other existing prepackaged first-line treatment options for eradicating Helicobacter pylori (H. pylori) in the United States. The findings suggest that vonoprazan triple therapy provides the greatest net health and monetary benefit for US healthcare payers.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Mohiuddin Ahsanul Kabir Chowdhury, James W. Hardin, Bryan L. Love, Anwar T. Merchant, Suzanne McDermott
Summary: The study examined the association between nonsteroidal anti-inflammatory drug (NSAID) use during pregnancy and autism spectrum disorder (ASD) and intellectual disability (ID) in children. A retrospective cohort study was conducted using multiple datasets in South Carolina between 2010 and 2017. Results showed that NSAID use during pregnancy was associated with ID only, but not with ASD.
JOURNAL OF WOMENS HEALTH
(2023)
Letter
Gastroenterology & Hepatology
Ismaeel Yunusa, Bryan L. Love
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Clinical Neurology
Margaret A. Turk, Suzanne McDermott, Wanfang Zhang, Bo Cai, Bryan L. Love, NaTasha Hollis
Summary: The purpose of this study was to investigate the association between filling opioid prescriptions and healthcare service utilization among adults with disability. The results showed that a higher proportion of adults with inflammatory conditions or longstanding physical disability filled opioid prescriptions compared to those without these conditions. Additionally, individuals who filled opioid prescriptions were more likely to have higher rates of emergency department visits and hospitalizations.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Health Care Sciences & Services
Rouen Brockmann, Joanna Nixon, Bryan L. Love, Ismaeel Yunusa
Summary: In 2021, the FDA approved aducanumab for early-stage Alzheimer's disease without clear clinical evidence of cognitive benefits. The initial price of the drug was $56,000 per year, later reduced to $28,200. However, CMS will only cover individuals in clinical trials and limit coverage for future antiamyloid antibodies, causing confusion and concerns. These decisions raise questions about the approval process and accessibility of the drug, impacting future Alzheimer's treatments. Stakeholders need to work together to address these challenges and ensure access to effective and affordable treatments.
LANCET REGIONAL HEALTH-AMERICAS
(2023)
Article
Health Policy & Services
Eric E. Chinaeke, Minghui Li, Bryan L. Love, Brandon Bookstaver, Xiaoming Li, Gene Reeder, Kevin Lu
Summary: The comorbidity of Type-II Diabetes Mellitus imposes a significant economic burden on HIV/AIDS patients and Medicare, especially among African Americans.
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2023)
Article
Health Policy & Services
Eric E. Chinaeke, Minghui Li, Brandon Bookstaver, Bryan L. Love, Xiaoming Li, Gene Reeder, Kevin Lu
Summary: This study found an association between the use of protease inhibitors (PI) in HIV/AIDS patients and an increased risk of developing type II diabetes mellitus (T2DM), with African Americans having a higher risk compared to Caucasians.
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2023)
Meeting Abstract
Public, Environmental & Occupational Health
Eric Chinaeke, Joseph Magagnoli, Bryan Love, Gene Reeder
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2020)
Article
Health Care Sciences & Services
T. Joseph Mattingly, Bryan L. Love
JOURNAL OF MANAGED CARE & SPECIALTY PHARMACY
(2020)