Article
Endocrinology & Metabolism
Beibei Luo, Lei Feng, Qianye Bi, Rui Shi, Huiying Cao, Yanbi Zhang
Summary: This study aimed to determine the predictive value of fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c) in the development of hypertension. The results revealed that prediabetes was independently associated with an increased risk for hypertension, and FPG was a better predictor of hypertension than HbA1c, regardless of the group.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Clinical Neurology
Tengfei Shao, Hui Liu, Guochao Yang, Huan Wang, Di Li, Huanyu Ni, Yun Xu, Jinping Zhang
Summary: This study examined the relationship between stress hyperglycemia and outcomes in patients with acute ischemic stroke, and found that stress hyperglycemia was associated with functional outcomes, especially in patients without diabetes. Therefore, stress hyperglycemia is important in patients with stroke.
FRONTIERS IN NEUROLOGY
(2023)
Review
Medical Laboratory Technology
Neha Yadav, Amit Kumar Mandal
Summary: Fasting blood glucose and glycated hemoglobin (HbA1c) are widely used biomarkers for diabetes screening and monitoring. While blood glucose level reflects short-term control, HbA1c provides an average measure of long-term glucose control. However, quantification of HbA1c can be affected by genetic variants of hemoglobin. Mass spectrometry, which measures total glycation of hemoglobin, is not impacted by the presence of genetic variants and may be a better analytical choice for diabetes.
CLINICA CHIMICA ACTA
(2023)
Article
Geriatrics & Gerontology
Zhong-ming Cai, Man-man Zhang, Ren-qian Feng, Xu-dong Zhou, Hao-man Chen, Zhi-peng Liu, Yan-zhi Wu, Qun-li Lin, Sheng-lie Ye, Cheng-wei Liao, Xue-rong Huang, Le-qiu Sun, Bo Yang, Bei-lei Zhu
Summary: The study found a link between stress hyperglycemia and adverse outcomes in stroke patients, including increased risk of all-cause death, infectious complications, and dysfunction.
Article
Endocrinology & Metabolism
Yingkui Si, Anping Wang, Yunshuang Yang, Hongzhou Liu, Shi Gu, Yiming Mu, Zhaohui Lyu
Summary: Higher fasting plasma glucose (FPG) and 2-hour postprandial blood glucose (2hPG) levels, but not glycated hemoglobin (HbA1c) levels, are independent risk factors for developing hypertension in an urban Northern Chinese population.
Article
Public, Environmental & Occupational Health
Yerin Hwang, Jiyoung Jang, Myung-Hee Shin
Summary: Previous studies have suggested that vitamin D deficiency may increase the risk of type 2 diabetes, and that it may continue to affect glucose control in individuals with diabetes. Results of the study showed a significant association between vitamin D deficiency and abnormal HbA1c levels, particularly in male and postmenopausal female participants. However, there was no significant association between vitamin D and fasting glucose levels.
EPIDEMIOLOGY AND HEALTH
(2022)
Article
Endocrinology & Metabolism
Y. -C. Lin, H. -P. Tu, T. -N. Wang
Summary: This study, using a cohort study and two-sample Mendelian randomization, found that high-density lipoprotein cholesterol (HDL-C) is negatively associated with HbA1c, fasting glucose, and diabetes. The study also observed causal associations between HDL-C and HbA1c and diabetes.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Ashot Mkrtumyan, Alexander Ametov, Tatiana Demidova, Anna Volkova, Ekaterina Dudinskaya, Arkady Vertkin, Sergei Vorobiev
Summary: Subetta therapy effectively improves 2-hour plasma glucose levels in patients with IGT, with a low incidence of adverse events.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Food Science & Technology
Felipe Mendes Delpino, Lilian Munhoz Figueiredo
Summary: The systematic review with meta-analysis showed that resveratrol supplementation has protective effects on diabetes parameters. The analysis revealed significant reduction in insulin resistance and glycated hemoglobin, and a significant impact on fasting blood glucose in individuals with diabetes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Endocrinology & Metabolism
Emily Borgundvaag, Jessica Mak, Caroline K. Kramer
Summary: Studies evaluating intermittent fasting (IF) in patients with type 2 diabetes mellitus (T2DM) suggest that IF leads to greater weight loss compared to standard diet, while showing similar impact on glycemic control.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Food Science & Technology
Felipe Mendes Delpino, Lilian Munhoz Figueiredo, Bruna Goncalves Cordeiro da Silva, Taiciane Goncalves da Silva, Gicele Costa Mintem, Renata Moraes Bielemann, Denise Petrucci Gigante
Summary: The study found that omega-3 supplementation has significant effects in reducing fasting blood glucose and insulin resistance, but not on glycated hemoglobin levels in diabetes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Endocrinology & Metabolism
Wanying Su, Meiyi Tao, Lin Ma, Ke Tang, Fang Xiong, Xuan Dai, Yuelan Qin
Summary: This meta-analysis confirms the beneficial impact of resistance training (RT) on glycated hemoglobin (HbA1c) and fasting blood glucose (FBG) levels in patients with type 2 diabetes mellitus (T2DM). Additionally, the study identifies critical training parameters that are important for enhancing HbA1c and FBG reductions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Beatriz Isabel Garcia-Martinez, Mirna Ruiz-Ramos, Jose Pedraza-Chaverri, Edelmiro Santiago-Osorio, Victor Manuel Mendoza-Nunez
Summary: The findings of the study indicate that resveratrol has a significant dose-response effect on glucose concentrations, HbA1c, and insulin levels. However, there is currently no established therapeutic dose.
Article
Medicine, General & Internal
Jeongseon Yoo, Youngah Choi, Shin Ae Park, Ji Yeon Seo, Chul Woo Ahn, Jaehyun Han
Summary: The study found that glycated albumin and GA/HbA1c ratio in patients with type 2 diabetes mellitus were associated with the progression of COVID-19 from mild to severe disease. Patients with high blood sugar are more likely to develop severe disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Felipe Mendes Delpino, Lilian Munhoz Figueiredo, Bruno Pereira Nunes
Summary: This study reviewed randomized clinical trials on the effects of melatonin supplementation in diabetes and found that melatonin can help reduce diabetes parameters such as fasting blood glucose, glycated hemoglobin, and insulin resistance compared to placebo.
CLINICAL NUTRITION
(2021)
Article
Oncology
Thomas Heisser, Rafael Cardoso, Tobias Niedermaier, Michael Hoffmeister, Hermann Brenner
Summary: The study assessed the potential of using a low threshold fecal immunochemical test (FIT) as a gateopener for screening colonoscopy. The results showed that this approach could significantly improve cancer detection rates and prevent colorectal cancer compared to conventional screening methods.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Psychology, Clinical
Olivier Desrichard, Neele Heiser, Olivier Renaud, Sascha Zuber, Michel Oris, Matthias Kliegel
Summary: According to this research, examiners' characteristics can influence participants' performance, especially when they activate stereotypes of the participant group. The study found that younger examiners, who activate age stereotypes, led to worse performance among older individuals.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Article
Oncology
Xuechen Chen, Thomas Heisser, Rafael Cardoso, Michael Hoffmeister, Hermann Brenner
Summary: Colorectal cancer (CRC) has higher incidence and mortality rates in men compared to women. A study estimated the risk advancement periods (RAPs) for men compared to women to determine at what age men reach comparable levels of risk. The results showed that men had significantly higher CRC risk in the age groups 50-59 and 60-69, with RAPs as high as 8.7 and 6.2 years earlier, respectively. This suggests the need for gender-specific screening starting ages in countries where screening starts above age 50.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Matteo Giaccherini, Riccardo Farinella, Manuel Gentiluomo, Beatrice Mohelnikova-Duchonova, Emanuele Federico Kauffmann, Matteo Palmeri, Faik Uzunoglu, Pavel Soucek, Dalius Petrauskas, Giulia Martina Cavestro, Romanas Zykus, Silvia Carrara, Raffaele Pezzilli, Marta Puzzono, Andrea Szentesi, John Neoptolemos, Livia Archibugi, Orazio Palmieri, Anna Caterina Milanetto, Gabriele Capurso, Casper H. J. van Eijck, Hannah Stocker, Rita T. Lawlor, Pavel Vodicka, Martin Lovecek, Jakob R. Izbicki, Francesco Perri, Rita Kupcinskaite-Noreikiene, Mara Gotz, Juozas Kupcinskas, Tamas Hussein, Peter Hegyi, Olivier R. Busch, Thilo Hackert, Andrea Mambrini, Hermann Brenner, Maurizio Lucchesi, Daniela Basso, Francesca Tavano, Ben Schottker, Giuseppe Vanella, Stefania Bunduc, Agota Petranyi, Stefano Landi, Luca Morelli, Federico Canzian, Daniele Campa
Summary: This study analyzed the common genetic variability of PDAC familial genes and found that the CDKN2B-AS1/ANRIL gene located in the 9p21.3 region plays an important role in the development of PDAC. The results strongly support the association between genetic variability in the 9p21.3 region and PDAC pathogenesis.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Genetics & Heredity
Stefanie H. Mueller, Alvina G. Lai, Maria Valkovskaya, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Michael Lush, Zomoruda Abu-Ful, Thomas U. Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Volker Arndt, Kristan J. Aronson, Annelie Augustinsson, Thais Baert, Laura E. Beane Freeman, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Bernardo Bonanni, Hermann Brenner, Sara Y. Brucker, Saundra S. Buys, Jose E. Castelao, Tsun L. Chan, Jenny Chang-Claude, Stephen J. Chanock, Ji-Yeob Choi, Wendy K. Chung, Sarah Colonna, Sten Cornelissen, Fergus J. Couch, Kamila Czene, Mary B. Daly, Peter Devilee, Thilo Dork, Laure Dossus, Miriam Dwek, Diana M. Eccles, Arif B. Ekici, A. Heather Eliassen, Christoph Engel, D. Gareth Evans, Peter A. Fasching, Olivia Fletcher, Henrik Flyger, Manuela Gago-Dominguez, Yu-Tang Gao, Montserrat Garcia-Closas, Jose A. Garcia-Saenz, Jeanine Genkinger, Aleksandra Gentry-Maharaj, Felix Grassmann, Pascal Guenel, Melanie Gundert, Lothar Haeberle, Eric Hahnen, Christopher A. Haiman, Niclas Hakansson, Per Hall, Elaine F. Harkness, Patricia A. Harrington, Jaana M. Hartikainen, Mikael Hartman, Alexander Hein, Weang-Kee Ho, Maartje J. Hooning, Reiner Hoppe, John L. Hopper, Richard S. Houlston, Anthony Howell, David J. Hunter, Dezheng Huo, Abctb Investigators, Hidemi Ito, Motoki Iwasaki, Anna Jakubowska, Wolfgang Janni, Esther M. John, Michael E. Jones, Audrey Jung, Rudolf Kaaks, Daehee Kang, Elza K. Khusnutdinova, Sung-Won Kim, Cari M. Kitahara, Stella Koutros, Peter Kraft, Vessela N. Kristensen, Katerina Kubelka-Sabit, Allison W. Kurian, Ava Kwong, James Lacey, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Martha Linet, Wing-Yee Lo, Jirong Long, Artitaya Lophatananon, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Keitaro Matsuo, Dimitrios Mavroudis, Usha Menon, Kenneth Muir, Rachel A. Murphy, Heli Nevanlinna, William G. Newman, Dieter Niederacher, Katie M. O'Brien, Nadia Obi, Kenneth Offit, Olufunmilayo Olopade, Andrew F. Olshan, Hakan Olsson, Sue K. Park, Alpa Patel, Achal Patel, Charles M. Perou, Julian Peto, Paul D. P. Pharoah, Dijana Plaseska-Karanfilska, Nadege Presneau, Brigitte Rack, Paolo Radice, Dhanya Ramachandran, Muhammad U. Rashid, Gad Rennert, Atocha Romero, Kathryn J. Ruddy, Matthias Ruebner, Emmanouil Saloustros, Dale P. Sandler, Elinor J. Sawyer, Marjanka K. Schmidt, Rita K. Schmutzler, Michael O. Schneider, Christopher Scott, Mitul Shah, Priyanka Sharma, Chen-Yang Shen, Xiao-Ou Shu, Jacques Simard, Harald Surowy, Rulla M. Tamimi, William J. Tapper, Jack A. Taylor, Soo Hwang Teo, Lauren R. Teras, Amanda E. Toland, Rob A. E. M. Tollenaar, Diana Torres, Gabriela Torres-Mejia, Melissa A. Troester, Therese Truong, Celine M. Vachon, Joseph Vijai, Clarice R. Weinberg, Camilla Wendt, Robert Winqvist, Alicja Wolk, Anna H. Wu, Taiki Yamaji, Xiaohong R. Yang, Jyh-Cherng Yu, Wei Zheng, Argyrios Ziogas, Elad Ziv, Alison M. Dunning, Douglas F. Easton, Harry Hemingway, Ute Hamann, Karoline B. Kuchenbaecker
Summary: This study identified 14 genes associated with breast cancer using gene-based aggregation analysis, including two newly discovered genes FMNL3 and AC058822.1. Furthermore, associations with established candidate genes like ESR1 were found through the collaboration of multi-ancestral cohorts, highlighting the importance of diversifying study cohorts. These findings provide new insights into the development of breast cancer.
Article
Public, Environmental & Occupational Health
Sha Sha, Tafirenyika Gwenzi, Li-Ju Chen, Hermann Brenner, Ben Schoettker
Summary: This study investigated the interrelationships between vitamin D deficiency, biomarkers of systemic inflammation response (SIR), and mortality. It found that vitamin D deficiency was associated with disadvantageous levels of blood cell count-based SIR biomarkers, but not with C-reactive protein (CRP)-based biomarkers. Vitamin D deficiency and all SIR biomarkers were significantly associated with all-cause mortality and mortality from cancer, cardiovascular, and respiratory disease. The study suggests that clinical interventions targeting both vitamin D deficiency and underlying causes of systemic inflammation may be beneficial.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Oncology
Justin R. Gregg, Jeri Kim, Christopher Logothetis, Sam Hanash, Xiaotao Zhang, Ganiraju Manyam, Kenneth Muir, Janet L. UKGPCS Collaborative Grp, Graham G. Giles, Janet L. Stanford, Sonja I. Berndt, Manolis Kogevinas, Hermann Brenner, Rosalind A. Eeles, Carrie R. PRACTICAL Consortium, Peng Wei, Carrie R. Daniel
Summary: In this study, high coffee intake was found to be potentially associated with longer prostate cancer-specific survival. This association was more pronounced in men with the CYP1A2 -163AA (*1F/*1F) genotype. However, further research is needed to confirm these findings.
EUROPEAN UROLOGY ONCOLOGY
(2023)
Review
Psychology, Experimental
G. Laera, F. Borghese, A. Hering, M. Kliegel, G. Mioni
Summary: In older adults' everyday life, time-based prospective memory (TBPM) is relevant, but it is still unclear which task-related factors can potentially moderate the age-related differences. The present meta-analysis aimed to quantify age-related differences in laboratory TBPM tasks and investigate how specific task-related factors potentially moderate the age effects. The results showed that older adults performed worse in TBPM and checked the clock less often than younger adults, especially for shorter intervals. Furthermore, the duration of the PM target time interacted with the frequency of the PM task, suggesting that learning effects may attenuate the age differences in TBPM performance.
Review
Computer Science, Artificial Intelligence
Tanwei Yuan, Dominic Edelmann, Ziwen Fan, Elizabeth Alwers, Jakob Nikolas Kather, Hermann Brenner, Michael Hoffmeister
Summary: This systematic review discusses the use of machine learning in epigenome-wide studies for identifying DNA methylation biomarkers associated with cancer prognosis. The study reveals that there is a lack of performance evaluation and methodological flaws in the current approaches.
ARTIFICIAL INTELLIGENCE IN MEDICINE
(2023)
Article
Oncology
Fatemeh Safizadeh, Marko Mandic, Dianne Pulte, Tobias Niedermaier, Michael Hoffmeister, Hermann Brenner
Summary: This study aimed to investigate the association between excess weight and colorectal cancer (CRC) risk, taking into account prediagnostic weight loss. The results showed that the association between overweight/obesity and CRC risk became stronger with longer follow-up duration, and excluding the initial years of follow-up further strengthened the association. Therefore, the impact of excess weight on CRC risk has been underestimated.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Andrei-Emil Constantinescu, Caroline J. Bull, Nicholas Jones, Ruth Mitchell, Kimberley Burrows, Niki Dimou, Stephane Bezieau, Hermann Brenner, Daniel D. Buchanan, Mauro D'Amato, Mark A. Jenkins, Victor Moreno, Rish K. Pai, Caroline Y. Um, Emily White, Neil Murphy, Marc Gunter, Nicholas J. Timpson, Jeroen R. Huyghe, Emma E. Vincent
Summary: Observational studies have shown that eosinophils may protect against colorectal cancer (CRC) development, while neutrophils may be implicated in its risk. This study used Mendelian randomisation (MR) to estimate the causal effect of circulating white blood cell (WBC) counts, specifically basophils, eosinophils, monocytes, lymphocytes, and neutrophils, on CRC risk. The results suggest that increased basophil and eosinophil counts are protective against CRC, and increased lymphocyte count may also have a protective effect.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Public, Environmental & Occupational Health
Tafirenyika Gwenzi, Anna Zhu, Petra Schrotz-King, Ben Schoettker, Michael Hoffmeister, Dominic Edelmann, Hermann Brenner
Summary: Post-operative inflammation in cancer patients can be modulated by drugs and diets, but evidence on its prognostic role remains limited. This study systematically reviewed and meta-analysed the prognostic value of post-operative C-reactive protein (CRP)-based inflammatory biomarkers among patients with colorectal cancer (CRC). The results showed that post-operative CRP and Glasgow Prognostic Score (GPS) or modified Glasgow Prognostic Score (mGPS) were associated with overall survival (OS), CRC-specific survival (CSS) and recurrence-free survival (RFS). Post-operative CRP-based inflammatory biomarkers have a significant prognostic role for patients with CRC.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Oncology
Pooja K. Middha, Xiaoliang Wang, Sabine Behrens, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Thomas U. Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J. Aronson, Paul L. Auer, Annelie Augustinsson, Thais Baert, Laura E. Beane Freeman, Heiko Becher, Matthias W. Beckmann, Javier Benitez, Stig E. Bojesen, Hiltrud Brauch, Hermann Brenner, Angela Brooks-Wilson, Daniele Campa, Federico Canzian, Angel Carracedo, Jose E. Castelao, Stephen J. Chanock, Georgia Chenevix-Trench, Emilie Cordina-Duverger, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Laure Dossus, Pierre-Antoine Dugue, A. Heather Eliassen, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Jonine Figueroa, Olivia Fletcher, Henrik Flyger, Marike Gabrielson, Manuela Gago-Dominguez, Graham G. Giles, Anna Gonzalez-Neira, Felix Grassmann, Anne Grundy, Pascal Guenel, Christopher A. Haiman, Niclas Hakansson, Per Hall, Ute Hamann, Susan E. Hankinson, Elaine F. Harkness, Bernd Holleczek, Reiner Hoppe, John L. Hopper, Richard S. Houlston, Anthony Howell, David J. Hunter, Christian Ingvar, Karolin Isaksson, Helena Jernstroem, Esther M. John, Michael E. Jones, Rudolf Kaaks, Renske Keeman, Cari M. Kitahara, Yon-Dschun Ko, Stella Koutros, Allison W. Kurian, James V. Lacey, Diether Lambrechts, Nicole L. Larson, Susanna Larsson, Loic Le Marchand, Flavio Lejbkowicz, Shuai Li, Martha Linet, Jolanta Lissowska, Maria Elena Martinez, Tabea Maurer, Anna Marie Mulligan, Claire Mulot, Rachel A. Murphy, William G. Newman, Sune F. Nielsen, Borge G. Nordestgaard, Aaron Norman, Katie M. O'Brien, Janet E. Olson, Alpa V. Patel, Ross Prentice, Erika Rees-Punia, Gad Rennert, Valerie Rhenius, Kathryn J. Ruddy, Dale P. Sandler, Christopher G. Scott, Mitul T. Shah, Xiao-Ou Shu, Ann Smeets, Melissa C. Southey, Jennifer Stone, Rulla M. Tamimi, Jack A. Taylor, Lauren R. Teras, Katarzyna Tomczyk, Melissa A. Troester, Therese Truong, Celine M. Vachon, Sophia S. Wang, Clarice R. Weinberg, Hans Wildiers, Walter Willett, Stacey J. Winham, Alicja Wolk, Xiaohong Yang, M. Pilar Zamora, Wei Zheng, Argyrios Ziogas, Alison M. Dunning, Paul D. P. Pharoah, Montserrat Garcia-Closas, Marjanka K. Schmidt, Peter Kraft, Roger L. Milne, Sara Lindstroem, Douglas F. Easton, Jenny Chang-Claude
Summary: A genome-wide study identified two independent SNP-risk factor pairs associated with breast cancer risk and estrogen receptor positive (ER +) breast cancer risk. Overall, gene-environment interactions have a very small contribution to the heritability of breast cancer. At the population level, these interactions do not significantly contribute to risk prediction for breast cancer.
BREAST CANCER RESEARCH
(2023)
Article
Biology
Margherita Piccardi, Manuel Gentiluomo, Stefania Bertoncini, Raffaele Pezzilli, Balint Eross, Stefania Bunduc, Faik G. Uzunoglu, Renata Talar-Wojnarowska, Tomas Vanagas, Cosimo Sperti, Martin Oliverius, Mateus Nobrega Aoki, Stefano Ermini, Tamas Hussein, Ugo Boggi, Krzysztof Jamroziak, Evaristo Maiello, Luca Morelli, Ludmila Vodickova, Gregorio Di Franco, Stefano Landi, Andrea Szentesi, Martin Lovecek, Marta Puzzono, Francesca Tavano, Hanneke W. M. van Laarhoven, Alessandro Zerbi, Beatrice Mohelnikova-Duchonova, Hannah Stocker, Eithne Costello, Gabriele Capurso, Laura Ginocchi, Rita T. Lawlor, Giuseppe Vanella, Francesca Bazzocchi, Jakob R. Izbicki, Anna Latiano, Bas Bueno-de-Mesquita, Ruggero Ponz de Leon Pisani, Ben Schoettker, Pavel Soucek, Peter Hegyi, Maria Gazouli, Thilo Hackert, Juozas Kupcinskas, Lina Poskiene, Matteo Tacelli, Susanne Roth, Silvia Carrara, Francesco Perri, Viktor Hlavac, George E. Theodoropoulos, Olivier R. Busch, Andrea Mambrini, Casper H. J. van Eijck, Paolo Arcidiacono, Aldo Scarpa, Claudio Pasquali, Daniela Basso, Maurizio Lucchesi, Anna Caterina Milanetto, John P. Neoptolemos, Giulia Martina Cavestro, Dainius Janciauskas, Xuechen Chen, Roger Chammas, Mara Goetz, Hermann Brenner, Livia Archibugi, Michael Dannemann, Federico Canzian, Sergio Tofanelli, Daniele Campa
Summary: This study investigated the association between specific genes and the risk of pancreatic ductal adenocarcinoma (PDAC). The results showed no significant association in the European population, but identified a gene associated with increased risk in the East Asian population.
BIOLOGICAL RESEARCH
(2023)
Article
Oncology
Melissa S. Y. Thong, Daniela Doege, Linda Weisser, Lena Koch-Gallenkamp, Lina Jansen, Heike Bertram, Andrea Eberle, Bernd Holleczek, Alice Nennecke, Annika Waldmann, Sylke Ruth Zeissig, Hermann Brenner, Volker Arndt
Summary: This study aimed to compare the health-related quality of life (HRQOL) between colorectal cancer (CRC) survivors and non-cancer controls. The results showed that CRC survivors had poorer social functioning but better health status/QOL. They also experienced a higher level of symptom burden, especially diarrhea and constipation, regardless of demographic or clinical factors. HRQOL differed based on factors such as age, sex, cancer type, and having a permanent stoma.
