Article
Clinical Neurology
Anna Pink, Janina Krell-Roesch, Jeremy A. Syrjanen, Maria Vassilaki, Val J. Lowe, Prashanthi Vemuri, Gorazd B. Stokin, Teresa J. Christianson, Walter K. Kremers, Clifford R. Jack, David S. Knopman, Ronald C. Petersen, Yonas E. Geda
Summary: This study found that cortical amyloid deposition, anxiety, and depression independently increased the risk of incident mild cognitive impairment. Additionally, anxiety modified the association between cortical amyloid deposition and incident mild cognitive impairment.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
HyunChul Youn, Won Seok William Hyung, Junhyung Kim, Eun Seong Lee, Jae Seon Eo, Cheol E. Han, Changsu Han, Seung-Hyun Kim, Hyun-Ghang Jeong
Summary: This study investigated the 1-year changes in neuropsychological test results in older adults with late-life depression and mild cognitive impairment, based on the presence or absence of brain amyloidopathy. The findings showed differences in the extent of change depending on the severity of depressive symptoms and amyloidopathy status. Clinicians should consider exploring neuropathology when assessing older adults with depression and cognitive impairment.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Megan E. Shepherd-Banigan, Cassie B. Ford, Valerie A. Smith, Emmanuelle Belanger, Terrie T. Wetle, Brenda L. Plassman, James R. Burke, Nicole DePasquale, Emily C. O'Brien, Corinna Sorenson, Courtney H. Van Houtven
Summary: This study examines the association between amyloid-beta PET scan results and care-partner wellbeing. The results suggest that elevated amyloid levels are not significantly associated with changes in care-partner wellbeing.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Joseph Therriault, Tharick A. Pascoal, Andrea L. Benedet, Cecile Tissot, Melissa Savard, Mira Chamoun, Firoza Lussier, Min Su Kang, Gleb Berzgin, Tina Wang, Jaime Fernandes-Arias, Gassan Massarweh, Jean-Paul Soucy, Paolo Vitali, Paramita Saha-Chaudhuri, Serge Gauthier, Pedro Rosa-Neto
Summary: The study found good agreement between clinically defined probable AD dementia and biologically defined AD. Biologically defined AD was not rare in cognitively unimpaired elderly, with abnormal tau-PET almost exclusively observed in individuals with abnormal amyloid-PET.
Article
Medicine, General & Internal
Hong-Chun Wei, Bing Li, Kok Pin Ng, Qing-Xi Fu, Sheng-Jie Dong, Mao-Wen Ba, Min Kong
Summary: This study compared clinical and biomarker features between A+T+MCI individuals progressing to pMCI and those remaining stable sMCI, identifying CSF and cognitive measures at baseline predictive of dementia progression within 2 years. Subset differences in biomarkers, cognitive assessment, and MRI imaging were observed, with CSF t-tau levels and cognitive scores serving as potential risk factors for dementia progression in A+T+MCI individuals.
CHINESE MEDICAL JOURNAL
(2021)
Article
Medicine, General & Internal
Min Young Chun, Jongmin Lee, Jee Hyang Jeong, Jee Hoon Roh, Seung Jun Oh, Minyoung Oh, Jungsu S. Oh, Jae Seung Kim, Seung Hwan Moon, Sook-young Woo, Young Ju Kim, Yeong Sim Choe, Hee Jin Kim, Duk L. Na, Hyemin Jang, Sang Won Seo
Summary: This study suggests that increased 18F-THK5351 uptake may be a useful predictor of cognitive decline among AB- aMCI patients. The patients in the 18F-THK5351-positive group were older and had a faster rate of deterioration in clinical dementia rating-sum of boxes (CDR-SOB) scores.
YONSEI MEDICAL JOURNAL
(2022)
Article
Geriatrics & Gerontology
Hyun Jeong Lee, Eun-Chong Lee, Seongho Seo, Kwang-Pil Ko, Jae Myeong Kang, Woo-Ram Kim, Ha-Eun Seo, Sang-Yoon Lee, Yeong-Bae Lee, Kee Hyung Park, Byeong Kil Yeon, Nobuyuki Okamura, Duk L. Na, Joon-Kyung Seong, Young Noh
Summary: Using cluster analyses with [F-18]THK5351 retention patterns, it is possible to identify clinically-distinct subgroups of MCI patients and those at greater risk of progression to dementia. These subgroups show significant differences in cognitive function and risk of dementia progression.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Psychology, Clinical
Beatrix Krause-Sorio, Prabha Siddarth, Kelsey T. Laird, Linda Ercoli, Katherine Narr, Jorge R. Barrio, Gary Small, Helen Layretsky
Summary: Using PET imaging, this study found that [F-18]FDDNP binding may predict cognitive response to antidepressant treatment in geriatric depression. Higher frontal lobe [F-18]FDDNP binding at baseline was associated with improvement in executive function at 6 months, but this effect was no longer significant at 12 months. There was no association of regional [F-18]FDDNP binding with change in mood symptoms.
INTERNATIONAL PSYCHOGERIATRICS
(2021)
Article
Neurosciences
Christopher Gonzalez, Nicole S. Tommasi, Danielle Briggs, Michael J. Properzi, Rebecca E. Amariglio, Gad A. Marshall
Summary: This study found an association between financial capacity impairment and regional tau burden in early-stage AD patients, suggesting the potential utility of such assessments in detecting meaningful decline that may aid clinical trials of early-stage AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Immunology
Erin E. Sundermann, Mark W. Bondi, Laura M. Campbell, Ben Gouaux, Raeanne C. Moore, Virawudh Soontornniyomkij, David J. Moore
Summary: This study aimed to distinguish aMCI from HAND in PWH using a neuropsychological method, finding a higher prevalence of high aMCI risk in the HAND group, with beta-amyloid pathology being associated with high aMCI risk, while phospho-Tau pathology did not differ by aMCI classification.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Medicine, General & Internal
Philip Scheltens, Bart De Strooper, Miia Kivipelto, Henne Holstege, Gael Chetelat, Charlotte E. Teunissen, Jeffrey Cummings, Wiesje M. van der Flier
Summary: Alzheimer's disease is projected to see a significant increase in prevalence in the future, with genetics playing a key role. Novel biomarkers and lifestyle-based prevention trials show promising therapeutic potential. Promising pharmacological treatments are advancing in clinical trials, targeting amyloid beta, tau, and inflammation.
Article
Clinical Neurology
Hana Florian, Deli Wang, Steven E. Arnold, Merce Boada, Qi Guo, Ziyi Jin, Hui Zheng, Nahome Fisseha, Hari Varun Kalluri, Beatrice Rendenbach-Mueller, Kumar Budur, Michael Gold, Thomas Aware Investigators, Lealani Acosta, Thomas Ala, Sanka Amadoru, Jeffrey Apter, Steven Arnold, Merce Boada-Rovira, Anne Boerjesson-Hanson, Wendy Bond, Michael Borrie, Gabriella Bottini, Bruce Brew, Mark Brody, James Burke, Jeffrey Burns, Annalisa Chiari, Roger Clarnette, Sharon Cohen, Martin Farlow, Simon Fishman, Norman Foster, Kristian Frederiksen, Giovanni Frisoni, Nigel Gilchrist, Darren Gitelman, Ira Goodman, Marc Gordon, Neill Graff-Radford, Merja Hallikainen, Adrian Ivanoiu, Gregory Jicha, Michael Jonsson, Diana Kerwin, Dineke Koek, James Lah, Ayesha Lall, Elly Lee, Gabriel Leger, Peter Ljubenkov, Camillo Marra, Pablo Martinez-Lage, Joseph Masdeu, Scott McGinnis, Patrizia Mecocci, Philip Morris, Marshall Nash, Allison Perrin, Aimee Pierce, Robert Riesenberg, Juha Rinne, Raquel Sanchez Del Valle, Elio Scarpini, Paul Schulz, Ronald Schwartz, Amanda Smith, Bryan Spann, Sylvie Van Snick, Rik Vandenberghe, Cherian Verghese, Alberto Villarejo, Chuang-Kuo Wu
Summary: Tau accumulation in patients with Alzheimer's disease is closely related to cognitive decline. This study evaluated tilavonemab, an anti-tau monoclonal antibody, in treating patients with early Alzheimer's disease. The results showed that tilavonemab did not demonstrate efficacy in treating early Alzheimer's disease.
Article
Clinical Neurology
Alexandra J. Weigand, Kelsey R. Thomas, Katherine J. Bangen, Graham M. L. Eglit, Lisa Delano-Wood, Paul E. Gilbert, Adam M. Brickman, Mark W. Bondi
Summary: The study revealed that APOE may interact with tau independently of Aβ, and elevated MTL tau levels have negative cognitive consequences in Aβ-negative ε4 carriers.
ALZHEIMERS & DEMENTIA
(2021)
Article
Clinical Neurology
Pierre-Francois Meyer, Nicholas J. Ashton, Thomas K. Karikari, Cherie Strikwerda-Brown, Theresa Kobe, Julie Gonneaud, Alexa Pichet Binette, Hazal Ozlen, Yara Yakoub, Joel Simren, Josef Pannee, Juan Lantero-Rodriguez, Anne Labonte, Suzanne L. Baker, Michael Scholl, Eugeen Vanmechelen, John C. S. Breitner, Henrik Zetterberg, Kaj Blennow, Judes Poirier, Sylvia Villeneuve
Summary: This study evaluated novel plasma p-tau231 and p-tau181, as well as A beta(40) and A beta(42) assays as indicators of tau and A beta pathologies measured with positron emission tomography (PET) and their association with cognitive change in cognitively unimpaired older adults. The findings showed that plasma p-tau231 had stronger associations with PET biomarkers compared to p-tau181 in presymptomatic individuals. The combination of p-tau and A beta(42/40) biomarkers detected early AD pathology and cognitive decline.
ANNALS OF NEUROLOGY
(2022)
Article
Psychology, Multidisciplinary
Kimberly D. Mueller, Lianlian Du, Davide Bruno, Tobey Betthauser, Bradley Christian, Sterling Johnson, Bruce Hermann, Rebecca Langhough Koscik
Summary: This study demonstrates that the Logical Memory (LM) task is effective in discriminating ability levels and amyloid status, and that individual items vary in difficulty and discrimination based on amyloid status. These findings can inform the development of sensitive tasks or composite scores for early detection of cognitive decline.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Behavioral Sciences
Shulamite A. Green, Leanna Hernandez, Susan Y. Bookheimer, Mirella Dapretto
Article
Neuroimaging
Jamie D. Feusner, Andreas Lidstrom, Teena D. Moody, Cecilia Dhejne, Susan Y. Bookheimer, Ivanka Savic
BRAIN IMAGING AND BEHAVIOR
(2017)
Article
Neurosciences
Taylor Kuhn, Daniel Schonfeld, Philip Sayegh, Alyssa Arentoft, Jacob D. Jones, Charles H. Hinkin, Susan Y. Bookheimer, April D. Thames
HUMAN BRAIN MAPPING
(2017)
Article
Biochemistry & Molecular Biology
L. M. Hernandez, K. Krasileva, S. A. Green, L. E. Sherman, C. Ponting, R. McCarron, J. K. Lowe, D. H. Geschwind, S. Y. Bookheimer, M. Dapretto
MOLECULAR PSYCHIATRY
(2017)
Article
Neurosciences
Christopher F. Benjamin, Patricia D. Walshaw, Kayleigh Hale, William D. Gaillard, Leslie C. Baxter, Madison M. Berl, Monika Polczynska, Stephanie Noble, Rafeed Alkawadri, Lawrence J. Hirsch, R. Todd Constable, Susan Y. Bookheimer
HUMAN BRAIN MAPPING
(2017)
Article
Clinical Neurology
Martin P. Paulus, Murray B. Stein, Michelle G. Craske, Susan Bookheimer, Charles T. Taylor, Alan N. Simmons, Natasha Sidhu, Katherine S. Young, Boyang Fan
JOURNAL OF AFFECTIVE DISORDERS
(2017)
Article
Multidisciplinary Sciences
Theresa M. Harrison, Donald G. McLaren, Teena D. Moody, Jamie D. Feusner, Susan Y. Bookheimer
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2017)
Article
Neuroimaging
Monika Polczynska, Kevin Japardi, Susan Curtiss, Teena Moody, Christopher Benjamin, Andrew Cho, Celia Vigil, Taylor Kuhn, Michael Jones, Susan Bookheimer
NEUROIMAGE-CLINICAL
(2017)
Article
Neurosciences
Soonjo Hwang, Harma Meffert, Michelle R. VanTieghem, Stuart F. White, Stephen Sinclair, Susan Y. Bookheimer, James Blair
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2017)
Article
Multidisciplinary Sciences
Adriana Di Martino, David O'Connor, Bosi Chen, Kaat Alaerts, Jeffrey S. Anderson, Michal Assaf, Joshua H. Balsters, Leslie Baxter, Anita Beggiato, Sylvie Bernaerts, Laura M. E. Blanken, Susan Y. Bookheimer, B. Blair Braden, Lisa Byrge, F. Xavier Castellanos, Mirella Dapretto, Richard Delorme, Damien A. Fair, Inna Fishman, Jacqueline Fitzgerald, Louise Gallagher, R. Joanne Jao Keehn, Daniel P. Kennedy, Janet E. Lainhart, Beatriz Luna, Stewart H. Mostofsky, Ralph-Axel Muller, Mary Beth Nebel, Joel T. Nigg, Kirsten O'Hearn, Marjorie Solomon, Roberto Toro, Chandan J. Vaidya, Nicole Wenderoth, Tonya White, R. Cameron Craddock, Catherine Lord, Bennett Leventhal, Michael P. Milham
Article
Neurosciences
Taylor Kuhn, Tobias Kaufmann, Nhat Trung Doan, Lars T. Westlye, Jacob Jones, Rodolfo A. Nunez, Susan Y. Bookheimer, Elyse J. Singer, Charles H. Hinkin, April D. Thames
HUMAN BRAIN MAPPING
(2018)
Article
Neurosciences
Prabha Siddarth, Berna Rahi, Natacha D. Emerson, Alison C. Burggren, Karen J. Miller, Susan Bookheimer, Helen Lavretsky, Bruce Dobkin, Gary Small, David A. Merrill
JOURNAL OF ALZHEIMERS DISEASE
(2018)
Review
Psychology, Developmental
Duncan B. Clark, Celia B. Fisher, Susan Bookheimer, Sandra A. Brown, John H. Evans, Christian Hopfer, James Hudziak, Ivan Montoya, Margaret Murray, Adolf Pfefferbaum, Deborah Yurgelun-Todd
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2018)
Article
Psychology, Developmental
Shulamite A. Green, Leanna M. Hernandez, Hilary C. Bowman, Susan Y. Bookheimer, Mirella Dapretto
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2018)
Article
Geriatrics & Gerontology
Somayeh Meysami, Cyrus A. Raji, David A. Merrill, Verna R. Porter, Mario F. Mendez
Summary: Investigators found that early onset Alzheimer's Disease (EOAD) patients have greater parietal tau deposition and alternate frontoparietal network involvement compared to typical late onset AD (LOAD) patients. Additionally, EOAD patients show smaller parietal lobes on clinical MRI scans, while late onset AD patients have smaller left putamen and hippocampus. This study suggests that parietal atrophy less than 30% of normal on clinical MRI scans may be indicative of EOAD compared to LOAD.
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
(2021)