Article
Clinical Neurology
Paul C. C. Donaghy, Calum Hamilton, Rory Durcan, Sarah Lawley, Sally Barker, Joanna Ciafone, Nicola Barnett, Kirsty Olsen, Michael Firbank, Gemma Roberts, Jim Lloyd, Louise M. M. Allan, Ranjan Saha, Ian G. G. McKeith, John T. T. O'Brien, John-Paul Taylor, Alan J. J. Thomas
Summary: Through the investigation of patients with mild cognitive impairment with Lewy bodies (MCI-LB), it was found that MCI-LB patients have more symptoms, and a 10-point symptom scale can effectively differentiate MCI-LB and MCI-AD. These findings are important for clinicians to diagnose and treat MCI.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Behavioral Sciences
Victor N. Almeida, Marcia Radanovic
Summary: This theoretical review critically examines linguistic and semantic processing in Mild Cognitive Impairment and Alzheimer's disease, focusing on a neurobiological perspective. The authors propose that most linguistic alterations result from inhibited semantic discrimination, caused by a cluster of cholinergic dysfunction, A?? load, and somatostatin-positive cell loss. These changes lead to failures in accurate retrieval, verbal fluency anomalies, semantic interference, dampened N400 effects, and other semantic deviations.
Review
Clinical Neurology
Lei Zhuang, Yan Yang, Jianqun Gao
Summary: Mild cognitive impairment (MCI) is a clinical condition with a high risk of progressing to dementia. Early diagnosis and intervention at the MCI stage are considered critical strategies in disease management. Lack of consensus on guidelines for routine screening of MCI leads to a considerable number of undiagnosed patients in the community.
JOURNAL OF NEUROLOGY
(2021)
Article
Medicine, General & Internal
Hong-Chun Wei, Bing Li, Kok Pin Ng, Qing-Xi Fu, Sheng-Jie Dong, Mao-Wen Ba, Min Kong
Summary: This study compared clinical and biomarker features between A+T+MCI individuals progressing to pMCI and those remaining stable sMCI, identifying CSF and cognitive measures at baseline predictive of dementia progression within 2 years. Subset differences in biomarkers, cognitive assessment, and MRI imaging were observed, with CSF t-tau levels and cognitive scores serving as potential risk factors for dementia progression in A+T+MCI individuals.
CHINESE MEDICAL JOURNAL
(2021)
Review
Clinical Neurology
Jonathan Blackman, Marta Swirski, James Clynes, Sam Harding, Yue Leng, Elizabeth Coulthard
Summary: Suboptimal sleep can lead to cognitive decline and accelerate Alzheimer's Disease progression. Early intervention in MCI and mild AD is necessary, but there is a lack of evidence for sleep interventions in these stages, highlighting the need for high quality experimental studies exploring alternative interventions.
JOURNAL OF SLEEP RESEARCH
(2021)
Review
Cell Biology
Michael K. Yeung, Anson Kwok-yun Chau, Jason Yin-chuen Chiu, Jay Tsz-lok Shek, Jody Po-yi Leung, Toby Chun-ho Wong
Summary: The study found significant differences in neuroimaging abnormalities between amnestic mild cognitive impairment (aMCI) and nonamnestic mild cognitive impairment (naMCI), with aMCI showing more and more significant abnormalities, while naMCI showing more limited abnormalities, with shared features but unique neuroimaging abnormalities in aMCI.
AGEING RESEARCH REVIEWS
(2022)
Article
Clinical Neurology
Tommaso Romagnoli, Beatrice Ortolani, Juana Maria Sanz, Alessandro Trentini, Davide Seripa, Edoardo Dalla Nora, Eleonora Capatti, Carlo Cervellati, Angelina Passaro, Giovanni Zuliani, Gloria Brombo
Summary: This study evaluated serum ApoJ levels in 196 MCI subjects and found that low ApoJ levels may be associated with an increased risk of developing dementia. The risk of dementia conversion doubled in subjects with lower ApoJ levels compared to those with higher levels, especially after two years of follow up.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Hajime Takechi, Hiroshi Yoshino
Summary: The study utilized the CogEvo computerized cognitive assessment and training tool to distinguish patients with mild Alzheimer's disease and mild cognitive impairment from cognitively normal older people. The results indicated that CogEvo showed good correlation and was able to differentiate between the three groups effectively. Further research is needed to assess the effectiveness of CogEvo as a combined assessment and training tool for early-stage cognitive impairment.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2021)
Review
Environmental Sciences
Yijia Zhang, Liping Lu, Cheng Chen, Ka Kahe, R. William Field, Mary D' Alton
Summary: Radon, a radioactive gas, is potentially associated with the development of dementia. Evidence suggests that disproportionately high deposition of radon decay products (RDPs) occurs in the brains of AD patients, with selective accumulation within protein fractions. Geographical distribution of radon also shows a significant positive correlation with AD mortality in the US.
ENVIRONMENTAL RESEARCH
(2022)
Article
Geriatrics & Gerontology
Antonio Muscari, Fabio Clavarino, Vincenzo Allegri, Andrea Farolfi, Maria Macchiarulo, Lorenzo Maestri, Elisa Sessagesimi, Luca Spinardi, Maria Lia Lunardelli
Summary: This study proposed a two-step procedure to assess the risk of CAD in MCI patients, initially evaluating MMSE, MoCA, and MTA before deciding whether to perform FDG-PET. The results showed that patients with 2-3 points in the first step had a higher risk of CAD, and in the second step, FDG-PET had significant diagnostic value in identifying high-risk patients.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Masataka Kikuchi, Kaori Kobayashi, Sakiko Itoh, Kensaku Kasuga, Akinori Miyashita, Takeshi Ikeuchi, Eiji Yumoto, Yuki Kosaka, Yasuto Fushimi, Toshihiro Takeda, Shirou Manabe, Satoshi Hattori, Akihiro Nakaya, Kenichi Kamijo, Yasushi Matsumura
Summary: In this study, a model was developed to subtypes individuals with mild cognitive impairment (MCI) and predict their conversion to Alzheimer's disease (AD), and the underlying biological characteristics of each subtype were analyzed. Based on different levels of abnormality in cerebrospinal fluid (CSF) biomarkers, brain atrophy, and cognitive decline, MCI was classified into five subtypes, further categorized into three groups based on their conversion rates to AD. The identified subtypes showed varying conversion rates and biological profiles.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Oncology
Shuang Yang, Jiang Bian, Thomas J. George, Karen Daily, Dongyu Zhang, Dejana Braithwaite, Yi Guo
Summary: The study found that women with mild or severe cognitive impairment were less likely to have undergone mammogram screening for breast cancer compared to those without cognitive impairment. Similarly, men with mild or severe cognitive impairment were less likely to have had a recent colonoscopy for colorectal cancer compared to those without cognitive impairment. Further research is needed to understand the factors contributing to these differences in cancer screening utilization among individuals with cognitive impairment.
Article
Clinical Neurology
Filippo Cieri, Xiaowei Zhuang, Dietmar Cordes, Nikki Kaplan, Jeffery Cummings, Jessica Caldwell
Summary: This study, based on ADNI data, found that women have greater cortical thickness and better memory performance compared to men. Furthermore, differences in memory and cortical thickness between sexes may play a key role in the vulnerability and progression of ADD in women compared to men. Machine learning techniques showed that sex differences in cortical thickness are most relevant in the early stages of ADD neurodegeneration.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Clinical Neurology
James E. Galvin, Stephanie Chrisphonte, Iris Cohen, Keri K. Greenfield, Michael J. Kleiman, Claudia Moore, Mary Lou Riccio, Amie Rosenfeld, Niurka Shkolnik, Marcia Walker, Lun-Ching Chang, Magdalena I. Tolea
Summary: The study tested the performance of the LBD-MOD module in characterizing Lewy body dementia (DLB) and distinguishing it from Alzheimer's disease (AD). Results showed differences between DLB and AD in various symptoms, as well as differences between MCI-DLB and MCI-AD. The LBD-MOD module provided excellent characterization of core features and supportive features to differentiate DLB from AD and also characterize features of MCI-DLB.
ALZHEIMERS & DEMENTIA
(2021)
Article
Environmental Sciences
Teresa Urbano, Annalisa Chiari, Carlotta Malagoli, Andrea Cherubini, Roberta Bedin, Sofia Costanzini, Sergio Teggi, Giuseppe Maffeis, Marco Vinceti, Tommaso Filippini
Summary: Exposure to outdoor air pollutants, particularly PM10, may nonlinearly increase the risk of conversion from MCI to dementia. Higher PM10 levels were associated with increased concentrations of cerebrospinal fluid tau proteins and decreased beta-amyloid levels. The risk of dementia was positively associated with mean PM10 levels above 10 μg/m3 and maximum PM10 levels above 35 μg/m3.
ENVIRONMENTAL RESEARCH
(2023)
Article
Clinical Neurology
Lisandra Mendoza, Patricia Garcia, Ranjan Duara, Monica Rosselli, David Loewenstein, Maria T. Greig-Custo, Warren Barker, Pamela Dahlin, Miriam J. Rodriguez
Summary: The study examined the effect of acculturation on cognition among older Hispanics. It found that highly acculturated individuals performed better on tests of episodic memory, auditory attention, working memory, cognitive flexibility, and processing speed. However, these effects were not observed in other cognitive impairment groups. Caution should be exercised when interpreting neurocognitive results in the absence of acculturation scales.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Clinical Neurology
Miriam Rodriguez, Lisandra Mendoza, Ivan Rodriguez, Monica Rosselli, David Loewenstein, Shanna Burke, Amanda Orozco, Ranjan Duara
Summary: This study examines the relationship between cultural factors, literacy, and neuropsychological performance and brain atrophy in Hispanic elders diagnosed with amnestic Mild Cognitive Impairment (aMCI). The results suggest that higher literacy levels are associated with better performance in certain language measures, while higher levels of acculturation to the U.S. are associated with poorer performance in other language measures. Additionally, higher literacy levels are associated with greater atrophy in brain regions susceptible to neurodegenerative disease.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Multidisciplinary Sciences
Joshua Caballero, Robin J. Jacobs, Raymond L. Ownby
Summary: The study aimed to develop a culturally adapted computerized health literacy intervention for older Hispanics with type 2 diabetes and evaluate its usability and acceptability. Results showed that the developed intervention was perceived as easy to use, culturally appropriate, and relevant by participants, while clinical pharmacists acknowledged the streamlined counseling process, tailored approach, and time-saving potential of the intervention.
Article
Clinical Neurology
Maria T. Greig Custo, Merike K. Lang, Warren W. Barker, Joanna Gonzalez, Idaly Velez-Uribe, Fernanda Arruda, Joshua Conniff, Miriam J. Rodriguez, David A. Loewenstein, Ranjan Duara, Malek Adjouadi, Rosie E. Curiel, Monica Rosselli
Summary: This study explores the cross-cultural differences in the association between neuropsychiatric symptoms and Alzheimer's disease biomarkers. The findings indicate that there are differences in the frequency of depressive symptoms and apathy across different diagnostic groups and ethnicities. The study also reveals correlations between apathy and reduced volume in the rostral anterior cingulate cortex, as well as a relationship between apathy and A beta levels.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Neurosciences
David A. Loewenstein, Rosie E. Curiel Cid, Marcela Kitaigorodsky, Alexandra Ortega, Diana Hincapie, D. Diane Zheng, Alexandra Amaya, Liz Gallardo, Leslie Manso, Jaylene Sosa, Elizabeth A. Crocco
Summary: This study found that persistent difficulties in proactive semantic interference (PSI) were observed in early-stage Alzheimer's disease and mild cognitive impairment patients, which were not captured by existing memory measures. In addition, the inability to recover from PSI after repeated learning trials was also found in these patients.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
María Valles-Salgado, María Nieves Cabrera-Martín, Rosie E. Curiel-Cid, Alfonso Delgado-Alvarez, Cristina Delgado-Alonso, María José Gil-Moreno, Jorge Matías-Guiu, David A. Loewenstein, Jordi A. Matias-Guiu
Summary: This study examines the cognitive and neural basis of failure to recover from proactive and retroactive semantic interference, using the neuropsychological test LASSI-L. The results suggest that dysfunction in episodic memory and the involvement of the medial temporal lobe, precuneus, and posterior cingulate contribute to this failure.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Geriatrics & Gerontology
Mehdi Shojaie, Mercedes Cabrerizo, Steven T. DeKosky, David E. Vaillancourt, David Loewenstein, Ranjan Duara, Malek Adjouadi
Summary: This study presents an instance-based transfer learning framework based on gradient boosting machine (GBM) for early detection of Alzheimer's disease. The experimental results demonstrate that the proposed framework improves classification accuracy.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Health Policy & Services
Drenna Waldrop, Raphiel Murden, Mary Claire Montilus, Monique Balthazar, Crista Irwin, Marcia Holstad, Raymond L. Ownby
Summary: This study assessed predictors of stable HIV viral suppression in a racially diverse sample of persons living with HIV in the southern US. Age, number of antiretroviral medications, and availability of social support were found to be positively associated with durable viral suppression.
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2023)
Article
Gerontology
Miriam J. Rodriguez, Shanna Burke, Dilliana Padron, Andres Duarte, Monica Rosselli, Maria Grieg-Custo, Adrienne Grudzien, David A. Loewenstein, Ranjan Duara
Summary: This study examined cognitive functioning among older Hispanic adults living in the U.S., and found differences in cognitive performance between regions and diagnostic groups. Significant relationships were found between education country and cognitive functioning for South Americans, but not for Caribbean individuals. This is the first study to explore the impact of education source on cognitive functioning for individuals from different Spanish-speaking regions.
JOURNAL OF CROSS-CULTURAL GERONTOLOGY
(2022)
Article
Neurosciences
Che Liu, Sang H. Lee, David A. Loewenstein, James E. Galvin, Bonnie E. Levin, Alexander McKinney, Noam Alperin
Summary: This study compared total cerebral blood flow (tCBF), global cerebral perfusion (GCP), and volumes of AD-prone regions between cognitively normal and early amnestic mild cognitive impairment (aMCI) individuals. It was found that tCBF and GCP were significantly reduced in the early aMCI group compared to the cognitively normal group. Furthermore, tCBF and GCP were significantly associated with global cognition and memory scores.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Psychology, Clinical
Rosie E. Curiel E. Cid, Jordi A. A. Matias-Guiu, David A. A. Loewenstein
Summary: There is currently a lack of consensus among neuropsychologists about which cognitive assessment paradigms hold the most promise in identifying subtle cognitive deficits in preclinical Alzheimer's Disease (AD) and which are most useful for monitoring risk of cognitive deterioration. Many widely used instruments are older versions of tests originally developed for the assessment of dementia or traumatic brain injury. This work provides an overview of novel Cognitive Challenge Tests (CCTs) that employ semantic interference paradigms and other methods to measure meaningful cognitive change in early stage AD.
Editorial Material
Clinical Neurology
Raymond L. Ownby, Drenna Waldrop
Summary: The lack of effective treatments for cognitive decline in older adults has led to an interest in lifestyle interventions. Multiple lifestyle factors have been related to risk for decline, and intervention studies suggest changing behaviors can have a positive impact on cognition. A shared decision-making model is proposed to support clinicians' efforts to promote brain health in older persons, providing basic information and instruction in behavior change strategies.
CURRENT ALZHEIMER RESEARCH
(2023)
Article
Neurosciences
Juan Gonzalez, Neil Patel, Raymond L. L. Ownby
Summary: A significant number of COVID-19 survivors experience long-lasting physical and mental symptoms, including cognitive difficulties known as brain fog. This report examines the cognitive and driving function of a 62-year-old man with HIV infection who tested positive for COVID-19.
JOURNAL OF NEUROVIROLOGY
(2023)
Article
Geriatrics & Gerontology
Kamilah Thomas-Purcell, Rosemary Davenport, Victoria Ayala, Donrie Purcell, Raymond L. Ownby
Summary: This study aimed to explore the experiences of individuals with Post-Acute Sequelae of SARS-CoV-2 infection (PASC), including cognitive issues, fatigue, and sleep disturbances. The findings revealed themes such as disruption of everyday life, diverse physical symptoms, and cognitive problems. Quantitative analysis showed high levels of fatigue, negative mood, and overall reduction in health-related quality of life (HRQOL) among participants. Further development of mobile applications for individuals with PASC is necessary.
CLINICAL INTERVENTIONS IN AGING
(2023)
Article
Clinical Neurology
Ulyana Morar, Walter Izquierdo, Harold Martin, Parisa Forouzannezhad, Elaheh Zarafshan, Elona Unger, Zoran Bursac, Mercedes Cabrerizo, Armando Barreto, David E. Vaillancourt, Steven T. DeKosky, David Loewenstein, Ranjan Duara, Malek Adjouadi
Summary: This study aims to evaluate the usefulness of newly introduced biomarkers in assessing the early stages of Alzheimer's disease (AD) and to explore their relationship with AD pathology. Through longitudinal analysis of cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI), researchers found associations between certain biomarkers and MRI markers. Subjects with amyloid positivity showed changes in CSF biomarkers associated with AD pathology. The findings of this study are important for early diagnosis of AD and understanding its underlying mechanisms.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2022)
