Review
Geriatrics & Gerontology
Wa Cai, Xi-Fang Wei, Jing-Ruo Zhang, Chen Hu, Wei-Dong Shen
Summary: This systematic review and meta-analysis aimed to assess the clinical efficacy of acupuncture in late-life depression (LLD). A total of nine RCTs involving 603 participants were included. The results showed that acupuncture combined with antidepressants significantly reduced HAMD scores and had a higher cure rate compared with antidepressants alone. However, no significant difference was found between acupuncture and antidepressants in reducing HAMD scores and improving clinical outcomes. Acupuncture combined or not combined with antidepressants is an effective and safe treatment for LLD.
Review
Clinical Neurology
Min Zhang, Junjian Mo, Huiying Zhang, Yaoyin Tang, Kaiheng Guo, Xinyue OuYang, Linghua Huang, Xiaomei Zhong, Yuping Ning
Summary: The meta-analysis suggests that rTMS is an effective and well-tolerated treatment for patients with late-life depression (LLD). Further efforts are needed to improve study methodologies and increase the homogeneity of rTMS parameters to ensure comparability between studies.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Psychology, Developmental
Melissa P. DelBello, Aditi Kadakia, Vincent Heller, Rajpal Singh, Katsuhiko Hagi, Tadashi Nosaka, Antony Loebel
Summary: This systematic literature review and network meta-analysis assessed the efficacy and safety of second-generation antipsychotics in treating major depressive episodes in youths with bipolar disorder. The results showed that lurasidone and the olanzapine-fluoxetine combination were effective in improving depressive symptoms, while quetiapine was not. Furthermore, lurasidone had fewer side effects and less impact on weight, cholesterol, and triglycerides compared to quetiapine and the olanzapine-fluoxetine combination.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Review
Clinical Neurology
Mengmeng Ji, Yue Sun, Jia Zhou, Xinrui Li, Haishan Wei, Zhiwen Wang
Summary: This systematic review and network meta-analysis compared the effectiveness and acceptability of psychotherapies for late-life depression. The findings showed that all six psychotherapies were effective, with life review therapy being the most effective and acceptable option. However, the certainty of the evidence was mostly rated as low to very low.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Psychiatry
Amelia J. Scott, Louise Sharpe, Ben Colagiuri
Summary: The study found that there is little reporting on blinding in RCTs of antidepressants, with a high rate of blinding failure. Pharmaceutical company sponsorship predicted the assessment of blinding in trials, with unsponsored trials more likely to evaluate blinding.
PSYCHIATRY RESEARCH
(2022)
Review
Clinical Neurology
Gustavo H. Vazquez, Anees Bahji, Juan Undurraga, Leonardo Tondo, Ross J. Baldessarini
Summary: The findings suggest that several modern antipsychotics and esketamine can be useful adjuncts to antidepressants for acute major depressive episodes, but lithium is slightly more effective and better tolerated.
JOURNAL OF PSYCHOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Chenxia Wu, Xinyi Li, Zhengtian Lv, Qian Chen, Yang Lou, Wei Mao, Xinbin Zhou
Summary: Catheter ablation is a recommended treatment for patients with symptomatic atrial fibrillation, with pulmonary vein isolation as the cornerstone. Comparisons between cryoballoon ablation with a second-generation cryoballoon (CB2) and contact force radiofrequency (CF-RF) ablation remain controversial. Results indicate that CB2 and CF-RF are comparable in terms of freedom from atrial tachyarrhythmia and procedure-related complications, with CB2 having a shorter procedure time but a higher risk of phrenic nerve palsy compared to CF-RF. Further large-scale studies are needed for a more definitive comparison and up-to-date recommendation.
SCIENTIFIC REPORTS
(2021)
Review
Behavioral Sciences
Qi Zhou, Xinming Li, Dejiang Yang, Chongyu Xiong, Zhenrong Xiong
Summary: This meta-analysis aimed to quantify the short-term rates of neurological side effects (SEs) related to commonly used second-generation antidepressants. The results showed that most second-generation antidepressants increased the risk of neurological SEs compared to placebo. However, certain antidepressants exhibited reduced neurological SEs in specific symptoms.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Geriatrics & Gerontology
Bret R. Rutherford, C. Jean Choi, Jongwoo Choi, Ben Mass, Xiaofu He, Kaleigh O'Boyle, Joel Sneed, Patrick J. Brown, Adam Brickman, Melanie M. Wall, Steven P. Roose
Summary: This study investigated the impact of slowed processing speed and executive dysfunction on the development of positive treatment expectancies in late-life depression (LLD) patients. The results suggest that slowed processing speed impairs the development of expectancies in antidepressant trials for LLD, which may explain lower antidepressant response among older adults.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Review
Clinical Neurology
Pengpeng Cao, Yuhao Li, Bei An, Lanxian Ye, Zheng Xu
Summary: Repetitive transcranial magnetic stimulation (rTMS) combined with antidepressants improved the efficacy of antidepressant medication in adults with depression, but its effectiveness and safety in children and adolescents with depression are still controversial.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Psychiatry
Raghava Kalyan Maddukuri, Chava Hema, Kondaveeti Sri Tejaswi, Mutthineni Venkata Mounika, Bindu Priyanka Vegesana
Summary: Agomelatine is a novel antidepressant with similar efficacy compared to currently used antidepressants, showing significant SMD and response rate in acute phase studies.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Review
Psychology, Clinical
Harry Costello, Jonathan P. Roiser, Robert Howard
Summary: Depression in dementia is common and has negative effects on patients and carers. Antidepressants are widely used but lack evidence of efficacy, and may be harmful. More research is needed to understand why antidepressants are ineffective in dementia and to find new treatment targets. Clinicians continue to prescribe antidepressants, but novel approaches are needed to identify effective treatments for depression in dementia.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Lincheng Zhang, Bing Chen, Qigu Yao, Weiyan Chen, Weinan Yang, Weiji Yang, Lan He, Yuyan Zhang
Summary: The study found that acupuncture is more effective in improving post-stroke depression compared to antidepressant therapy, with significant clinical efficacy.
Review
Cardiac & Cardiovascular Systems
Yonghui Fu, Shenghui Feng, Yingxiang Xu, Yuanjian Yang, Haibo Chen, Wenfeng He, Wengen Zhu, Kang Yin, Zhengbiao Xue, Bo Wei
Summary: This meta-analysis study found a significant association between depression, the use of antidepressants, and an increased risk of incident atrial fibrillation (AF).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Clinical Neurology
Christopher Baethge, Cora Braun, Lena Rink, Guido Schwarzer, Jonathan Henssler, Tom Bschor
Summary: The study found that increasing the dose of tricyclic antidepressants has a slightly positive effect on antidepressant efficacy, but it is not statistically significant overall. While some comparisons showed a dose gradient, it was not significant in general, and higher doses of imipramine/desipramine were significantly superior to lower doses in efficacy. Drop-out rates increased with higher doses, but not significantly.
JOURNAL OF AFFECTIVE DISORDERS
(2022)