Review
Medicine, General & Internal
Agoston Patthy, Janos Murai, Janos Hanics, Anna Pinter, Peter Zahola, Tomas G. M. Hokfelt, Tibor Harkany, Alan Alpar
Summary: Alzheimer's disease (AD) is a devastating neurodegenerative disorder for which an effective therapy has yet to be found. Research suggests that early damage to the ascending monoaminergic system in the brainstem may be an early sign and potential trigger of AD. In addition, cortical malfunction and local neurohistopathology are also related to the progression of AD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Lindsay J. Agostinelli, Scott C. Seaman, Clifford B. Saper, Dustin P. Fykstra, Marco M. Hefti, Timothy R. Koscik, Brian J. Dlouhy, Alexander G. Bassuk
Summary: Researchers report a study that combines high-resolution MRI and detailed histology to study the impact of neurologic disease on specific cell groups in the human brainstem and cerebellum. These findings are crucial for understanding and diagnosing brainstem lesions.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Neurosciences
Cooper D. Grossman, Jeremiah Y. Cohen
Summary: This article discusses the evolution of nervous systems to adapt to the dynamics of the environment and explains this process through the study of learning and decision-making. The article focuses on the slow dynamics of neuronal networks and the role of neuromodulators in temporal scaling.
ANNUAL REVIEW OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Courtney S. Wilkinson, Harrison L. Blount, Marek Schwendt, Lori A. Knackstedt
Summary: This study used a rat model of PTSD to investigate the effects of stress on monoamine concentrations in brain regions associated with PTSD in female rats. The findings indicate that stress exposure can lead to long-term alterations in monoamine function in female rats, suggesting potential interventions using MAOIs as a treatment for PTSD in women.
Article
Pharmacology & Pharmacy
Stephen Daniels, Mostafa El Mansari, Rami Hamoudeh, Pierre Blier
Summary: Ketamine exerts its antidepressant effects by modulating neuronal activity, enhancing dopamine neuronal activity and normalizing norepinephrine neuronal activity in the locus coeruleus and ventral tegmental area.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Clinical Neurology
Sayed Ausim Azizi
Summary: Monoamines play important roles in regulating brain function and have both physiological and pathological significance in influencing perception and behavior.
Article
Clinical Neurology
Greg C. Bristow, Tory Eisenlohr-Moul, Krista Lotesto, Monsheel S. Sodhi
Summary: This study found gender differences in the transcription of monoaminergic genes in the DLPFC in MDD patients, indicating that abnormalities in the expression of monoaminergic genes may contribute to alterations in DLPFC activity observed in major depression.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Patsorn Wichit, Sekh Thanprasertsuk, Onanong Phokaewvarangkul, Roongroj Bhidayasiri, Saknan Bongsebandhu-Phubhakdi
Summary: The study found that PD patients had higher plasma norepinephrine levels but lower epinephrine and serotonin levels compared to control subjects. Additionally, PD patients showed a significantly higher HVA/DA ratio and lower VMA/NE ratio. The levels of different monoamines were associated with clinical profiles in PD patients.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Chidiebere M. Iro, Rami Hamati, Mostafa El Mansari, Pierre Blier
Summary: The firing activity of monoamine neurons did not change 1 day after a single ketamine injection, but showed robust increases in NE neurons and enhancement in DA neurons after repeated administration. The increased activity of NE neurons was no longer present 3 days after the last injection, while that of DA neurons remained. This suggests that the enhanced activity of NE and DA neurons may play a significant role in maintaining the antidepressant action of ketamine.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Neurosciences
Daniel J. Kushigian, Okeanis E. Vaou
Summary: The purpose of this review was to assess the current evidence regarding the associated physiological and cognitive effects of aspartame (APM) consumption and Parkinson's Disease (PD). Multiple studies demonstrated decreased brain dopamine, decreased brain norepinephrine, increased oxidative stress, increased lipid peroxidation, and decreased memory function in rodents after APM use. Based on the current evidence, long-term human based observational research is needed to further investigate the potential effect of APM on PD.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Cindy Bandala, Alberto Avila-Luna, Modesto Gomez-Lopez, Erendira Estrada-Villasenor, Sergio Montes, Alfonso Alfaro-Rodriguez, Angel Miliar-Garcia, Jose L. Cortes-Altamirano, Raul Peralta, Gabriela Ibanez-Cervantes, Saul Gomez-Manzo, Noemi Cardenas-Rodriguez, Eleazar Lara-Padilla
Summary: This study identified higher levels of 3,4-dihydroxyphenylacetic acid and norepinephrine in osteosarcoma tissue compared to adjacent and non-oncological bone, suggesting they could be potential molecular markers for osteosarcoma progression. Additionally, gene expression of key receptors and enzymes related to catecholamines was also found to be significantly higher in tumour tissue, indicating their potential role in the development of osteosarcoma.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Review
Neurosciences
Alexander Joseph McDonald
Summary: This review explores the neuroanatomical aspects of the three main monoaminergic systems involved in innervating the basolateral nuclear complex (BNC) of the amygdala. The focus is on studying the relationship between specific monoaminergic inputs, their receptors, and specific neuronal subtypes in order to understand how they modulate the BNC circuitry. The review discusses the identification of different BNC neuronal subpopulations, their local circuitry, connections with other neurons, and the receptor expression of the three monoaminergic systems.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Brooke A. Christensen, Erin S. Calipari
Summary: The study reveals the distinct and differential mechanisms of methamphetamine enantiomers on dopamine and norepinephrine release, providing critical insights into the pharmacodynamic properties of this stimulant.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Chemistry, Physical
O. A. Mostovaya, P. L. Padnya, D. N. Shurpik, I. E. Shiabiev, I. I. Stoikov
Summary: The study focuses on utilizing p-tert-butylthiacalix[4]arene as a macrocyclic scaffold to design and synthesize dendrimer-like compounds. By modifying the macrocycle with fragments containing amide and lactide groups, original analogs of dendrimers with symmetric and asymmetric structures can be obtained. The 1,3-alternate conformation is found to be most favorable for binding catechol-amines, while the cone conformation shows selectivity in binding epinephrine and norepinephrine.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemistry & Molecular Biology
Hsiao-Ying Kuo, Fu-Chin Liu
Summary: This article discusses the role of monoamine neurotransmitter systems in the pathophysiology of autism spectrum disorder (ASD), with a focus on the effects of valproic acid (VPA) on the monoamine neurotransmitter systems. It also reviews the potential interactions between the microbiota and monoamine neurotransmitter systems in ASD pathophysiology.