Article
Gastroenterology & Hepatology
Leonard Naymagon, Douglas Tremblay, Nicole Zubizarreta, Erin Moshier, John Mascarenhas, Thomas Schiano
Summary: Anticoagulation therapy appears to be safe and effective in cirrhotic patients with portal vein thrombosis, leading to higher rates of complete radiographic resolution and recanalization of occlusive PVT without increasing major bleeding rates. Additional prospective studies are needed to confirm these findings and evaluate other outcomes.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Oncology
Gang Dong, Xiao-Quan Huang, Yu-Li Zhu, Hong Ding, Feng Li, Shi-Yao Chen
Summary: In cirrhotic patients with portal vein thrombosis (PVT), an increased portal vein diameter is associated with a higher risk of PVT development. The portal diameter is the strongest independent risk factor for predicting PVT development, with a cutoff value of 12.5 mm. Patients with cirrhosis and an increased portal diameter may require thromboprophylaxis as a high-risk subgroup.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Hematology
Siyu Jiang, Yingjie Ai, Xiaowen Fan, Xiaoquan Huang, Ling Wu, Liyuan Ni, Feng Li, Shiyao Chen
Summary: The aim of this study was to investigate the role of factor VIII (FVIII) in the occurrence of portal vein thrombosis (PVT) in cirrhotic patients with gastroesophageal variceal bleeding. The study found that elevated FVIII activity was associated with the occurrence and severity of PVT in these patients, suggesting that it may be a useful marker for identifying those at risk of PVT.
THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Gastroenterology & Hepatology
Marco Senzolo, Guadalupe Garcia-Tsao, Juan Carlos Garcia-Pagan
Summary: Portal vein thrombosis (PVT) is a complication of cirrhosis with increasing incidence related to the severity of cirrhosis. Various risk factors contribute to PVT occurrence and progression. While the impact of complete PVT on liver transplant outcomes is clear, its effect on cirrhosis progression remains uncertain. Treatment options vary based on individual patient characteristics and thrombus features.
JOURNAL OF HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Antonio Guerrero, Laura del Campo, Fabio Piscaglia, Bernhard Scheiner, Guohong Han, Francesco Violi, Carlos-Noronha Ferreira, Luis Tellez, Thomas Reiberger, Stefania Basili, Javier Zamora, Agustin Albillos
Summary: This study used an individual patient data meta-analysis to demonstrate the safety and efficacy of anticoagulation in the recanalization of portal vein thrombosis in patients with cirrhosis. Anticoagulation reduces all-cause mortality, but at the expense of increasing non-portal hypertension-related bleeding.
JOURNAL OF HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Luis Manuel Barrera-Lozano, Jaime Alberto Ramirez-Arbelaez, Cristian Leonardo Munoz, Jorge Andres Becerra, Luis Guillermo Toro, Carlos M. Ardila
Summary: This study analyzes the perioperative complications and survival of liver transplant patients with portal vein thrombosis (PVT). PVT significantly influenced early vascular complications. Additionally, PVT Yerdel 2 or higher impacted the survival of liver grafts in the short and long term.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Swathi Prakash, Jared Bies, Mariam Hassan, Adriana Mares, S. Claudia Didia
Summary: Portal Vein Thrombosis (PVT) is a common complication of advanced liver disease, characterized by the obstruction of the portal vein due to thrombus formation. Recent studies have revealed that decreased blood flow caused by portal hypertension contributes to an increased risk of PVT. Cirrhosis patients with higher MELD and Child Pugh scores have a higher incidence of PVTs. The management of PVTs in cirrhotics remains controversial due to the complex hemostatic profile of these patients.
FRONTIERS IN MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Shinya Yokoyama, Yoji Ishizu, Takashi Honda, Norihiro Imai, Takanori Ito, Kenta Yamamoto, Tomoyuki Tsuzuki, Masatoshi Ishigami
Summary: Portal vein thrombosis (PVT) in patients with liver cirrhosis may improve spontaneously when large collateral vessels are absent. In these cases, observation without anticoagulation therapy can be considered in expectation of spontaneous reduction of PVT.
HEPATOLOGY RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Abhinav Talwar, Jeffrey Varghese, Gabriel M. Knight, Nitin Katariya, Juan-Carlos Caicedo, Zach Dietch, Daniel Borja-Cacho, Daniella Ladner, Derrick Christopher, Talia Baker, Michael Abecassis, Samdeep Mouli, Kush Desai, Ahsun Riaz, Bart Thornburg, Riad Salem
Summary: This study compares the outcomes of patients with chronic obliterative portal vein thrombosis (PVT) who received portal vein recanalization-transjugular intrahepatic portosystemic shunt (PVR-TIPS) followed by liver transplantation (LT) to those with partial nonocclusive PVT who underwent LT without an intervention. The results show that PVR-TIPS is effective in resolving PVT and simplifies the surgical aspects of LT.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Oncology
Fang Fang, Bin Qiu, Peng Zhen, Junjie Wang
Summary: This study retrospectively evaluated the efficacy and safety of hypofractionated radiotherapy for portal vein tumor thrombosis (PVTT) in cirrhotic patients with hepatocellular carcinoma. Results showed a high rate of tumor response with complete response in 25% of cases and no severe complications observed.
FRONTIERS IN ONCOLOGY
(2022)
Review
Gastroenterology & Hepatology
Suprabhat Giri, Ankita Singh, Kailash Kolhe, Aditya Kale, Akash Shukla
Summary: The natural history of portal vein thrombosis (PVT) in cirrhosis shows that approximately 25% of cases progress, 30% improve, and 45% remain stable. Further research is needed to analyze the predictors of spontaneous regression.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Ahmed Abdel-Razik, Nasser Mousa, Walaa Shabana, Ahmed H. Yassen, Mostafa Abdelsalam, Mohamed M. Wahba, Eman Mohamed Helmy, Ahmed M. Tawfik, Khaled Zalata, Ahmad S. Hasan, Rania Elhelaly, Rasha Elzehery, Aya Ahmed Fathy, Niveen El-Wakeel, Waleed Eldars
Summary: This study found that increased central obesity and leptin/adiponectin ratio (LAR) were independently associated with the development of PVT in non-cirrhotic NAFLD patients, suggesting that they may be considered as risk factors in the multifactorial pathogenesis of PVT.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Simon Johannes Gairing, Peter Robert Galle, Joern M. Schattenberg, Karel Kostev, Christian Labenz
Summary: Portal vein thrombosis (PVT) is associated with an increased risk of developing depression and anxiety disorders, with a particularly significant association with incident depression.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Ho Soo Chun, A. Reum Choe, Minjong Lee, Yuri Cho, Hwi Young Kim, Kwon Yoo, Tae Hun Kim
Summary: For patients with cirrhosis, the prevalence of portal vein thrombosis (PVT) can be up to 26%, making anticoagulation an important consideration for prevention and management. While there is a paradigm shift towards using direct-acting oral anticoagulants (DOACs) for PVT treatment in cirrhosis patients, the safety and efficacy of DOACs in this population is not well-known.
CLINICAL AND MOLECULAR HEPATOLOGY
(2021)
Article
Health Care Sciences & Services
Jingnuo Ding, Fazhi Zhao, Youhan Miao, Yunnuo Liu, Huiting Zhang, Weifeng Zhao
Summary: The aim of this study was to develop a simple and effective model to predict portal vein thrombosis (PVT) in cirrhotic patients. Clinical data of 656 patients were collected and a predictive model was constructed. The model showed high predictive value in internal and external validation, and it was confirmed that PVT patients had poor prognosis and were prone to recurrent esophageal and gastric variceal bleeding.
JOURNAL OF PERSONALIZED MEDICINE
(2023)