Article
Medicine, Research & Experimental
Chunlan Huang, Zehua Huang, Ling Ding, Yang Fu, Junjie Fan, Qixiang Mei, Lihong Lou, Jingjing Wang, Nuoming Yin, Yingying Lu, Sanwei Guo, Yue Zeng
Summary: This study compared the efficacy and safety of fecal microbiota transplantation (FMT) with glucocorticoids as induction therapy in ulcerative colitis (UC). The results showed that FMT was as effective as glucocorticoids in inducing remission in active mild to moderate UC, with fewer adverse events. Changes in certain cytokines in the serum might be related to the efficacy of FMT therapy in UC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Xiaochen Zhang, Dai Ishikawa, Kei Nomura, Naoyuki Fukuda, Mayuko Haraikawa, Keiichi Haga, Tomoyoshi Shibuya, Toshihiro Mita, Akihito Nagahara
Summary: Fecal microbiota transplantation is considered a promising treatment for dysbiosis-related diseases. The authors report their experience with donor screening and provide references to improve future donor screening criteria.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Manuel Ponce-Alonso, Carlota Garcia-Hoz, Ana Halperin, Javier Nuno, Pilar Nicolas, Adolfo Martinez-Perez, Juan Ocana, Juan Carlos Garcia-Perez, Antonio Guerrero, Antonio Lopez-Sanroman, Rafael Canton, Garbine Roy, Rosa del Campo
Summary: The study aimed to design and validate an individualized immune-based test to optimize fecal donor selection for fecal microbiota transplantation (FMT). Through in vitro validation and a clinical pilot study, it was found that selecting donors based on recipient's local immunological response may not influence the clinical success of FMT in patients with ulcerative colitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Essi K. Karjalainen, Laura Renkonen-Sinisalo, Reetta Satokari, Harri Mustonen, Ari Ristimaki, Perttu Arkkila, Anna H. Lepisto
Summary: The fecal microbiota transplantation treatment did not show efficacy in treating chronic pouchitis, however the safety profile was good. Among patients who were using continuous antibiotics before the study, the relapse-free survival was shorter in the intervention group.
INFLAMMATORY BOWEL DISEASES
(2021)
Review
Microbiology
Haixia Liu, Jing Li, Jiaxin Yuan, Jinke Huang, Youqi Xu
Summary: This study aims to systematically gather, evaluate, and synthesize solid evidence for using fecal microbiota transplantation (FMT) to treat ulcerative colitis (UC) based on the current overview of published systematic reviews and meta-analyses.
Article
Immunology
Qiongyun Chen, Yanyun Fan, Bangzhou Zhang, Changsheng Yan, Zhangran Chen, Lin Wang, Yiqun Hu, Qingwen Huang, Jingling Su, Jianlin Ren, Hongzhi Xu
Summary: This study examined the association between gut fungal community and capsulized FMT outcomes in ulcerative colitis (UC) patients. The results showed that capsulized FMT improved fungal diversity and induced remission in UC patients. Specific fungal species were identified to be associated with the induction of remission. This study provides important insights into the mechanism of FMT treatment for UC.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Loris Riccardo Lopetuso, Lucrezia Laterza, Valentina Petito, Silvia Pecere, Gianluca Quaranta, Federica Del Chierico, Pierluigi Puca, Elisa Schiavoni, Daniele Napolitano, Andrea Poscia, Gianluca Ianiro, Daniela Pugliese, Lorenza Putignani, Maurizio Sanguinetti, Alessandro Armuzzi, Luca Masucci, Antonio Gasbarrini, Giovanni Cammarota, Franco Scaldaferri
Summary: This study aimed to evaluate the effectiveness of exercise therapy for patients with cervical spondylosis. The results showed that patients who received exercise therapy had significantly better pain levels, functional recovery, and quality of life compared to those who received traditional treatment.
Review
Medicine, General & Internal
Magdalena Stojek, Anna Jablonska, Krystian Adrych
Summary: The exact pathogenesis of inflammatory bowel disease is not fully understood, but it is believed to involve genetic predisposition, environmental triggers, and exaggerated immune responses. Current management strategies focus on correcting immune responses, with potential new treatments like FMT showing promising results.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Heather J. Galipeau, Alberto Caminero, Williams Turpin, Miriam Bermudez-Brito, Alba Santiago, Josie Libertucci, Marco Constante, Juan Antonio Raygoza Garay, Gaston Rueda, Sarah Armstrong, Alex Clarizio, Michelle Smith, Michael G. Surette, Premysl Bercik, Kenneth Croitoru, Elena F. Verdu
Summary: Increased fecal proteolytic activity was found before the clinical diagnosis of UC, which may serve as a noninvasive biomarker of inflammation associated with changes in gut microbiota. The study suggests potential therapeutic targets for at-risk populations based on antiprotease treatments.
Article
Cell Biology
Chunlan Huang, Qixiang Mei, Lihong Lou, Zehua Huang, Yang Fu, Junjie Fan, Jingjing Wang, Nuoming Yin, Yi Zheng, Yingying Lu, Yue Zeng
Summary: The colonization of Faecalibacterium after fecal microbiota transplantation plays a crucial role in the remission of ulcerative colitis by alleviating intestinal inflammation. This anti-inflammatory effect of Faecalibacterium may be achieved by regulating the imbalance of Th17/Treg levels in ulcerative colitis.
Review
Medicine, General & Internal
Xiaochen Zhang, Dai Ishikawa, Toshifumi Ohkusa, Shinji Fukuda, Akihito Nagahara
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the intestinal mucosa with a complex etiology. The altered gut microbiota in IBD patients is associated with dysbiosis, leading to disease. Fecal microbiota transplantation (FMT) has shown promising efficacy and safety in the treatment of IBD, but further optimization is needed for its implementation.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Jan Brezina, Lukas Bajer, Pavel Wohl, Dana Duricova, Pavel Hrabak, Ales Novotny, Jana Kozeluhova, Milan Lukas, Jakub Mrazek, Katerina Olsa Fliegerova, Simona Kvasnova, Mekadim Chahrazed, Jan Mares, Julius Spicak, Pavel Drastich
Summary: The study found that FMT is an effective treatment for left-sided UC, with increased recipient microbiome diversity. FMT was noninferior to 5-ASA in achieving the primary study endpoint, with no significant difference in adverse events between the two groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Agriculture, Multidisciplinary
Tao Wang, Caihong Shi, Shuxuan Wang, Yu Zhang, Shuang Wang, Mohamedelfaieh Ismael, Jing Zhang, Xin Wang, Xin Lu
Summary: This study used fecal microbiota transplantation (FMT) to verify the potential of Companilactobacillus crustorum MN047 (CCMN) in regulating gut microbiota and alleviating inflammation in ulcerative colitis (UC).
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Microbiology
Fangyuan Zhu, Yifan Ke, Yiting Luo, Jiaqian Wu, Pei Wu, Fangxiao Ma, Yingchao Liu
Summary: Ulcerative colitis (UC) is a chronic inflammatory bowel disease, and fecal microbiota transplantation (FMT) has been shown to improve UC symptoms. Results of the study indicate that frozen FMT has a better therapeutic effect in treating UC in rat models compared to fresh FMT.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ruiqiao He, Pan Li, Jinfeng Wang, Bota Cui, Faming Zhang, Fangqing Zhao
Summary: Fecal microbiota transplantation is a promising treatment for microbiota dysbiosis associated diseases. This study investigated the effect of different types of donor-derived microbiota on FMT efficacy. The research found two dominant types of microbiota in CDI and IBD patients, and observed the interaction between recipient and donor-derived microbiota during FMT.
