Review
Biochemistry & Molecular Biology
Adrian Boicean, Victoria Birlutiu, Cristian Ichim, Paula Anderco, Sabrina Birsan
Summary: Inflammatory bowel diseases (IBD) are complex diseases characterized by chronic inflammation in the gastrointestinal tract. Fecal microbiota transplantation (FMT) has shown increasing effectiveness and safety in treating recurrent Clostridium difficile infection (CDI) and co-infection of SARS-CoV-2 and CDI. By modifying the gut microbiota, FMT offers an alternative approach to indirectly influence the host's immune system in a safe way, improving clinical symptoms and endoscopic findings in IBD patients. Further validation is needed to establish a clinical protocol for FMT in IBD.
Review
Biochemistry & Molecular Biology
Adrian Boicean, Victoria Birlutiu, Cristian Ichim, Olga Brusnic, Danusia Maria Onisor, Amedeo Amedei, Ryota Niikura
Summary: Imbalances in the gut microbiota play a crucial role in the development of liver diseases, and fecal microbiota transplantation has shown promise as an effective treatment for chronic liver diseases and cirrhosis.
Article
Hematology
Melissa K. Hyde, Barbara M. Masser, Lianne Spears
Summary: Blood collection agencies hosting stool donor programs often defer a high percentage of potential donors, resulting in the loss of future eligible donors. This study explored the experiences of ineligible donors and found that many did not know the reason for their ineligibility, leading to permanent loss of potential donors. Motives for donation included altruism, curiosity, and a desire to contribute to scientific research.
Review
Gastroenterology & Hepatology
Rohma Ghani, Benjamin H. Mullish, Lauren A. Roberts, Frances J. Davies, Julian R. Marchesi
Summary: Disruption to the intestinal microbiota increases the risk of infection, and restoring its composition is a potential strategy to mitigate this risk. Fecal microbiota transplantation is currently the major therapeutic approach, with potential use in treating other infectious diseases.
Article
Immunology
Jiuxi Liu, Jiapei Cai, Naisheng Zhang, Jiandong Tai, Peng Fan, Xue Dong, Yongguo Cao
Summary: Salidroside, a plant compound, can ameliorate high-fat diet-induced obesity by modulating gut microbiota. It reduces body weight and fat accumulation, decreases liver inflammation and metabolic endotoxemia, and repairs intestinal damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ning He, Gerong Shen, Xiaoqin Jin, Heyangzi Li, Jingyu Wang, Lintao Xu, Jun Chen, Xi Cao, Chunyan Fu, Dongling Shi, Xinghui Song, Shuangshuang Liu, Yanwei Li, Tengfei Zhao, Jun Li, Jinjie Zhong, Yueliang Shen, Mingzhi Zheng, Ying-ying Chen, Lin-lin Wang
Summary: Spinal cord injury can alter the gut microbiota and metabolites, affecting the prognosis of the injury. Resveratrol, with its anti-inflammatory properties, can restore the disrupted gut microbiota and increase the concentration of butyrate, promoting functional recovery after spinal cord injury.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Immunology
Hui Xu, Chenxi Cao, Yuqing Ren, Siyuan Weng, Long Liu, Chunguang Guo, Libo Wang, Xinwei Han, Jianzhuang Ren, Zaoqu Liu
Summary: This review systematically summarizes the role of fecal microbiome transplantation (FMT) in regulating tumor immunity and highlights its importance in treating refractory tumors and improving the efficacy of immunotherapy. Ongoing clinical trials combining FMT with immunotherapy are also summarized, along with a focus on refined protocols for FMT in cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ruiqiao He, Pan Li, Jinfeng Wang, Bota Cui, Faming Zhang, Fangqing Zhao
Summary: Fecal microbiota transplantation is a promising treatment for microbiota dysbiosis associated diseases. This study investigated the effect of different types of donor-derived microbiota on FMT efficacy. The research found two dominant types of microbiota in CDI and IBD patients, and observed the interaction between recipient and donor-derived microbiota during FMT.
Article
Environmental Sciences
Jing Xu, Mingzhu Wang, Qiuping Liu, Xiaoying Lin, Kefeng Pu, Zhixing He
Summary: Nitrite has toxic effects on mice, and gut microbiota can mediate the toxicity of nitrite. High doses of nitrite can cause dysbiosis in the gut microbiota, affecting metabolism and stress response.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Immunology
Lei Wang, Zhimin Wei, Fei Pan, Chuan Song, Lihua Peng, Yunsheng Yang, Feng Huang
Summary: This article reports a patient with refractory ankylosing spondylitis (AS) and comorbid ulcerative colitis (UC) who underwent three fecal microbiota transplantations (FMTs). FMT led to notable improvements in both AS and UC at 1 week post-FMT1, and further recovery was observed after the other two FMTs. More studies are needed to validate the effectiveness of FMT in AS and its mechanisms.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Veterinary Sciences
Maimaiti Tuniyazi, Wenqing Wang, Naisheng Zhang
Summary: Fecal microbiota transplantation (FMT) is a technique that involves transferring fecal matter from a healthy donor to a recipient in order to restore a healthy gut microbiome. It has been used in horses to treat gastrointestinal disorders such as colitis and diarrhea. The authors conducted a systematic review of the existing literature to evaluate the efficacy, safety, and potential applications of FMT in horses.
VETERINARY SCIENCES
(2023)
Review
Immunology
Lena Van Dingenen, Charlotte Segers, Shari Wouters, Mohamed Mysara, Natalie Leys, Samir Kumar-Singh, Surbhi Malhotra-Kumar, Rob Van Houdt
Summary: Colorectal cancer is a common and burdensome disease. Current treatment includes surgery, chemotherapy, radiotherapy, and immunotherapy. The gut microbiome may influence treatment efficacy and toxicity, and fecal microbiota transplantation can reduce toxicity and enhance efficacy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Medicine, General & Internal
Yuanyuan Zhao, Chen Gong, Jing Xu, Dong Chen, Bo Yang, Zhishui Chen, Lai Wei
Summary: A growing body of evidence suggests that gut microbiota plays a role in liver diseases through the gut-liver axis. The imbalance of gut microbiota is associated with various liver diseases, including ALD, NAFLD, viral hepatitis, cirrhosis, PSC, and HCC. FMT, as a method to restore the gut microbiota, has been widely studied and regarded in clinical trials. This review summarizes the role of FMT in liver disease treatment, explores the gut-liver axis, and discusses the definition, objectives, advantages, and procedures of FMT. The clinical value of FMT therapy in LT recipients is also briefly discussed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Qiaomai Xu, Shumeng Zhang, Jiazheng Quan, Zhengjie Wu, Silan Gu, Yunbo Chen, Beiwen Zheng, Longxian Lv, Lanjuan Li
Summary: Vancomycin is the preferred treatment for CDI but has a high recurrence rate. FMT has emerged as a successful treatment for recurrent CDI. Our study suggests that FMT can better restore gut microbiota and metabolites, promoting the recovery of colonization resistance in mice compared to vancomycin.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Fernanda Rosa, Tainara Cristina Michelotti, Benoit St-Pierre, Erminio Trevisi, Johan S. Osorio
Summary: Early life fecal microbiota transplantation in neonatal dairy calves is a relatively safe method that can influence growth, development, and possibly alleviate the stress caused by weaning procedures. The transplantation has positive effects on mediating the inflammatory response and gut microbial maturation in the calves.
