Review
Endocrinology & Metabolism
Gareth M. Rurak, Barbara Woodside, Argel Aguilar-Valles, Natalina Salmaso
Summary: Astroglial cells play a crucial role in the development and function of the brain, interacting with gonadal hormones to influence sexual differentiation of the brain and potentially leading to gender differences in neuropsychiatric disorders. This provides insights into forebrain sexual dimorphisms in human populations.
FRONTIERS IN NEUROENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Ingvild Ulsaker-Janke, Torgeir Waaga, Tanja Waaga, Edvard I. Moser, May - Britt Moser
Summary: This study found that rats can develop grid-like neuron firing patterns in a specific environment, even without stable reference boundaries to guide them. After a few trials of training, these patterns become more clear. While some experience with external spatial boundaries is required for the expression of grid patterns in a new environment, this restricted spatial experience can be overcome with short-term training.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Eriko Abe, Takashi J. Fuwa, Kyoka Hoshi, Takashi Saito, Takenobu Murakami, Masakazu Miyajima, Norihiro Ogawa, Hiroyasu Akatsu, Yoshio Hashizume, Yasuhiro Hashimoto, Takashi Honda
Summary: Iron is an essential nutrient in the body and needs to be bound to carrier proteins like transferrin. The study found that Tf mRNA is expressed by neural cells, while Tf protein is expressed at low levels in different brain regions, especially in the hippocampus.
Review
Neurosciences
Daniel Reyes-Haro
Summary: Anorexia is a common eating disorder, especially among adolescent females, characterized by a fear of gaining weight due to body image distortion, leading to reduced food intake and severe weight loss. Glial cells may play a significant role in anorexia.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Ellen McMullen, Helen Hertenstein, Katrin Strassburger, Leon Deharde, Marko Brankatschk, Stefanie Schirmeier
Summary: Glia cells in Drosophila can utilize fatty acids to supply neurons under restrictive conditions and act as a metabolic sensor to induce mobilization of peripheral energy stores.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Tomaz Martini, Juergen A. Ripperger, Jimmy Stalin, Andrej Kores, Michael Stumpe, Urs Albrecht
Summary: The expression of Per2 in glial cells plays a crucial role in regulating mood-related behaviors without affecting circadian activity rhythms.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Xiaosu Li, Guoping Liu, Lin Yang, Zhenmeiyu Li, Zhuangzhi Zhang, Zhejun Xu, Yuqun Cai, Heng Du, Zihao Su, Ziwu Wang, Yangyang Duan, Haotian Chen, Zicong Shang, Yan You, Qi Zhang, Miao He, Bin Chen, Zhengang Yang
Summary: The study elucidates the development of mouse cortical radial glial cells into intermediate progenitors and different subtypes of neural cells. It provides insights into the genetic logic underlying the specification and differentiation of cortical glial cells and OB interneurons.
NEUROSCIENCE BULLETIN
(2021)
Review
Cell Biology
Marit Knoop, Marie-Laure Possovre, Alice Jacquens, Alexandre Charlet, Olivier Baud, Pascal Darbon
Summary: The neonatal period is critical for brain development, but also carries the risk of brain injuries. Brain injury can lead to long-term neurological problems and is associated with neuroinflammation. The neuropeptide oxytocin (OT) plays an important role in the perinatal period and has potential neuroprotective effects for early brain development.
Article
Multidisciplinary Sciences
Lu Wang, Caleb Heffner, Keng Loi Vong, Chelsea Barrows, Yoo-Jin Ha, Sangmoon Lee, Pablo Lara-Gonzaleze, Ishani Jhamb, Dennis Van der Meer, Robert Loughnan, Nadine Parker, David Sievert, Swapnil Mittal, Mahmoud Y. Issa, Ole A. Andreassen, Anders Dale, William B. Dobyns, Maha S. Zaki, Stephen A. Murray, Joseph G. Gleeson
Summary: TMEM161B is a widely expressed transmembrane protein of unknown function in human, and mutations in this gene cause recessive polymicrogyria (PMG) and intellectual disability. Studies in mice and patient-derived brain organoids show that TMEM161B is involved in the development of the neocortex through regulation of apical cell polarity and radial glial scaffolding. TMEM161B modulates actin filopodia, acting upstream of the Rho-GTPase CDC42. These findings link TMEM161B to human PMG and provide insights into the role of TMEM161B in neocortical development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Robyn A. Umans, Carolyn Pollock, William A. Mills, Kareem C. Clark, Y. Albert Pan, Harald Sontheimer
Summary: Researchers utilized zebrafish as a model to study the interactions between different glial cell populations and brain blood vessels, revealing their diverse roles during blood vessel development and providing a suitable model for elucidating glial-vascular relationships in vertebrate brain development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pediatrics
Tingting Zhou, Wei Liu, Xiaofang Yu, Zengcai Cao, Weijing Mu, Peimin Hou, Chuantao Ren, Aiwu Li
Summary: Aberrant development of myenteric EGCs was observed in the colon of HSCR, potentially affecting the survival of enteric neurons. Protein and mRNA expression of glial fibrillary acidic protein and S100 calcium-binding protein B showed a decreasing trend from proximal, dilated, and transitional segments to the aganglionic segment.
FRONTIERS IN PEDIATRICS
(2021)
Review
Geriatrics & Gerontology
Hiroyuki Shimada, Seongryu Bae, Kenji Harada, Keitaro Makino, Ippei Chiba, Osamu Katayama, Sangyoon Lee
Summary: This study found a positive association between driving and brain health, with drivers having larger hippocampal volumes. Additionally, individuals who drove less frequently had smaller occipital cortex volumes compared to drivers and high-frequency drivers. Active drivers had larger volumes in the temporal cortex and cingulate cortex, as well as larger hippocampal volumes compared to non-drivers.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Neurosciences
Yanbo Lian, Simon Williams, Andrew S. Alexander, Michael E. Hasselmo, Anthony N. Burkitt
Summary: Recent research has found neurons in the retrosplenial cortex and other structures that could facilitate the transformation from egocentric views to allocentric maps. These egocentric boundary cells respond to visual barriers in relation to an animal's viewpoint, and computational models show that they can be generated through a simple synaptic learning rule. Some of these egocentric boundary cells can still function in new environments without retraining, offering insights into the properties necessary for integrating sensory information with spatial maps.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Katie M. Lavigne, Delphine Raucher-Chene, Michael D. Bodnar, Carolina Makowski, Ridha Joober, Ashok Malla, Alan C. Evans, Martin Lepage
Summary: This study found distinct structural brain changes associated with persistent negative symptoms (PNS) in the left medial temporal lobe (MTL) and suggests that basal ganglia alterations may contribute to PNS regardless of their etiology. Reductions in left MTL volume were most evident after 1 year of treatment, highlighting the importance of targeted early interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Behavioral Sciences
Michelle R. Dickerson, Susan F. Murphy, Michael J. Urban, Zakar White, Pamela J. VandeVord
Summary: Long-term neuropsychiatric impairments, such as anxiety and depression, are common comorbidities following blast-related traumatic brain injury in military personnel and Veterans. Studies have shown a link between chronic behavioral outcomes and neuropathology, particularly related to the hippocampus and motor cortex. Pathological changes in these brain regions contribute to the development of anxiety and depression, emphasizing the importance of understanding the mechanisms underlying these neuropsychiatric impairments.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Clinical Neurology
Andrea Righini, Claudia Cesaretti, Giorgio Conte, Cecilia Parazzini, Carolina Frassoni, Gaetano Bulfamante, Laura Avagliano, Francesca Inverardi, Giana Izzo, Mariangela Rustico
Article
Clinical Neurology
Carolina Frassoni, Laura Avagliano, Francesca Inverardi, Luigina Spaccini, Cecilia Parazzini, Maria Angela Rustico, Gaetano Bulfamante, Andrea Righini
Article
Anatomy & Morphology
Ramona Frida Moroni, Francesco Deleo, Maria Cristina Regondi, Laura Madaschi, Alida Amadeo, Carolina Frassoni
BRAIN STRUCTURE & FUNCTION
(2018)
Article
Neurosciences
Ana Rita Salgueiro-Pereira, Fabrice Duprat, Paula A. Pousinha, Alexandre Loucif, Vincent Douchamps, Cristina Regondi, Marion Ayrault, Martine Eugie, Marion I. Stunault, Andrew Escayg, Romain Goutagny, Vadym Gnatkovsky, Carolina Frassoni, Helene Marie, Ingrid Bethus, Massimo Mantegazza
NEUROBIOLOGY OF DISEASE
(2019)
Article
Clinical Neurology
Dalia De Santis, Laura Rossini, Laura Tassi, Giuseppe Didato, Giovanni Tringali, Massimo Cossu, Manuela Bramerio, Francesco Padelli, Maria Cristina Regondi, Francesca Colciaghi, Eleonora Aronica, Roberto Spreafico, Rita Garbelli
Article
Biochemistry & Molecular Biology
Michele Bertacchi, Anna Lisa Romano, Agnes Loubat, Frederic Tran Mau-Them, Marjolaine Willems, Laurence Faivre, Philippe Khau van Kien, Laurence Perrin, Francoise Devillard, Arthur Sorlin, Paul Kuentz, Christophe Philippe, Aurore Garde, Francesco Neri, Rossella Di Giaimo, Salvatore Oliviero, Silvia Cappello, Ludovico D'Incerti, Carolina Frassoni, Michele Studer
Article
Neurosciences
Ramona Frida Moroni, Maria Cristina Regondi, Marco de Curtis, Carolina Frassoni, Laura Librizzi
Article
Anatomy & Morphology
Benedetta Foglio, Laura Rossini, Rita Garbelli, Maria Cristina Regondi, Sara Mercurio, Michele Bertacchi, Laura Avagliano, Gaetano Bulfamante, Roland Coras, Antonino Maiorana, Silvia Nicolis, Michele Studer, Carolina Frassoni
Summary: The neocortex is characterized by unique areal and laminar organization, with distinct cortical layers and areas identified by graded expression of transcription factors and molecular determinants. Key cortical genes NR2F1 and SOX2 exhibit dynamic expression patterns across physiological conditions and in the pathological context of focal cortical dysplasia (FCD), providing insight into human cortical development. The high co-expression of NR2F1 and SOX2 in basal radial glia progenitors of the outer sub-ventricular zone suggests their role in cortical expansion and complexity in humans.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Multidisciplinary Sciences
Sara Mercurio, Linda Serra, Alessia Motta, Lorenzo Gesuita, Luisa Sanchez-Arrones, Francesca Inverardi, Benedetta Foglio, Cristiana Barone, Polynikis Kaimakis, Ben Martynoga, Sergio Ottolenghi, Michele Studer, Francois Guillemot, Carolina Frassoni, Paola Bovolenta, Silvia K. Nicolis
Article
Chemistry, Multidisciplinary
Barbara Sanavio, Laura Librizzi, Paolo Pennacchio, Galina V. Beznoussenko, Fernanda Sousa, Paulo Jacob Silva, Alexander A. Mironov, Carolina Frassoni, Francesco Stellacci, Marco de Curtis, Silke Krol