Article
Gastroenterology & Hepatology
Rahul Deshmukh, Akash Shukla, Sanjay Chandnani, Pravin M. Rathi, Pratik Tibdewal, Shubham Jain, Nitin Ramani, Parmeshwar Junare, Partha Debnath, Leela Shinde, Asif Bagwan, Megha Meshram
Summary: This study provides normal data for high-resolution anorectal manometry (HRAM) in a healthy Indian population and evaluates the impact of gender, age, and body mass index (BMI) on anorectal functions. The results indicate that there is no significant difference in anal pressures between males and females, but rectal pressure and anal pressure during simulated evacuation without rectal distention are higher in males. Additionally, females have a lower threshold for the first sensation, and subjects under the age of 40 have higher anal residual pressure. Moreover, individuals with a BMI below 23 kg/m(2) have higher maximum anal squeeze pressure and maximum rectal pressure during push.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Le Manh Cuong, Ha Van Quyet, Tran Manh Hung, Nguyen Ngoc Anh, Tran Thu Ha, Vu Van Du, Do Van Loi, Ha Huu Hoang Khai, Vu Duy Kien
Summary: This study identified normal HRAM values for healthy young adults in Vietnam and found that sex may influence anal pressure and first rectal sensation values in this cohort. Further research is needed to improve the quality of HRAM normal values and confirm the effects of sex.
BMC GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Leila Neshatian, Mary-Jane O. U. Williams, Eamonn M. Quigley
Summary: Rectal balloon distension during simulated evacuation can improve rectoanal gradient and reduce dysynergia in patients with chronic constipation, particularly those with normal rectal sensory function and balloon expulsion test results.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Hui Su, Amanda J. Krause, Melina Masihi, Jacqueline Prescott, Alex Decorrevont, Emma Germond, Dave Karasik, Wenjun Kou, John E. Pandolfino, Dustin A. Carlson
Summary: This study investigated a comprehensive HRM testing protocol on 30 healthy asymptomatic volunteers, reporting normal values and findings. Isolated abnormalities of IRP and contractile parameters were observed in 80% of subjects, while all subjects also displayed normal features.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Pharmacology & Pharmacy
M. Banasiuk, M. Dobrowolska, B. Skowronska, J. Konys, A. Chorazyk, E. Szudejko, A. Banaszkiewicz
Summary: This study evaluated constipated children with 3DHRAM and determined a new pediatric cut-off for DD variables. The analysis showed that the percent anal relaxation during straining significantly differed between patients and controls, leading to a new cut-off value of 31% for this variable.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Marcin Banasiuk, Magdalena Elzbieta Dobrowolska, Barbara Skowronska, Justyna Konys, Aleksandra Banaszkiewicz
Summary: This study demonstrated significantly different pressure values obtained with different types of catheters. Normal ranges for conventional manometry cannot be applied to high-resolution systems, and results obtained by different types of manometry cannot be compared without adjustments.
DIGESTIVE DISEASES
(2022)
Article
Gastroenterology & Hepatology
Ricardo A. Arbizu, Maureen Amicangelo, Leonel Rodriguez, Samuel Nurko
Summary: This study investigated the changes in intra-anal pressure and characteristics of the rectoanal inhibitory reflex during anorectal manometry in patients undergoing anesthesia induction with propofol. The results showed that propofol can be used to assess the presence of the rectoanal inhibitory reflex in uncooperative children. Additionally, propofol significantly reduces resting intra-anal pressure and increases the percentage of internal anal sphincter relaxation.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Gastroenterology & Hepatology
David O. Prichard, Jeffrey R. Fetzer
Summary: This study found that there are significant differences in results obtained by different operators during high-resolution anorectal manometry (HRM), despite using similar instructions. These differences may have a significant impact on the diagnoses and therapies offered to constipated patients.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Pharmacology & Pharmacy
M. Banasiuk, M. Dziekiewicz, L. Dembinski, D. Piotrowski, A. Kaminski, A. Banaszkiewicz
Summary: 3DHRAM is a useful tool for assessing the function of the anorectum in children after surgery for anorectal disorders. The study found that patients with anal atresia had the lowest pressure values, while those with non-retentive fecal incontinence had significantly lower resting pressures compared to asymptomatic children. Additionally, constipated patients had significantly higher urge thresholds compared to asymptomatic patients.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Cathrine Gatzinsky, Staffan Redfors, Helena Borg, Christina Linner, Ulla Sillen, Sofia Sjostrom
Summary: This study provides HRAM data in healthy infants at 2 and 6 months of age. Repeated HRAM in healthy infants showed that all subjects had a normal RAIR. HRAM is safe, easy to tolerate, and can be recommended in infants with or without FGD.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Desiree F. Baaleman, Samir Mishra, Ilan J. N. Koppen, Jac. M. Oors, Marc A. Benninga, Neetu Bali, Karla H. Vaz, Desale Yacob, Carlo Di Lorenzo, Peter L. Lu
Summary: This study aimed to investigate the difference in detecting rectoanal inhibitory reflex (RAIR) between awake and under general anesthesia conditions during anorectal manometry (ARM). A retrospective review of ARM studies found that in 26% of the children, RAIR was only identified under general anesthesia and not during awake ARM. General anesthesia also caused a decrease in anal canal pressure, leading to inconclusive test results.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Review
Gastroenterology & Hepatology
Luis G. Alcala Gonzalez, Renske A. B. Oude Nijhuis, Andreas J. P. M. Smout, Albert J. Bredenoord
Summary: The systematic review highlighted the large variation in normative values for high-resolution esophageal manometry depending on equipment and protocols used. Clinicians should consider these differences when interpreting measurements in clinical practice and comparing results.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
David O. Prichard, Jeffrey Fetzer
Summary: This study suggests that constipated men and women exhibit different recto-anal pressure patterns, with women being more prone to defecatory disorders and men being more likely to have abnormal balloon expulsion tests. These findings are independent of sex-specific physiological differences.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Pediatrics
Anna Maria Caruso, Denisia Bommarito, Vincenza Girgenti, Glenda Amato, Ugo Calabrese, Adele Figuccia, Fabio Baldanza, Francesco Grasso, Emanuela Giglione, Alessandra Casuccio, Mario Pietro Marcello Milazzo, Maria Rita Di Pace
Summary: This study analyzed anal sphincter activity in patients with anorectal malformation (ARM) using Three-Dimensional High Resolution Anorectal Manometry (3D-HRAM). The results revealed a correlation between manometric parameters and clinical outcomes, highlighting spinal malformations and ARM type as important prognostic risk factors for a bad outcome. Specific sphincteric defects can be explored with manometry, enabling tailored bowel management strategies.
Article
Gastroenterology & Hepatology
Annika M. P. Rasijeff, Karla Garcia-Zermeno, Emma Carrington, Charles Knowles, S. Mark Scott
Summary: Anorectal manometry is commonly used to assess anorectal function, and this study examined anorectal pressure responses to cough in healthy individuals and those with fecal incontinence. The study found differences in anal function between nulliparous and parous healthy volunteers, as well as patients with fecal incontinence, which were not detected using traditional measures. Cough-anorectal measurements may improve the yield of anorectal manometry.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)