期刊
AMERICAN JOURNAL OF GASTROENTEROLOGY
卷 107, 期 3, 页码 448-450出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ajg.2011.465
关键词
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资金
- NIDDK NIH HHS [R01 DK-092179, R01 DK092179] Funding Source: Medline
Ohman et al. report increased fecal granins in patients with irritable bowel syndrome (IBS). Several interesting questions arise from their observations. Are the granins a cause of the pathophysiology or phenotype in IBS? Is the elevation of granins specific to IBS? What is the cause of increased fecal granin levels? Can fecal granin levels be used to diagnose IBS? Are increased fecal granins an expression of intestinal or colonic irritation? This paper adds to the body of evidence suggesting there are gastrointestinal disturbances in IBS; understanding these disturbances may provide clues to its pathogenesis and optimize management.
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