Review
Geriatrics & Gerontology
Leonard Radu Pinosanu, Bogdan Capitanescu, Daniela Glavan, Sanziana Godeanu, Israel Fernaundez Cadenas, Thorsten R. Doeppner, Dirk M. Hermann, Adrian-Tudor Balseanu, Catalin Bogdan, Aurel Popa-Wagner
Summary: The functions and activities of astroglia cells in brain development, aging, and neurodegenerative diseases differ. Comparing the transcriptomic activity of astroglia cells in these processes may provide new therapeutic strategies to protect the aging brain and improve clinical outcomes.
Article
Biochemistry & Molecular Biology
Qiuling Liu, Tujing Song, Bing Chen, Jingjing Zhang, Wen Li
Summary: Hypoxia is crucial for the development of various disorders, especially hypoxic cerebropathy. The damage to the blood-brain barrier (BBB) caused by hypoxia is well known. This study explored the correlation between endothelial ferroptosis and hypoxia-induced BBB damage using in vivo zebrafish and in vitro bEnd.3 cells. The results showed that hypoxic treatment could induce BBB disruption by down-regulating claudin-5 (CLDN5) expression in both zebrafish cerebrovascular endothelial cells and bEnd.3 cells.
Article
Neurosciences
Qiyan Fan, Mika Takarada-Iemata, Nahoko Okitani, Takashi Tamatani, Hiroshi Ishii, Tsuyoshi Hattori, Sumiko Kiryu-Seo, Hiroshi Kiyama, Osamu Hori
Summary: The unfolded protein response (UPR) is a signal transduction network that plays an important role in maintaining cell viability and protein homeostasis in response to endoplasmic reticulum (ER) stress. This study investigated the activation of the UPR in both neuronal and non-neuronal cells, particularly endothelial cells and astrocytes, after acute brain injuries, suggesting that they could be potential therapeutic targets.
Article
Clinical Neurology
Lucia Beckmann, Stefanie Obst, Nicole Labusek, Hanna Abberger, Christian Koester, Ludger Klein-Hitpass, Sven Schumann, Christoph Kleinschnitz, Dirk M. Hermann, Ursula Felderhoff-Mueser, Ivo Bendix, Wiebke Hansen, Josephine Herz
Summary: Clinical and experimental studies suggest sexual dimorphism in neonatal brain injury and therapy responses caused by hypoxia-ischemia (HI). This study found that regulatory T cells (Tregs) from neonatal female mice provide neuroprotection, while Tregs from male mice increase secondary neurodegeneration, which may be associated with intrinsic transcriptional differences between sexes. There is an urgent need for sex-stratified clinical and preclinical analyses.
Article
Immunology
Kerstin Muelling, Alexa Josephine Fischer, Elena Siakaeva, Mathis Richter, Sharareh Bordbari, Ilona Spyra, Christian Koester, Dirk M. Hermann, Matthias Gunzer, Ursula Felderhoff-Mueser, Ivo Bendix, Jadwiga Jablonska, Josephine Herz
Summary: This study found that neutrophils in the neonatal brain are rapidly activated after experimental hypoxia-ischemia, producing reactive oxygen species and showing an increased proportion of hyperactivated/aged cells compared to peripheral neutrophils. Delayed neutrophil depletion led to reduced cellular neurodegeneration and decreased microglial and astroglial activation, offering new possibilities for therapeutic approaches in post-hypoxic brain injury.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Pharmacology & Pharmacy
Jose Martinez-Orgado, Maria Villa, Aaron del Pozo
Summary: CBD shows neuroprotective effects in newborn pigs and rodents with HIBI, modulating the major components of HIBI pathophysiology. It has the potential to be an effective treatment for neonatal HIBI.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Marit Knoop, Marie-Laure Possovre, Alice Jacquens, Alexandre Charlet, Olivier Baud, Pascal Darbon
Summary: The neonatal period is critical for brain development, but also carries the risk of brain injuries. Brain injury can lead to long-term neurological problems and is associated with neuroinflammation. The neuropeptide oxytocin (OT) plays an important role in the perinatal period and has potential neuroprotective effects for early brain development.
Article
Cell & Tissue Engineering
Manasi Suchit Halurkar, Jinju Wang, Shuzhen Chen, Ji Chen Bihl
Summary: The study confirms that EPC-EXs can protect astrocytes from damage caused by HG and H/R, and miR-126 enriched EPC-EXs enhance their protective effects.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Food Science & Technology
Paula Brielle Pontes, Ana Elisa Toscano, Diego Cabral Lacerda, Eulalia Rebeca da Silva Araujo, Paulo Cesar Trindade da Costa, Swane Miranda Alves, Jose Luiz de Brito Alves, Raul Manhaes-de-Castro
Summary: Polyphenol supplementation during early life has been found to reduce oxidative stress and neuroinflammation in diseases caused by oxygen deprivation. Evidence suggests that it may also alleviate brain injury and modulate adaptive responses involving phenotypical plasticity. The administration of polyphenols during early life period shows potential in modulating inflammatory and oxidative stress that cause impairments in locomotion, cognitive, and behavioral functions throughout life.
Article
Pharmacology & Pharmacy
Takahisa Suzuki, Yoshiaki Suzuki, Kiyofumi Asai, Yuji Imaizumi, Hisao Yamamura
Summary: Hypoxia upregulates the expression of TMEM16A and increases whole-cell Cl-Ca currents, leading to cell proliferation and enhanced endothelial permeability, which can be attenuated by Cl-Ca channel blockers or TMEM16A siRNA. These findings provide insights into the pathological role of TMEM16A Cl-Ca channels in the BBB during cerebral ischemia.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Article
Hematology
Gauri Arolkar, Sneha K. Kumar, Hanjay Wang, Karen M. Gonzalez, Suraj Kumar, Bhavnesh Bishnoi, Pamela Rios E. Coronado, Y. Joseph Woo, Kristy Red-Horse, Soumyashree Das
Summary: In this study, researchers found that neonatal artery endothelial cells have the ability to regenerate and develop into functional collateral arteries in ischemic regions of the heart. However, adult artery endothelial cells lack this regenerative ability due to their limited capacity for dedifferentiation and proliferation. These findings are significant for understanding the mechanisms of cardiac regeneration and could lead to the development of related therapeutic strategies.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Rehabilitation
Jackson M. Gray, Megan E. Kramer, Stacy J. Suskauer, Beth S. Slomine
Summary: This study describes the characteristics of children with anoxic or hypoxic brain injuries, explores functional outcomes at discharge, and examines differences between children with cardiac arrest and those with respiratory arrest only.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Chemistry, Multidisciplinary
Seyong Chung, Si Yeong Kim, Kyubae Lee, Sewoom Baek, Hyun-Su Ha, Dae-Hyun Kim, Suji Park, Chan Hee Lee, Hye-Seon Kim, Young Min Shin, Seung Eun Yu, Hak-Joon Sung
Summary: This study explores the liposomal targeting of splenic CD11b(+) cells and the induction of in situ reprogramming through the use of hypoxic-mimetic agent-loaded liposomes. The reprogrammed cells show enhanced vasculogenic potential, leading to accelerated regeneration in inflamed tissues. Advanced tools such as intravital multiphoton microscopy, F-19 2D/3D MRI, and microchannel hydrogel chips are used to validate the strategy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Neurosciences
Michele Siqueira, Joice Stipursky
Summary: Ethanol consumption during pregnancy or lactation permanently impairs the development of the central nervous system, resulting in fetal alcohol spectrum disorders (FASD). FASD encompasses a range of deficits in the embryo caused by alcohol exposure during gestation, with fetal alcohol syndrome (FAS) being the most severe. FAS is characterized by facial abnormalities, stunted growth, low body weight, and structural and/or functional damage to the central nervous system. Ethanol has deleterious effects on different brain regions, leading to microcephaly, abnormal cortical development, corpus callosum agenesis or hypoplasia, and cognitive and behavioral deficits. Teratogenic ethanol particularly affects the CNS blood vessels, which constitute the neurovascular unit of the blood-brain barrier (BBB). BBB disruption can worsen neurodegenerative and neurological diseases.
Article
Immunology
Alize Proust, Christophe J. J. Queval, Ruth Harvey, Lorin Adams, Michael Bennett, Robert J. J. Wilkinson
Summary: This study investigates the effect of different SARS-CoV-2 variants on brain cells and blood-brain barrier integrity. The results suggest that SARS-CoV-2 is neurotropic and can cause deleterious effects on the central nervous system. The findings provide insights into the potential neurological consequences of SARS-CoV-2 infection.
JOURNAL OF NEUROINFLAMMATION
(2023)
