Article
Gastroenterology & Hepatology
Takanori Yoshimoto, Tadayuki Oshima, Xinyi Huang, Toshihiko Tomita, Hirokazu Fukui, Hiroto Miwa
Summary: In patients with irritable bowel syndrome (IBS), an increase in duodenal mast cells and intraepithelial lymphocytes (IELs) was observed, with a positive correlation between the number of duodenal and ileal IELs and the frequency of diarrhea. Further studies are needed to clarify the pathophysiological functions associated with micro-inflammation in IBS, as this study was strictly observational.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ruidi Li, Shuhui Chen, Xinpei Gu, Shuhong An, Zhaojin Wang
Summary: The activation of mast cells and mediator release are closely related to the pathophysiology of irritable bowel syndrome (IBS). The Nr4a family of orphan nuclear receptors may play a regulatory role in this process. A better understanding of Nr4a members and their modulators could lead to the development of more effective therapies for IBS patients.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Gastroenterology & Hepatology
Iam van Thiel, W. J. de Jonge, R. M. van den Wijngaard
Summary: Although the gut microbiota consists of bacteria, viruses, and fungi, most studies on the microbiota-gut-brain axis in IBS have primarily focused on bacteria due to their higher presence. However, recent research on the intestinal mycobiome in inflammatory bowel disease suggests that the low numbers of fungi and viruses may still have relevance. This review discusses the current IBS mycobiome data and how these findings could relate to previous observations in IBS, as well as identifies questions for future research.
Article
Immunology
Guanqun Chao, Zhaojun Wang, Shuo Zhang
Summary: The study revealed that patients with diarrheapredominant IBS exhibited more serious levels of anxiety and depression, down-regulated expression of neuropeptide S, neuropeptide Y, and NPY receptor 2. Additionally, there was a significant increase in total mast cells and tryptase-positive mast cells, along with an up-regulation of Protease-activated receptor 2 expression in the colon tissue of IBS-D patients.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Lifang Fan, Mary Wong, Xuemo (Sean) Fan, Yuntian Hong, Kongliang Sun, Congqing Jiang, Xiaoyu Xie, Hanlin L. Wang
Summary: The density of intramucosal mast cells showed no significant difference between IBS, IBD, and normal control groups. In IBS patients, the number of intramucosal mast cells does not correlate with symptoms.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xi Li, Qingqing Liu, Jiaoyan Yu, Ruitao Zhang, Ting Sun, Wei Jiang, Na Hu, Peng Yang, Li Luo, Jing Ren, Qinhui Wang, Yan Wang, Qi Yang
Summary: The study showed that costunolide (COS) can alleviate intestinal dysfunction and depressive behavior in stress-induced IBS mice by inhibiting mast cell activation in the colon and regulating 5-HT metabolism in the central nervous system.
Article
Biochemistry & Molecular Biology
Sanghyun Kim, Bora Keum, Junhyoung Byun, Byoungjae Kim, Kijeong Lee, Jiwoo Yeon, Jaemin Lee, Hyuksoon Choi, Eunsun Kim, Yoontae Jeen, Hongsik Lee, Hoonjai Chun, Taehoon Kim
Summary: Recent studies have found a possible link between allergic airway diseases (AADs) and irritable bowel syndrome (IBS), suggesting a common pathophysiology. This study used a mouse model to investigate the induction of AAD and its effects on the intestinal mucosa, similar to IBS. The results show that AAD can induce inflammation in the colonic mucosa, which can be suppressed by treatment with salbutamol. Salbutamol may have the potential to alleviate the inflammatory response in IBS patients with allergic components.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Article
Gastroenterology & Hepatology
Michael Camilleri, Guy Boeckxstaens
Summary: This article evaluates the evidence that targeted pathophysiological mechanisms and customized treatments can be an alternative approach to treating patients with irritable bowel syndrome (IBS). The authors conducted a literature review on the mechanisms and treatments of IBS, identifying various noninvasive clinical tests that can assess the underlying mechanisms responsible for symptom generation. These mechanisms include rectal evacuation disorders, abnormal transit, visceral hypersensitivity or hypervigilance, bile acid diarrhea, sugar intolerances, barrier dysfunction, the microbiome, immune activation, and chemicals released by these mechanisms. The authors also recognized the basic molecular mechanisms contributing to these pathophysiologies, offering opportunities for interventions with medications targeted at specific food components, receptors, and potentially the microbiome. Although the evidence supporting interventions for each mechanism varies, the current state-of-the-art allows for a shift from symptom-based treatment to individualized treatment guided by pathophysiology and clinically identified biomarkers.
Review
Gastroenterology & Hepatology
Rebecca Kuang, David J. Levinthal, Amir A. Ghaffari, Claudia Ramos del Aguila de Rivers, Aylin Tansel, David G. Binion
Summary: The Solanaceae family of plants, commonly known as Nightshade vegetables, have significant culinary, economic, and cultural importance. However, some compounds derived from Nightshades may have adverse effects on human health, including intestinal damage and activation of mast cells. Edible Nightshades are gaining attention as potential triggers for gut symptoms in gastrointestinal disorders.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Michael Kurin, Abbinaya Elangovan, Muhammed Mustafa Alikhan, Basmah Al Dulaijan, Eli Silver, David C. Kaelber, Gregory Cooper
Summary: There is a strong association between irritable bowel syndrome (IBS) and mast cell disorders (MCDs), especially with mast cell activation syndrome. Patients in overlap cohorts are predominantly female, and comorbid mood disorders and migraines are more common in IBS patients with MCDs. Further research on mast cell involvement in the pathogenesis of IBS is warranted.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Review
Gastroenterology & Hepatology
Li Cheng, Qing Qing Luo, Sheng Liang Chen
Summary: Mast cells play a crucial role in the pathogenesis of irritable bowel syndrome (IBS), with alterations in mast cell density and infiltration in the intestinal mucosa of IBS patients. Factors such as diet, psychological factors, infection, and dysbiosis are implicated in inducing intestinal mast cell infiltration. Interactions between mast cells, enteric neurons, and other immune cells, as well as the release of various mediators, may contribute to the development of IBS.
JOURNAL OF DIGESTIVE DISEASES
(2021)
Review
Medicine, General & Internal
Mihaela Fadgyas Stanculete, Abdulrahman Ismaiel, Stefan-Lucian Popa, Octavia Oana Capatina
Summary: Irritable bowel syndrome (IBS) is a disorder characterized by altered gut-brain interaction and dysfunction of the brain-gut-microbiota axis. Prior studies have shown significant impairments in the health-related quality of life of patients with IBS. Resilience, as a psychosocial ability, plays a crucial role in promoting health and enhancing stress response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Syed Ahsan Rizvi, Chukwuemeka Oriala, Jessina Thomas, Shuan Li, Yamen Smadi
Summary: This study compared the number of mast cells (MCs) in children with and without irritable bowel syndrome (IBS) and established histopathological reference values in pediatrics.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Agnieszka Chlebicz-Wojcik, Katarzyna Slizewska
Summary: Irritable bowel syndrome is not life-threatening but significantly impacts quality of life and economic loss. Research focuses on the role of intestinal microbiota in disease development, with an emphasis on therapies modulating the microbiota such as probiotics, prebiotics, and synbiotics. Most studies have focused on probiotics, but there are also promising results from studies on prebiotics and synbiotics.
Article
Marine & Freshwater Biology
Daniel L. Harris, Hannah E. Power, Michael A. Kinsela, Jody M. Webster, Ana Vila-Concejo
ESTUARINE COASTAL AND SHELF SCIENCE
(2018)
Article
Multidisciplinary Sciences
Tristan Salles, Xuesong Ding, Jody M. Webster, Ana Vila-Concejo, Gilles Brocard, Jodie Pall
SCIENTIFIC REPORTS
(2018)
Article
Geosciences, Multidisciplinary
Thomas E. Fellowes, Ana Vila-Concejo, Shari L. Gallop
Article
Geography, Physical
Stephanie Duce, Belinda Dechnik, Jody M. Webster, Quan Hua, James Sadler, Gregory E. Webb, Luke Nothdurft, Marcos Salas-Saavedra, Ana Vila-Concejo
QUATERNARY SCIENCE REVIEWS
(2020)
Article
Environmental Sciences
Luci Cajueiro Carneiro Pereira, Wellington Trindade, Anderson Thiago do Nascimento, Ana Vila Concejo, Jose A. Jimenez
JOURNAL OF COASTAL RESEARCH
(2020)
Article
Marine & Freshwater Biology
Daniel L. Harris, Ana Vila-Concejo, Timothy Austin, Javier Benavente
ESTUARINE COASTAL AND SHELF SCIENCE
(2020)
Article
Multidisciplinary Sciences
Amin Riazi, Ana Vila-Concejo, Tristan Salles, Umut Turker
SCIENTIFIC REPORTS
(2020)
Article
Geography, Physical
Shari L. Gallop, Ana Vila-Concejo, Thomas E. Fellowes, Mitchell D. Harley, Maryam Rahbani, John L. Largier
EARTH SURFACE PROCESSES AND LANDFORMS
(2020)
Article
Environmental Sciences
Lara Talavera, Ana Vila-Concejo, Jody M. Webster, Courtney Smith, Stephanie Duce, Thomas E. Fellowes, Tristan Salles, Daniel Harris, Jon Hill, Will Figueira, Jorg Hacker
Summary: Rubble islands are dynamic sedimentary features on reef platforms, providing valuable land for small island nations and critical habitat for species, but facing threats from climate change. The evolution of One Tree Island (OTI) is influenced by factors such as cyclone activity, El Nino Southern Oscillation (ENSO) phases, and mechanisms involving sediment transport and wave overtopping. Further research is needed to understand the future trajectory of OTI and other rubble islands under climate change scenarios.
Article
Ecology
Ana B. Bugnot, Katherine A. Dafforn, Ross A. Coleman, Megan Ramsdale, Jayden T. Gibbeson, Katherine Erickson, Ana Vila-Concejo, William F. Figueira, Paul E. Gribben
Summary: Habitat interactions, particularly in aquatic ecosystems, are important for regulating biodiversity and ecosystem functions. Oyster reefs, a highly degraded habitat, have unknown effects on sediment infaunal communities. This study found that sediments close to oyster reefs had more labile organic matter, positively impacting taxonomic biodiversity. Functional biodiversity, however, varied between estuaries, suggesting the importance of estuarine environmental conditions. Incorporating seascape interactions into restoration initiatives can inform the recovery of biodiversity and functions beyond the target habitat.
Article
Oceanography
Ana Vila-Concejo, Kristen D. Splinter, Mitchell D. Harley, Ryan Lowe, Thomas E. Fellowes, R. Jak McCarroll, Giovanni Coco
Summary: The global COVID-19 pandemic has led many countries to lockdown and travel restrictions since early 2020, but activities like Zoom seminars and podcast series have still allowed researchers to share scientific findings and build community connections.
CONTINENTAL SHELF RESEARCH
(2022)
Review
Environmental Sciences
Thomas E. Fellowes, Frances Anggadi, Maria Byrne, Ana Vila-Concejo, Eleanor Bruce, Elaine Baker
Summary: Coral reef islands are important and can support large maritime zones. However, they are facing numerous climate threats, and it is crucial to ensure their future and the wellbeing of the communities that depend on them, particularly in Small Island Developing States (SIDS). This review focuses on the bio-physical interactions of coral islands and reefs in the face of changing climates, and the implications for legal maritime zones and SIDS.
ENVIRONMENTAL RESEARCH LETTERS
(2022)
Article
Marine & Freshwater Biology
Courtney Smith, Ana Vila-Concejo, Tristan Salles
Summary: The Great Barrier Reef is of global ecological and scientific importance, as well as economic and iconic value for Australia. This study provides a detailed analysis of its offshore wave climate, showing the modal conditions and extreme events. Results indicate that the wave climate varies among different regions of the reef, with decreasing trends in wave height and energy for the northern and central regions over the past 33 years.
Article
Geosciences, Multidisciplinary
Timothy P. Austin, Ana Vila-Concejo, Andrew D. Short, Roshanka Ranasinghe
Article
Social Sciences, Interdisciplinary
Ana Vila-Concejo, Shari L. Gallop, Sarah M. Hamylton, Luciana S. Esteves, Karin R. Bryan, Irene Delgado-Fernandez, Emilia Guisado-Pintado, Siddhi Joshi, Graziela Miot da Silva, Amaia Ruiz de Alegria-Arzaburu, Hannah E. Power, Nadia Senechal, Kristen Splinter
PALGRAVE COMMUNICATIONS
(2018)
