Article
Multidisciplinary Sciences
Wenjing Yang, Ya Ma, Haiting Xu, Zhenhua Zhu, Jiaxue Wu, Cheng Xu, Wei Sun, Erhu Zhao, Min Wang, Rui L. Reis, Subhas C. Kundu, Xiaoxiao Shi, Bo Xiao
Summary: This study synthesized a fluorinated pluronic and functionalized nanoparticles with resveratrol nanocrystals. These nanoparticles exhibited improved stability and penetration capacities in the colon, and showed potential for treating ulcerative colitis by reconstructing epithelial barriers and alleviating inflammation.
Article
Multidisciplinary Sciences
Wenjing Yang, Ya Ma, Haiting Xu, Zhenhua Zhu, Jiaxue Wu, Cheng Xu, Wei Sun, Erhu Zhao, Min Wang, Rui L. Reis, Subhas C. Kundu, Xiaoxiao Shi, Bo Xiao
Summary: A fluorinated nanoparticle has been developed to improve the therapeutic outcomes of ulcerative colitis (UC). The results showed that the nanoparticles efficiently delivered drugs to the colon, promoted mucosal penetration, and had anti-oxidative and anti-inflammatory effects. In animal models, the nanoparticles significantly improved the therapeutic efficacy, reduced inflammation, and restored intestinal microbiota balance.
Article
Pharmacology & Pharmacy
Shwe Phyu Hlaing, Jiafu Cao, Juho Lee, Jihyun Kim, Aruzhan Saparbayeva, Dongmin Kwak, Hyunwoo Kim, Seonghwan Hwang, Hwayoung Yun, Hyung Ryong Moon, Yunjin Jung, Jin-Wook Yoo
Summary: In this study, curcumin-loaded nanoparticles targeted inflamed colitis tissue and demonstrated better therapeutic efficacy compared to non-targeted nanoparticles. The nanoparticles reduced inflammation and accelerated recovery, making them a promising delivery platform for treating ulcerative colitis.
Article
Biochemistry & Molecular Biology
Mengfan Luo, Qiaoyue Yuan, Mingzhen Liu, Xingye Song, Yingjie Xu, Tao Zhang, Xiaoqun Zeng, Zhen Wu, Daodong Pan, Yuxing Guo
Summary: This study aimed to develop a novel astaxanthin nanoparticle using gum arabic (GA) and whey protein powder enriched with milk fat globule membranes (MFGM-WPI) as carriers and investigated its effect and alleviation mechanism on colitis in mice. Results showed that MFGM-GA-astaxanthin effectively improved bioaccessibility of astaxanthin, reduced oxidative stress, alleviated colitis symptoms, repaired intestinal barrier function, and restored abnormalities of gut flora. This study provides a promising therapeutic approach for colon diseases using astaxanthin nanoparticles.
Article
Biochemistry & Molecular Biology
Wei Hao, Zhejie Chen, Qin Yuan, Meiling Ma, Caifang Gao, Yangyang Zhou, Hefeng Zhou, Xu Wu, Dingtao Wu, Mohamed A. Farag, Shengpeng Wang, Yitao Wang
Summary: Ginger polysaccharides (GP) have potential in alleviating ulcerative colitis (UC) by inhibiting inflammatory cytokines, repairing intestinal barrier, and regulating gut microbiota.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Multidisciplinary Sciences
Karolinny Cristiny de Oliveira Vieira, Ana Beatriz Batista da Silva, Suelen Aparecida Felicio, Fabio Santos Lira, Caique de Figueiredo, Eugenia Bezirtzoglou, Valeria Cataneli Pereira, Wilson Romero Nakagaki, Gisele Alborghetti Nai, Lizziane Kretli Winkelstroter
Summary: This study evaluated the effects of probiotic orange juice containing Pediococcus acidilactici CE51 in a mouse model of colitis. The probiotic treatment reduced inflammation and modulated the gut microbiota composition.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Marina Liso, Giulio Verna, Elisabetta Cavalcanti, Stefania De Santis, Raffaele Armentano, Angela Tafaro, Antonio Lippolis, Pietro Campiglia, Antonio Gasbarrini, Mauro Mastronardi, Theresa Torres Pizarro, Fabio Cominelli, Loris Riccardo Lopetuso, Marcello Chieppa
Summary: This study provides new insights and alternative approaches to treat ulcerative colitis (UC) patients. It suggests that anti-interleukin (IL)1 strategies, such as anakinra, may be a more effective therapeutic option for primary nonresponders to anti-tumor necrosis factor (TNF) therapy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Immunology
Yuan Cheng, Junxiang Li, Xiaosi Zhang, Yalan Li, Xiaojun Shi, Rui Shi, Tangyou Mao, Fushun Kou, Lei Shi
Summary: This study explores and verifies the pharmacological mechanisms of Qingchang Wenzhong Decoction (QCWZD) in the treatment of ulcerative colitis (UC) and ulcerative colitis-associated carcinogenesis (UCAC) through microarray analysis, network pharmacology, and biological verification. The results demonstrate that QCWZD may treat UC and UCAC by activating the IL-17, NF-kB, and TLR4 signaling pathways to protect the intestinal mucosal barrier, regulate inflammation, and improve intestinal fibrosis.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Plant Sciences
Zi-Wei Yu, Yu Xie, Ze-Cheng Huang, Ke Yang, Zhan-Guo Wang, Hui-Ling Hu
Summary: The study found that both rVR and pVR have a significant therapeutic effect on UC, with pVR seeming more suitable for treating gastrointestinal diseases. Both rVR and pVR have a regulatory effect on intestinal flora and metabolism, but with slightly different mechanisms.
Article
Gastroenterology & Hepatology
Nathaniel A. Cohen, Maryam Zafer, Namrata Setia, Michael J. Anderson, Atsushi Sakuraba, Sushila Dalal, Joel Pekow, Russell D. Cohen, David T. Rubin, Dejan Micic
Summary: This study found that serum CMV PCR can be used as a non-invasive test for diagnosing CMV colitis in UC patients, and it has excellent negative predictive value and a strong correlation with CMV positivity on histology.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Cristina Bauset, Lluis Lis-Lopez, Sandra Coll, Laura Gisbert-Ferrandiz, Dulce C. Macias-Ceja, Marta Seco-Cervera, Francisco Navarro, Juan Esplugues, Sara Calatayud, Dolores Ortiz-Masia, Maria D. Barrachina, Jesus Cosin-Roger
Summary: This study found that the succinate receptor SUCNR1 plays a role in both basal and stimulated inflammatory pathways in intestinal epithelial cells. It is significantly involved in inflammasome activation in Ulcerative Colitis (UC).
Article
Gastroenterology & Hepatology
Kaline Arnauts, Padhmanand Sudhakar, Sare Verstockt, Cynthia Lapierre, Selina Potche, Clara Caenepeel, Bram Verstockt, Jeroen Raes, Severine Vermeire, Joao Sabino, Catherine Verfaillie, Marc Ferrante
Summary: Microbial dysbiosis is a known phenomenon in patients with inflammatory bowel disease, but the exact mechanism behind host-microbial interactions remains unclear. This study found that the transcriptional response of epithelial cells was not different between patients with ulcerative colitis (UC) and non-IBD controls following exposure to microbiota. However, UC microbiota exposure led to a significant decrease in epithelial barrier integrity, regardless of the origin of the epithelial cells. Furthermore, UC microbiota induced stress responses in all epithelial cells, while responses to healthy volunteer (HV) microbiota were milder.
Article
Biochemistry & Molecular Biology
Zewen Mei, Xingxi Huang, Heng Zhang, Danyi Cheng, Xin Xu, Mingyue Fang, Jutuan Hu, Yangyang Liu, Yunxiang Liang, Yuxia Mei
Summary: Chitin derivatives have a therapeutic effect in ulcerative colitis mice model by relieving inflammation symptoms, protecting the colon, and increasing the abundance of gut microbiota and concentrations of short-chain fatty acids.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Medicine, General & Internal
Yafei Qin, Grace Wang, Dejun Kong, Guangming Li, Hongda Wang, Hong Qin, Hao Wang
Summary: CMV reactivation in patients with ulcerative colitis (UC) is significantly associated with disease severity, pancolitis, older age of UC onset, and the use of glucocorticoids, immunosuppressants, and azathioprine. However, infliximab treatment does not increase the risk of CMV reactivation, while 5-aminosalicylic acid is linked to a lower risk. Monitoring for these risk factors is crucial for timely diagnosis and treatment in UC patients.
Article
Gastroenterology & Hepatology
Luca Massimino, Orazio Palmieri, Amanda Facoetti, Davide Fuggetta, Salvatore Spano, Luigi Antonio Lamparelli, Silvia D'Alessio, Stefania Cagliani, Federica Furfaro, Ferdinando D'Amico, Alessandra Zilli, Gionata Fiorino, Tommaso Lorenzo Parigi, Daniele Noviello, Anna Latiano, Fabrizio Bossa, Tiziana Latiano, Alessandra Pirola, Luca Mologni, Rocco Giovanni Piazza, Danilo Abbati, Francesco Perri, Chiara Bonini, Laurent Peyrin-Biroulet, Alberto Malesci, Vipul Jairath, Silvio Danese, Federica Ungaro
Summary: This study found that the virome-associated protein encoded by the hepatitis B virus (HBx) is detected in about 45% of patients with ulcerative colitis (UC) and is associated with UC progression. Experimental findings showed that HBx induces colonic inflammation and its silencing reverses the colitis phenotype. HBx acts as a transcriptional regulator in epithelial cells, leading to barrier leakage and altering mucosal immunity. This study provides a new perspective on targeted treatments for the virome composition of the gut microbiota.
Article
Genetics & Heredity
Jean-Philippe Mergnac, Arnaud Wiedemann, Celine Chery, Jean-Marie Ravel, Fares Namour, Jean-Louis Gueant, Francois Feillet, Abderrahim Oussalah
Summary: The study retrospectively observed the diagnostic yield of CES as a first-tier genetic test in 128 pediatric patients, with an overall diagnostic yield of 55%.CES was able to accurately diagnose conditions such as hyperlipidemia (81%), osteogenesis imperfecta (75%), and metabolic disorders (64%).The results demonstrate that CES can effectively establish a molecular diagnosis in pediatric patients suspected of genetic disorders, with a median test-to-report time of 5 months.
Article
Dentistry, Oral Surgery & Medicine
Youssouf Sereme, Tabata Larissa S. Polvora, Nicolas Rochereau, Lucas Ribeiro Teixeira, Rodrigo Carvalho Santana, Stephane Paul, Benedito Antonio Lopes da Fonseca, Thomas Bourlet, Bruno Pozzetto, Alan Grupioni Lourenco, Ana Carolina F. Motta
Summary: This study found the presence of HIV-1 p24 antigen in the gingival tissue of HIV-1 and CP patients undergoing cART treatment, suggesting the existence of a reservoir for the virus in gingival tissue.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Environmental Sciences
Elise Verot, Paul Bonjean, Robin Chaux, Julie Gagnaire, Amandine Gagneux-Brunon, Bruno Pozzetto, Philippe Berthelot, Elisabeth Botelho-Nevers, Franck Chauvin
Summary: This study developed and validated a COVID-19 knowledge and behavior questionnaire for teenagers and adults in France. The questionnaire showed good psychometric properties and can be used by public health teams or caregivers for public health and research purposes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Letter
Infectious Diseases
Julie Gagnaire, Paul Bonjean, Elise Verot, Billal Boulamail, Remi Labetoulle, Sylvie Gonzalo, Delphine Hilliquin, Sylvie Pillet, Patrick Michaud, Amelie Brebion, Florence Morfin, Jerome Le Goff, Carole Pelissier, Thomas Bourlet, Franck Chauvin, Philippe Berthelot, Elisabeth Botelho-Nevers, Bruno Pozzetto
JOURNAL OF INFECTION
(2022)
Article
Public, Environmental & Occupational Health
Benoit Morel, Guillaume Bouleux, Alain Viallon, Maxime Maignan, Luc Provoost, Jean-Christophe Bernadac, Sarah Devidal, Sylvie Pillet, Aymeric Cantais, Olivier Mory
Summary: This study found that visits and bed occupancy for CRD in adult EDs significantly increased during bronchiolitis and pediatric influenza outbreaks. Therefore, prediction tools like PREDAFLU can be used to provide early warnings of increased activity in adult EDs for CRD visits.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2022)
Article
Virology
Alexandre Jentzer, Sebastien Fauteux-Daniel, Paul Verhoeven, Aymeric Cantais, Melyssa Yaugel Novoa, Fabienne Jospin, Blandine Chanut, Nicolas Rochereau, Thomas Bourlet, Xavier Roblin, Bruno Pozzetto, Sylvie Pillet
Summary: This study investigated the impact of chemically induced enteritis on cytomegalovirus reactivation using a mouse model. The results showed that chemically induced enteritis had no effect on the reactivation of cytomegalovirus in intestinal tissues.
Article
Virology
Sylvie Pillet, Julien Courtieux, Sylvie Gonzalo, Issam Bechri, Thomas Bourlet, Martine Valette, Antonin Bal, Bruno Pozzetto
Summary: This study evaluated the ability of four commercially available RLFTs in the French market to recognize different strains of SARS-CoV-2. Although all tests were able to recognize all tested variants, significant differences in sensitivity were observed among the four RLFTs.
Review
Allergy
Ramia Safar, Abderrahim Oussalah, Lina Mayorga, Stefan Vieths, Domingo Barber, Maria Jose Torres, Jean-Louis Gueant
Summary: The objective of this study was to review the evidence on DNA methylome variations in relation to food allergy. A systematic review and meta-analysis were conducted, identifying 16 relevant studies primarily focused on pediatric food allergy. These studies revealed differential DNA methylation in genes associated with Th1/Th2 imbalance, regulatory T cell function, Toll-like receptors pathway, and digestive barrier integrity. Additionally, differential methylation sites and transcription factors related to food allergy were identified. Overall, the findings provide insights into the mechanisms of food allergy pathogenesis and potential epigenome-based biomarkers for food allergy.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Article
Cell Biology
Veronique Barateau, Loic Peyrot, Carla Saade, Bruno Pozzetto, Karen Brengel-Pesce, Mad-Helenie Elsensohn, Omran Allatif, Nicolas Guibert, Christelle Compagnon, Natacha Mariano, Julie Chaix, Sophia Djebali, Jean-Baptiste Fassier, Bruno Lina, Katia Lefsihane, Maxime Espi, Olivier Thaunat, Jacqueline Marvel, Manuel Rosa-Calatrava, Andres Pizzorno, Delphine Maucort-Boulch, Laetitia Henaff, Mitra Saadatian-Elahi, Philippe Vanhems, Stephane Paul, Thierry Walzer, Sophie Trouillet-Assant, Thierry Defrance
Summary: The history of infection and vaccination modality impact the immune memory of individuals vaccinated against SARS-CoV-2. A long-term follow-up study was conducted on unvaccinated and vaccinated COVID-19 convalescent individuals, as well as infection-naive vaccinated individuals, to understand how these factors affect immune memory. The study found that convalescent vaccinated individuals had the highest concentrations of spike protein-specific antibodies and increased frequencies of a specific memory B cell subset, suggesting enhanced protection at mucosal sites.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Carla Saade, Bruno Pozzetto, Melyssa Yaugel-Novoa, Guy Oriol, Laurence Josset, Bruno Lina, Stephane Paul, Antonin Bal, Sophie Trouillet-Assant
Summary: This study examines the humoral immune response in vaccinated patients who are simultaneously infected with Delta and Omicron BA.1 variants of SARS-CoV-2. The findings indicate that exposure to both Delta and BA.1 S proteins does not provide an additional immune advantage compared to exposure to BA.1 S protein alone.
Article
Computer Science, Artificial Intelligence
Clement Pealat, Guillaume Bouleux, Vincent Cheutet, Maxime Maignan, Luc Provoost, Sylvie Pillet, Olivier Mory
Summary: During winter, respiratory viruses create immense pressure on Emergency Departments (ED) worldwide. Anticipating the influx of patients with respiratory symptoms is crucial to alleviate hospital stress. However, the lack of systematic testing, as seen in the Covid-19 pandemic, hampers real-time knowledge of the virus' presence in ED patients. To address this issue, a new framework utilizing manifold-based clustering of clinical codes associated with respiratory viruses is proposed. By embedding time series onto the Stiefel manifold and employing density-based clustering (HDBSCAN) enhanced by dimension reduction (UMAP), significant advantages of geometric approaches for time series clustering over traditional methods are demonstrated using real data from two academic hospitals in France.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Martin Fayolle, Amelie Epercieux, Cyrille H. Haddar, Sylvie Pillet, Philippe Berthelot, Bruno Pozzetto, Anne Carricajo, Florence Grattard, Paul O. Verhoeven
Summary: This study assessed the performance of the BD MAX StaphSR assay with liquid Amies elution swabs in routine care of intensive care unit patients. The results showed that the BD MAX StaphSR assay is reliable for S. aureus and MRSA detection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Virology
Bruno Pozzetto, Gilda Grard, Guillaume Durand, Marie-Claire Paty, Pierre Gallian, Sophie Lucas-Samuel, Stephanie Dieterle, Muriel Fromage, Marc Durand, Didier Lepelletier, Christian Chidiac, Bruno Hoen, Xavier Nicolas de Lamballerie
Summary: Diseases caused by arboviruses are increasing worldwide. Apart from arthropod bites, most arboviruses can be transmitted through other routes. Mainland France and its overseas territories face a complex environment with imported and endemic arboviral diseases, with risks varying by location. This review examines the risks of acquiring arboviral diseases from human products in the French context, focusing on solid organs and hematopoietic stem cells, and outlines the guidelines issued by the French High Council of Public Health.