Article
Medicine, General & Internal
Yifei Huang, Wenhui Zhang, Huiling Xiang, Yanna Liu, Lili Yuan, Liyao Zhang, Shengjuan Hu, Dongli Xia, Jia Li, Min Gao, Xing Wang, Xingsi Qi, Lijun Peng, Ying Song, Xiqiao Zhou, Jing Zeng, Xiaoyan Tan, Mingming Deng, Haiming Fang, Shenglin Qi, Song He, Yongfeng He, Bin Ye, Wei Wu, Tong Dang, Jiangbo Shao, Wei Wei, Jianping Hu, Xin Yong, Chaohui He, Jinlun Bao, Yuening Zhang, Guo Zhang, Rui Ji, Yang Bo, Wei Yan, Hongjiang Li, Yanling Wang, Mengmeng Li, Fengmei Wang, Jia Lian, Chang'en Liu, Ping Cao, Zhenbei Liu, Aimin Liu, Lili Zhao, Shuang Li, Yunhai Wu, Ye Gu, Yan Wang, Yanfei Fang, Pan Jiang, Bin Wu, Chuan Liu, Xiaolong Qi
Summary: This study compared the outcomes of emergency endoscopic injection sclerotherapy (EIS) and endoscopic variceal ligation (EVL) in cirrhotic patients with acute esophageal variceal bleeding (EVB). The results showed that both EIS and EVL were efficient strategies for the treatment of acute EVB, with EIS being a cost-effective option.
FRONTIERS IN MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Lolwa N. Al-Obaid, Ahmad Najdat Bazarbashi, Marvin Ryou
Summary: This article highlights alternative therapies for gastric and esophageal variceal bleeding and their potential role in management.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Review
Surgery
Juan Su, Huilin Zhang, Maifang Ren, Yanan Xing, Yuefei Yin, Lihua Liu
Summary: The meta-analysis showed that endoscopic variceal ligation (EVL) was safer than the combination of EVL and endoscopic injection sclerotherapy (EIS), but no significant difference was found in terms of efficacy. Future studies should focus on larger sample sizes, multiple centers, and randomized controlled trials to further assess the effects of these clinical interventions.
FRONTIERS IN SURGERY
(2021)
Article
Gastroenterology & Hepatology
Kunyi Liu, Rui Zhang, Chengyi Shi, Botao Wu, Siqi Liu, Hui Tian, Hongwei Du, Yan Li, Na Wang
Summary: The study aimed to identify the risk factors for emergency endoscopic variceal ligation (EVL) failure in acute variceal bleeding (AVB) patients. The presence of Child-Pugh class C, active bleeding on endoscopy, and portal vein thrombosis (PVT) were found to increase the risk of emergency EVL failure.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Jung Hee Kim, Se Woo Park, Jang Han Jung, Da Hae Park, Chang Seok Bang, Chan Hyuk Park, Ji Won Park, Jae Gun Park
Summary: A new risk-scoring model was developed to predict 6-week mortality in cirrhotic patients undergoing endoscopic band ligation for acute variceal bleeding. The model demonstrated superior predictive accuracy and discriminative performance compared to existing scoring systems, aiding in the individualized treatment strategies for high-risk cirrhotic patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Education, Scientific Disciplines
Jen-Hao Yeh, Gin-Ho Lo, Ru-Yi Huang, Chih-Wen Lin, Wen-Lun Wang, Daw-Shyong Perng
Summary: Endoscopic variceal ligation with short-course vasoconstrictors is highly effective for acute esophageal variceal bleeding, showing similar outcomes to standard therapy, but further studies are needed to determine the necessity of subsequent vasoconstrictor use.
Article
Gastroenterology & Hepatology
Andreas Drolz, Christoph Schramm, Oliver Seiz, Stefan Groth, Eik Vettorazzi, Thomas Horvatits, Malte H. Wehmeyer, Christoph Schramm, Tobias Goeser, Thomas Roesch, Ansgar W. Lohse, Johannes Kluwe
Summary: Prophylactic endoscopic variceal band ligation (EVL) in cirrhosis patients is generally safe, with factors such as bilirubin levels and varices size being associated with early upper gastrointestinal bleeding (UGIB) after the procedure. This study did not find a significant relationship between coagulation indices and post-EVL UGIB, suggesting that routine substitution of blood or coagulation products may not be necessary.
Article
Medicine, General & Internal
Manas Vaishnav, Sagnik Biswas, Abhinav Anand, Piyush Pathak, Shekhar Swaroop, Arnav Aggarwal, Umang Arora, Anshuman Elhence, Shivanand Gamanagatti, Amit Goel, Ramesh Kumar, Shalimar
Summary: This study aims to evaluate the role of hepatic venous pressure gradient (HVPG) in predicting further decompensation in cirrhosis patients with acute variceal bleeding (AVB). The study found that 27.6% of patients developed further decompensation within 42 days after the bleeding episode, with gastrointestinal bleeding and new-onset/worsening ascites being the most common events. HVPG was found to be an independent predictor of further decompensation in patients with esophageal variceal bleeding.
Article
Medicine, General & Internal
Aalam Sohal, Hunza Chaudhry, Armaan Dhaliwal, Piyush Singla, Gagan Gupta, Raghav Sharma, Dino Dukovic, Devang Prajapati
Summary: Gender differences have an impact on outcomes in hospitalizations related to esophageal variceal bleeding. Women hospitalized with esophageal variceal bleeding have a lower risk of death and are less likely to receive TIPS treatment.
ANNALS OF MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Saleh A. Alqahtani, Sunguk Jang
Summary: Cirrhosis is the fifth leading cause of death in adults, with variceal bleeding posing a significant risk in patients with advanced cirrhosis. Management involves primary prophylaxis, active bleeding intervention, and secondary prophylaxis, all aimed at preventing variceal bleeding. Emergency swift intervention is required for active variceal bleeding to achieve durable hemostasis.
Article
Pediatrics
Jean P. Molleston, William E. Bennett
Summary: The 6-week mortality rate for esophageal variceal bleeding in children is 8.8%. Black or Hispanic children are at higher risk of mortality. Serious complications associated with variceal hemorrhage contribute to increased mortality rates.
JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, General & Internal
Carla Luiza de Souza Aluizio, Ciro Garcia Montes, Glaucia Fernanda Soares Ruppert Reis, Cristiane Kibune Nagasako
Summary: This study aimed to compare different scoring systems for risk stratification in patients with acute variceal bleeding. The study found that Rockall, Blatchford, and AIMS65 scores were not useful for predicting 6-week rebleeding or mortality, while Child and MELD scores showed acceptable performance in predicting 6-week mortality but not rebleeding.
Article
Gastroenterology & Hepatology
Jianbo Wang, Shenghui Chen, Yehia M. Naga, Junwei Liu, Mugen Dai, Shangwen Yang, Liangjing Wang, Bin Ye
Summary: Combining EVL with EIS in the treatment of esophageal varices resulted in significantly lower rebleeding rates and recurrence at six months, as well as reduced chest pain, making it more cost-effective compared to EVL alone.
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
News Item
Gastroenterology & Hepatology
Benjamin Meier, Andreas Wannhoff, Ulrike Denzer, Petros Stathopoulos, Brigitte Schumacher, David Albers, Albrecht Hoffmeister, Juergen Feisthammel, Benjamin Walter, Alexander Meining, Edris Wedi, Markus Zachaeus, Tilman Pickartz, Armin Kuellmer, Arthur Schmidt, Karel Caca
Summary: This study compared the efficacy of first-line over-the-scope-clips (OTSC) therapy with standard endoscopic treatment in patients with acute non-variceal upper gastrointestinal bleeding (NVUGIB). The results showed that OTSC therapy had a higher clinical success rate and a lower rate of persistent bleeding compared to standard treatment.
Article
Medicine, General & Internal
Iulia Ratiu, Raluca Lupusoru, Alina Popescu, Ioan Sporea, Adrian Goldis, Mirela Danila, Bogdan Miutescu, Tudor Moga, Andreea Barbulescu, Roxana Sirli
Summary: This observational retrospective study aimed to investigate the differences and associated factors between variceal and nonvariceal upper gastrointestinal bleeding (UGIB). The results showed that there was a higher rebleeding rate in patients with variceal bleeding.
Review
Gastroenterology & Hepatology
John A. Damianos, Sanjeevani K. Tomar, Fernando Azpiroz, Elizabeth Barba
Summary: Chronic bloating and abdominal distension are common and bothersome gastrointestinal symptoms often associated with gut-brain interaction disorders. Functional abdominal bloating may be due to visceral hypersensitivity, while abdominal distension appears to be a response to abdominophrenic dyssynergia. This article reviews the literature on abdominophrenic dyssynergia and discusses its epidemiology, diagnosis, treatment, and future research directions.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Juan M. Pericas, Frank Tacke, Quentin M. Anstee, Nicholas A. Di Prospero, Mette Skalshoj Kjaer, Peter Mesenbrink, Franz Koenig, Joan Genesca, Vlad Ratziu, EU-PEARL NASH Invest
Summary: Non-alcoholic fatty liver disease affects 25% of the population and non-alcoholic steatohepatitis (NASH) is a progressive form of the disease with severe complications. The traditional clinical trials in NASH pose challenges for drug development, and platform trials, utilizing a master protocol and adaptive randomization, offer an alternative approach to evaluate multiple investigational medicinal products concurrently or sequentially.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Elizabeth Barba, Dan M. Livovsky, Lucia Relea, Luis G. Alcala-Gonzalez, Sergio Quiroga, Anna Accarino, Fernando Azpiroz
Summary: The reliability of plain abdominal radiographs for evaluating abdominal gas content in patients with functional digestive symptoms is limited, as the gas volumes estimated in these radiographs differ significantly from those measured by CT.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Luis G. Alcala-Gonzalez, Carolina Malagelada, Hugo Monrroy, Marianela Mego, Anna Accarino, Juan-Ramon Malagelada, Fernando Azpiroz
Summary: The aim of this study was to determine the diagnostic outcome of patients with minute rhythm (MRP) and prolonged simultaneous contractions (PSC) detected by intestinal manometry. The results showed that partial mechanical obstruction of the distal intestine and systemic disorders causing intestinal neuropathy were detected in some patients, but a substantial proportion of patients had no underlying disease identified. Colonic fecal retention might play a role in these patients.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Elizabeth Barba, Emanuel Burri, Sergio Quiroga, Anna Accarino, Fernando Azpiroz
Summary: This study found that in most patients with visible abdominal distension, their subjective claims were supported by objective evidence, and an increase in intestinal gas volume did not explain the visible abdominal distension. Abdominophrenic dyssynergia was consistently evidenced by dynamic EMG recording, but static CT imaging was less sensitive.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Ian Rowe, Candid E. Villanueva, Jessica Shearer, Ferran Torres, Agustin Albillos, Joan C. Genesca, Joan Garcia-Pagan, Dhiraj C. Tripathi, Peter Hayes, Jaume G. Bosch, Juan Abraldes
Summary: This study conducted a Bayesian reanalysis of PREDESCI and found that beta-blocker treatment is highly likely to prevent decompensation and provides a substantial gain in decompensation-free life years at the population level.
Article
Nutrition & Dietetics
Adoracion Nieto, Dan M. Livovsky, Fernando Azpiroz
Summary: This study aimed to investigate the effect of aversive conditioning on the postprandial reward of a comfort meal. The findings showed that the aversive conditioning significantly reduced the postprandial reward of the comfort meal. This suggests that aversive conditioning can impair the enjoyment of a comfort meal in healthy women.
Article
Medicine, General & Internal
Bernat Orellana, Eva Monclus, Isabel Navazo, Alvaro Bendezu, Carolina Malagelada, Fernando Azpiroz
Summary: This study presents an automated method based on magnetic resonance imaging that accurately segments the colon and extracts colonic content and morphology data, providing valuable insights into the effects of diets and abdominal distension mechanisms.
Article
Gastroenterology & Hepatology
Luis G. Alcala-Gonzalez, Anna Accarino, Ramon Marti, Daniel Sanchez-Tejerina, Arnau Llaurado, Fernando Azpiroz, Carolina Malagelada
Summary: This study aims to describe gastrointestinal motor dysfunction in MNGIE patients using advanced techniques and evaluate the relationship between motor abnormalities and symptoms. The results show that MNGIE patients have characteristic motor dysfunction in the small bowel, even in the presence of mild digestive symptoms. Early investigation is necessary.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Letter
Gastroenterology & Hepatology
Jesus Rivera-Esteban, Aurora Barbera, Maria Teresa Salcedo, Maria Martell, Joan Genesca, Juan M. Pericas
Article
Surgery
Piero Alberti, Elizabeth Pando, Monder Abu-Suboh, Miquel Masachs, Xavier Merino, Maite Salcedo, Teresa Macarulla, Joaquin Balsells, Ramon Charco
Summary: This study demonstrates the potential application of EUS-EG in preoperatively exploring the integrity of Inoue's level III in patients with borderline resectable or locally advanced pancreatic adenocarcinoma, providing valuable information for the feasibility of periarterial divestment technique.
LANGENBECKS ARCHIVES OF SURGERY
(2023)