期刊
AMERICAN JOURNAL OF GASTROENTEROLOGY
卷 106, 期 2, 页码 337-339出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1038/ajg.2010.440
关键词
-
资金
- Italian Ministry of Education, University and Research [2002052573, 2007Z292XF]
- University of Bologna
Evidence suggests that mucosal and luminal factors, including low-grade immune activation, increased mucosal permeability and altered host-microbiota interactions, contribute to IBS pathophysiology. In this issue of the American Journal of Gastroenterology, Brint and colleagues provide the first evidence of increased expression of toll-like receptors (TLRs) in patients with IBS. TLRs are known to be involved in the translation of bacterial signals into anti-bacterial innate immune responses. These results hold promise for a better understanding of the role of microbiota and immune activation in the pathophysiology of IBS and also provide novel pharmacological targets for this common troublesome disorder.
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