Article
Biochemistry & Molecular Biology
Huawei Zeng, Bryan D. Safratowich, Wen-Hsing Cheng, Andrew D. Magnuson, Matthew J. Picklo
Summary: High-fat diet-induced obesity is a risk factor for colon cancer. A study found that mice fed a high-fat diet exhibited different fecal metabolomic profiles after AOM treatment. Accumulation of specific fecal lipid species may alter the overall metabolism during colon tumorigenesis.
Article
Food Science & Technology
Yuko Murase Hetrick, Meseret Fesseha, Mee Young Hong
Summary: This study showed that watermelon powder and L-arginine supplementation can reduce the risk of colorectal cancer by upregulating gene expression of cell cycle regulators, leading to decreased proliferation and inhibition of aberrant crypt foci formation in all anatomical regions of the colon.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Nutrition & Dietetics
Luane Aparecida do Amaral, Taina da Silva Fleming de Almeida, Gabriel Henrique Oliveira de Souza, Adrivanio Baranoski, Rafael Souza Maris, Felipe Francisco Bittencourt Junior, Bruna Paola Murino Rafacho, Antonio Carlos Duenhas Monreal, Candida Aparecida Leite Kassuya, Andreia Conceicao Milan Brochado Antoniolli-Silva, Elisvania Freitas dos Santos, Rodrigo Juliano Oliveira
Summary: The study aimed to formulate a natural fiber-rich food product (NFRFP) for colorectal cancer prevention and evaluate its safety and effects in a preclinical model. Results showed that NFRFP exhibited a chemopreventive effect and reduced the incidence of aberrant crypts in the colon.
Article
Medicine, General & Internal
Marek Kowalczyk, Lukasz Klepacki, Ewa Zielinski, Waldemar Kurpiewski, Krzysztof Zinkiewicz, Lukasz Dysko, Wieslaw Pesta
Summary: Smoking has a significant influence on the occurrence of precursors and advanced colorectal cancer. Smokers have a greater number of ACFs in the rectum, with the most common type being hyperplastic ACF. As age increases, the likelihood of developing ACFs and colon polyps is higher in smokers than non-smokers.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Food Science & Technology
Weerachai Chantana, Rentong Hu, Songphon Buddhasiri, Parameth Thiennimitr, Payungsak Tantipaiboonwong, Teera Chewonarin
Summary: This study investigated the chemoprotective action of perilla frutescens (PF) seed residue crude ethanolic extract (PCE) on the promotion stage of colon carcinogenesis and cell culture models. The results showed that PCE reduced the number of aberrant crypt foci (ACF) and decreased pro-inflammatory cytokines. PCE could also modulate inflammation in macrophage cells and suppress cancer cell proliferation induced by inflammation.
Article
Food Science & Technology
Mariana Araujo Vieira do Carmo, Marina Fidelis, Pollyanna Francielli de Oliveira, Lais Quellen Feitoza, Marcos Jose Marques, Eric Batista Ferreira, Won Young Oh, Fereidoon Shahidi, Jarkko Hellstrom, Leonardo Augusto Almeida, Romulo Dias Novaes, Daniel Granato, Luciana Azevedo
Summary: The study demonstrated that Jabuticaba seed extract (LJE) may provide chemopreventive protection against colon cancer development by reducing inflammation and increasing proapoptotic pathways.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Pathology
Sara Gomes Espirito Santo, Tereza Cristina Da Silva, Bruno Cogliati, Luis Fernando Barbisan, Guilherme Ribeiro Romualdo
Summary: Colorectal cancer is a leading cause of cancer-related deaths globally and is characterized by preneoplastic aberrant crypt foci (ACF) as an early manifestation. The role of Panx1 protein, which forms hemichannels, in colon carcinogenesis has not been explored. This study found that Panx1 knockout increased genotoxicity, oxidative stress, and apoptosis in the colon. Moreover, Panx1 knockout led to an increase in ACF development. Overall, these findings suggest a protective role of Panx1 in preventing the development of preneoplastic ACF during chemically induced colon carcinogenesis.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2023)
Article
Medicine, General & Internal
Marek Kowalczyk, Dawid Sigorski, Lukasz Dysko, Ewa Zielinski, Dana Zupanovich Lucka, Lukasz Klepacki
Summary: The study aimed to evaluate the chemopreventive effect of low dose ASA on ACF and adenoma development. The results showed that patients who took low dose ASA for a long period of time had fewer ACFs and adenomas.
MEDICINA-LITHUANIA
(2022)
Article
Multidisciplinary Sciences
Jeonghee Han, Jong Ho Kim, Jin-Won Lee, Sang Hyup Han, Haesung Kim
Summary: This study found that the use of metformin before preoperative CCRT is significantly associated with good tumor response in rectal cancer.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Gregor S. Zimmermann, Tobias Ruether, Franz von Ziegler, Martin Greif, Janine Tittus, Jan Schenzle, Christoph Becker, Alexander Becker
Summary: Smokers have significantly higher pericardial adipose tissue (PAT) volume compared to non-smokers, independent from metabolic risk factors, which may indicate increased inflammatory activity in smokers compared to non-smokers.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Engineering, Chemical
Nileema R. R. Divate, Katharina Ardanareswari, Yu-Ping Yu, Ya-Chen Chen, Jiunn-Wang Liao, Yun-Chin Chung
Summary: This study evaluated the efficacy of tempeh on colorectal cancer cells in vitro and colon precancerous lesions in vivo. The results showed that tempeh water extract could inhibit the proliferation of Caco-2 cells and decrease the level of Clostridium perfringens in rats. The bioactive peptides in tempeh might inhibit colon cancer by suppressing the growth of C. perfringens in the intestinal tract.
Article
Chemistry, Multidisciplinary
Zheng Zhou, Keying Li, Yun Guo, Peixin Liu, Qinjun Chen, Hongrui Fan, Tao Sun, Chen Jiang
Summary: Medicinal treatment of epilepsy faces challenges due to the inability of clinical antiepileptic drugs (AEDs) to block epileptogenesis. Abnormal neuronal circuits interact with the inflammatory microenvironment in epileptic foci, resulting in recurrent seizures and refractory epilepsy. In this study, we developed a nanogel that can target epileptic foci, release the model drug phenytoin (PHT) in response to high levels of reactive oxygen species (ROS), and inhibit overexcited circuits. This nanogel can also reduce oxidative stress and alleviate microenvironment inflammation, offering a comprehensive strategy for antiepileptic treatment.
Article
Obstetrics & Gynecology
Ting Zhai, Brenda Diergaarde, David O. Wilson, Huining Kang, Akshay Sood, Samuel H. Bayliss, Jian-Min Yuan, Maria A. Picchi, Qing Lan, Steven A. Belinsky, Jill M. Siegfried, Linda S. Cook, Shuguang Leng
Summary: This study examines the associations between early menopause and lung health, lung cancer risk, and mortality in middle-aged and older female smokers. The results show that early natural menopause is a risk factor for lung diseases and mortality in this population.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Neurosciences
Caitlin Dale, Delshad Kalantary, Eileen Luders, Florian Kurth
Summary: This study found that ex-smokers have weaker interhemispheric connectivity compared to non-smokers, specifically between frontal and temporal areas.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2022)
Article
Oncology
Andre Luis Nunes Avelino, Nina Victoria Ribeiro e Silva, Gilson Brito De Oliveira, Antonio Adailson De Sousa Silva, Bruno Coelho Cavalcanti, Francisco Vagnaldo Fechine Jamacaru, Conceicao Aparecida Dornelas
Summary: Gum arabic shows potential in inhibiting colorectal carcinogenesis by reducing the formation of aberrant crypts and decreasing genotoxicity and oxidative stress in the colon, liver, and systemic levels. These results suggest a promising role for gum arabic as an antioxidant in the development of treatments for colorectal cancer.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)