Review
Immunology
Carin Andren Aronsson, Daniel Agardh
Summary: A higher intake of gluten during childhood is associated with increased risk of celiac disease. Gastrointestinal infections may increase gut permeability and exposure to gluten, leading to the development of celiac disease. Different gluten interventions have been proposed, but further randomized clinical trials are needed to determine their effectiveness.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Saori Miyagishima, Hiroki Mani, Yui Sato, Takahiro Inoue, Tadayoshi Asaka, Naoki Kozuka
Summary: This study investigated the developmental changes and controlling mechanisms of straight gait using two indices. The results showed that straight gait improved with age and was influenced by step velocity, step width, and the coefficient of variation. These findings have important implications for physical therapy methods targeting gait disorders in children.
Review
Biochemistry & Molecular Biology
Marco Valvano, Stefano Fabiani, Sabrina Monaco, Mauro Calabro, Antonio Mancusi, Sara Frassino, Claudia Rolandi, Marta Mosca, Susanna Faenza, Emanuele Sgamma, Nicola Cesaro, Giovanni Latella
Summary: Celiac disease is a chronic enteropathy caused by gluten ingestion in genetically susceptible individuals. The only recommended treatment is a gluten-free diet, but unintentional gluten ingestion or refractory celiac disease with persistent villous atrophy poses a major challenge. This review analyzed data from randomized controlled trials and observational studies to evaluate adjunctive and novel therapies for CD and RCD. Although a gluten-free diet remains the only effective treatment, steroids, mesalamine, and biological therapies have shown promise in managing RCD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Fardowsa Abdi, Saania Zuberi, Jedid-Jah Blom, David Armstrong, Maria Ines Pinto-Sanchez
Summary: A gluten-free diet is essential for treating celiac disease and may improve symptoms in non-celiac gluten/wheat sensitivity. However, adopting a gluten-free diet or a gluten-restricted diet may increase the risk of malnutrition and nutrient deficiencies. Therefore, patients with these conditions should undergo nutritional assessment and monitoring, and receive multidisciplinary care for long-term nutrition management.
Article
Pediatrics
Pornthep Tanpowpong, Sijia Li, Janice A. Espinola, Ludmilla Candido Santos, Kaitlyn E. James, Camille E. Powe, Carlos A. Camargo Jr
Summary: The study aimed to investigate the relationship between pregnancy and birth-related factors and the risk of celiac disease (CD) in a large US mother-child cohort. The results showed that being born by Caesarean delivery without labor was associated with a higher risk of CD, while infants born by Caesarean delivery with labor did not show a significant association.
Article
Medicine, General & Internal
Rakel Nurmi, Camilla Pasternack, Teea Salmi, Kaisa Hervonen, Inka Koskinen, Jutta Jarvelin, Heini Huhtala, Pekka Collin, Jukka Mustonen, Katri Kaukinen, Satu Makela
Summary: Patients with celiac disease have an increased risk of kidney diseases, particularly IgA nephropathy. This risk is phenotype-dependent and is not observed in patients with dermatitis herpetiformis.
JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Serena Scapaticci, Annamaria Venanzi, Francesco Chiarelli, Cosimo Giannini
Summary: Celiac disease is an immune-mediated disorder caused by the ingestion of gluten. It can present as asymptomatic or with multiple systemic symptoms. The rising obesity rates have led to an increased possibility of diagnosing celiac disease in obese patients, who may also have obesity-related disorders such as metabolic associated fatty liver disease (MAFLD). The exact mechanisms linking celiac disease and obesity-related disorders are not yet known, but a gluten-free diet and alterations in the gut-liver axis may play a role.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Agnieszka Koziol-Kozakowska, Dominika Salamon, Zofia Grzenda-Adamek, Agnieszka Krawczyk, Mariusz Duplaga, Tomasz Gosiewski, Kinga Kowalska-Duplaga
Summary: The study showed that a proper gluten-free diet for children with celiac disease can lead to increased weight and height, while not significantly changing the overall nutritional status. The diet of these children before diagnosis was similar to that of the general Polish population, lacking in various nutrients such as energy, fiber, calcium, iodine, iron, folic acid, vitamins D, K, and E.
Article
Veterinary Sciences
Magdalena Wozna-Wysocka, Marta Rybska, Beata Blaszak, Bartlomiej M. Jaskowski, Magdalena Kulus, Jedrzej M. Jaskowski
Summary: The study aimed to determine morphological variables in uterine diseases in bitches and create a new classification system for uterine pathological changes in the development of CEH-P. The results indicated the necessity of microscopic examinations in analyzing uterine diseases in bitches and the frequent lack of consistency between macroscopic assessment and histological analysis.
BMC VETERINARY RESEARCH
(2021)
Article
Psychology, Developmental
Aysegul Efe, Aysegul Tok
Summary: This study investigated the association between ADHD-related cognitive and behavioral traits and certain vitamin levels, body-mass index, and gluten-free diet compliance in children with biopsy-proven celiac disease (CD). The results showed that ADHD-like cognitive issues and psychosomatic symptoms were associated with noncompliance to a gluten-free diet in children with CD.
JOURNAL OF ATTENTION DISORDERS
(2023)
Article
Meteorology & Atmospheric Sciences
Kevin Schwarzwald, Andrew Poppick, Maria Rugenstein, Jonah Bloch-Johnson, Jiali Wang, David McInerney, Elisabeth J. Moyer
Summary: Changes in precipitation variability may increase more steeply than its mean in future climate projections, leading to concerns about societal impacts. At local scales, changes in precipitation distributions are complex, while at aggregated scales they become simpler. Precipitation variability changes are especially concerning in subtropical regions.
JOURNAL OF CLIMATE
(2021)
Article
Pediatrics
Shruti Sakhuja, Lori R. Holtz
Summary: A subset of patients initially with negative biopsy for celiac disease later develop histopathologic celiac disease, with slower progression in some cases. Regular reassessment is recommended for children with serological signs of celiac disease despite normal small bowel biopsy results.
Article
Gastroenterology & Hepatology
German Tapia, Katerina Chuda, Christian R. Kahrs, Lars C. Stene, Lenka Kramna, Karl Marild, Trond Rasmussen, Kjersti S. Ronningen, Ondrej Cinek, Ketil Stordal
Summary: Parechovirus infections in early life are associated with the development of CD in genetically at-risk children, while anellovirus does not show significant differences. The results support the hypothesis.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Thomas A. Auchtung, Christopher J. Stewart, Daniel P. Smith, Eric W. Triplett, Daniel Agardh, William A. Hagopian, Anette G. Ziegler, Marian J. Rewers, Jin-Xiong She, Jorma Toppari, Ake Lernmark, Beena Akolkar, Jeffrey P. Krischer, Kendra Vehik, Jennifer M. Auchtung, Nadim J. Ajami, Joseph F. Petrosino
Summary: By analyzing stool samples of infants and young children, the authors found that there are changes in fungal composition and abundance at weaning, but overall fungal diversity remains relatively constant over time. Fungal composition is influenced by geography, diet, and the use of probiotics. The study also showed subtle fungal differences between children who developed autoimmune diseases and those who did not.
NATURE COMMUNICATIONS
(2022)
Review
Nutrition & Dietetics
Valentina Talarico, Laura Giancotti, Giuseppe Antonio Mazza, Roberto Miniero, Marco Bertini
Summary: Iron absorption primarily takes place in the proximal duodenum, which is typically damaged in CD, leading to decreased iron absorption and IDA. The most common extra-intestinal manifestation of CD is IDA, which can be managed effectively with GFD.