Article
Hematology
Sanne Bakker, Johanna Louise I. Burggraaf, Marieke J. H. A. Kruip, Felix J. M. van der Meer, Willem M. Lijfering, Nienke van Rein
Summary: Selective serotonin reuptake inhibitors (SSRIs) may increase the risk of major bleeding, particularly for CYP2C9-inhibiting SSRIs, by affecting platelet function and VKA metabolism. The use of SSRIs is associated with an increased risk of a high INR, indicating potential bleeding complications.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Elli Anna Kotsailidi, Catherine Gagnon, Lucy Johnson, Abdul Barmak Basir, Alexandra Tsigarida
Summary: This retrospective study evaluated the association between the use of selective serotonin reuptake inhibitors (SSRIs) and changes in peri-implant marginal bone levels. The results showed a significant correlation between SSRI use and marginal bone loss around dental implants.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Pharmacology & Pharmacy
Soon H. Yang, Charles F. Seifert
Summary: The use of serotonergic antidepressants (SADs) during the perioperative period is associated with an increased risk of bleeding in patients undergoing orthopedic surgery. Patients on SADs had a higher percentage of requiring transfusion and a longer hospital stay compared to those not on SADs.
ANNALS OF PHARMACOTHERAPY
(2023)
Article
Medicine, General & Internal
Jakob Christensen, Betina B. Trabjerg, Yuelian Sun, Julie Werenberg Dreier
Summary: This study examined the association between maternal antidepressant prescription during pregnancy and standardized test scores among Danish schoolchildren. Results showed that children born to mothers filling antidepressant prescriptions during pregnancy had significantly lower math test scores but no significant difference in language test scores compared to children whose mothers did not fill antidepressant prescriptions. The difference in math scores was small and of uncertain clinical importance, suggesting the need to balance the findings against the benefits of treating maternal depression during pregnancy.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Oncology
Naiqi Zhang, Jan Sundquist, Kristina Sundquist, Jianguang Ji
Summary: This population-based cohort study suggests that the use of SSRIs is associated with a reduced risk of CRC among individuals with a family history of CRC. The decreased risk of CRC showed a non-linear, dose-dependent pattern. Furthermore, the use of SSRIs was strongly associated with advanced-stage CRC rather than early-stage CRC.
Review
Chemistry, Analytical
Ilona Oledzka, Alina Plenis, Piotr Kowalski, Tomasz Baczek, Anna Roszkowska
Summary: The pharmacotherapy of depression relies on different types of antidepressants, with SSRIs being the most commonly used first-line treatment. There is a growing demand for fast and accurate methods to monitor SSRI levels during depression therapy. Recent efforts have focused on developing instrumental methods that enable lower detection limits, better quantitation, and separation of multiple analytes, resulting in more reliable and selective determination of SSRIs. However, the preparation of biological samples for analysis remains a bottleneck in most analytical procedures. This review discusses recent advancements in methods for preparing various conventional and non-conventional complex biological matrices for precise determination of SSRI levels, as well as the advantages, challenges, and potential applications of these developed methodologies in clinical studies.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Syed Mobashshir Alam, Mohammed Qasswal, Muhammad Junaid Ahsan, Ryan W. Walters, Subhash Chandra
Summary: This study aimed to investigate whether the addition of selective serotonin reuptake inhibitors (SSRIs) significantly increases the risk of upper gastrointestinal (GI) bleeding in patients already taking nonsteroidal anti-inflammatory drugs (NSAIDs). The results showed that the concomitant use of SSRIs and NSAIDs in patients already on NSAID therapy significantly increases the risk of upper GI bleeding.
SCIENTIFIC REPORTS
(2022)
Review
Anesthesiology
Li Wang, Joshua Tobe, Emily Au, Cody Tran, Jane Jomy, Yvgeniy Oparin, Rachel J. Couban, James Paul
Summary: The systematic review and meta-analysis found that SSRIs and SNRIs as adjuncts for postoperative pain management significantly reduced postoperative pain, opioid consumption, and improved patient satisfaction without increasing adverse events compared with placebo. SSRIs tend to be less effective than SNRIs, but the effects of SSRIs remain inconclusive due to limited evidence.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Clinical Neurology
Shuzhe Zhou, Qinhong Ma, Yiwei Lou, Xiaozhen Lv, Hongjun Tian, Jing Wei, Kerang Zhang, Gang Zhu, Qiaoling Chen, Tianmei Si, Gang Wang, Xueyi Wang, Nan Zhang, Yu Huang, Qi Liu, Xin Yu
Summary: This study utilized machine learning models to explore baseline variables for predicting the 8-week treatment outcome of patients with MDD receiving SSRIs. Results showed that neurocognitive functions and anxiety symptoms were important predictors, with SVM achieving an accuracy of 74.49% and sensitivity and specificity of 0.899 and 0.422, respectively.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Public, Environmental & Occupational Health
Avital Fischer, Hedy S. Rennert, Gad Rennert
Summary: The study found that the use of SSRIs before and after breast cancer diagnosis is associated with increased mortality in breast cancer patients. Research is needed to further understand the mechanisms behind this association.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Medicine, General & Internal
Surapon Nochaiwong, Chidchanok Ruengorn, Ratanaporn Awiphan, Chatree Chai-Adisaksopha, Apichat Tantraworasin, Chabaphai Phosuya, Penkarn Kanjanarat, Wilaiwan Chongruksut, Manish M. Sood, Kednapa Thavorn
Summary: This systematic review and meta-analysis found that the use of serotonin reuptake inhibitor (SRI) antidepressants in patients receiving antithrombotic therapy is associated with a higher risk of bleeding complications, including major bleeding, gastrointestinal bleeding, and any bleeding events. The risk is elevated among individuals receiving anticoagulants or antiplatelet therapy. Caution should be exercised in co-prescribing SRIs with antithrombotic therapy due to safety concerns regarding bleeding risks.
ANNALS OF MEDICINE
(2022)
Article
Psychiatry
Fredrik Hieronymus, Alexander Lisinski, Elias Eriksson, Soren Dinesen Ostergaard
Summary: This study analyzed patient-level data to assess the relationship between antidepressant side effects and HDRS-17 ratings, finding that some HDRS-17 items are associated with common antidepressant side effects, potentially leading to an underestimation of antidepressant efficacy.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Kinsley Tate, Brenna Kirk, Alisia Tseng, Abigail Ulffers, Karen Litwa
Summary: The developing prenatal brain is sensitive to environmental disturbances, with factors like pharmaceuticals potentially affecting synapse formation and increasing the risk of neurodevelopmental abnormalities. However, there is still a lack of research on how specific environmental factors impact the developing neural circuitry of the human brain. Recent studies show that the selective serotonin reuptake inhibitor fluoxetine can acutely alter synaptic function in developing neural circuits, but the effects are not long-lasting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Julie A. Vignato, S. Banu Gumusoglu, Heather A. Davis, Sabrina M. Scroggins, Wendy S. Hamilton, Debra S. Brandt, Gary L. Pierce, Boyd A. Knosp, Donna A. Santillan, Mark K. Santillan
Summary: Depression and preeclampsia are bi-directionally associated with each other, and SSRIs may attenuate the risk of preeclampsia. This study found that SSRIs use was associated with decreased risk of preeclampsia and reduced copeptin levels in early pregnancy, suggesting a potential therapeutic effect.
REPRODUCTIVE SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Michal Wicinski, Bartlomiej J. Kaluzny, Slawomir Liberski, Daria Marczak, Jakub J. Kaluzny
Summary: Acute angle closure (AAC) is a rare but serious ophthalmological condition, often associated with the use of selective serotonin reuptake inhibitors (SSRIs). AAC in individuals receiving SSRIs is mainly caused by pupillary block mechanism, but may also result from other mechanisms such as uveal effusion.
APPLIED SCIENCES-BASEL
(2021)
Article
Gastroenterology & Hepatology
James K. Stone, Leigh Anne Shafer, Lesley A. Graff, Lisa Lix, Kelcie Witges, Laura E. Targownik, Clove Haviva, Kathryn Sexton, Charles N. Bernstein
Summary: The Medication Adherence Report Scale-5 (MARS-5) is a useful tool for assessing medication adherence in patients with inflammatory bowel disease (IBD). The study found that disease type (CD) was the only significant predictor of medication adherence in this highly adherent sample.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Casandra Dolovich, Charles N. Bernstein, Harminder Singh, Zoann Nugent, Aruni Tennakoon, Leigh Ann Shafer, Ruth Ann Marrie, Jitender Sareen, Laura E. Targownik
Summary: Patients with IBD and pre-existing AMDs within 2 years before starting anti-TNF therapy are at increased risk of discontinuing therapy, but there is no significant association between AMDs and subsequent risk of IBD-related adverse events.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Psychiatry
Jitender Sareen, Shay-Lee Bolton, Natalie Mota, Tracie O. Afifi, Murray W. Enns, Tamara Taillieu, Ashley Stewart-Tufescu, Renee El-Gabalawy, Ruth Ann Marrie, J. Don Richardson, Murray B. Stein, Charles N. Bernstein, James M. Bolton, Jianli Wang, Gordon J. G. Asmundson, James M. Thompson, Linda VanTil, Mary Beth MacLean, Sarvesh Logsetty
Summary: Findings from this study indicate a high burden of mental disorders, particularly mood and anxiety disorders, among Canadian military members and veterans, with increasing comorbidity between mental disorders observed over the follow-up period.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2021)
Article
Critical Care Medicine
Kendiss Olafson, Ruth Ann Marrie, James M. Bolton, Charles N. Bernstein, O. Joseph Bienvenu, Maia S. Kredentser, Sarvesh Logsetty, Dan Chateau, Yao Nie, Marcus Blouw, Tracie O. Afifi, Murray B. Stein, William D. Leslie, Laurence Y. Katz, Natalie Mota, Renee El-Gabalawy, Murray W. Enns, Christine Leong, Sophia Sweatman, Jitender Sareen
Summary: The study aims to understand the relationship between critical illness and mental disorders by comparing the treated prevalence of mental disorders and psychotropic medication use before and after ICU admission. The results show that while ICU patients had lower prevalence of mental disorders before hospitalization compared to non-ICU patients, the prevalence significantly increased post-discharge. ICU exposure was associated with an increase in mood, anxiety, and psychotic disorders, as well as sedative-hypnotic use.
INTENSIVE CARE MEDICINE
(2021)
Article
Nutrition & Dietetics
Casandra Dolovich, Leigh Anne Shafer, Kathy Vagianos, Kelcie Witges, Laura E. Targownik, Charles N. Bernstein
Summary: The study found that there is an association between diet quality (based on the HDS score) and IBD symptoms, intestinal inflammation, and self-reported IBD flares. Individuals with a moderate healthy diet score were less likely to have active inflammation but more likely to experience symptomatic flares.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2022)
Article
Multidisciplinary Sciences
Ruth Ann Marrie, Randy Walld, James M. Bolton, Jitender Sareen, Scott B. Patten, Alexander Singer, Lisa M. Lix, Carol A. Hitchon, James J. Marriott, Renee El-Gabalawy, Alan Katz, John D. Fisk, Charles N. Bernstein
Summary: This study aimed to compare rates of breast and cervical cancer screening in women with immune-mediated inflammatory diseases (IMID) such as inflammatory bowel disease (IBD), multiple sclerosis (MS), and rheumatoid arthritis (RA) to matched cohorts without IMID, and to examine the influence of psychiatric comorbidity on screening behaviors. Results showed that women with IMID had lower rates of mammography, with IBD cohort having higher rates and MS and RA cohort having lower rates. Active mood/anxiety disorders were associated with increased mammography use in the IMID cohorts.
Article
Psychology, Clinical
Jordana L. Sommer, Caitlin Blaney, Natalie Mota, Elena Bilevicius, Brooke Beatie, Kayla Kilborn, Unice Chang, Jitender Sareen, Renee El-Gabalawy
Summary: This study examined the association between dissociation and suicidality among individuals with PTSD and BPD, with results indicating a significant correlation between dissociation and self-harm and suicide attempts, especially in those with BPD.
JOURNAL OF TRAUMATIC STRESS
(2021)
Article
Psychology, Clinical
Gagan K. Gill, Jordana L. Sommer, Natalie Mota, Jitender Sareen, Renee El-gabalawy
Summary: This study is the first to examine the lifetime prevalence of illness-induced post-traumatic stress disorder (PTSD) and its correlates among military personnel and veterans. The results highlight differences between illness-induced PTSD and other trauma-induced PTSD, primarily the potential chronicity of this manifestation. This has implications for assessment strategies and targeted interventions.
JOURNAL OF ANXIETY DISORDERS
(2022)
Article
Education & Educational Research
Joanna Bhaskaran, Tracie O. Afifi, Jitender Sareen, Norah Vincent, James M. Bolton
Summary: This research aimed to investigate the unique impact of sudden death bereavement on the mental health of university students compared to non-sudden death bereaved students. The findings revealed that sudden death bereavement was associated with an increased risk of complicated grief among university students, indicating their specific needs in coping with sudden loss.
JOURNAL OF AMERICAN COLLEGE HEALTH
(2023)
Article
Psychology, Clinical
Dylan Davidson, Jolene Kinley, Jacquelyne Y. Wong, Debbie Whitney, Vishal K. Thakur, Joshua Palay, Jitender Sareen
Summary: Group-based CBTm classes, whether delivered in person or via telepsychology, appear to be an effective avenue for improving mental well-being and service access among rural community members. Results suggested a need for research on predictors of and reducing antecedents to class dropout in this population.
JOURNAL OF RATIONAL-EMOTIVE AND COGNITIVE-BEHAVIOR THERAPY
(2022)
Article
Psychiatry
Hayley Chartrand, Bruce Tefft, Jitender Sareen, Diane Hiebert-Murphy, Laurence Y. Katz, E. David Klonsky, Yunqiao Wang, Huntae Kim, James M. Bolton
Summary: The objective of this study was to compare the correlates and discharge disposition of adults who engage in NSSI and SA, and evaluate the rate of re-presentation. The findings indicate that individuals who engage in NSSI are more likely to re-present and exhibit a trajectory of escalation in self-harm behavior.
ARCHIVES OF SUICIDE RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Essence Perera, James M. Thompson, Gordon J. G. Asmundson, Renee El-Gabalawy, Tracie O. Afifi, Jitender Sareen, Shay-Lee Bolton
Summary: Chronic pain, lasting three to six months or longer, has significant impacts on individuals' physical and mental health. A higher prevalence of chronic pain is observed among Veterans compared to the general population. Both serving members and Veterans experience chronic pain, with Veterans reporting higher rates.
JOURNAL OF MILITARY VETERAN AND FAMILY HEALTH
(2021)
Article
Health Policy & Services
Ross McCallum, Jino Distasio, Dan Chateau, Jitender Sareen, Maria I. Medved, Diane Hiebert-Murphy
Summary: This Canadian study identified various predictors of emergency department (ED) use among homeless adults, with participant ill health being the primary driver. The findings challenge misconceptions about the appropriateness of ED use among people who are homeless.
JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED
(2021)
Meeting Abstract
Rheumatology
Cristiano Moura, Jeffrey Curtis, Denis Choquette, Gilles Boire, Vivian Bykerk, Carter Thorne, Walter Maksymowych, Peter Lakatos, Lawrence Svenson, Laura Targownik, Waqqas Afif, Sasha Bernatsky
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Behavioral Sciences
Holly A. Parkerson, Jitender Sareen, Gordon J. G. Asmundson
Summary: This study examined the relationship between smoking and pain, finding that pain-related anxiety may be a risk factor for maintaining smoking dependence and successful smoking cessation can lead to meaningful decreases in pain and pain-related disability. Participants with pain who quit smoking experienced positive outcomes, while those who failed to start a quit-attempt had higher levels of pain disability, depression, and anxiety. The findings suggest the importance of addressing pain-related anxiety in smoking cessation programs.
COGNITIVE BEHAVIOUR THERAPY
(2021)