Article
Gastroenterology & Hepatology
Belen Herreros, Alejandro Espi, Cristina Monton Rodriguez, Eduardo Garcia-Granero, Vicente Sanchiz, Francisco L. Ferriols, Pedro Almela, Vicente Hernandez, Francisco Mora, Miguel Minguez
Summary: This study compared the effects of combined therapy with botulinum toxin injection and topical diltiazem with botulinum toxin injection alone in the treatment of chronic anal fissure. The results showed that combined therapy was not superior to botulinum toxin injection in terms of healing rates, with both options offering suboptimal outcomes. Long-term recurrence rates were high (>80% at 10 years) and could occur at any time after healing.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Food Science & Technology
Yao-Lin Kao, Yin-Chien Ou, Kuen-Jer Tsai, Hann-Chorng Kuo
Summary: Urethral sphincter BoNT-A injection is an effective treatment for refractory non-neurogenic voiding dysfunction, with a success rate of 64%, and has significant clinical implications.
Review
Food Science & Technology
Pengxu Wei
Summary: This article focuses on the treatment methods and effects of botulinum toxin injection for UES dysfunction. The research suggests that the entire UES should be targeted for injection rather than just the cricopharyngeal muscle. The article also discusses the therapeutic mechanisms of botulinum toxin and the strengths and weaknesses of guiding techniques.
Article
Surgery
Beatrice D'Orazio, Girolamo Geraci, Guido Martorana, Carmelo Sciume, Giovanni Corbo, Gaetano Di Vita
Summary: In this study, the long-term results of fissurectomy and anoplasty with V-Y cutaneous flap advancement associated with 30 IU of botulinum toxin injection for CAPF with IAS hypertonia were evaluated. The findings showed good outcomes at 5 years post-surgery, indicating that surgical section of the IAS is not essential for the healing process of CAPF.
UPDATES IN SURGERY
(2021)
Review
Food Science & Technology
Shu-Yu Wu, Shang-Jen Chang, Stephen Shei-Dei Yang, Chun-Kai Hsu
Summary: The study evaluated the use of BTX-A injection in children with medically refractory neurogenic bladder, finding it to be a safe and effective treatment option. Improvements in clinical and urodynamic parameters were observed as the main outcomes of the treatment.
Review
Surgery
Jennifer L. Crook, Alireza Hamidian Jahromi, Petros Konofaos
Summary: The current knowledge on the long-term outcomes of repeated cosmetic BT injections is limited. The available literature does not provide sufficient evidence to determine how prolonged effects could affect the clinical use of BT. Further clinical studies, with extended follow-up periods and inclusion of subjective and objective measures of appearance and muscle function, are required to better understand the long-term impacts of repeated BT injections.
ANNALS OF PLASTIC SURGERY
(2022)
Article
Gastroenterology & Hepatology
Marco La Torre, Marta Goglia, Alessandro Micarelli, Enrico Fiori, Vito D'Andrea, Ugo Grossi, Simone Maria Tierno, Federico Tomassini, Gaetano Gallo
Summary: Video-assisted anal fistula treatment (VAAFT) is a safe sphincter-sparing technique, but its long-term effectiveness decreases over time and is related to the complexity of the disease.
COLORECTAL DISEASE
(2023)
Article
Clinical Neurology
Lena C. O'Flynn, Kristina Simonyan
Summary: This study investigated the short-term and long-term effects of BoNT treatment on brain function in patients with LD. The results suggest that BoNT-treated patients who benefited from the treatment had reduced activity in the left precuneus compared to untreated patients and patients who did not benefit from the treatment. Additionally, BoNT-treated patients with adductor LD showed decreased activity in the right thalamus, while patients with abductor LD showed reduced activity in the left inferior frontal cortex. There were no significant differences in brain activity between patients with shorter and longer treatment durations. However, patients with intermediate treatment duration of 6-12 years showed reduced activity in the right cerebellum and right prefrontal cortex compared to patients with shorter treatment duration.
Article
Medicine, General & Internal
Stefan Evers, Alexandra Buchheister, Doris Reichelt, Ingo W. Husstedt, Achim Frese
Summary: This study investigated the efficacy and safety of BTX treatment in HIV-infected patients. The results showed that BTX treatment was effective and well-tolerated in long-term use, with no interaction with antiretroviral treatment. Therefore, BTX treatment can be considered as an additional therapeutic option for HIV-infected patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Philip Roelandt, Georges Coremans, Jan Wyndaele
Summary: Chronic anal fissures can be effectively treated with surgical procedures such as fissurectomy, but the additional injection of botulinum toxin can significantly increase the efficiency of the surgery without causing additional complications.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Article
Food Science & Technology
Cheng-Ling Lee, Jia-Fong Jhang, Yuan-Hong Jiang, Hann-Chorng Kuo
Summary: This study aimed to investigate the improvement in voiding condition after the initial botulinum toxin A (BoNT-A) injection into the urethral sphincter among patients with chronic spinal cord injury (SCI) and voiding dysfunction. The results showed that BoNT-A injections into the urethral sphincter significantly improved voiding condition. Patients who converted their treatment to other bladder managements or underwent surgical procedures also achieved satisfactory treatment outcomes.
Article
Health Care Sciences & Services
Yu-Hua Fan, Hann-Chorng Kuo
Summary: This study aimed to evaluate the efficacy of intravesical botulinum toxin A (BoNT-A) injections for the treatment of pediatric overactive bladder (OAB). The study demonstrated that intravesical BoNT-A injection is effective and safe for the treatment of neurogenic and non-neurogenic OAB in children refractory to conventional therapies.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Multidisciplinary Sciences
Tae-Hyeon Cho, Ju-Eun Hong, Hun-Mu Yang
Summary: In this study, the dominant fibers within each compartment of the subscapularis muscle were determined using immunohistochemistry with fresh cadavers. The results showed distinct fascia demarcating the superior and inferior compartments of the muscle. The innervation of the muscle by the upper and lower subscapular nerves was also observed, and the densities of type I and type II fibers were found to differ between the compartments.
SCIENTIFIC REPORTS
(2023)
Article
Food Science & Technology
Yin-Chien Ou, Kuan-Hsun Huang, Hau-Chern Jan, Hann-Chorng Kuo, Yao-Lin Kao, Kuen-Jer Tsai
Summary: Female external urethral sphincter (EUS) dysfunction has different types, and the therapeutic outcome is influenced by bladder neck narrowing and history of catheterization.
Article
Otorhinolaryngology
Min Seok Kang, Seung Jin Lee, Hong-Shik Choi, Jae-Yol Lim
Summary: The study aimed to evaluate the outcomes of long-term botulinum toxin type A treatment for adductor spasmodic dysphonia and determine factors predictive of treatment response. Patients generally received stable low doses of BoNTA, with age, gender, and VHI scores being correlated with poor treatment responses such as frequent dose changes and shorter intervals between injections.
CLINICAL OTOLARYNGOLOGY
(2021)
Editorial Material
Pediatrics
Neil L. Schechter, Rachael Coakley, Samuel Nurko
Summary: This Viewpoint explores how patient and clinician expectations and biases influence feedback discussions following assessments for pediatric chronic pain.
Article
Gastroenterology & Hepatology
Julie Khlevner, Rachel Rosen, Lusine Ambartsumyan, Sarah Shrager Lusman, John M. Rosen, Desale Yacob, Hayat Mousa, Samuel Nurko, Carlo Di Lorenzo, Mary Boruta, Elyanne M. Ratcliffe, Laurence Feinstein, Julie Snyder, Richard J. Wood, Kahleb Graham, Miguel Saps, C. Prakash Gyawali, Leonel Rodriguez, Jaime Belkind-Gerson
Summary: This article discusses the commonality of neurogastroenterology and motility disorders in children and the lack of training in this area. Guidelines for training in North America are outlined, covering clinical knowledge, skills, and management elements across various anatomical regions. The aim is to break barriers to pursuing a career in NGM and provide uniform training expectations for pediatric gastroenterology fellows.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Lusine Ambartsumyan, Michele Shaffer, Kristen Carlin, Samuel Nurko
Summary: The study found that children with anorectal malformations had abnormal sensation and lower pressures longitudinally and radially along all quadrants of the anal canal. Manometric properties at rest were not associated with reported predictors of fecal continence.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Letter
Gastroenterology & Hepatology
Thomas S. C. Ng, Niharika Putta, Neha S. Kwatra, Laura A. Drubach, Rachel Rosen, Frederic H. Fahey, Alejandro Flores, Samuel Nurko, Stephan D. Voss
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Pankaj J. Pasricha, Madhusudan Grover, Katherine P. Yates, Thomas L. Abell, Cheryl E. Bernard, Kenneth L. Koch, Richard W. McCallum, Irene Sarosiek, Braden Kuo, Robert Bulat, Jiande Chen, Robert J. Shulman, Linda Lee, James Tonascia, Laura A. Miriel, Frank Hamilton, Gianrico Farrugia, Henry P. Parkman
Summary: This study found that patients with functional dyspepsia (FD) and gastroparesis were indistinguishable in terms of clinical and pathologic features or gastric emptying assessment in a tertiary referral setting. Gastric-emptying results were unreliable in capturing the pathophysiology of clinical symptoms in either condition, suggesting that FD and gastroparesis should be considered as part of the same spectrum of gastric neuromuscular disorders.
Article
Gastroenterology & Hepatology
Beate C. Beinvogl, Mhd Louai Manini, Michael Camilleri, Leslie J. Donato, William Scott Harmsen, Imad Absah, Elizabeth Burch, Neil L. Schechter, Samuel Nurko
Summary: This study aimed to investigate the association of bile acid levels with bile acid diarrhea in pediatric IBS-D patients, with 20% of pediatric IBS-D patients showing abnormal fasting serum C4 levels and 28% having low FGF-19 values. Fecal primary bile acids were significantly correlated with stool frequency, suggesting that these biomarkers may help diagnose bile acid diarrhea in pediatric IBS-D.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Marc A. Benninga, Sunny Z. Hussain, Manu R. Sood, Samuel Nurko, Paul Hyman, Robert A. Clifford, Molly O'Gorman, Taryn Losch-Beridon, Shadreck Mareya, Peter Lichtlen, Carlo Di Lorenzo
Summary: In pediatric patients with functional constipation, lubiprostone did not show statistically significant effectiveness over placebo, but exhibited a safety profile similar to that in adults. Both doses of lubiprostone were well tolerated in children and adolescents.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
James W. Varni, Robert J. Shulman, Mariella M. Self, Liz Febo-Rodriguez, Heather Charron, Kent Williams, Sam Nurko, Rachel L. Rosen, Bruno P. Chumpitazi
Summary: This study developed the new Pediatric Quality of Life Inventory Gastroparesis Symptoms Module through qualitative methods, consisting of 10 individual scales. The study supported the content validity of the module and a field test study will be conducted in a multisite national study in the future.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Beate Beinvogl, Nathan Palmer, Isaac Kohane, Samuel Nurko
Summary: Research shows significant differences in healthcare spending and utilization between pediatric IBS patients and controls, with IBS patients more likely to have mental health and chronic pain comorbidities.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Jeng-Jung Chen, R. N. Kitzia Colliard, Samuel Nurko, Leonel Rodriguez
Summary: Melanosis coli is associated with the use of sennosides, but it does not affect colonic motility or increase the need for surgery in pediatric functional constipation.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Ricardo A. Arbizu, Maureen Amicangelo, Leonel Rodriguez, Samuel Nurko
Summary: This study investigated the changes in intra-anal pressure and characteristics of the rectoanal inhibitory reflex during anorectal manometry in patients undergoing anesthesia induction with propofol. The results showed that propofol can be used to assess the presence of the rectoanal inhibitory reflex in uncooperative children. Additionally, propofol significantly reduces resting intra-anal pressure and increases the percentage of internal anal sphincter relaxation.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Jessica L. Yasuda, Steven J. Staffa, Samuel Nurko, Madeline Kane, Stephanie Wall, Edward B. Mougey, James P. Franciosi, Michael A. Manfredi, Rachel Rosen
Summary: Regardless of the CYP2C19 metabolizer phenotype, patients with esophageal atresia (EA) are more likely to experience PPI-refractory, non-allergic esophagitis, suggesting that factors other than CYP2C19 genetics, including dysmotility, play a primary role in esophagitis in EA.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Pediatrics
Beate Beinvogl, Alexandra Cohen, Courtney DiFilippo, Madeline Kane, Samuel Nurko, Rachel Rosen
Summary: This study aimed to examine the effects of the COVID-19 quarantine on pediatric patients with aerodigestive disease, including their baseline health, medication use, health anxiety, and healthcare utilization. The results showed that despite increased health-related anxiety, patients with aerodigestive disease experienced improvements in airway symptoms and decreased medication use during the pandemic. Additionally, all patient groups continued to access healthcare despite the challenges of the lockdown.
JOURNAL OF PEDIATRICS
(2022)
Review
Gastroenterology & Hepatology
Michael Camilleri, Samuel Nurko
Summary: Bile acids play a central role in the diagnosis of BAD, with idiopathic BAD potentially being caused by reduced synthesis of FGF-19 by the ileal mucosa or genetic variation in hepatocyte proteins. Diagnosis of BAD in adults and adolescents primarily involves serum and fecal testing.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Pediatrics
Suzanna Hirsch, Samuel Nurko, Paul Mitchell, Rachel Rosen
Summary: In a retrospective study of children prescribed prucalopride for upper GI symptoms at a single tertiary care center, 65% of patients showed symptomatic improvement at their first follow-up after prucalopride initiation. Patients with enteral tubes, pulmonary comorbidities, and neurologic comorbidities were more likely to experience improvement. Among patients with feeding difficulties, 79% showed improvements in oral or tube feeding.
