Article
Gastroenterology & Hepatology
Paolo Muratori, Alessandro Granito, Marco Lenzi, Luigi Muratori
Summary: Autoimmune Hepatitis (AIH) is a chronic inflammatory liver disease with unknown cause, characterized by autoantibodies, elevated IgG, and interface hepatitis. Its clinical presentation varies from asymptomatic to severe hepatic failure, and diagnosis can be challenging during acute onset. Specific scoring systems can aid in diagnosis, especially in cases with normal IgG levels and low autoantibody positivity.
LIVER INTERNATIONAL
(2021)
Review
Immunology
Xinhe Zhang, Xuyong Lin, Xuedan Li, Lin Guan, Yiling Li, Ningning Wang
Summary: This case report describes a patient with ulcerative colitis, primary biliary cholangitis, and autoimmune hepatitis, ultimately diagnosed with overlap syndrome. The accurate diagnosis of overlap syndrome requires multiple laboratory tests and pathological examinations.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Jie Long, Si-Yu Yang, Meng-Xing Huang, Pan-Yue Luo, Liang Li, Koichi Tsuneyama, Aftab A. Ansari, Ling Lu, M. Eric Gershwin, Zhe-Xiong Lian, Zhi-Bin Zhao
Summary: Aire and TGF-beta signaling are important in central and peripheral tolerance. Aire helps eliminate autoreactive T cells, while TGF-beta suppresses their activity. We studied mice with a defect in TGF-beta signaling and introduced the Aire gene. Surprisingly, these mice developed autoimmune cholangitis and hepatitis, resembling the AIH-PBC overlap syndrome.
JOURNAL OF PATHOLOGY
(2023)
Article
Medicine, General & Internal
Markus Graf, Christian M. Lange, Mona M. Langer, Joern M. Schattenberg, Jessica Seessle, Julia Dietz, Annika Vermehren, Florian A. Michael, Antonia Mondorf, Stefan Zeuzem, Anita Pathil, Christiana Graf, David E. Kaplan, Hideaki Kato
Summary: This study aimed to assess the prevalence, biochemical, and serological features, as well as the clinical course, of AIH-PBC VS. The results showed that the biochemical Paris criteria were rarely detected and should be redefined. Combined therapy of UDCA and IS appeared to be more effective than monotherapy with UDCA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Kailing Wang, Yong Li, Jianfeng Pan, Huifang He, Ziyi Zhao, Yiming Guo, Xiaomei Zhang
Summary: This study established two noninvasive predictive models for the diagnosis of autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) overlap syndrome (OS), which showed better performance compared to the traditional Paris criteria.
Article
Immunology
Mingxia Li, Kunli Yan, Peisheng Jia, Erhu Wei, Huaili Wang
Summary: This article reports a case of atypical cat-scratch disease (CSD) diagnosed using metagenomic next-generation sequencing (mNGS). The patient's peripheral blood sample was tested using mNGS, and Bartonella henselae was detected, leading to successful treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yi Jiang, Bing-Hong Xu, Brandon Rodgers, Nikolaos Pyrsopoulos
Summary: This retrospective trial used national data to examine the characteristics and outcomes of patients hospitalized with overlapping PBC and AIH. The study found that PBC/AIH patients had lower rates of Crohn's disease, higher rates of Sjogren's syndrome, higher rates of cirrhosis-related complications, and significantly increased risk of septic shock compared to PBC and AIH individually.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Pathology
Maylee Hsu, Jennifer Y. Ju, Meredith M. Pearson, Lei Yu, Paul E. Swanson, Matthew M. Yeh
Summary: This study found that the number of IgM-positive plasma cells is higher in explants of cirrhotic PBC compared with AIH, which may be helpful in the evaluation of cryptogenic cirrhosis.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2022)
Review
Medicine, General & Internal
Imran Shahid, Abdullah R. Alzahrani, Saeed S. Al-Ghamdi, Ibrahim M. Alanazi, Sidra Rehman, Sajida Hassan
Summary: The simplification and emergence of advanced HCV diagnostic platforms have revolutionized hepatitis C diagnosis worldwide, with new diagnostic methods being crucial to achieving the WHO's set goals by 2030. Despite some progress, challenges remain regarding affordability, accessibility, and health system-related barriers.
Article
Immunology
Kaan Yilmaz, Stefanie Haeberle, Yong Ook Kim, Marvin J. Fritzler, Shih-Yen Weng, Benjamin Goeppert, Verena K. Raker, Kerstin Steinbrink, Detlef Schuppan, Alexander Enk, Eva N. Hadaschik
Summary: Our study demonstrates that Treg-deficient scurfy mice spontaneously develop clinical, serological, and immunopathological characteristics of autoimmune liver diseases (AILD), with overlapping features of primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Lin Chen, Xiaodong Shi, Jinglan Jin, Wei Han, Limei Qu, Wanyu Li
Summary: A 37-year-old female patient diagnosed with PBC-AIH overlap syndrome and PNH was successfully treated with a combination of prednisolone and ursodeoxycholic acid, showing good recovery at the 24-month follow-up evaluation. While this represents a single case, it expands knowledge on immunological diseases associated with PNH and suggests an immune-mediated pathogenic pathway between PNH and PBC-AIH overlap syndrome.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Pathology
Yuanxin Liang, Binny Khandakar, Yansheng Hao, Yiqin Xiong, Bella L. Liu, Xuchen Zhang
Summary: This study compared the histologic features of autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and AIH-PBC overlap syndrome (OS). The results showed distinct morphologic differences between AIH and PBC, especially in terms of bile duct-centered processes and interface-centered processes.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Liling Deng, Wuquan Deng
Summary: This article is linked to papers by Jalal et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Clinical Neurology
Hesham Abboud, John C. Probasco, Sarosh Irani, Beau Ances, David R. Benavides, Michael Bradshaw, Paulo Pereira Christo, Russell C. Dale, Mireya Fernandez-Fournier, Eoin P. Flanagan, Avi Gadoth, Pravin George, Elena Grebenciucova, Adham Jammoul, Soon-Tae Lee, Yuebing Li, Marcelo Matiello, Anne Marie Morse, Alexander Rae-Grant, Galeno Rojas, Ian Rossman, Sarah Schmitt, Arun Venkatesan, Steven Vernino, Sean J. Pittock, Maarten J. Titulaer
Summary: This paper evaluates evidence and expert opinions in the management of autoimmune encephalitis, presenting choices for first-line and second-line therapies based on survey responses from clinicians worldwide. The preferences for corticosteroids and rituximab as treatments are highlighted, with a focus on individual responses and the consensus among the surveyed members.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Review
Medicine, General & Internal
Silvia Nastasio, Antonella Mosca, Tommaso Alterio, Marco Sciveres, Giuseppe Maggiore
Summary: Juvenile autoimmune hepatitis is a severe immune-mediated liver disease that can progress to liver failure without treatment. Clinical, laboratory, and histological findings are used for diagnosis, and the prothrombin ratio can predict the need for liver transplant. Early and continuous immune suppression treatment is crucial to prevent liver damage and fibrosis. Recent studies suggest treatment discontinuation is possible after prolonged normal aminotransferase levels without liver biopsy.
Letter
Gastroenterology & Hepatology
Nahum Mendez-Sanchez, Elisabetta Bugianesi, Robert G. Gish, Frank Lammert, Herbert Tilg, Mindie H. Nguyen, Shiv K. Sarin, Nuria Fabrellas, Shira Zelber-Sagi, Jian-Gao Fan, Gamal Shiha, Giovanni Targher, Ming-Hua Zheng, Wah-Kheong Chan, Shlomo Vinker, Takumi Kawaguchi, Laurent Castera, Yusuf Yilmaz, Marko Korenjak, C. Wendy Spearman, Mehmet Ungan, Melissa Palmer, Mortada El-Shabrawi, Hans-Juergen Gruss, Jean-Francois Dufour, Anil Dhawan, Heiner Wedemeyer, Jacob George, Luca Valenti, Yasser Fouad, Manuel Romero-Gomez, Mohammed Eslam
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Sanchit Sharma, Samagra Agarwal, Anoop Saraya, Ashok Choudhury, Mamun Al Mahtab, Mohd Shahinul Alam, Sanjiv Saigal, Dong Joon Kim, C. E. Eapen, Ashish Goel, Qin Ning, Harshad Devarbhavi, Virendra Singh, Akash Shukla, Saeed Hamid, Jinhua Hu, Soek-Siam Tan, Anil Arora, Manoj Kumar Sahu, Mohd Rela, Dinesh Jothimani, P. N. Rao, Anand Kulkarni, Hashmik Ghaznian, Guan Huei Lee, Duan Zhongping, Ajit Sood, Omesh Goyal, Laurentius A. Lesmana, Rinaldi C. Lesmana, Sombat Treeprasertsuk, Nan Yuemin, Samir Shah, Han Tao, V. M. Dayal, Xin Shaojie, Fazal Karim, Zaigham Abbas, Jose D. Sollano, Kemal Fariz Kalista, Ananta Shreshtha, Diana Payawal, Masao Omata, Shiv Kumar Sarin
Summary: This study evaluated the outcomes of acute variceal bleeding (AVB) in patients with acute-on-chronic liver failure (ACLF) and found that patients with AVB had a higher mortality rate.
HEPATOLOGY INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Nipun Verma, Ashok Choudhury, Virendra Singh, Ajay Duseja, Manum Al-Mahtab, Harshad Devarbhavi, Chundamannil E. Eapen, Ashish Goel, Qin Ning, Zhongping Duan, Saeed Hamid, Wasim Jafri, Amna Shubhan Butt, Akash Shukla, Soek-Siam Tan, Dong Joon Kim, Jinhua Hu, Ajit Sood, Omesh Goel, Vandana Midha, Hashmik Ghaznian, Manoj Kumar Sahu, Guan Huei Lee, Sombat Treeprasertsuk, Samir Shah, Laurentius A. Lesmana, Rinaldi C. Lesmana, V. G. Mohan Prasad, Shiv K. Sarin
Summary: This study utilizes artificial intelligence models to predict outcomes in acute on chronic liver failure (ACLF) and finds that the AARC-AI model outperforms standard models. The study also identifies key factors such as creatinine, international normalized ratio (INR), and circulatory failure that contribute to outcome predictions.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Sakkarin Chirapongsathorn, Wattana Sukeepaisarnjaroen, Sombat Treeprasertsuk, Roonguedee Chaiteerakij, Pichaporn Surawongsin, Chanunta Hongthanakorn, Sith Siramolpiwat, Naichaya Chamroonkul, Chalermrat Bunchorntavakul, Watcharasak Chotiyaputta, Kittiyod Poovorawan, Rattana Boonsirichan, Saranath Lawpoolsri, Chinnavat Sutivana, Abhasnee Sobhonslidsuk
Summary: This study compared the incidence and outcomes of drug-induced liver injury (DILI) in patients with and without chronic liver disease (CLD). The results showed that herbal and alternative medicine were the most common causative agents of DILI in both CLD and non-CLD patients. The severity and mortality rate were similar between patients with CLD and without CLD.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Kessarin Thanapirom, Sirinporn Suksawatamnuay, Panarat Thaimai, Sombat Treeprasertsuk, Piyawat Komolmit, Pisit Tangkijvanich
Summary: This study aimed to assess and validate the TREAT-B score as an alternative criteria for indicating treatment eligibility in Asian patients with chronic HBV infection.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Tongluk Teerasarntipan, Kessarin Thanapirom, Sakkarin Chirapongsathorn, Tanita Suttichaimongkol, Naichaya Chamroonkul, Chalermrat Bunchorntavakul, Sith Siramolpiwat, Siwaporn Chainuvati, Abhasnee Sobhonslidsuk, Apinya Leerapun, Teerha Piratvisuth, Wattana Sukeepaisarnjaroen, Tawesak Tanwandee, Sombat Treeprasertsuk
Summary: In Thai patients, the CLIF-C OF score was the best predictor for 30-day and 90-day mortalities in ACLF patients, while appropriate prognostic factors for AD patients remained inconclusive.
Article
Medicine, General & Internal
Kessarin Thanapirom, Monton Wongwandee, Sirinporn Suksawatamnuay, Panarat Thaimai, Napaporn Siripon, Wanwisar Makhasen, Sombat Treeprasertsuk, Piyawat Komolmit
Summary: The study aimed to establish the normative data of PHES in healthy Thai individuals, assess the prevalence of MHE, and validate the use of S-ANT1 in detecting MHE in cirrhotic patients. The results showed that MHE was present in 26.6% of cirrhotic patients. S-ANT1 had a moderate positive correlation with PHES.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Virendra Singh, Arka De, Rohit Mehtani, Paolo Angeli, Rakhi Maiwall, Sanjaya Satapathy, Ashwini K. Singal, Anoop Saraya, B. C. Sharma, C. E. Eapen, P. N. Rao, Akash Shukla, Shalimar, Narendra S. Choudhary, Diana Alcantara-Payawal, Vinod Arora, Guru Aithal, Anand Kulkarni, Akash Roy, Ananta Shrestha, Mamun al Mahtab, Madunil A. Niriella, Tan Soek Siam, Chun-Qing Zhang, Lee Guan Huei, Ming-Lung Yu, Stuart K. Roberts, Cheng-Yuan Peng, Tao Chen, Jacob George, Vincent Wong, Yusuf Yilmaz, Sombat Treeprasertsuk, Juferdy Kurniawan, Seung Up Kim, Zobair M. Younossi, Shiv Kumar Sarin
HEPATOLOGY INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Xiao-Dong Zhou, Giovanni Targher, Christopher D. Byrne, Virend Somers, Seung Up Kim, C. Anwar A. Chahal, Vincent Wai-Sun Wong, Jingjing Cai, Michael D. Shapiro, Mohammed Eslam, Philippe Gabriel Steg, Ki-Chul Sung, Anoop Misra, Jian-Jun Li, Carlos Brotons, Yuli Huang, George V. Papatheodoridis, Aijun Sun, Yusuf Yilmaz, Wah Kheong Chan, Hui Huang, Nahum Mendez-Sanchez, Saleh A. Alqahtani, Helena Cortez-Pinto, Gregory Y. H. Lip, Robert J. de Knegt, Ponsiano Ocama, Manuel Romero-Gomez, Marat Fudim, Giada Sebastiani, Jang Won Son, John D. Ryan, Ignatios Ikonomidis, Sombat Treeprasertsuk, Daniele Pastori, Monica Lupsor-Platon, Herbert Tilg, Hasmik Ghazinyan, Jerome Boursier, Masahide Hamaguchi, Mindie H. Nguyen, Jian-Gao Fan, George Boon-Bee Goh, Mamun Al Mahtab, Saeed Hamid, Nilanka Perera, Jacob George, Ming-Hua Zheng
Summary: Metabolic (dysfunction)-associated fatty liver disease (MAFLD) is closely linked to cardiovascular disease (CVD), but the CVD risk is often underestimated. An international panel of experts conducted a Delphi survey to establish the association between MAFLD and CVD risk, and identified potential areas for future research.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Sanchit Sharma, Samagra Agarwal, Anoop Saraya, Ashok Kumar Choudhury, Sanjiv Saigal, A. S. Soin, Akash Shukla, Manoj K. Sahu, Laurentius A. Lesmana, Renaldi C. Lesmana, Samir N. N. Shah, Jinhua Hu, Soek Siam Tan, Dinesh Jothimani, Mohammed Rela, Hasmik L. Ghazinyan, D. N. Amrapurkar, C. E. Eapen, Ashish Goel, Diana Alcantra Payawal, Saeed Hamid, Amna S. Butt, Zhongping Duan, Virender Singh, Ajay Duseja, Ajit Sood, Vandana Midha, Mamun Al Mahtab, Dong Joon Kim, Qin Ning, Anand V. Kulkarni, P. N. Rao, Guan Huei Lee, Sombat Treeprasertsuk, Shaojie Xin, Md. Fazal Karim, Jose D. Sollano, Kemal Fariz Kalista, Rino Alvani Gani, V. G. Mohan Prasad, Shiv Kumar Sarin
Summary: This study aimed to assess whether non-response to steroids in patients with autoimmune hepatitis (AIH) causing acute-on-chronic liver failure (ACLF) can be accurately identified within the first few days of treatment. The results showed that baseline AARC score, MELD score, and dynamic SURFASA score on day 3 can accurately identify early non-response to steroids in AIH-ACLF patients.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Jeffrey V. Lazarus, Henry E. Mark, Alina M. Allen, Juan Pablo Arab, Patrizia Carrieri, Mazen Noureddin, William Alazawi, Naim Alkhouri, Saleh A. Alqahtani, Marco Arrese, Ramon Bataller, Thomas Berg, Paul N. Brennan, Patrizia Burra, Graciela E. Castro-Narro, Helena Cortez-Pinto, Kenneth Cusi, Nikos Dedes, Ajay Duseja, Sven M. Francque, Hannes Hagstrom, Terry T. -K. Huang, Dana Ivancovsky Wajcman, Achim Kautz, Christopher J. Kopka, Aleksander Krag, Veronica Miller, Philip N. Newsome, Mary E. Rinella, Diana Romero, Shiv Kumar Sarin, Marcelo Silva, C. Wendy Spearman, Emmanuel A. Tsochatzis, Luca Valenti, Marcela Villota-Rivas, Shira Zelber-Sagi, Jorn M. Schattenberg, Vincent Wai-Sun Wong, Zobair M. Younossi
Summary: This study aimed to develop a research agenda for fatty liver disease, and 28 priorities were identified to address the individual and societal harms caused by this disease. Adopting this agenda can accelerate global efforts to respond to this public health threat.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Dan-Qin Sun, Giovanni Targher, Christopher D. Byrne, David C. Wheeler, Vincent Wai-Sun Wong, Jian-Gao Fan, Herbert Tilg, Wei-Jie Yuan, Christoph Wanner, Xin Gao, Michelle T. Long, Mehmet Kanbay, Mindie H. Nguyen, Sankar D. Navaneethan, Yusuf Yilmaz, Yuli Huang, Rino A. Gani, Pierluigi Marzuillo, Jerome Boursier, Huijie Zhang, Chan-Young Jung, Jin Chai, Luca Valenti, George Papatheodoridis, Giovanni Musso, Yu-Jun Wong, Mohamed El-Kassas, Nahum Mendez-Sanchez, Silvia Sookoian, Michael Pavlides, Ajay Duseja, Adriaan G. Holleboom, Junping Shi, Wah-Kheong Chan, Yasser Fouad, Junwei Yang, Sombat Treeprasertsuk, Helena Cortez-Pinto, Masahide Hamaguchi, Manuel Romero-Gomez, Mamun Al Mahtab, Ponsiano Ocama, Atsushi Nakajima, Chunsun Dai, Mohammed Eslam, Lai Wei, Jacob George, Ming-Hua Zheng
Summary: A multidisciplinary panel of 50 international experts reached a consensus on the link between MAFLD and CKD using a Delphi-based approach. This consensus statement provides guidance on the epidemiology, mechanisms, management, and treatment of MAFLD and CKD, as well as the relationship between the severity of MAFLD and the risk of CKD, establishing a framework for early prevention and management of these two common and interconnected diseases.
HEPATOBILIARY SURGERY AND NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Pakanat Decharatanachart, Wirichada Pan-ngum, Thoetchai Peeraphatdit, Natthaporn Tanpowpong, Pisit Tangkijvanich, Sombat Treeprasertsuk, Rungsun Rerknimitr, Roongruedee Chaiteerakij
Summary: Ultrasonography has low sensitivity for detecting early-stage hepatocellular carcinoma (HCC) in cirrhotic patients. Non-contrast abbreviated magnetic resonance imaging (aMRI) was found to be cost-effective and may be useful for HCC surveillance in cirrhotic patients, especially in those with high HCC risks.
Article
Gastroenterology & Hepatology
Jasmohan S. Bajaj, Ashok K. Choudhury, Qing Xie, Patrick S. Kamath, Mark Topazian, Peter C. Hayes, Aldo Torre, Hailemichael Desalegn, Ramazan Idilman, Zhujun Cao, Mario R. Alvares-da-Silva, Jacob George, Brian J. Bush, Leroy R. Thacker, Florence Wong
Summary: This study aimed to assess predictors of death in inpatients with cirrhosis and found that patients from low-income countries have higher mortality rates, which may be due to disparities in access to essential diagnostic and treatment services.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Sakkarin Chirapongsathorn, Wattana Sukeepaisarnjaroen, Sombat Treeprasertsuk, Roongruedee Chaiteerakij, Pichaporn Surawongsin, Chanunta Hongthanakorn, Sith Siramolpiwat, Naichaya Chamroonkul, Chalermrat Bunchorntavakul, Watcharasak Chotiyaputta, Kittiyod Poovorawan, Rattana Boonsirichan, Saranath Lawpoolsri, Chinnavat Sutthivana, Abhasnee Sobhonslidsuk