Article
Nutrition & Dietetics
Claire Ferrua, Anais Lemoine, Alexis Mosca, Anne-Aurelie Lopes
Summary: CMV-associated protein-losing enteropathy (PLE) in children has a benign course but can lead to generalized edema. This study retrospectively describes CMV-associated PLE in children between 2009 and 2019 in two French hospitals. The study found that immunocompetent children had digestive symptoms, while immunosuppressed children had more severe symptoms. Non-invasive tests confirmed CMV infection in the majority of patients. CMV-associated PLE should be suspected in children with generalized edema and can be confirmed using non-invasive tests.
Review
Multidisciplinary Sciences
Yating Wang, Xuequn Zhang
Summary: This case report describes a patient with immunocompromise who presented with weight loss, vomiting, and diarrhea. Through a series of tests and histopathology, the cause was determined to be protein-losing enteropathy caused by Strongyloides stercoralis infection. This highlights the importance of considering Strongyloides stercoralis infection in immunocompromised patients with vague gastrointestinal symptoms, and the need for more sensitive diagnostic methods.
Article
Nutrition & Dietetics
Gavriela Feketea, Alina Popp, Daniela Marcela Ionescu, Elena Camelia Berghea
Summary: Food-protein induced protein-losing enteropathy (FPIPLE) is a type of food allergy in infants characterized by low levels of protein in the blood, edema, anemia, eosinophilia, and high levels of alpha 1-antitrypsin in the stool. This study proposes a definition, diagnostic criteria, and treatment approach for FPIPLE, suggesting that dietary modification can effectively manage this condition.
FRONTIERS IN NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Varun J. Sharma, Ajay J. Iyengar, Diana Zannino, Thomas Gentles, Robert Justo, David S. Celermajer, Andrew Bullock, David Winlaw, Gavin Wheaton, Luke Burchill, Rachael Cordina, Yves D'Udekem
Summary: Protein losing enteropathy and plastic bronchitis are severe complications in Fontan circulation, mainly affecting patients with dominant right single ventricle, with older age being a predictor of developing these diseases and having a poorer prognosis. Heart transplantation remains the ultimate treatment option, with 30% of patients either dying or requiring transplantation within 5 years.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Pediatrics
Yue Xi, Zhi Chen, Kun Hao, Xiaorong Liu
Summary: Protein-losing enteropathy (PLE) is a serious clinical disorder that can result in hypoproteinemia and malnutrition. PLE is often associated with gastrointestinal disorders and constrictive pericarditis. This case report highlights the marked improvement of severe hypoalbuminemia caused by PLE associated with tuberculosis-related constrictive pericarditis achieved through pericardiectomy.
FRONTIERS IN PEDIATRICS
(2022)
Review
Rheumatology
Jozelio Freire de Carvalho, Aaron Lerner, Caio Marco Goncalves, Yehuda Shoenfeld
Summary: The research found good correlation between the clinical manifestations, antibody detection results, and therapeutic effectiveness in patients with Sjogren's syndrome and protein-losing enteropathy. Early diagnosis of protein-losing enteropathy is crucial for improving clinical outcomes.
CLINICAL RHEUMATOLOGY
(2021)
Review
Nutrition & Dietetics
Karolina Graczykowska, Joanna Kaczmarek, Dominika Wilczynska, Ewa Los-Rycharska, Aneta Krogulska
Summary: Cow's milk is an important component of a child's diet, but excessive consumption can lead to health issues such as anemia and protein-losing enteropathy. Overconsumption of cow's milk may trigger iron deficiency anemia, and even children without food allergies could be affected significantly.
Article
Genetics & Heredity
Yang Ou, Jun-Chao Yuan, Yao Zheng, Jin-Man Zhang, Tian He, Zhi Liang, Yi-Kun Zhou
Summary: This article reports a rare case of Noonan syndrome with protein-losing enteropathy. The gene mutation results of the patient indicate that the mutation in the PTPN11 gene may be related to protein-losing enteropathy.
FRONTIERS IN GENETICS
(2023)
Article
Medicine, General & Internal
Song Xia, Zhong Liu, Huifang Yan, Kun Chang, Yuguang Sun, Jingmin Wang, Wenbin Shen
Summary: 22q13.3 deletion syndrome is a rare genetic disorder that can be associated with both protein-losing enteropathy and lymphedema. Research suggests that these two phenotypes may share a common genetic etiology.
Review
Pharmacology & Pharmacy
O. K. Bakkaloglu, I. Bavunoglu, S. Aslan, T. Eskazan, S. Celik, N. Kepil, I. Hatemi, Y. Erzin, A. F. Celik
Summary: This case report discusses a case of NSAID-enteropathy with a diaphragm-like disease that presented with Protein Losing Enteropathy (PLE) rather than obstruction. The hypoalbuminemia recovered immediately after resection of the obstructive segment, despite ongoing annular ulcerations in the early postoperative period. The possible role of a slow-onset obstructive pathology in the physiopathology of NSAID-induced and other PLE needs to be further elucidated.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Veterinary Sciences
Charles Jones, Sara A. Jablonski, Brian K. Petroff, Daniel K. Langlois
Summary: This study investigated the relationship between ionized magnesium levels and the development of secondary hyperparathyroidism (SHPT) in dogs with chronic gastrointestinal disease and abnormally low 25(OH)D. The results suggest that hypomagnesemia may contribute to alterations in ionized calcium and parathyroid hormone in dogs with chronic enteropathy and abnormally low 25(OH)D.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Veterinary Sciences
Sara A. Jablonski, Allison S. W. Mazepa, M. Katherine Tolbert
Summary: This study describes the use of octreotide in dogs with protein-losing enteropathy (PLE). The results showed that octreotide was well tolerated by most dogs and had some improvement in treatment.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Review
Agriculture, Dairy & Animal Science
Sara A. Jablonski
Summary: This review summarizes the current knowledge of the pathophysiology, diagnosis, and management of canine intestinal lymphangiectasia (IL). Despite being described over 50 years ago, IL in dogs remains poorly understood and challenging to manage. It can occur as a primary or secondary condition, with a genetic predisposition in certain breeds. Definitive diagnosis of canine IL is done via intestinal histopathology, although other diagnostic results can suggest its presence. Treatment strategies differ between humans and dogs, with corticosteroids and immunosuppressive therapies commonly used in dogs.
Article
Immunology
Sebastien Sanges, Nicolas Germain, Stephane Vignes, David Seguy, Sarah Stabler, Nicolas Etienne, Louis Terriou, David Launay, Eric Hachulla, Damien Huglo, Sylvain Dubucquoi, Myriam Labalette, Guillaume Lefevre
Summary: Protein-losing enteropathy (PLE) can occur during common variable immunodeficiency (CVID) and requires higher IgG replacement therapy dosage. PLE can also mimic CVID and is associated with milder immunological abnormalities, notably mildly decreased to normal serum IgA and switched memory B cell levels.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Editorial Material
Immunology
Rhituparna Das, Ritu Khetawat, P. P. Mansoor, Moumita Sengupta
Summary: Malabsorption is a significant disease burden, especially in tropical countries. Intestinal parasitic infections are a major cause of secondary malabsorption, leading to a wide range of symptoms. Diagnosis often requires endoscopic biopsy and histopathological examination to identify the underlying condition.
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2023)