Article
Microbiology
Angelica Perez-Rodriguez, Esperanza Duarte-Escalante, Maria Guadalupe Frias-De-Leon, Gustavo Acosta Altamirano, Beatriz Meraz-Rios, Erick Martinez-Herrera, Roberto Arenas, Maria del Rocio Reyes-Montes
Summary: This study aimed to identify dermatophyte isolates through phenotypic and genotypic methods and determine their phylogenetic relationships. The isolates were classified into different genera based on their morphological characteristics, and genotypic analysis revealed the most frequent species. The study demonstrated the usefulness of genotypic markers for phylogenetic analysis of dermatophytes.
Article
Medicine, General & Internal
Tamara Perez-Jeldres, Benjamin Pizarro, Gabriel Ascui, Matias Orellana, Mauricio Cerda-Villablanca, Danilo Alvares, Andres de la Vega, Macarena Cannistra, Barbara Cornejo, Pablo Baez, Veronica Silva, Elizabeth Arriagada, Jesus Rivera-Nieves, Ricardo Estela, Cristian Hernandez-Rocha, Manuel alvarez-Lobos, Felipe Tobar
Summary: Inflammatory bowel disease (IBD) is increasing worldwide, and there are clinical differences between Chilean and North American IBD patients, with Chilean patients being diagnosed at a later age and having a more limited disease extent.
Article
Mathematical & Computational Biology
Lacey-Anne Sanderson, Carolyn T. Caron, Reynold L. Tan, Kirstin E. Bett
Summary: Researchers are looking for cost-effective solutions to manage and analyze large-scale genotypic and phenotypic data, where open-source software and Tripal can fulfill this need. Tripal utilizes the GMOD Chado database schema in PostgreSQL for flexible storage and follows FAIR principles for data provision.
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
(2021)
Article
Multidisciplinary Sciences
Xin Kang, Virginia Yip, Stephen Matthews, Patrick C. M. Wong
Summary: This paper introduces the L3HK Repository, a database of spoken narratives in French, German, and Spanish from Cantonese-speaking young adults learning these languages as their third language. The database includes audio recordings, transcripts, and various demographic and experimental data. It is invaluable for studying interdisciplinary changes in foreign language learning.
Article
Gastroenterology & Hepatology
Ariel Jordan, Krystal Mills, Timothy Sobukonla, Sancia Bredy, Alexander Kelly, Michael Flood
Summary: This study found that rates of depression among minority patients with inflammatory bowel disease, predominantly African American, were higher than previously reported for all patients with inflammatory bowel disease. Over 40% experienced moderate to severe depression, and there was a low screening rate for depression.
COLORECTAL DISEASE
(2022)
Article
Pharmacology & Pharmacy
Melanie Fourgeaud, Louis Lebreton, Khaldia Belabbas, Mathilde Di Filippo, Vincent Rigalleau, Thierry Couffinhal, Yann Pucheu, Pascal Barat, Cecile Ged, Annie M. Berard
Summary: This study retrospectively analyzed 147 patients with clinical FH in France, and found that the diagnosis of monogenic FH in pediatric group could be optimized by screening their LDL-C levels and conducting reverse-cascade screening of relatives when the children serve as index cases.
JOURNAL OF CLINICAL LIPIDOLOGY
(2022)
Article
Biochemistry & Molecular Biology
T. Van-Anh Le, T. P. Mai Nga, P. Nhi Nguyen, T. Kieu-Oanh Nguyen
Summary: Golden Camellias are widely used in China and Vietnam for food, cosmetic, and traditional medicine purposes. To better understand the genetic diversity and relationship among six species of Golden Camellias, we conducted a study using three chloroplast DNA-barcodes and analyzed their anatomical characteristics and chemical profiles. The results showed significant differences in leaf characteristics and chemical compositions, suggesting the potential use of these criteria in taxonomy and chemotaxonomy of Golden Camellias.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Gastroenterology & Hepatology
Claire Dupont-Lucas, Ariane Leroyer, Delphine Ley, Claire Spyckerelle, Valerie Bertrand, Dominique Turck, Guillaume Savoye, Vincent Maunoury, Nathalie Guillon, Mathurin Fumery, Helene Sarter, Corinne Gower-Rousseau
Summary: This study demonstrates that patients with paediatric-onset inflammatory bowel disease have an increased risk of developing cancer and mortality in adulthood. Colorectal cancer poses the highest risk, which is associated with smoking, exposure to anti-tumour necrosis factor, and combination therapy. Additionally, extraintestinal manifestations are associated with mortality.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Plant Sciences
Ingrid E. Jordon-Thaden, Jonathan P. Spoelhof, Lyderson Facio Viccini, Joseph Combs, Francisco Gomez Jr, Imari Walker, Douglas E. Soltis, Pamela S. Soltis
Summary: A study on allopolyploids and their parental species in Tragopogon genus shows that allopolyploidy results in some phenotypic changes, such as larger physical traits and increased photosynthetic capacity. However, there is no significant reproductive advantage for polyploid species. Comparison between natural and synthetic allopolyploids revealed minimal differences in traits.
AMERICAN JOURNAL OF BOTANY
(2023)
Article
Endocrinology & Metabolism
Jing Hu, Xiaoyun Lin, Peng Gao, Qian Zhang, Bingna Zhou, Ou Wang, Yan Jiang, Weibo Xia, Xiaoping Xing, Mei Li
Summary: Mutations in the WNT1 gene can cause rare inherited disorders such as osteogenesis imperfecta (OI) and early-onset osteoporosis (EOOP), with biallelic nonsense or frameshift mutations leading to earlier occurrence of fragility fractures and more severe skeletal phenotypes. Rare comorbidities including cerebral abnormalities, hematologic diseases, and pituitary adenoma were identified in patients with WNT1 mutations.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Gastroenterology & Hepatology
Adam G. Clooney, Julia Eckenberger, Emilio Laserna-Mendieta, Kathryn A. Sexton, Matthew T. Bernstein, Kathy Vagianos, Michael Sargent, Feargal J. Ryan, Carthage Moran, Donal Sheehan, Roy D. Sleator, Laura E. Targownik, Charles N. Bernstein, Fergus Shanahan, Marcus J. Claesson
Summary: The study found reduced microbiota diversity and increased variability in patients with CD and UC compared to controls. Longitudinal analysis showed decreased temporal microbiota stability in IBD, especially in patients with changes in disease activity. Machine learning was able to separate disease from controls and active from inactive disease.
Review
Nutrition & Dietetics
Yolanda Ber, Santiago Garcia-Lopez, Carla J. Gargallo-Puyuelo, Fernando Gomollon
Summary: This article discusses the different functions of the small intestine and large intestine in nutrient absorption, as well as the causes, consequences, and management of malnutrition in patients with inflammatory bowel diseases, short bowel syndrome, and malignant and benign digestive tumors.
Article
Surgery
Lisa Corbiere, Alexandre Scanff, Veronique Desfourneaux, Aude Merdrignac, Anne Ingels, Ronan Thibault, Guillaume Bouguen, Damien Bergeat
Summary: This study evaluated the risks and complications of weight loss surgery in patients with chronic inflammatory bowel disease. The results showed that in patients with well-controlled disease, weight loss surgery did not increase mortality or morbidity rates, but patients with Crohn's disease had a higher risk of IBD-related complications after surgery.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Weam El Hajj, Anne Buisson, Alain Olympie, Marie Helene Ravel, Corinne Devos, Caroline Trang-Poisson, Gilles Macaigne, Stephane Nahon
Summary: Caregivers of patients with inflammatory bowel disease face various difficulties in their psychological, social, and professional lives. Adequate psychosocial interventions may help improve their quality of life. A survey conducted on caregivers of IBD patients found that the disease has a significant impact on different aspects of their lives, with parents experiencing higher psychological burden and partners facing challenges in leisure activities.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Dermatology
Khalaf Kridin, Ralf J. Ludwig
Summary: Isotretinoin does not increase the risk of Crohn's disease, but it may be associated with a slight and temporary increase in the risk of ulcerative colitis. However, it can lower the risk of irritable bowel syndrome.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Yoichi Kakuta, Tsuyoshi Shirai, Dermot P. B. Mcgovern, Jonathan Braun, Hiroshi Fujii, Atsushi Masamune
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Nghia H. Nguyen, Jiyu Luo, Paulina Paul, Jihoon Kim, Gaurav Syal, Christina Ha, Vivek Rudrapatna, Sunhee Park, Nimisha Parekh, Kai Zheng, Jenny S. Sauk, Berkeley Limketkai, Phillip Fleshner, Samuel Eisenstein, Sonia Ramamoorthy, Gil Melmed, Parambir S. Dulai, Brigid S. Boland, Uma Mahadevan, William J. Sandborn, Lucila Ohno-Machado, Dermot McGovern, Siddharth Singh
Summary: Hispanic patients with IBD who are treated with biologic therapy have a higher risk of hospitalization, surgery, and serious infections compared to non-Hispanic patients. Further research is needed to investigate the biological, social, and environmental factors underlying these differences.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Phillip Gu, Shishir Dube, Dermot P. B. McGovern
Summary: Alterations in mesenteric adipose tissue play a significant role in Crohn's disease, but their clinical significance is still unclear. Current studies have limitations, but they suggest that mesenteric adipose tissue may serve as a marker for disease severity, surgical risk, and postoperative outcomes. Additionally, it could be a potential target for mitigating postoperative recurrence of Crohn's disease.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Gastroenterology & Hepatology
Julia J. Liu, Bincy P. Abraham, Paula Adamson, Edward L. Barnes, Kelly A. Brister, Oriana M. Damas, Sarah C. Glover, Kimberly Hooks, Ana Ingram, Gilaad G. Kaplan, Edward V. Loftus, Dermot P. B. McGovern, Melodie Narain-Blackwell, Florence-Damilola Odufalu, Sandra Quezada, Vonda Reeves, Bo Shen, Thaddeus S. Stappenbeck, Latonia Ward
Summary: This comprehensive review examines the epidemiology, clinical presentations, disease phenotypes, treatment outcomes, social determinants of health, and genetic and environmental factors in the pathogenesis of IBD in Black and Hispanic patients in the United States. To improve health equity for underserved minorities with IBD, researchers identified priority areas for further investigation.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Amanda M. Johnson, Maria Barsky, Waseem Ahmed, Samantha Zullow, Jonathan Galati, Vipul Jairath, Neeraj Narula, Farhad Peerani, Benjamin H. Click, Elliot S. Coburn, ThucNhi Tran Dang, Stephanie Gold, Manasi Agrawal, Rajat Garg, Manik Aggarwal, Danah Mohammad, Brendan Halloran, Gursimran S. Kochhar, Hannah Todorowski, Nabeeha Mohy Ud Din, James Izanec, Amanda Teeple, Chris Gasink, Erik Muser, Zhijie Ding, Arun Swaminath, Komal Lakhani, Dan Hogan, Samit Datta, Ryan C. Ungaro, Brigid S. Boland, Matthew Bohm, Monika Fischer, Sashidhar Sagi, Anita Afzali, Thomas Ullman, Garrett Lawlor, Daniel C. Baumgart, Shannon Chang, David Hudesman, Dana Lukin, Ellen J. Scherl, Jean-Frederic Colombel, Bruce E. Sands, Corey A. Siegel, Miguel Regueiro, William J. Sandborn, David Bruining, Sunanda Kane, Edward V. Loftus, Parambir S. Dulai
Summary: This study evaluated the real-world effectiveness and safety of ustekinumab in patients with Crohn's disease. The results demonstrated that ustekinumab is a safe and effective treatment option for Crohn's disease, especially for biologic-naive patients.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Andres J. Yarur, Dermot McGovern, Maria T. Abreu, Adam Cheifetz, Konstantinos Papamichail, Parakkal Deepak, Alexandra Bruss, Poonam Beniwal-Patel, Marla Dubinsky, Stephan R. Targan, Gil Y. Melmed
Summary: This study assessed the relationship between 6-thioguanine nucleotide (6-TGN) levels and the use of oral methotrexate with the pharmacokinetics of biologics. The results showed that higher 6-TGN levels and the use of methotrexate improved the pharmacokinetics of infliximab but did not have the same effect on vedolizumab and ustekinumab. These findings have important implications for clinical treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Samuel Tanner, Jeffry Katz, Fabio Cominelli, Miguel Regueiro, Gregory Cooper, Emad Mansoor
Summary: This article examines the prevalence of inflammatory bowel disease in patients with gastritis, duodenitis, and peptic ulcer disease, taking into consideration the presence of Helicobacter pylori infection. It is found that inflammatory bowel disease is less common in patients with H. pylori, and there is no increased risk of developing IBD after undergoing H. pylori eradication therapy.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Medicine, Research & Experimental
Miguel Regueiro, Theresa Hunter, Rina Lukanova, Mingyang Shan, Rosie Wild, Hannah Knight, Priyanka Bannikoppa, April N. Naegeli
Summary: This study assessed the prevalence of fatigue and its association with disease activity and patient-reported outcomes among patients with ulcerative colitis (UC) or Crohn's disease (CD). The results showed that fatigue is a common symptom among patients with UC or CD and is associated with higher disease activity levels and decreased work productivity. Managing fatigue may require a multidisciplinary approach.
ADVANCES IN THERAPY
(2023)
Article
Gastroenterology & Hepatology
Yaara Zisman-Ilani, Kimberly D. Thompson, Lori S. Siegel, Todd Mackenzie, Damara J. Crate, Joshua R. Korzenik, Gil Y. Melmed, Patricia Kozuch, Bruce E. Sands, David T. Rubin, Miguel D. Regueiro, Raymond Cross, Douglas C. Wolf, John S. Hanson, Ronald M. Schwartz, Raluca Vrabie, Michael D. Kreines, Timothy Scherer, Marla C. Dubinsky, Corey A. Siegel
Summary: This study aimed to test the impact of shared decision making (SDM) on choice of therapy, decision quality, and provider trust in patients with Crohn's disease. The results showed that patients who received the SDM intervention more frequently chose combination therapy, had lower decisional conflict, and had greater trust in their provider.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Medicine, General & Internal
Rafael Luis Luporini, Pamela Cristina Bellaz Do Amaral Campos Silva, Miguel Regueiro
FRONTIERS IN MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Martin E. Baumdick, Annika Niehrs, Frauke Degenhardt, Maria Schwerk, Ole Hinrichs, Ana Jordan-Paiz, Benedetta Padoan, Lucy H. M. Wegner, Sebastian Schloer, Britta F. Zecher, Jakob Malsy, Vinita R. Joshi, Christin Illig, Jennifer Schroeder-Schwarz, Kimberly J. Moeller, Maureen P. Martin, Yuko Yuki, Mikki Ozawa, Juergen Sauter, Alexander H. Schmidt, Daniel Perez, Anastasios D. Giannou, Mary Carrington, Randall S. Davis, Udo Schumacher, Guido Sauter, Samuel Huber, Victor G. Puelles, Nathaniel Melling, Andre Franke, Marcus Altfeld, Madeleine J. Bunders
Summary: The study identified HLA-DP401 as a risk haplotype and HLA-DP301 as a protective haplotype for UC in European populations. Higher expression of HLA-DP was observed on IECs of individuals with UC compared to controls. Interaction between HLA-DP401 and NKp44 resulted in increased damage to intestinal epithelial cells, while blocking this interaction reduced NK cell-mediated destruction in UC.
Article
Gastroenterology & Hepatology
Jill K. J. Gaidos, Badr Al Bawardy, Francis A. Farraye, Miguel Regueiro
Summary: This study investigated the utilization rates of IBD endoscopic scoring systems in clinical practice and associated factors. The study found that the Mayo Endoscopic Subscore (MES) and the Rutgeerts Score were more commonly used, while endoscopic scores for Crohn's disease and pouchitis had lower rates of use. Regular attendance at IBD conferences, higher patient volumes, and incorporation of scoring systems into endoscopy software were associated with increased utilization of these scoring systems.
CROHNS & COLITIS 360
(2023)
Article
Multidisciplinary Sciences
Cantin Baron, Sarah Cherkaoui, Sandra Therrien-Laperriere, Yann Ilboudo, Raphael Poujol, Pamela Mehanna, Melanie E. Garrett, Marilyn J. Telen, Allison E. Ashley-Koch, Pablo Bartolucci, John D. Rioux, Guillaume Lettre, Christine Des Rosiers, Matthieu Ruiz, Julie G. Hussin
Summary: Metabolite genome-wide association studies (mGWAS) have contributed to our understanding of the genetic regulation of metabolite levels. However, interpreting these associations is still challenging due to the lack of tools for annotating gene-metabolite pairs. This study introduces the shortest reactional distance (SRD) metric, based on the comprehensive KEGG database, to improve the biological interpretation of mGWAS results.
Article
Genetics & Heredity
Michael H. Guo, Laurent C. Francioli, Sarah L. Stenton, Julia K. Goodrich, Nicholas A. Watts, Moriel Singer-Berk, Emily Groopman, Philip W. Darnowsky, Matthew Solomonson, Samantha Baxter, Grace Tiao, Benjamin M. Neale, Joel N. Hirschhorn, Heidi L. Rehm, Mark J. Daly, Anne O'Donnell-Luria, Konrad J. Karczewski, Daniel G. MacArthur, Kaitlin E. Samocha
Summary: This study developed a strategy to infer the phase for rare variant pairs within genes using genotypes observed in the Genome Aggregation Database. The approach showed high accuracy in determining phase in both trio data and patients with Mendelian conditions, providing a valuable resource for interpreting rare co-occurring variants in the context of recessive diseases.
Article
Genetics & Heredity
Courtney Astore, Shivam Sharma, Sini Nagpal, David J. Cutler, John D. Rioux, Judy H. Cho, Dermot P. B. Mcgovern, Steven R. Brant, Subra Kugathasan, I. King Jordan, Greg Gibson
Summary: This study found that rare variants associated with Crohn's disease in Europeans are even rarer in African Americans and mainly contribute to disease risk due to admixture. Additionally, the proportion of European ancestry is correlated with the number of rare CD European variants carried by each African American individual and their polygenic risk of disease.
