Article
Nutrition & Dietetics
Rakel Nurmi, Ilma Korponay-Szabo, Kaija Laurila, Heini Huhtala, Onni Niemela, Jukka Mustonen, Satu Makela, Katri Kaukinen, Katri Lindfors
Summary: IgA-tTG deposits were found in the kidney biopsies of IgAN patients with celiac disease and non-celiac IgAN patients consuming gluten, suggesting limited specificity to celiac disease.
Article
Cell Biology
Christian Buechold, Martin Hils, Uwe Gerlach, Johannes Weber, Christiane Pelzer, Andreas Heil, Daniel Aeschlimann, Ralf Pasternack
Summary: ZED1227 is a small molecule inhibitor designed for the treatment of celiac disease. It selectively binds to the active state of TG2, inhibiting its function. Celiac disease is an autoimmune condition triggered by dietary gluten, causing damage to the small intestine and the production of TG2 autoantibodies.
Article
Medical Laboratory Technology
Sara Aboulaghras, Daniela Piancatelli, Khadija Oumhani, Abdelaali Balahbib, Abdelhakim Bouyahya, Khalid Taghzouti
Summary: Celiac disease is a chronic inflammatory enteropathy caused by gluten, with genetic and environmental factors playing important roles in its development. Studying these factors can lead to a better understanding of the pathogenesis of the disease.
CLINICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Sebastian Stricker, Silvia Rudloff, Jan De Laffolie, Klaus-Peter Zimmer
Summary: The study investigated the localization of ERp57 and its regulation on TG2 and mTG in celiac disease (CD). The decreased presence of ERp57 in CD patients led to the oxidative inhibition of TG2 by PX12 and L-cystine, while mTG remained unaffected.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Helka Kaunisto, Teea Salmi, Katri Lindfors, Esko Kemppainen
Summary: Dermatitis herpetiformis is a skin manifestation of celiac disease characterized by blistering rash on specific body parts. The role of immunocomplexes in the pathogenesis of DH is still unknown. Although gluten intolerance develops similarly in both DH and celiac disease, their manifestations differ widely.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Peter H. R. Green, Shirley Paski, Cynthia W. Ko, Alberto Rubio-Tapia
Summary: This article summarizes the diagnosis and management of refractory celiac disease, providing guidance on evaluation, nutritional support, potential therapeutic options, and surveillance for complications. The article emphasizes the importance of regular follow-up and multidisciplinary care for patients with refractory celiac disease.
Article
Nutrition & Dietetics
Elisa Farina, Leda Roncoroni, Vincenza Lombardo, Alice Scricciolo, Maurizio Vecchi, Luisa Doneda, Luca Elli
Summary: This study evaluated the significance of tTGA in monitoring celiac disease patients and found that tTGA positivity did not have relevant clinical significance, with no association with autoimmune comorbidities or mucosal damage.
Article
Nutrition & Dietetics
Anna Rita Di Biase, Giovanni Marasco, Federico Ravaioli, Luigi Colecchia, Elton Dajti, Marco Lecis, Erica Passini, Luigina Vanessa Alemanni, Davide Festi, Lorenzo Iughetti, Antonio Colecchia
Summary: The study evaluated 410 pediatric CD patients and found that 11.2% were asymptomatic, while 88.2% were symptomatic, with over half having both gastrointestinal and atypical symptoms. The ESPGHAN non-biopsy criteria are accurate for CD diagnosis and allow half of unnecessary EGD procedures to be avoided.
Review
Gastroenterology & Hepatology
Giuseppe Losurdo, Milena Di Leo, Edoardo Santamato, Monica Arena, Maria Rendina, Carmelo Luigiano, Enzo Ierardi, Alfredo Di Leo
Summary: The European Society of Pediatric Gastroenterology, Hepatology, and Nutrition has approved new criteria for diagnosing celiac disease in children, allowing for biopsy avoidance in specific antibody value and positivity cases, while adults still require histological biopsy for diagnosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Pediatrics
Rishi Bolia, Nikhil Thapar
Summary: Celiac disease is a chronic immune-mediated enteropathy caused by the ingestion of gluten in genetically predisposed individuals. It has a wide range of clinical manifestations and can affect people of all ages. The diagnosis is based on clinical history, serologic testing and duodenal biopsies. The management involves lifelong complete dietary avoidance of gluten, and monitoring of IgA-TGA for mucosal healing.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Medicine, General & Internal
Detlef Schuppan, Markku Maki, Knut E. A. Lundin, Jorma Isola, Tina Friesing-Sosnik, Juha Taavela, Alina Popp, Jari Koskenpato, Jost Langhorst, Oistein Hovde, Marja-Leena Lahdeaho, Stefano Fusco, Michael Schumann, Helga P. Torok, Juozas Kupcinskas, Yurdagul Zopf, Ansgar W. Lohse, Mika Scheinin, Karin Kull, Luc Biedermann, Valerie Byrnes, Andreas Stallmach, Jorgen Jahnsen, Jonas Zeitz, Ralf Mohrbacher, Roland Greinwald
Summary: In this study, treatment with ZED1227, a selective oral transglutaminase 2 inhibitor, was found to attenuate gluten-induced duodenal mucosal damage in patients with celiac disease at all three dose levels, with the highest dose potentially improving symptoms and quality of life for patients. Common adverse events included headache, nausea, diarrhea, vomiting, abdominal pain, and rash in a small percentage of patients.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medical Laboratory Technology
Daan A. R. Castelijn, A. H. Leontine Mulder, Pieter van der Pol, Jolien C. Hollander, Tietie Kuiper, Caroline Bijnens, Jan Damoiseaux, Hetty J. Bontkes
Summary: This study compared the diagnostic performance of three tTG-IgA assay methods for the diagnosis of celiac disease. The results showed that the chemiluminescence immunoassays (CLIA) were more sensitive compared to the fluorescence enzyme-linked immunoassay (FEIA). Lowering the cut-off threshold of the FEIA improved its diagnostic accuracy in adult cases. There were also differences in tTG-IgA levels between different age groups of patients.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Adam Dios, Bharani Srinivasan, Judit Gyimesi, Katharina Werkstetter, Rudolf Valenta, Sibylle Koletzko, Ilma R. Korponay-Szabo
Summary: Celiac disease is an autoimmune disorder characterized by immune response and antibody production to gluten. TG2 plays a role in the pathomechanism of celiac disease. This study investigates early antibody responses to reveal the development of celiac disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Francesco Valitutti, Maureen M. Leonard, Victoria Kenyon, Monica Montuori, Pasqua Piemontese, Ruggiero Francavilla, Basilio Malamisura, Lorenzo Norsa, Angela Calvi, Maria Elena Lionetti, Mariella Baldassarre, Chiara Maria Trovato, Michela Perrone, Tiziana Passaro, Naire Sansotta, Marco Crocco, Annalisa Morelli, Lidia Celeste Raguseo, Federica Malerba, Luca Elli, Fernanda Cristofori, Carlo Catassi, Alessio Fasano, CD-GEMM Team
Summary: The purpose of this study was to identify potential serum biomarkers predicting the onset of celiac disease (CD) in at-risk children. The results showed that 73.6% of the children had an increase in anti-deamidated gliadin peptides (DGPs) IgG levels before their first seroconversion of anti-tissue transglutaminase (anti-tTG) IgA antibodies, indicating that anti-DGPs IgG may serve as an early preclinical biomarker predicting CD onset in children.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Melis G. Celdir, Claire L. Jansson-Knodell, Isabel A. Hujoel, Larry J. Prokop, Zhen Wang, M. Hassan Murad, Joseph A. Murray
Summary: This meta-analysis reveals that higher latitudes are associated with a greater prevalence of serology-based celiac disease.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Joseph A. Murray
Article
Gastroenterology & Hepatology
David Bergman, James King, Benjamin Lebwohl, Mark S. Clements, Bjorn Roelstraete, Gilaad G. Kaplan, Peter H. R. Green, Joseph A. Murray, Jonas F. Ludvigsson
Summary: The incidence of CD in Sweden peaked in 2002-2003 for females and in 2006 for males. Despite increasing duodenal/jejunal biopsies, the incidence of CD has declined, indicating that increased awareness and investigation are unlikely to elevate the disease incidence in Sweden. The lifetime risk of developing CD is relatively high in Sweden, with 1 in 44 females and 1 in 72 males expected to be diagnosed.
Article
Gastroenterology & Hepatology
Rok Seon Choung, Ayush Sharma, Victor G. Chedid, Imad Absah, Zongming Eric Chen, Joseph A. Murray
Summary: This study reports the use of topical budesonide as an alternative therapy for collagenous gastritis (CG). The results show that most patients with CG had a clinical and histologic response to topical budesonide treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Immunology
Julia Reinhardt, Virag Sharma, Antigoni Stavridou, Annett Lindner, Susanne Reinhardt, Andreas Petzold, Mathias Lesche, Fabian Rost, Ezio Bonifacio, Anne Eugster
Summary: In this study, resting and antigen-responsive T effector (Tconv) and Treg cells were distinguished using single-cell technologies. Machine learning was used to identify a minimal set of 27 genes that could accurately discriminate the four-cell populations. TRIM was identified as a novel marker to distinguish Treg cells.
Article
Endocrinology & Metabolism
Jessica Melin, Kristian F. Lynch, Markus Lundgren, Carin Andren Aronsson, Helena Elding Larsson, Suzanne Bennett Johnson
Summary: This study found that sociodemographic factors, parental characteristics, and study-related variables were all related to parent study satisfaction. The factors that can be modified are particularly important for improving parent study satisfaction.
BMC ENDOCRINE DISORDERS
(2022)
Article
Endocrinology & Metabolism
Marie-Luise Zielmann, Manja Jolink, Christiane Winkler, Anne Eugster, Denise Mueller, Marlon Scholz, Anette-G Ziegler, Ezio Bonifacio
Summary: Relatives of patients with type 1 diabetes who have risk genotypes are at very high risk for the development of autoimmunity against gastric and other organs.
PEDIATRIC DIABETES
(2022)
Article
Medicine, Research & Experimental
David B. Dunger, Sylvaine F. A. Bruggraber, Adrian P. Mander, M. Loredana Marcovecchio, Timothy Tree, Piotr Jaroslaw Chmura, Mikael Knip, Anke M. Schulte, Chantal Mathieu
Summary: The INNODIA consortium has established an infrastructure to evaluate clinical data and identify biomarkers for future clinical trials in newly diagnosed type 1 diabetes. They have developed a master protocol to improve phase 2 studies, including standardized assessment, collection of mechanistic data, and evaluation of combination therapies.
Letter
Medicine, General & Internal
Marian Rewers, Ezio Bonifacio, Dominik Ewald, Cristy Geno Rasmussen, Xiaofan Jia, Laura Pyle, Anette-Gabriele Ziegler
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Immunology
Anne Eugster, Denise Mueller, Anne Gompf, Susanne Reinhardt, Annett Lindner, Michelle Ashton, Nick Zimmermann, Stefan Beissert, Ezio Bonifacio, Claudia Guenther
Summary: This study analyzed the composition of dendritic cell subsets in patients with TREX1 deficiency and identified a novel myeloid dendritic cell subpopulation that is highly enriched in these patients and associated with upregulation of interferon pathway genes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Peter Achenbach, Markus Hippich, Jose Zapardiel-Gonzalo, Beate Karges, Reinhard W. Holl, Agnese Petrera, Ezio Bonifacio, Anette-G Ziegler
Summary: This study identified subgroups of young patients with diabetes using the multivariable classification and regression tree analysis method. These subgroups showed significant differences in clinical and biochemical characteristics and had potential pathogenetic and therapeutic relevance.
Article
Pediatrics
Owen Martyn Bendor-Samuel, Tabitha Wishlade, Louise Willis, Parvinder Aley, Edward Choi, Rachel Craik, Yama Mujadidi, Ginny Mounce, Fenella Roseman, Arancha De la Horra Gozalo, James Bland, Nazia Taj, Ian Smith, Anette-Gabriele Ziegler, Ezio Bonifacio, Christiane Winkler, Florian Haupt, John A. Todd, Laurent Servais, Matthew D. Snape, Manu Vatish
Summary: This study investigates the use of prospective consent in a research study on genetic risk for Type 1 Diabetes using newborn screening blood spots. The methodology serves as a model for future population-based genetic research.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Cell Biology
Yannick F. Fuchs, Jonathan Brunner, Marc Weigelt, Anja Schieferdecker, Robert Morgenstern, Andrea Sturm, Boris Winter, Helena Jambor, Friedrich Stolzel, Leo Ruhnke, Malte von Bonin, Elke Rucker-Braun, Falk Heidenreich, Anke Fuchs, Ezio Bonifacio, Martin Bornhauser, David M. Poitz, Heidi Altmann
BIOPRESERVATION AND BIOBANKING
(2023)
Correction
Endocrinology & Metabolism
Andreas Weiss, Jose Zapardiel-Gonzalo, Franziska Voss, Manja Jolink, Joanna Stock, Florian Haupt, Kerstin Kick, Tiziana Welzhofer, Anja Heublein, Christiane Winkler, Peter Achenbach, Anette-Gabriele Ziegler, Ezio Bonifacio
Review
Biophysics
Manisha Goel, Anne Eugster, Johannes Schetelig, Ezio Bonifacio, Martin Bornhaeuser, Cornelia S. Link-Rachner
Summary: Graft-versus-host disease (GvHD) is a common complication following allogeneic haematopoietic stem cell transplantation (allo-HSCT), in which T cells play a key role. Monitoring the changes in the T cell receptor (TCR) repertoire can provide insights into the dynamics of the T cell population and the underlying mechanisms of GvHD.
BONE MARROW TRANSPLANTATION
(2023)
Editorial Material
Gastroenterology & Hepatology
Joseph A. Murray