Article
Gastroenterology & Hepatology
Tarek Sawas, Shawn A. Zamani, Sarah Killcoyne, Andrew Dullea, Kenneth K. Wang, Prasad G. Iyer, Rebecca C. Fitzgerald, David A. Katzka
Summary: Existing Barrett's esophagus screening guidelines have limitations in detecting prevalent esophageal adenocarcinoma. An optimized approach is needed to identify individuals most suitable for esophageal adenocarcinoma screening, particularly one that does not rely on chronic reflux symptoms.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Abhiram Duvvuri, Madhav Desai, Sreekar Vennelaganti, April Higbee, Venkat Subhash Gorrepati, Chandra Dasari, Viveksandeep Thoguluva Chandrasekar, Prashanth Vennalaganti, Divyanshoo Kohli, Anjana Sathyamurthy, Tarun Rai, Prateek Sharma
Summary: In this pilot study, it was found that the novel esophageal capsule is not suitable for population screening of Barrett's esophagus. Further studies integrating artificial intelligence into improved quality novel esophageal capsule should be conducted for BE screening.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Sarmed S. Sami, James P. Moriarty, Jordan K. Rosedahl, Bijan J. Borah, David A. Katzka, Kenneth K. Wang, John B. Kisiel, Krish Ragunath, Joel H. Rubenstein, Prasad G. Iyer
Summary: In GERD-independent scenarios, most non-sEGD BE screening tests were cost-effective, with swallowable esophageal cell collection devices with biomarkers being the optimal choice. However, exhaled volatile organic compounds had the highest ICERs in all scenarios.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ahmed Sam Beydoun, Kaleigh A. Stabenau, Kenneth W. Altman, Nikki Johnston
Summary: Esophageal adenocarcinoma (EAC) is increasing rapidly and has a poor prognosis, often preceded by Barrett's esophagus (BE). This review provides an overview of BE, EAC, and the progression from BE to EAC. The definition, diagnosis, epidemiology, and risk factors for both conditions are discussed, with special attention given to areas of debate. The progression from BE to EAC is likely driven by inflammatory pathways, pepsin exposure, upregulation of growth factor pathways, and mitochondrial changes. Surveillance is conducted through serial endoscopic evaluation, with shorter intervals recommended for high-risk features.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Theresa H. Nguyen, Aaron P. Thrift, Massimo Rugge, Hashem B. El-Serag
Summary: This study examined the prevalence of Barrett's esophagus in a previously unscreened primary care population and evaluated the performance of various BE screening guidelines. The findings suggest that guidelines requiring GERD symptoms have low sensitivity, while those not requiring GERD have low specificity. The study proposes a screening guideline with better utilization of known risk factors.
GASTROINTESTINAL ENDOSCOPY
(2021)
Review
Biochemistry & Molecular Biology
Jan Bilski, Monika Pinkas, Dagmara Wojcik-Grzybek, Marcin Magierowski, Edyta Korbut, Agnieszka Mazur-Bialy, Gracjana Krzysiek-Maczka, Slawomir Kwiecien, Katarzyna Magierowska, Tomasz Brzozowski
Summary: Both obesity and esophageal adenocarcinoma (EAC) rates have seen a significant increase in recent years in the United States and Western Europe. Obesity plays a key role in the development of EAC, with increased body mass index correlating with higher risk. Pathologically altered visceral fat in obesity is believed to contribute to this process. Visceral obesity may promote EAC through direct effects on gastroesophageal reflux disease and Barrett's esophagus (BE), as well as through the release of pro-inflammatory adipokines and insulin resistance. Disrupted adipokine production, such as the imbalance of leptin and adiponectin, is implicated in the pathogenesis of BE and EAC. This review discusses the epidemiology, pathophysiology, and molecular alterations associated with obesity in BE and EAC, with a focus on the potential role of adipokines and myokines. The review also highlights the possible crosstalk of adipokines and myokines during exercise and suggests lifestyle interventions, specifically regular physical activity, as a promising strategy for preventing the development of BE and EAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Yongsheng Shi, Ningli Chai, Lisen Zhong, Longsong Li, Jiale Zou, Jingyuan Xiang, Xiangyao Wang, Enqiang Linghu
Summary: Esophageal granular cell tumors are rare tumors that are more common in men and predominantly located in the distal esophagus. Some patients with these tumors present with regurgitation and/or heartburn symptoms and are confirmed to have reflux esophagitis through endoscopy. Endoscopic resection is an effective method for diagnosis and treatment of esophageal GCTs.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Immunology
Ikenna C. Okereke, Aaron L. Miller, Daniel C. Jupiter, Catherine F. Hamilton, Gabriel L. Reep, Timothy Krill, Clark R. Andersen, Richard B. Pyles
Summary: The microbial community structures differ between patients with and without Barrett's esophagus, with certain organisms less likely to be detected as the severity of Barrett's esophagus worsens.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Chika Kusano, Rajvinder Singh, Yeong Yeh Lee, Yu Sen Alex Soh, Prateek Sharma, Khek-Yu Ho, Takuji Gotoda
Summary: Endoscopic diagnosis is crucial for early detection of esophageal adenocarcinoma and esophagogastric junction cancer. However, there are significant differences in diagnostic methods for Barrett's esophagus among international guidelines. Clarifying the location of the gastroesophageal junction is important for defining Barrett's esophagus, but it can be difficult due to air entry or reflux esophagitis. Non-targeted biopsies are commonly used to detect intestinal metaplasia, dysplasia, and cancer in Barrett's esophagus. Advanced imaging technologies and artificial intelligence have shown promising results in diagnosing Barrett's esophagus.
DIGESTIVE ENDOSCOPY
(2022)
Review
Gastroenterology & Hepatology
Gary E. Markey, Claire L. Donohoe, Eoin N. McNamee, Joanne C. Masterson
Summary: MicroRNAs (miRNAs) are small endogenous RNA molecules that regulate mRNA targets through RNA interference. They play a crucial role in physiological and pathological processes including cell proliferation, differentiation, apoptosis, and inflammation. This review discusses the potential of miRNAs in overall esophageal disease, focusing on eosinophilic esophagitis (EoE), gastroesophageal reflux disease (GERD), and the progression from Barrett's esophagus (BE) to esophageal adenocarcinoma (EAC). The dysregulation of miRNA expression in these diseases highlights their key role in disease progression and suggests their potential as diagnostic and prognostic biomarkers. Furthermore, targeting miRNAs could be a therapeutic option for esophageal disease.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Bashar J. Qumseya, Yazan Qumsiyeh, Sandeep A. Ponniah, David Estores, Dennis Yang, Crystal N. Johnson-Mann, Jeffrey Friedman, Alexander Ayzengart, Peter V. Draganov
Summary: After analyzing 10 studies, it was found that the prevalence of BE is high in patients undergoing EGD after SG, with no significant correlation with postoperative GERD symptoms. Most cases of BE were observed after 3 years.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Public, Environmental & Occupational Health
Xuening Zhang, Xiaorong Yang, Tongchao Zhang, Xiaolin Yin, Jinyu Man, Ming Lu
Summary: Educational attainment is related to the risk of esophageal cancer, Barrett's esophagus, and gastroesophageal reflux disease. Genetically predicted higher educational attainment has a protective effect on these diseases, partly mediated by reducing adiposity, smoking, and depression.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Gastroenterology & Hepatology
Majid Alsahafi, Hebah Mimish, Fatma Salem, Mohammed Hijazi, Emad Aljahdli, Hani Jawa, Salim Bazarah, Rana Bokhary, Yousef Qari, Mahmoud Mosli
Summary: BE was reported endoscopically in 0.64% and histologically confirmed in 0.32% of this cohort of Saudi patients. Male gender was the only factor associated with BE.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Yuto Shimamura, Haruhiro Inoue, Mayo Tanabe, Kei Ushikubo, Kazuki Yamamoto, Yoshiaki Kimoto, Yohei Nishikawa, Ryohei Ando, Kazuya Sumi, Marc Julius Navarro, Carlos Teruel Sanchez-Vegazo, Beatriz Penas, Sofia Parejo, Alba Martinez Sanchez, Enrique Vazquez-Sequeiros, Manabu Onimaru, Agustin Albillos, Enrique Rodriguez de Santiago
Summary: This study aimed to evaluate the feasibility, effectiveness, and safety of anti-reflux mucosal ablation (ARMA) in the treatment of gastroesophageal reflux disease (GERD). The results showed that ARMA is a feasible and safe procedure that effectively reduces GERD symptoms in the short term, with clinical success achieved in approximately two-thirds of patients. Both reflux hypersensitivity and confirmed GERD patients, regardless of their response to acid suppression medication, may be suitable candidates for ARMA treatment.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Elissa M. Ozanne, Elisabeth R. Silver, Sameer D. Saini, Joel H. Rubenstein, Iris Lansdorp-Vogelaar, Nicole Bowers, Sarah Xinhui Tan, John M. Inadomi, Chin Hur
Summary: Physicians' recommendations for BE surveillance cessation vary based on patient age, comorbidities, and BE length, with age showing the most significant variation in decisions. It appears that age and comorbidities influence BE surveillance cessation decisions, but with differences among clinicians. Clear guidelines balancing the risks and benefits of BE surveillance cessation are needed.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)