Article
Medicine, Research & Experimental
Wen-Ying Chang, Yi-Ting Yang, Meng-Ping She, Chia-Hung Tu, Tsung-Chun Lee, Ming-Shiang Wu, Chin-Hung Sun, Ling-Wei Hsin, Linda Chia-Hui Yu
Summary: Irritable bowel syndrome (IBS) is associated with abnormal serotonin metabolism and mucosal neurite outgrowth, and 5-HT7 receptor plays a role in the process. Increased mucosal density of 5-HT7-expressing nerve fibers and elevated levels of neurotrophins contribute to visceral hypersensitivity in IBS. A novel 5-HT7 antagonist may be used as an oral analgesic for IBS-related pain.
LABORATORY INVESTIGATION
(2022)
Article
Multidisciplinary Sciences
Jae Ho Park, Sun Hyung Kang, Ju Seok Kim, Hee Seok Moon, Jae Kyu Sung, Hyun Yong Jeong
Summary: Post-infectious irritable bowel syndrome (PI-IBS) occurs in approximately 10% of cases following gastroenteritis. The incidence of IBS is higher in females, but it is unclear whether this is due to biological or psychosocial factors. A study investigated the influence of gender roles on the incidence of PI-IBS and considered traditional risk factors. The study found that the KSRI-SF undifferentiated type and higher C-reactive protein (CRP) levels were associated with PI-IBS.
SCIENTIFIC REPORTS
(2023)
Review
Neurosciences
Enfu Tao, Zhenya Zhu, Chenmin Hu, Gao Long, Bo Chen, Rui Guo, Marong Fang, Mizu Jiang
Summary: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder, and the pathophysiology is still not clear. Early life stress (ELS) is a common risk factor for the development of IBS. Enterochromaffin cells (ECs) play a crucial role in intestinal function and can sense various stimuli and microbiota metabolites. Evidence suggests that an imbalance in ECs-5-HT signaling is involved in ELS-induced IBS.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Microbiology
Jingze Yang, Peng Wang, Tong Liu, Lin Lin, Lixiang Li, Guanjun Kou, Ruchen Zhou, Pan Li, Yanqing Li
Summary: This study found differences in the microbial composition of the caecum and descending colon in IBS-D patients, with increased numbers of EC cells and higher TPL1 expression levels compared to controls. The Ruminococcus torques group and Dorea appear to be promising targets for future research in treating IBS-D patients.
Article
Gastroenterology & Hepatology
Reiko Kyodo, Takahiro Kudo, Natsuki Ito, Kazuhide Tokita, Nobuyasu Arai, Masamichi Sato, Tamaki Ikuse, Keisuke Jimbo, Yoshikazu Ohtsuka, Toshiaki Shimizu
Summary: This study found that the combination of neonatal maternal separation and acute stress effectively induced increased 5-HT concentration or EC cell density via the 5-HT pathway in the proximal colon of adolescent rats.
Review
Biochemistry & Molecular Biology
Yoshiyuki Mishima, Shunji Ishihara
Summary: Irritable bowel syndrome (IBS) is a chronic functional disorder affecting the gastrointestinal tract, with the dysregulation of the brain-gut-microbiome (BGM) axis potentially playing a major role in its pathogenesis. Serotonin is a key neurotransmitter involved in IBS pathology, and genome studies have identified susceptible genes. Treatment strategies targeting 5-HT have shown effectiveness in certain IBS cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Peijun Tian, Huiyue Zhu, Renying Zou, Qinming Kong, Mengshu Xu, Jianxin Zhao, Hao Zhang, Wei Chen, Gang Wang
Summary: This study developed an in vitro screening method based on RIN14B to screen probiotics with antidepressant-like potential, identifying certain strains that can produce neurobehavioral effects by enhancing Tph1 expression.
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Article
Gastroenterology & Hepatology
Michael Camilleri, Guy Boeckxstaens
Summary: This article evaluates the evidence that targeted pathophysiological mechanisms and customized treatments can be an alternative approach to treating patients with irritable bowel syndrome (IBS). The authors conducted a literature review on the mechanisms and treatments of IBS, identifying various noninvasive clinical tests that can assess the underlying mechanisms responsible for symptom generation. These mechanisms include rectal evacuation disorders, abnormal transit, visceral hypersensitivity or hypervigilance, bile acid diarrhea, sugar intolerances, barrier dysfunction, the microbiome, immune activation, and chemicals released by these mechanisms. The authors also recognized the basic molecular mechanisms contributing to these pathophysiologies, offering opportunities for interventions with medications targeted at specific food components, receptors, and potentially the microbiome. Although the evidence supporting interventions for each mechanism varies, the current state-of-the-art allows for a shift from symptom-based treatment to individualized treatment guided by pathophysiology and clinically identified biomarkers.
Review
Immunology
Ying Gao, Peilun Ding, Junmin Wang, Caiyun Zhang, Guang Ji, Tao Wu
Summary: "Application of Metabolomics in Irritable Bowel Syndrome: A Review" provides an updated overview of metabolomics studies related to irritable bowel syndrome (IBS) in the past 5 years, including clinical studies, animal studies, and traditional Chinese medicine interventions. The review highlights the potential of metabolomics in the diagnosis and treatment of IBS, as well as the role of traditional Chinese medicine in improving IBS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Jayne E. Wiarda, Sage R. Becker, Sathesh K. Sivasankaran, Crystal L. Loving
Summary: Epithelial cell RNA expression in the small intestine of pigs was analyzed, revealing regional specialization and differences in localization and transcriptional profiles. Understanding the regional distribution and specialization of these cells is crucial for controlling appetite, stress, and nutrient uptake in swine.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Gastroenterology & Hepatology
Yoshitatsu Sei, Jianying Feng, Xilin Zhao, Pradeep Dagur, J. Philip McCoy, Juanita L. Merchant, Stephen A. Wank
Summary: Small intestinal neuroendocrine tumors, originating from putative enterochromaffin (EC) cells, are the most common malignancy in the small intestine. This study reveals that the tissue- and cell-specific properties of EC cells, including rapid cell turnover and homeostatic dedifferentiation, affect the fate and rate of tumorigenesis induced by genetic alterations. These findings provide important insights into the tumorigenesis of EC cell-derived tumors.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
A. Das, E. O'Herlihy, F. Shanahan, P. W. O'Toole, I. B. Jeffery
Summary: Alterations in the gut mycobiome were found to be significantly different between patients with Irritable Bowel Syndrome (IBS) and control subjects, but not among clinical subtypes of IBS. The mycobiome changes were significantly associated with alterations in the bacteriome and metabolome, but did not show a link with dietary habits. Despite co-variation with bacterial components, the mycobiome presents limited therapeutic and diagnostic potential for IBS.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Aleksandra Grozic, Keaton Coker, Christopher M. Dussik, Marya S. Sabir, Zhela Sabir, Arianna Bradley, Lin Zhang, Jin Park, Steven Yale, Ichiro Kaneko, Maryam Hockley, Lucinda A. Harris, Tisha N. Lunsford, Todd R. Sandrin, Peter W. Jurutka
Summary: This study aimed to identify potential biomarkers and unique gene expression patterns that define the pathological state of irritable bowel syndrome (IBS). Gene expression profiling of colonic tissue samples from 29 participants, including IBS patients and healthy controls, revealed 858 differentially expressed genes potentially characteristic of IBS. After screening and analysis, seven putative IBS biomarkers, including genes involved in serotonin metabolism, were identified.
Article
Pharmacology & Pharmacy
Lijuan Yu, Chunhua Huang, Wei Yang, Zhenxing Ren, Lifeng Li, Huiyuan Cheng, Chengyuan Lin, Lixiang Zhai, Ziwan Ning, Hoileong Xavier Wong, Quanbin Han, Wei Jia, Zhaoxiang Bian, Ling Zhao
Summary: This study evaluated the effect of cinnamon extract on bowel symptoms in rat models of irritable bowel syndrome with diarrhea (IBS-D). It found that cinnamon extract reduced defecation frequency and visceral hyperalgesia in the rat models, and the efficacy was comparable to a positive drug. Furthermore, cinnamon extract directly inhibited the expression of Tph1 and controlled serotonin synthesis, providing a scientific viewpoint for the traditional use of cinnamon in treating IBS.
FRONTIERS IN PHARMACOLOGY
(2023)