Article
Infectious Diseases
Candace C. Fuller, Austin Cosgrove, Kenneth Sands, Karla M. Miller, Russell E. Poland, Edward Rosen, Alfred Sorbello, Henry Francis, Robert Orr, Sarah K. Dutcher, Gregory T. Measer, Noelle M. Cocoros
Summary: This study analyzed the relationship between treatment timing during hospitalization and influenza severity, revealing that patients who were treated later or not treated at all tended to have more comorbidities and higher rates of mortality and need for intensive care.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2022)
Review
Biotechnology & Applied Microbiology
Rodney Stuart Daniels, John William McCauley
Summary: The availability of Next Generation Sequencing has played a crucial role in tracking the evolution of SARS-CoV-2 during the COVID-19 pandemic. Existing influenza surveillance networks, such as GISRS and OFFLU, have greatly facilitated the response to the pandemic. While human seasonal influenza circulation decreased due to COVID-19 measures, highly pathogenic avian influenza subtype H5N1 continued to spread in the animal sector, posing a potential risk for future pandemics. It is important to maintain and improve influenza surveillance in both human and animal sectors to be prepared for the next influenza pandemic.
JOURNAL OF GENERAL VIROLOGY
(2023)
Article
Immunology
Tor Kristian Andersen, Johanna Bodin, Fredrik Oftung, Bjarne Bogen, Siri Mjaaland, Gunnveig Grodeland
Summary: The 2009 swine flu pandemic exposed the limitations of egg-based vaccines in terms of global supply, prompting the urgent need for efficient new vaccine platforms; DNA vaccines have since been developed as a temperature stable, cost-effective option for pandemic responses, capable of inducing rapid protective immune responses without the need for adjuvants.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Biotechnology & Applied Microbiology
Robert A. Johnson, Richard C. White, Gary L. Disbrow
Summary: The COVID-19 pandemic has disrupted medical research and innovation, but also accelerated the development of countermeasures. Lessons learned from this experience include the need for sustainable funding, equitable access to medical countermeasures, and better preparation for future outbreaks.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Walter N. Harrington, Christina M. Kackos, Richard J. Webby
Summary: The long history of preparing for and fighting influenza pandemics can inform the response to novel coronaviruses like SARS-Cov-2. Global influenza surveillance networks and detailed risk assessment tools have proven successful in containing outbreaks, such as the H7N9 influenza in 2013, and could serve as models for managing coronaviruses with pandemic potential. Containment efforts must continually adapt and incorporate new research and information gathered from global crises.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Jeremy C. Jones, Hui-Ling Yen, Peter Adams, Kimberly Armstrong, Elena A. Govorkova
Summary: Effective antivirals play a crucial role in the early phase of an influenza pandemic, before vaccines are available. Currently, two classes of antiviral drugs are approved for influenza treatment, but resistance has been observed. Therefore, it is important to develop novel antiviral options that target both the virus and the host. This review explores the drawbacks of current antivirals and ongoing research on new agents or combination therapies to address these limitations.
ANTIVIRAL RESEARCH
(2023)
Editorial Material
Multidisciplinary Sciences
Richard Hodson
Summary: Researchers provide clear guidelines on what countries should do to prevent another disease outbreak with pandemic potential.
Article
Multidisciplinary Sciences
Zubair Akhtar, Fahmida Chowdhury, Mahmudur Rahman, Probir Kumar Ghosh, Md. Kaousar Ahmmed, Md Ariful Islam, Joshua A. Mott, William Davis
Summary: Limited data from several countries indicated reduced seasonal influenza circulation during the COVID-19 pandemic in 2020. A study in Bangladesh found that the 2020 influenza season started later, was shorter, and less intense than previous seasons, likely due to community mitigation measures implemented to control the pandemic. These findings contribute to the growing evidence that influenza seasons were altered globally in 2020.
Article
Immunology
Norman W. W. Baylor, Jesse L. L. Goodman
Summary: The response to SARS-CoV-2 demonstrated the potential of vaccine research and development, but there is still room for improvement in combating pandemics. This review focuses on enhancing research and evaluation processes and emphasizes the importance of moving vaccine development and evaluation to the pre-pandemic period.
Review
Immunology
Steven Rockman, Beverly Taylor, John W. McCauley, Ian G. Barr, Ray Longstaff, Ranbir Bahra
Summary: The COVID-19 pandemic has led to rapid investigation and deployment of vaccine platforms never used before. Both new and existing vaccine platforms are likely to play a crucial role in combating future pandemics, especially influenza. The field of influenza vaccine manufacturing has a long history of successes and advancements in the past decade.
Article
Infectious Diseases
Francisco Averhoff, Michael Berg, Mary Rodgers, Saladin Osmanov, Xinxin Luo, Mark Anderson, Todd Meyer, Alan Landay, Amiran Gamkrelidze, Esper G. Kallas, Karl Ciuoderis, Juan Pablo Hernandez, Jean Hugues Henry, Jorge Osorio, John Lindo, Johnson Deshommes, Joshua Anzinger, Justen Manasa, Maia Alkashvili, Mboup Souleyman, Pontiano Kaleebu, Rodrigo Correa-Oliveira, Sunil Solomon, Tulio de Olivera, Yupin Suputtamongkol, Gavin Cloherty
Summary: Detection and epidemiologic characterization of infectious disease outbreaks are crucial for early identification and response to potential pandemics. The Abbott Pandemic Defense Coalition (APDC) is a global partnership focused on early detection and mitigation of infectious disease threats.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Livia V. Patrono, Bram Vrancken, Matthias Budt, Ariane Duex, Sebastian Lequime, Sengul Boral, M. Thomas P. Gilbert, Jan F. Gogarten, Luisa Hoffmann, David Horst, Kevin Merkel, David Morens, Baptiste Prepoint, Jasmin Schlotterbeck, Verena J. Schuenemann, Marc A. Suchard, Jeffery K. Taubenberger, Luisa Tenkhoff, Christian Urban, Navena Widulin, Eduard Winter, Michael Worobey, Thomas Schnalke, Thorsten Wolff, Philippe Lemey, Sebastien Calvignac-Spencer
Summary: The 1918 influenza pandemic had a significant impact on the genomic make-up of subsequent human influenza A viruses, and the analysis of 1918 IAV genomes revealed diversity consistent with local transmission and long-distance dispersal. Variations in the nucleoprotein gene were found before and during the pandemic peak, suggesting possible adaptation of the 1918 IAV to humans. This study provides valuable insights into the origin and evolution of the 1918 influenza pandemic.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Perrine Marcenac, Margaret McCarron, William Davis, Ledor S. Igboh, Joshua A. Mott, Kathryn E. Lafond, Weigong Zhou, Marjorie Sorrells, Myrna D. Charles, Philip Gould, Carmen Sofia Arriola, Vic Veguilla, Erica Guthrie, Vivien G. Dugan, Rebecca Kondor, Eric Gogstad, Timothy M. Uyeki, Sonja J. Olsen, Gideon O. Emukule, Siddhartha Saha, Carolyn Greene, Joseph S. Bresee, John Barnes, David E. Wentworth, Alicia M. Fry, Daniel B. Jernigan, Eduardo Azziz-Baumgartner
Summary: Countries utilized existing surveillance systems and resources to track, study, and respond to SARS-CoV-2 infections during the COVID-19 pandemic, highlighting the importance of incorporating COVID-19 surveillance into global respiratory virus monitoring.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Business, Finance
Wenxuan Hou, Mao Li, Brian G. M. Main, Xiaofan Liu
Summary: This study examines the impact of the 1918 influenza pandemic on present-day financial development. The findings suggest that regions with higher historical death rates are associated with lower levels of trust, leading to financial obstacles for firms and decreased use of credit cards and mortgages by households.
JOURNAL OF CORPORATE FINANCE
(2023)
Review
Immunology
Celine H. Lemoine, Reviany V. Nidom, Roland Ventura, Setyarina Indrasari, Irine Normalina, Kuncoro Puguh Santoso, Francis Derouet, Christophe Barnier-Quer, Gerrit Borchard, Nicolas Collin, Chairul A. Nidom
Summary: Adequate global vaccine coverage is crucial during an influenza pandemic to mitigate morbidity, mortality, and economic impact. Adjuvant technologies can help increase vaccine doses, extend protection, and potentially enable single-dose vaccination. International cooperation is necessary to meet global vaccine demand.
