Review
Oncology
Johanna C. Maedge, Andreas Stallmach, Lisa Kleebusch, Peter Schlattmann
Summary: Aspirin can improve the survival of patients with colorectal cancer, and PIK3CA mutation and high expression of PTGS2 are associated with longer survival.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Review
Medicine, General & Internal
Mirza Balaj, Hunter Wade York, Kam Sripada, Elodie Besnier, Hanne Dahl Vonen, Aleksandr Aravkin, Joseph Friedman, Max Griswold, Magnus Rom Jensen, Talal Mohammad, Erin C. Mullany, Solvor Solhaug, Reed Sorensen, Donata Stonkute, Andreas Tallaksen, Joanna Whisnant, Peng Zheng, Emmanuela Gakidou, Terje Andreas Eikemo
Summary: The study found that higher levels of maternal and paternal education are associated with reduced under-5 mortality, with a dose-response relationship. Maternal education was a stronger predictor of child survival, and even a single additional year of schooling showed significant reductions in child mortality.
Review
Medicine, General & Internal
Danny Conde Monroy, Milciades Ibanez-Pinilla, Juan Carlos Sabogal, Carlos Rey Chaves, Andres Isaza-Restrepo, Felipe Giron, Marco Vanegas, Rafael Ibanez-Villalba, Lutz Mirow, Timo Siepmann
Summary: This systematic review and meta-analysis evaluated the survival outcomes and predictors of hepatectomy for gastric cancer liver metastasis (GCLM). The results showed that hepatectomy resulted in favorable overall survival rates at one, three, and five years post-surgery. Factors such as metachronous presentation, small tumoral size, R0 resection, and solitary lesions were associated with higher overall survival. Metachronous presentation, smaller primary tumoral size, and solitary metastasis were also linked to longer disease-free survival.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Marina Junqueira Clemente, Anderson Sousa Martins Silva, Maria Olivia Pozzolo Pedro, Henrique Soares Paiva, Cintia de Azevedo Marques Perico, Julio Torales, Antonio Ventriglio, Joao Mauricio Castaldelli-Maia
Summary: There is a relative lack of research on Obsessive-Compulsive Personality Disorder (OCPD), despite being recognized for over 100 years. This study aimed to review the global prevalence of OCPD in different populations. The findings show a high prevalence rate of OCPD, particularly among psychiatric and clinical patients. The prevalence rates have remained stable worldwide in the past 28 years. Age might be a factor in the decrease of OCPD prevalence rates. Further investigation should be conducted using updated classification systems.
Review
Oncology
Elycia Kazemian, Mark Solinski, William Adams, Mary Moore, Eric J. Thorpe
Summary: This study conducted a systematic review and meta-analysis to investigate the relationship between perineural invasion and survival outcomes in primary parotid malignancies. The results showed that perineural invasion is associated with poor survival outcomes in patients with parotid malignancies.
Review
Oncology
Wen-Li Lin, Thi-Hoang-Yen Nguyen, Cheng-Yao Lin, Li-Min Wu, Wen-Tsung Huang, How-Ran Guo
Summary: This study evaluates the association between sarcopenia and survival among patients with gynecologic cancer by aggregating multiple studies. The results suggest that patients with sarcopenia have worse overall survival (OS) and progression-free survival (PFS) compared to patients without sarcopenia. Quality of studies was good, and no publication bias was detected.
FRONTIERS IN ONCOLOGY
(2023)
Review
Multidisciplinary Sciences
Viraraghavan Vadakkencherry Ramaswamy, Thangaraj Abiramalatha, Tapas Bandyopadhyay, Nasreen Banu Shaik, Prathik Bandiya, Debasish Nanda, Abdul Kareem S. Pullattayil, Srinivas Murki, Charles Christoph Roehr
Summary: This study aimed to evaluate the survival and morbidity of extremely low birth weight (ELBW) and extremely low gestational age neonates (ELGANs) in low- and middle-income countries. A total of 22,278 ELBW and 18,338 ELGANs were included in 192 studies. The study found varying survival rates for ELBW and ELGANs in different income countries, with higher morbidity rates compared to developed nations.
Article
Critical Care Medicine
Christopher Jer Wei Low, Kollengode Ramanathan, Ryan Ruiyang Ling, Maxz Jian Chen Ho, Ying Chen, Roberto Lorusso, Graeme Maclaren, Kiran Shekar, Daniel Brodie
Summary: This study found that, compared with conventional cardiopulmonary resuscitation, extracorporeal cardiopulmonary resuscitation reduced in-hospital mortality, improved long-term neurological outcomes, and increased post-arrest survival, particularly in patients with in-hospital cardiac arrest.
LANCET RESPIRATORY MEDICINE
(2023)
Review
Oncology
Stephanie Franco, Xue Geng, Valeriy Korostyshevskiy, Judith E. Karp, Catherine Lai
Summary: Acute myeloid leukemia (AML) is an oncologic emergency that typically requires immediate chemotherapy. However, with the introduction of targeted therapies, there may be a benefit in delaying treatment to identify actionable therapeutic targets. Unfortunately, cytogenetic/molecular testing can take more than 7 days to return, and the prognostic impact of time from diagnosis to treatment (TDT) in AML is not clear.
Review
Endocrinology & Metabolism
Alessandro Uleri, Michael Baboudjian, Alessandro Tedde, Pawel Rajwa, Benjamin Pradere, Andrea Gallioli, Alberto Breda, Guillaume Ploussard
Summary: This study found no association between the use of beta-blockers and overall survival or prostate cancer mortality, providing important data for clinical care and patient counseling.
Review
Hematology
Paula Cristina Galati, Carolina Martins Ribeiro, Louise Tavares Garcia Pereira, Angelica Amorim Amato
Summary: Obesity affects the prognosis of pediatric acute leukemia, with overweight/obese children having poorer event-free survival following treatment for acute lymphoblastic leukemia.
Review
Cell Biology
Sabine Kuznia, Anna Zhu, Taisuke Akutsu, Julie E. Buring, Carlos A. Camargo Jr, Nancy R. Cook, Li-Ju Chen, Ting-Yuan David Cheng, Sari Hantunen, I. -Min Lee, JoAnn E. Manson, Rachel E. Neale, Robert Scragg, Aladdin H. Shadyab, Sha Sha, John Sluyter, Tomi-Pekka Tuomainen, Mitsuyoshi Urashima, Jyrki K. Virtanen, Ari Voutilainen, Jean Wactawski-Wende, Mary Waterhouse, Hermann Brenner, Ben Schoettker
Summary: A systematic review and meta-analysis of randomized, placebo-controlled trials (RCTs) and individual patient data (IPD) was conducted to evaluate the effect of vitamin D3 supplementation on cancer mortality in the general population and on prognosis in cancer patients. The main meta-analysis of the 14 RCTs showed a non-significant reduction in cancer mortality by 6%. Subgroup analyses revealed a significant reduction in cancer mortality in trials with daily dosing, while no reduction was seen in trials using a bolus regimen. The IPD meta-analysis confirmed the findings of all trials.
AGEING RESEARCH REVIEWS
(2023)
Editorial Material
Psychology, Biological
Brittany Davidson, David A. Ellis, Clemens Stachl, Paul J. Taylor, Adam N. Joinson
Summary: Psychology's focus on confirmatory analyses without clear and accurate definitions of constructs worsens the generalizability crisis. However, new technologies offer opportunities to enhance conceptualizations, theories, and measurement practices.
BEHAVIORAL AND BRAIN SCIENCES
(2022)
Review
Pharmacology & Pharmacy
H. -Y. Xu, W. -D. Chen, C. -Y. Chen, Y. -F. Chen
Summary: This review examined the impact of previous extrapulmonary malignancies on the overall survival (OS) of lung cancer patients. Nine retrospective studies were eligible for analysis, including a total of 267,892 lung cancer patients with prior extrapulmonary malignancy. The meta-analysis showed that a history of prior extrapulmonary malignancy results in poor OS in patients with lung cancer.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Rehabilitation
Megan G. Weishaar, Jaclyn A. Stephens, Bradley T. Conner
Summary: This study aimed to investigate the associations between personality dimensions and sports-related concussion outcomes. The results showed that extraversion and experience seeking were positively associated with both outcomes, while motor inhibition was negatively associated with both outcomes. Other personality dimensions showed differential relations with each outcome.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2022)
Article
Family Studies
Kateryna Savelieva, Markus Jokela, Anna Rotkirch
Summary: This study examined the reasons for postponing childbearing during fertility decline in Finland in the 2010s and found that uncertain life situation and lifestyle preferences independently influence childbearing decisions regardless of sociodemographic characteristics.
MARRIAGE AND FAMILY REVIEW
(2023)
Article
Clinical Neurology
Tea Teras, Suvi Rovio, Jaana Pentti, Jenny Head, Mika Kivimaki, Sari Stenholm
Summary: Increasing and decreasing sleep difficulties may be associated with accelerated decline in cognitive function during retirement transition and post-retirement.
Editorial Material
Medicine, General & Internal
Severine Sabia, Archana Singh-Manoux
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Geriatrics & Gerontology
Benjamin Landre, Celine Ben Hassen, Mika Kivimaki, Mikaela Bloomberg, Aline Dugravot, Alexis Schniztler, Severine Sabia, Archana Singh-Manoux
Summary: This study examined changes in physical and mental functioning before the onset of frailty using repeat data spanning 25 years. The results showed that differences in trajectories of physical and mental functioning were observable 25 years before the onset of frailty. Furthermore, lower physical and mental functioning scores at age 50 were associated with an increased risk of developing frailty at older ages.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Geriatrics & Gerontology
Mikaela Bloomberg, Aline Dugravot, Andrew Sommerlad, Mika Kivimaki, Archana Singh-Manoux, Severine Sabia
Summary: Education plays a crucial role in explaining sex differences in cognitive function, with middle-income countries showing larger disadvantages for females compared to the United States.
Article
Cardiac & Cardiovascular Systems
Pyry N. Sipila, Joni V. Lindbohm, G. David Batty, Nelli Heikkila, Jussi Vahtera, Sakari Suominen, Ari Vaananen, Aki Koskinen, Solja T. Nyberg, Seppo Meri, Jaana Pentti, Charlotte Warren-Gash, Andrew C. Hayward, Mika Kivimaki
Summary: This study found that severe infections are associated with an increased risk of major cardiovascular events, with the highest risk occurring in the first month after infection. The association remained elevated throughout the follow-up period. There is a small excess risk of long-term cardiovascular disease associated with severe infections.
Article
Clinical Neurology
Veera K. Malkki, Tom H. Rosenstrom, Markus M. Jokela, Suoma E. Saarni
Summary: This study examined the impact of depression symptoms on functioning improvement during psychotherapy. The findings showed that changes in depressed mood or hopelessness, sleep problems, fatigue, and lack of interest or pleasure were associated with improved functioning during psychotherapy, while baseline measures of depression symptoms were not related to changes in functioning.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Markus Jokela, Michael Laakasuo
Summary: The purpose of this study was to examine the changes in trajectories of health and health behaviors for individuals who first reported active religious attendance but then stopped attending religious activities. The study found that there were no negative changes in the 10-year trajectories of health or health behaviors after the change from active to inactive religious attendance. Instead, the adverse trends were already observed during the period of active religious attendance. These findings suggest that religious disengagement is a correlate, rather than a cause, of poorer health and health behaviors.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Clinical Neurology
Melina Regy, Aline Dugravot, Severine Sabia, Elodie Bouaziz-Amar, Claire Paquet, Bernard Hanseeuw, Archana Singh-Manoux, Julien Dumurgier
Summary: This study found that ATN profiles are associated with mortality, with patients showing isolated evidence of neurodegeneration having a higher short-term mortality rate, and AD patients having the highest long-term mortality rate.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Psychiatry
Philipp Frank, G. David Batty, Jaana Pentti, Markus Jokela, Lydia Poole, Jenni Ervasti, Jussi Vahtera, Glyn Lewis, Andrew Steptoe, Mika Kivimaeki
Summary: Depression is associated with an increased risk of physical illness and the most common causes of hospitalization among people with depression are endocrine, musculoskeletal, and vascular diseases, rather than psychiatric disorders.
Review
Medicine, General & Internal
G. David Batty, Philipp Frank, Urho M. Kujala, Seppo J. Sarna, Jaakko Kaprio
Summary: This study quantified the occurrence of depression and suicide in retired athletes compared to the general population. The results showed that former boxers, Olympic-style wrestlers, and soccer players did not have statistically higher rates of major depressive disorder or suicide. Retired soccer players had a lower rate of depression and former American football players had a lower risk of suicide compared to the control groups.
Letter
Cardiac & Cardiovascular Systems
Pyry N. Sipila, Mika Kivimaki
Review
Psychiatry
Markus Jokela, Michael Laakasuo
Summary: Obesity is associated with increased risk of depression. Mendelian randomization studies suggest that obesity is a causal risk factor for depression. However, other quasi-experimental methods are needed to confirm these findings.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Review
Medicine, General & Internal
G. David Batty, Philipp Frank, Urho M. Kujala, Seppo J. Sarna, Carlos A. Valencia-Hernandez, Jaakko Kaprio
Summary: This study found that retired amateur athletes have a higher risk of dementia compared to the general population, with professional boxers having the highest risk. Retired wrestlers and soccer players also have an increased risk, although lower in magnitude. Furthermore, professional American football players may have a higher risk compared to amateurs.
Article
Cell Biology
Andrew Sommerlad, Mika Kivimaki, Eric B. Larson, Susanne Roehr, Kokoro Shirai, Archana Singh-Manoux, Gill Livingston
Summary: The increasing number of people with dementia globally highlights the urgent need to reduce its scale and impact. Lifetime social participation may play a crucial role in reducing dementia risk and could have implications for individual behavior and public health policy. However, more research is needed to fully understand the causal relationship.
