Article
Multidisciplinary Sciences
Samit Ghosal, Debasis Datta, Binayak Sinha
Summary: GLP1-RA treatment shows significant improvement in liver function, weight reduction, decrease in liver fat content, better glycemic control, and reduction in hepatic inflammation for patients with both T2D and NAFLD.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Xiongfeng Pan, Atipatsa C. Kaminga, Shi Wu Wen, Aizhong Liu
Summary: This meta-analysis summarized the results of previous studies on the association between the chemokines system and T2DM/PDM. The findings revealed that concentrations of certain chemokines were significantly higher in T2DM patients compared to controls, while no difference was found in PDM patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Environmental Sciences
Jielin Zhou, Yan Lin, Yong Liu, Keyang Chen
Summary: The study revealed a link between antibiotic exposure and an increased risk of type 2 diabetes mellitus, especially in individuals over the age of 50. This suggests that caution should be exercised by physicians when prescribing antibiotics to potentially reduce the risk of T2DM.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Athanasia Athanasaki, Konstantinos Melanis, Ioanna Tsantzali, Maria Ioanna Stefanou, Sofia Ntymenou, Sotirios G. Paraskevas, Theodosis Kalamatianos, Eleni Boutati, Vaia Lambadiari, Konstantinos Voumvourakis, George Stranjalis, Sotirios Giannopoulos, Georgios Tsivgoulis, George P. Paraskevas
Summary: Alzheimer's disease is the most common type of dementia and is closely linked to type 2 diabetes mellitus through various molecular pathways.
Article
Medicine, General & Internal
Milad Nazarzadeh, Zeinab Bidel, Dexter Canoy, Emma Copland, Malgorzata Wamil, Jeannette Majert, Karl Smith Byrne, Johan Sundstrom, Koon Teo, Barry R. Davis, John Chalmers, Carl J. Pepine, Abbas Dehghan, Derrick A. Bennett, George Davey Smith, Kazem Rahimi
Summary: Lowering blood pressure is an effective strategy for preventing new-onset type 2 diabetes. Different classes of antihypertensive drugs have varying effects on diabetes, with ACE inhibitors and ARBs showing the most favorable outcomes. Selective use of antihypertensive drugs can help prevent diabetes.
Review
Clinical Neurology
Yuqing Wang, Debiao Liu, Xuezhi Li, Yan Liu, Yili Wu
Summary: This study suggests that the use of antidepressants may be a risk factor for the new onset of T2DM, particularly tricyclic antidepressants. The risk of T2DM increases in a linear trend with the duration of antidepressant use. Routine T2DM screening is recommended for antidepressant users.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Endocrinology & Metabolism
Yuting Gao, Tianyi Zhao, Shuoning Song, Yanbei Duo, Junxiang Gao, Tao Yuan, Weigang Zhao
Summary: This meta-analysis found that lean nonalcoholic fatty liver disease (NAFLD) individuals have a higher risk of developing type 2 diabetes mellitus (T2DM), and this risk is associated with the severity of NAFLD.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Review
Nutrition & Dietetics
Nerea Becerra-Tomas, Indira Paz-Graniel, Pablo Hernandez-Alonso, David J. A. Jenkins, Cyril W. C. Kendall, John L. Sievenpiper, Jordi Salas-Salvado
Summary: This meta-analysis did not find an association between total nut, peanut, or tree nut consumption and type 2 diabetes. However, peanut butter consumption may be inversely associated with the incidence of this disease.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Multidisciplinary Sciences
Melkamu A. Zeru, Endalamaw Tesfa, Aweke A. Mitiku, Awoke Seyoum, Tesfaye Abera Bokoro
Summary: This study aimed to assess the prevalence and risk factors of type-2 DM in Ethiopian population. The pooled prevalence of DM in Ethiopia was 6.5%, with identified risk factors including older age, illiteracy, cigarette smoking, MBI >= 25, family history of DM, history of hypertension, and physical inactivity. Awareness of these risk factors is crucial for effective prevention and management of type-2 DM in this population.
SCIENTIFIC REPORTS
(2021)
Review
Sport Sciences
Ahmad Jayedi, Mahdieh-Sadat Zargar, Alireza Emadi, Dagfinn Aune
Summary: The study found that there is a negative association between walking speed and the risk of type 2 diabetes, with faster walking speeds associated with a more significant decrease in risk.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Sihan Peng, Lu Liu, Ziyan Xie, Xiyu Zhang, Chunguang Xie, Sha Ye, Xiangeng Zhang, Xiaoli Liang, Hongyan Wang, Ya Liu
Summary: This study evaluated the efficacy and safety of Chinese herbal medicine (CHM) for type 2 diabetes mellitus (T2DM) with nonalcoholic fatty liver disease (NAFLD). The results showed that CHM combined with western medicine (WM) was more effective than WM alone in improving lipid and glucose metabolism, liver function, insulin resistance, overall efficiency, and reducing body weight.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Jakub Morze, Clemens Wittenbecher, Lukas Schwingshackl, Anna Danielewicz, Andrzej Rynkiewicz, Frank B. Hu, Marta Guasch-Ferre
Summary: An updated systematic review and meta-analysis found that several plasma and serum metabolites, including amino acids, lipids, and carbohydrates, are associated with type 2 diabetes risk. However, there were substantial heterogeneity observed for some of the metabolites, indicating the need for further research in this area.
Review
Endocrinology & Metabolism
Jakub Morze, Clemens Wittenbecher, Lukas Schwingshackl, Anna Danielewicz, Andrzej Rynkiewicz, Frank B. Hu, Marta Guasch-Ferre
Summary: Based on this updated systematic review and meta-analysis, several plasma and serum metabolites, including amino acids, lipids, and carbohydrates, are associated with the risk of type 2 diabetes.
Article
Endocrinology & Metabolism
Svenja Meyhoefer, Alexander J. Eckert, Michael Hummel, Markus Laimer, Michael Roden, Stephan Kress, Jochen Seufert, Sebastian M. Meyhoefer, Reinhard W. Holl
Summary: This study aimed to assess the prevalence of elevated liver enzymes and associated comorbidities in patients with type 2 diabetes. The results showed that elevated liver enzymes were common in patients with type 2 diabetes and were associated with a higher prevalence of clinically relevant comorbidities such as cardiovascular and kidney diseases. Therefore, assessing liver enzymes is important in the clinical diagnosis of type 2 diabetes.
DIABETES OBESITY & METABOLISM
(2022)
Review
Public, Environmental & Occupational Health
Nanjing Shi, Yetan Shi, Jingsi Xu, Yuexiu Si, Tong Yang, Mengting Zhang, Derry Minyao Ng, Xiangyuan Li, Fei Xie
Summary: The association between sodium-glucose cotransporter 2 inhibitors (SGLT-2i) and malignancy risk in type 2 diabetes patients remains unclear. A meta-analysis showed that while some SGLT-2i drugs may increase the risk of malignancy, others could potentially reduce it. Overall, there is still uncertainty regarding the relationship between SGLT-2i and malignancy risk in type 2 diabetes patients.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Nutrition & Dietetics
Setor K. Kunutsor, Jari A. Laukkanen, Jyrki K. Virtanen
Summary: Egg or cholesterol intake is not associated with future risk of venous thromboembolism (VTE) in middle-aged and older Finnish men.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Sae Young Jae, Hyun Jeong Kim, Setor K. Kunutsor, Kanokwan Bunsawat, Sudhir Kurl, Jari A. Laukkanen, Yoon-Ho Choi
Summary: Higher cardiorespiratory fitness is independently associated with lower levels of remnant cholesterol and non-HDL-C, as well as lower odds of having elevated levels of remnant cholesterol and non-HDL-C in healthy men.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Nzechukwu M. Isiozor, Setor K. Kunutsor, Dorothea Vogelsang, Ifeanyichukwu Isiozor, Jussi Kauhanen, Jari A. Laukkanen
Summary: This study aims to investigate the association between serum copper levels and the risk of cardiovascular disease (CVD) death in Finnish men. It found that elevated serum copper levels were associated with an increased risk of CVD death, and this association was consistent across different body mass index categories.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Letter
Cardiac & Cardiovascular Systems
Setor K. Kunutsor, Sae Young Jae, Jari A. Laukkanen
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Setor K. Kunutsor, Sae Young Jae, Jari A. Laukkanen
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2023)
Article
Respiratory System
Setor K. Kunutsor, Ari Voutilainen, Jari A. Laukkanen
Summary: Increased serum Cu/Zn-ratio and Cu concentrations are linearly associated with an increased COPD risk in men.
Article
Cardiac & Cardiovascular Systems
Setor K. Kunutsor, Sudhir Kurl, Ari Voutilainen, Jari A. Laukkanen
Summary: This study aims to assess the association between C-reactive protein-to-albumin ratio (CAR) and risk of venous thromboembolism (VTE). The results showed that elevated CAR is associated with an increased risk of VTE in middle-aged and older men. Further research is needed to validate these findings and evaluate the potential value of CAR in VTE management.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Setor K. Kunutsor, Jari A. Laukkanen
Summary: This editorial discusses the 'U-shaped relationship between apolipoprotein A1 levels and mortality risk in men and women'.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Geriatrics & Gerontology
Setor K. Kunutsor, Nzechukwu M. Isiozor, Jonathan Myers, Samuel Seidu, Kamlesh Khunti, Jari A. Laukkanen
Summary: Chronic kidney disease (CKD) is a preventable global public health burden. High levels of cardiorespiratory fitness (CRF) are associated with a decreased risk of CKD, but the dose-response relationship and long-term relevance of CRF levels to CKD have not been fully addressed.
Article
Cardiac & Cardiovascular Systems
Jari Laukkanen, Nzechukwu M. Isiozor, Peter Willeit, Setor K. Kunutsor
Summary: The study investigated the association between haemodynamic gain index (HGI) and sudden cardiac death (SCD) risk using data from a long-term prospective cohort study. The results showed that higher HGI levels were associated with a lower risk of SCD, with a dose-response relationship and dependence on cardiorespiratory fitness (CRF) levels. Addition of HGI to a SCD risk prediction model improved risk discrimination and reclassification, but CRF remained a stronger predictor of SCD.
Article
Medicine, General & Internal
Setor K. Kunutsor, Jussi Kauhanen, Jari A. Laukkanen
Summary: This study found that frequent sauna bathing is not associated with impaired renal function or increased risk of chronic kidney disease (CKD).
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
Jari A. Laukkanen, Nzechukwu M. Isiozor, Peter Willeit, Setor K. Kunutsor
Summary: The study examines the association between hemodynamic gain index (HGI) and cardiovascular disease (CVD) mortality risk. The results show an inverse relationship between HGI and CVD mortality risk, which is partly dependent on cardiorespiratory fitness (CRF) levels.
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2023)
Letter
Cardiac & Cardiovascular Systems
Setor K. Kunutsor, Sudhir Kurl, Jari A. Laukkanen
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2023)
Article
Cardiac & Cardiovascular Systems
Nzechukwu M. Isiozor, Setor K. Kunutsor, Ari Voutilainen, Jari A. Laukkanen
Summary: This study found that improving healthy behaviors and LE8 scores can lower the risk of future heart disease mortality. Men with a total LE8 score of more than 550 had a lower risk of heart disease and overall mortality compared to those with a score of <=420. Increasing the LE8 score by 50 can lower the risk of heart disease and overall mortality.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Jari A. Laukkanen, Sae Young Jae, Sudhir Kurl, Setor K. Kunutsor
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)