Article
Biochemistry & Molecular Biology
Karl-Heinz Wagner, Nazlisadat Seyed Khoei, Claudia Anna Hana, Daniel Doberer, Rodrig Marculescu, Andrew Cameron Bulmer, Marlies Hoermann-Wallner, Christine Molzer
Summary: Subjects with Gilbert's syndrome show higher levels of antioxidant potential and protein oxidation products, as well as lower levels of apolipoprotein B, hs-C-reactive protein, interleukin 6, and interleukin 1 beta compared to healthy controls. Resting heart rate is also significantly lower in the GS group. Older subjects with GS demonstrate stronger protective effects.
Article
Environmental Sciences
Milena Andelkovic, Aleksandra Buha Djordjevic, Dragana Javorac, Katarina Baralic, Danijela Dukic-Cosic, Aleksandra Repic, Aleksandra Zeljkovic, Jelena Vekic, Natasa Colakovic, Zorica Bulat
Summary: This study found higher lead levels in the healthy tissues of breast cancer patients compared to cancerous tissues. Blood lead levels in breast cancer women did not differ significantly from the control group. Additionally, there were significantly higher triglyceride levels in the lipid profile of breast cancer patients, and triglycerides were identified as a significant predictor of breast cancer.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Oncology
Mohammad L. Rahman, Bryan A. Bassig, Hasmik Grigoryan, Wei Hu, H. Dean Hosgood, Wen-Yi Huang, Jason Y. Y. Wong, Paul Strickland, Stephen M. Rappaport, Qing Lan, Nathaniel Rothman
Summary: Environmental exposures can lead to oxidative stress and the formation of albumin adducts. In this study, we investigated the association between circulatory albumin adducts and acute myeloid leukemia (AML). Our findings suggest that oxidative stress may play a role in the pathogenesis of AML and provide insights into AML etiology and potential therapeutic targets.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Magdalena Nowaczewska, Stanislaw Osinski, Maria Marzec, Michal Wicinski, Katarzyna Bilicka, Wojciech Kazmierczak
Summary: The study found a significant decrease in serum 25(OH)D levels in tinnitus patients, with a higher prevalence of vitamin D deficiency compared to controls. Tinnitus severity was strongly correlated with 25(OH)D levels.
Article
Biochemistry & Molecular Biology
Jung-Wei Chang, Hsin-Chang Chen, Heng-Zhao Hu, Wan-Ting Chang, Po-Chin Huang, I-Jen Wang
Summary: The study shows that low-dose phthalate exposure enhances the immune system response in children with asthma. Monobenzyl phthalate is identified as the main contributing factor.
Article
Environmental Sciences
Danial Abdollahdokht, Gholamreza Asadikaram, Moslem Abolhassani, Hossein Pourghadamyari, Mojtaba Abbasi-Jorjandi, Sanaz Faramarz, Mohammad Hadi Nematollahi
Summary: The study evaluated the exposure of organophosphate pesticides (OPPs) and organochlorine pesticides (OCPs) in farmworkers' children aged 6 to 11 years in Jiroft city in southeastern Iran, finding harmful effects on the participants.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Dominika Granda, Maria Karolina Szmidt, Joanna Kaluza
Summary: The systematic review investigated inflammation markers, oxidative stress, and antioxidant status among women with PMS. Limited evidence suggested increased levels of inflammatory parameters and decreased antioxidant status in PMS women. However, insufficient data with inconsistent results made it impossible to formulate a firm conclusion on the contribution of oxidative stress in PMS occurrence. Further research with case-control design and large study groups is needed to better understand the role of inflammation, oxidative stress, and antioxidant status in the pathophysiology of PMS.
Article
Cell Biology
Elena Rosello-Diez, Leif Hove-Madsen, Virginia Perez-Grijalba, Christian Munoz-Guijosa, Vicenc Artigas, Josep Maria Padro, Elena Dominguez-Garrido
Summary: The study analyzed mitochondrial variables from different atrial samples and found that haplogroup H may offer protection against AF, while haplogroup U predispose to permanent AF. These findings contribute to a better understanding of the influence of mitochondria on AF pathogenesis.
Article
Biochemistry & Molecular Biology
Ayse Zehra Gul, Nil Atakul, Sahabettin Selek, Yildiz Atamer, Ufuk Sarikaya, Tugce Yildiz, Metin Demirel
Summary: The study found that copper levels were significantly elevated and thiol levels were decreased in patients with preeclampsia compared to the control group. The predictive cutoff value for copper in patients was 224 micrograms per deciliter, and the copper/native thiol ratio was 1.19. There was no difference in zinc levels between the two groups.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Immunology
Xu Wang, Yuanmin Xu, Longfei Dai, Zhen Yu, Ming Wang, Shixin Chan, Rui Sun, Qijun Han, Jiajie Chen, Xiaomin Zuo, Zhenglin Wang, Xianyu Hu, Yang Yang, Hu Zhao, Kongwang Hu, Huabing Zhang, Wei Chen
Summary: In this study, a prognostic signature related to OFRG was developed and showed excellent performance in predicting survival and therapeutic responses for CRC patients. Low-risk CRC patients exhibited better prognosis, higher immune cell infiltration levels, and better responses to treatment compared to high-risk patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
Gopal Agrawal, Sourabh Dutta, Rajendra Prasad, Mangat Ram Dogra
Summary: Fetal oxidative stress and micronutrient deficiencies are associated with retinopathy of prematurity, with high MDA levels and low micronutrients in cord and maternal blood being predictors of ROP.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Giovanni Delli Carpini, Luca Giannella, Jacopo Di Giuseppe, Nina Montik, Michele Montanari, Mariasole Fichera, Daniele Crescenzi, Carolina Marzocchini, Maria Liberata Meccariello, Donato Di Biase, Arianna Vignini, Andrea Ciavattini
Summary: This study suggests that the MTHFR C677T homozygous polymorphism may be a risk factor for endometriosis, potentially explaining the association through altered DNA methylation and reduced activity of antioxidant systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Shuman Yang, Lijie Feng, Lisa M. Lix, William D. Leslie, Dingjie Guo, Xianbao Shi, Baoming Yuan
Summary: This study investigated the association between oxidative stress and osteoporotic fractures, finding that higher levels of FlOP_360 and FlOP_400 were associated with an increased risk of fracture, regardless of the fracture site.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Yinhua Luo, Xiaohong He, Linbo Hu, Jinbo Zhao, Ke Su, Yuhua Lei, Yuanhong Li
Summary: Ischemic cardiomyopathy (ICM) is closely associated with abnormal circulation selenium levels, oxidative stress, and inflammatory responses. This study found that patients with ICM had significantly lower plasma selenium levels and higher levels of inflammation and oxidative stress indicators compared to healthy controls. Selenium deficiency is strongly associated with the development and progression of ICM, and it can prevent ICM by alleviating inflammatory responses.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yingzi Wu, Jinhai Luo, Baojun Xu
Summary: This study identified the mechanism of geniposide in regulating oxidative stress in colorectal cancer (CRC) through network pharmacology and bioinformatics analysis. The study found that geniposide can regulate oxidative stress and may exert anti-CRC effects through multiple biological processes and signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Caroline Y. Um, Peter T. Campbell, Brian Carter, Ying Wang, Susan M. Gapstur, Marjorie L. McCullough
EUROPEAN JOURNAL OF NUTRITION
(2020)
Editorial Material
Oncology
Melissa Maitin-Shepard, Marjorie L. McCullough, Elisa V. Bandera, Karen Basen-Engquist
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Article
Oncology
Mark A. Guinter, Susan M. Gapstur, Marjorie L. McCullough, W. Dana Flanders, Ying Wang, Erika Rees-Punia, Kassandra I. Alcaraz, Michael N. Pollak, Peter T. Campbell
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Article
Oncology
Ying Wang, Eric J. Jacobs, Roma A. Shah, Victoria L. Stevens, Ted Gansler, Marjorie L. McCullough
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Article
Oncology
Sonja Neumeyer, Katja Butterbach, Barbara L. Banbury, Sonja I. Berndt, Peter T. Campbell, Rowan T. Chlebowski, Andrew T. Chan, Edward L. Giovannucci, Amit D. Joshi, Shuji Ogino, Mingyang Song, Marjorie L. McCullough, Haifa Maalmi, Joann E. Manson, Lori C. Sakoda, Robert E. Schoen, Martha L. Slattery, Emily White, Aung K. Win, Jane C. Figueiredo, John L. Hopper, Finlay A. Macrae, Ulrike Peters, Hermann Brenner, Michael Hoffmeister, Polly A. Newcomb, Jenny Chang-Claude
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Article
Oncology
David Corley Gibbs, Roberd M. Bostick, Marjorie L. McCullough, Caroline Y. Um, W. Dana Flanders, Mazda Jenab, Elisabete Weiderpass, Bjorn Gylling, Inger T. Gram, Alicia K. Heath, Sandra Colorado-Yohar, Christina C. Dahm, Bas Bueno-de-Mesquita, Aurora Perez-Cornago, Antonia Trichopoulou, Rosario Tumino, Tilman Kuhn, Veronika Fedirko
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Nutrition & Dietetics
Alyssa N. Troeschel, Terryl J. Hartman, W. Dana Flanders, Ying Wang, Rebecca A. Hodge, Lauren E. McCullough, Diane C. Mitchell, Laura Sampson, Alpa Patel, Marjorie L. McCullough
JOURNAL OF NUTRITION
(2020)
Article
Multidisciplinary Sciences
James M. Hodge, Roma Shah, Marjorie L. McCullough, Susan M. Gapstur, Alpa Patel
Article
Oncology
Cheryl L. Rock, Cynthia Thomson, Ted Gansler, Susan M. Gapstur, Marji L. McCullough, Alpa Patel, Kimberly S. Andrews, Elisa Bandera, Colleen K. Spees, Kimberly Robien, Sheri Hartman, Kristen Sullivan, Barbara L. Grant, Kathryn K. Hamilton, Lawrence H. Kushi, Bette J. Caan, Debra Kibbe, Jessica Donze Black, Tracy L. Wiedt, Catherine McMahon, Kirsten Sloan, Colleen Doyle
CA-A CANCER JOURNAL FOR CLINICIANS
(2020)
Article
Oncology
Caroline Y. Um, Marjorie L. McCullough, Mark A. Guinter, Peter T. Campbell, Eric J. Jacobs, Susan M. Gapstur
CANCER EPIDEMIOLOGY
(2020)
Article
Oncology
Emily L. Deubler, Susan M. Gapstur, W. Ryan Diver, Mia M. Gaudet, James M. Hodge, Victoria L. Stevens, Marjorie L. McCullough, Laura G. Haines, Keith E. Levine, Lauren R. Teras
INTERNATIONAL JOURNAL OF CANCER
(2020)
Letter
Oncology
Caroline Y. Um, Marjorie L. McCullough, Susan M. Gapstur
CANCER EPIDEMIOLOGY
(2020)
Article
Oncology
David Corley Gibbs, Veronika Fedirko, John A. Baron, Elizabeth L. Barry, W. Dana Flanders, Marjorie L. McCullough, Rami Yacoub, Tapasya Raavi, Robin E. Rutherford, March E. Seabrook, Roberd M. Bostick
Summary: This study demonstrates that supplemental vitamin D and calcium can favorably modulate the balance of COX-2 and 15-HPGD expression in colorectal tissue, reducing markers of inflammation associated with colorectal carcinogenesis.
CANCER PREVENTION RESEARCH
(2021)
Article
Clinical Neurology
Kjetil Bjornevik, Eilis J. O'Reilly, Marianna Cortese, Jeremy D. Furtado, Laurence N. Kolonel, Loic Le Marchand, Marjorie L. Mccullough, Sabrina Paganoni, Michael A. Schwarzschild, Aladdin H. Shadyab, Joann E. Manson, Alberto Ascherio
Summary: Higher pre-diagnostic levels of high-density lipoprotein cholesterol (HDL-C), but not total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), or triglyceride (TG), are associated with a higher risk of Amyotrophic lateral sclerosis (ALS).
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2021)
Article
Nutrition & Dietetics
Marjorie L. McCullough, Ying Wang, Terryl J. Hartman, Rebecca A. Hodge, W. Dana Flanders, Victoria L. Stevens, Laura Sampson, Diane C. Mitchell, Alpa Patel
Summary: This study evaluated the reproducibility and validity of a food frequency questionnaire (FFQ) modified for the American Cancer Society's Cancer Prevention Study-3 (CPS-3) prospective cohort among a racially/ethnically diverse subgroup. The FFQ reproducibility and validity were comparable with similar studies for most nutrients, with slightly higher levels found among whites and slightly lower levels among blacks and Hispanics. These findings support future dietary analyses in the CPS-3 cohort and other similar cohorts.
JOURNAL OF NUTRITION
(2021)