Editorial Material
Physics, Multidisciplinary
Leonida A. Gizzi, Maria Grazia Andreassi
Summary: Laser accelerators have not been able to meet the requirements for dose control and stability in biomedical applications, but an experiment has now achieved translational research with proton beams at ultrahigh dose rate.
Review
Immunology
Erica L. Katz, John E. Harris
Summary: Vitiligo is a skin disease characterized by white spots, and significant progress has been made in understanding its pathogenesis over the past 30 years through perseverance, collaboration, and open-minded discussion. Researchers have explored various possible mechanisms through innervation, microvascular anomalies, oxidative stress, defects in melanocyte adhesion, autoimmunity, somatic mosaicism, and genetics, with animal models and improved patient sample collection methods playing important roles in translational studies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Alexander Malogolovkin, Alexander D. Egorov, Alexander Karabelsky, Roman A. Ivanov, Vladislav V. Verkhusha
Summary: Optogenetics, a technique that enables precise control of gene and cell activity using light, offers new possibilities for cancer treatment. By activating immune response, inhibiting tumor growth, and modulating cell signaling using specific wavelengths of light, optogenetics has the potential to revolutionize cancer therapy.
BIOTECHNOLOGY ADVANCES
(2022)
Editorial Material
Medicine, General & Internal
John C. Marshall, Aleksandra Leligdowicz
Summary: Infection leads to sepsis, and the development of clinical disease is triggered by the innate immune response of the host. However, the advancement of understanding in this biological response has not been matched by successful treatment development. The COVID-19 pandemic has brought about changes in this aspect, showing potential therapeutic approaches and the possibility of evaluating them. This article reviews the history of mediator-targeted therapy for sepsis and discusses the conceptual, biological, technological, and organizational challenges that need to be addressed to develop effective treatments for a leading cause of global morbidity and mortality.
Article
Biotechnology & Applied Microbiology
Elizabeth A. W. Sigston
Summary: The emergence of 3D printing is driving a major shift in translational medical research, introducing bidirectional translation and an entrepreneurial mindset. However, the rapid pace of development brings potential pitfalls and ethical concerns, requiring early recognition and management.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Cell Biology
Ruin Moaddel, Ceereena Ubaida-Mohien, Toshiko Tanaka, Alexey Lyashkov, Nathan Basisty, Birgit Schilling, Richard D. Semba, Claudio Franceschi, Myriam Gorospe, Luigi Ferrucci
Summary: The identification of blood plasma proteins that change with age and predict health deterioration apart from chronological age is a growing research area. These proteins are important for understanding the mechanisms of aging and can potentially lead to the development of new treatments for improving health expectancy.
Review
Oncology
Felix T. Kurz, Heinz -Peter Schlemmer
Summary: This review aims to present recent advancements in translational cancer imaging research, specifically focusing on novel, recently established, or soon to be established cross-sectional imaging techniques such as computed tomography (CT), magnetic resonance imaging (MRI), and positron-emission tomography (PET), as well as computational investigations based on machine-learning techniques.
CANCER BIOLOGY & MEDICINE
(2022)
Review
Urology & Nephrology
Giovanni Tripepi, Davide Bolignano, Kitty J. Jager, Friedo W. Dekker, Vianda S. Stel, Carmine Zoccali
Summary: Translational research aims to bridge the gap between prognostic research results and clinical practice, by developing, validating, and evaluating the impact of prognostic models on patient decision-making and outcomes.
CLINICAL KIDNEY JOURNAL
(2022)
Review
Oncology
Elaine M. Thomas, Josephine A. Wright, Stephen J. Blake, Amanda J. Page, Daniel L. Worthley, Susan L. Woods
Summary: Colorectal cancer (CRC) is a prevalent and lethal disease, and immune checkpoint inhibitors (ICIs) have limited efficacy in most CRC patients. The most responsive patients are those with dMMR/MSI disease, but reliable predictors of ICI response are lacking. Development of novel mechanisms to increase response rates and prevent resistance is crucial. This review focuses on preclinical testing in CRC to inform the development of immuno-regulatory treatment strategies, with an emphasis on the shortcomings and advantages of commonly used mouse models.
BRITISH JOURNAL OF CANCER
(2023)
Review
Medicine, Research & Experimental
Michael Beshiri, Supreet Agarwal, Juan Juan Yin, Kathleen Kelly
Summary: Organoid technology has revolutionized translational research in oncology by developing patient-specific living biobanks. Prostate cancer research has been limited to a few in vitro models, hindering the translation of experimental findings to heterogeneous patient populations. Organoid culture methods have expanded the diversity of tractable models, including luminal stem/progenitor cells and patient-derived cancers, enabling more accurate therapeutic predictions and informative clinical trials. This article examines the current use of prostate organoid technology, potential therapeutic applications, and existing challenges.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Immunology
Yinxi Zhou, Jinghua Xia, Shuonan Xu, Tao She, Yanning Zhang, Ying Sun, Miaomiao Wen, Tao Jiang, Yanlu Xiong, Jie Lei
Summary: The development and growth of tumors pose a significant and ongoing threat to human life globally. Despite the remarkable progress achieved by advanced therapeutic strategies such as immune checkpoint therapy and CAR-T in treating solid and hematological malignancies, the malignant initiation and progression of cancer remains controversial and requires further research. Experimental animal models not only have great advantages in simulating tumor occurrence, development, and malignant transformation mechanisms, but also can be used to evaluate the therapeutic effects of diverse clinical interventions, gradually becoming indispensable in cancer research. This paper reviews recent research progress in mouse and rat models, focusing on spontaneous, induced, transgenic, and transplantable tumor models, aiming to provide guidance for future studies on malignant mechanisms and tumor prevention.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Plant Sciences
Matthew P. Reynolds, Janet M. Lewis, Karim Ammar, Bhoja R. Basnet, Leonardo Crespo-Herrera, Jose Crossa, Kanwarpal S. Dhugga, Susanne Dreisigacker, Philomin Juliana, Hannes Karwat, Masahiro Kishii, Margaret R. Krause, Peter Langridge, Azam Lashkari, Suchismita Mondal, Thomas Payne, Diego Pequeno, Francisco Pinto, Carolina Sansaloni, Urs Schulthess, Ravi P. Singh, Kai Sonder, Sivakumar Sukumaran, Wei Xiong, Hans J. Braun
Summary: The review highlights the opportunities for enhancing heat and drought resilience in wheat through innovative breeding technologies, including the use of new tools in genetics and remote sensing, as well as identifying climate resilience traits from global wheat genetic resources. By improving crop design targets, developing field-based screening tools, applying genomic technologies, and advancing next-generation breeding methods, a research pipeline is created to boost heat and drought resilience.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Editorial Material
Pharmacology & Pharmacy
Magnus Ingelman-Sundberg, Jean L. Cadet, Gabriella Gobbi, David E. Olson, Samantha Yohn, Daniel J. Foster
Summary: Neuropsychiatric and mental health disorders have a significant impact on people's lives, and finding new treatment methods has become increasingly important. The Editor-in-Chief of Trends in Pharmacological Sciences invited experts in the field to share their interests and perspectives on the global challenges and opportunities for novel therapy discovery.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Gopika SenthilKumar, Cristhian A. Gutierrez-Huerta, Julie K. Freed, Andreas M. Beyer, Ibra S. Fancher, Amanda Jo LeBlanc
Summary: Microvascular disease is crucial in causing systemic end-organ dysfunction, and effective treatment can greatly reduce cardiovascular morbidity and mortality. This Call for Papers collection provides a concise summary of recent advances in translational microcirculatory research, focusing on the role of microvessels in chronic diseases and strategies to enhance microvascular function. The collection includes research articles, reviews, and therapeutic interventions, aiming to translate microcirculatory research from bench to bedside.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Iqra Ilyas, Peter J. Little, Zhiping Liu, Yanyong Xu, Danielle Kamato, Bradford C. Berk, Jianping Weng, Suowen Xu
Summary: This article reviews the current use and translational potential of mouse models in atherosclerosis research and drug discovery. Atherosclerotic cardiovascular disease is a chronic and progressive metabolic and inflammatory disease that causes premature human mortality. Despite promising preclinical studies, many drug candidates have not been translated to clinical use due to the complex disease mechanisms involved.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
