Article
Oncology
Fatemeh Asadian, Hadi Maleki, Sepideh Setayesh, Seyed Alireza Dastgheib, Mohamad Zare, Saeed Kargar, Seyed Hossein Shaker, Mahta Mazaheri, Hossein Neamatzadeh
Summary: This meta-analysis revealed that the COX-2 +202C>T polymorphism is associated with prostate cancer risk, while the -765G>C, -1195G>A, and +8473T>C polymorphisms are not. Stratified analyses indicated that the results vary by ethnicity.
EURASIAN JOURNAL OF MEDICINE AND ONCOLOGY
(2021)
Article
Oncology
Aasha Hoogland, Heather S. L. Jim, Brian D. Gonzalez, Brent J. Small, Danielle Gilvary, Elizabeth C. Breen, Julienne E. Bower, Mayer Fishman, Babu Zachariah, Paul B. Jacobsen
Summary: Increases in fatigue, depressive symptomatology, and cognitive impairment are common in prostate cancer patients after receiving androgen deprivation therapy (ADT). Circulating interleukin-6 (IL-6) may play a role in fatigue related to ADT, suggesting a need for further research on interventions to reduce inflammation and improve fatigue in this population.
Article
Urology & Nephrology
D. C. Cheung, S. M. H. Alibhai, L. J. Martin, M. Komisarenko, C. Dharma, P. Warde, S. S. Sridhar, N. E. Fleshner, G. S. Kulkarni, A. Finelli
Summary: In Ontario, only 16.4% of patients aged 65 and older with prostate cancer received intermittent androgen deprivation therapy (IADT), with variations observed across health-planning regions and physician specialties. Factors such as prior local therapy and higher patient income influenced the likelihood of receiving IADT. Radiation oncologists were more likely to use IADT, as were physicians with more experience.
JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Celestia S. Higano, Jason Hafron
Summary: This review discusses adherence rates, barriers to compliance, and strategies to overcome challenges in clinical settings. Nonadherence rates of prostate cancer patients with oral therapies range from 25% to 51%, with higher rates in older patients. Medication-related barriers include complex dosing schedules, medication management burden, fasting or dietary requirements, high costs, adverse effects, and drug interactions. Patient-specific barriers include suboptimal education, physical limitations, living alone, high symptom burden, needle phobia, and comorbid mental disorders. Interventions to improve adherence include automated reminders, treatment diaries, and involvement of patients, family members, care partners, and healthcare teams.
JOURNAL OF UROLOGY
(2023)
Review
Oncology
Bertrand Tombal, Arnulf Stenzl, David Cella, Yohann Loriot, Andrew J. Armstrong, Karim Fizazi, Tomasz Beer, Cora N. Sternberg, Maha Hussain, Cristina Ivanescu, Arijit Ganguli, Krishnan Ramaswamy, Fred Saad
Summary: Enzalutamide effectively reduces pain and symptom burden in prostate cancer patients, maintaining higher quality of life and delaying disease progression.
Article
Oncology
Tim J. Hartung, Ida Rask Moustsen, Signe Benzon Larsen, Elisabeth A. Wreford Andersen, Nis P. Suppli, Christoffer Johansen, Anne Tjonneland, Anne S. Friberg, Susanne K. Kjaer, Klaus Brasso, Lars Kessing, Anja Mehnert, Susanne Oksbjerg Dalton
Summary: The risk of receiving antidepressant medication is higher among men with prostate cancer compared to cancer-free men, with clinical characteristics such as treatment type, disease stage, and education level being significant risk factors. Female partners of prostate cancer patients do not show a significantly increased risk of antidepressant prescriptions. Prompt professional help and patient education are crucial in addressing symptoms of depression or anxiety in cancer survivors.
JOURNAL OF CANCER SURVIVORSHIP
(2021)
Article
Health Care Sciences & Services
Andrew J. Page, Katie Spencer, Matthew R. Mulvey, Barry J. A. Laird, Michael Bennett
Summary: This study analyzed a database from a regional radiotherapy center and found that using NSAIDs as adjuncts for cancer-induced bone pain is feasible, with 65.3% of patients dying within one year of radiotherapy.
PALLIATIVE MEDICINE
(2022)
Article
Medicine, Research & Experimental
Hanjiang Xu, Meng Zhang, Zongyao Hao, Chaozhao Liang
Summary: This case-control study and meta-analysis suggest that the hOGG1 rs1052133 polymorphism is associated with prostate cancer risk, but further verification is needed in the Chinese population.
MEDICAL SCIENCE MONITOR
(2022)
Article
Oncology
David H. Howard, Ruben G. W. Quek, Kathleen M. Fox, Bhakti Arondekar, Christopher P. Filson
Summary: The study evaluated the real-world effectiveness and value of drugs recently approved for advanced prostate cancer. Between 2007-2009 and 2014-2016, life expectancy increased by 12.6 months and lifetime medical costs increased by $87,000.
Article
Pharmacology & Pharmacy
Svetlana Alymova, Karel Kostev, Vicky Casey, Nina Schmidt, Matthias Kalder, Christoph Roderburg, Nicole Friedersdorf
Summary: The representativeness of the German Oncology Dynamics (OD) dataset was evaluated by comparing its projected patient population structure with published epidemiological literature. The study found that the OD's projected patient distributions were similar to those documented in the literature, with some differences in cancer types and sex-specific diagnosis timeline.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Cecilie D. de la Cour, Freija Verdoodt, Gitte L. Aalborg, Christian von Buchwald, Soren Friis, Christian Dehlendorff, Susanne K. Kjaer
Summary: The study found no association between the use of low-dose aspirin and overall HNC risk. However, there were slight differences observed in different age groups, with a potential increase in oral cancer risk associated with low-dose aspirin use in certain age ranges.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Urology & Nephrology
Ian -Seng Cheong, Yuh-Shyan Tsai, Chun-Hsiung Kang, Yeong-Chin Jou, Pi-Che Chen, Chang-Te Lin
Summary: This study investigated the use of biopsy needle tip culture after prostate biopsies for bacteria prediction and antibiotics selection. Positive needle cultures were associated with a higher rate of fever development, and both needle and blood cultures were consistent with susceptibility test results. Needle cultures can help administer target antibiotics earlier to febrile patients without waiting for blood cultures.
Article
Urology & Nephrology
Sang Hun Song, Eunae Kim, Eunjin Woo, Eunkyung Kwon, Sungroh Yoon, Jung Kwon Kim, Hakmin Lee, Jong Jin Oh, Sangchul Lee, Sung Kyu Hong, Seok-Soo Byun
Summary: An ethnic-specific polygenic risk score (PRS) was developed and validated in Korean males to predict susceptibility to clinically significant prostate cancer (csPCa). The selection of candidate SNPs and construction of PRS can serve as potential biomarkers to predict individual risk.
INVESTIGATIVE AND CLINICAL UROLOGY
(2022)
Article
Respiratory System
Mehmet Erdem Cakmak
Summary: The study demonstrated that selective COX-2 inhibitor NSAIDs are relatively safe in patients with N-ERD, with drug challenge tests showing a significantly lower allergic reaction rate with celecoxib compared to other drugs.
TUBERKULOZ VE TORAKS-TUBERCULOSIS AND THORAX
(2022)
Article
Medicine, General & Internal
Shigehisa Kubota, Susumu Kageyama, Masayuki Nagasawa, Akinori Wada, Ryo Ikari, Keiji Tomita, Tetsuya Yoshida, Mitsuhiro Narita, Akihiro Kawauchi
Summary: This case presents a rare example of sustained response to low-dose cabazitaxel, suggesting its potential as a treatment option for metastatic CRPC patients. In our patient, this approach achieved a good clinical response with manageable toxicity over the long term.
AMERICAN JOURNAL OF CASE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Reuben M. Buckley, Alex C. Harris, Guo-Dong Wang, D. Thad Whitaker, Ya-Ping Zhang, Elaine A. Ostrander
Summary: The study compared the accuracy and performance of low-pass whole genome sequencing and imputation in dogs, demonstrating that by optimizing a variant quality filtering strategy, the imputation error rate can be reduced and approximately 80% of imputed sites retained. For case-control GWAS, where small effect sizes were most impacted, guidelines for best practices in low-pass WGS-imputed genotypes in dogs were provided.
Article
Biochemistry & Molecular Biology
Jocelyn Plassais, Bridgett M. vonHoldt, Heidi G. Parker, Alberto Carmagnini, Nicolas Dubos, Ilenia Papa, Kevin Bevant, Thomas Derrien, Lauren M. Hennelly, D. Thad Whitaker, Alex C. Harris, Andrew N. Hogan, Heather J. Huson, Victor F. Zaibert, Anna Linderholm, James Haile, Thierry Fest, Bilal Habib, Benjamin N. Sacks, Norbert Benecke, Alan K. Outram, Mikhail Sablin, Mietje Germonpre, Greger Larson, Laurent Frantz, Elaine A. Ostrander
Summary: Domestic dogs display a 40-fold size difference between breeds, with body size being regulated by multiple genes. Insulin-like growth factor 1 (IGF1) is the main regulator, controlling approximately 15% of the body size variation. By analyzing genome sequences from different species, researchers identified a variant in an antisense long non-coding RNA (IGF1-AS) that interacts with the IGF1 gene, resulting in the dominance of derived mutation in modern wolves and large domestic breeds.
Article
Urology & Nephrology
Burcu F. Darst, Raymond Hughley, Aaron Pfennig, Ujani Hazra, Caoqi Fan, Peggy Wan, Xin Sheng, Lucy Xia, Caroline Andrews, Fei Chen, Sonja Berndt, Zsofia Kote-Jarai, Koveela Govindasami, Jeannette T. Bensen, Sue A. Ingles, Benjamin A. Rybicki, Barbara Nemesure, Esther M. John, Jay H. Fowke, Chad D. Huff, Sara S. Strom, William B. Isaacs, Jong Y. Park, Wei Zheng, Elaine A. Ostrander, Patrick C. Walsh, John Carpten, Thomas A. Sellers, Kosj Yamoah, Adam B. Murphy, Maureen Sanderson, Dana C. Crawford, Susan M. Gapstur, William S. Bush, Melinda C. Aldrich, Olivier Cussenot, Gyorgy Petrovics, Jennifer Cullen, Christine Neslund-Dudas, Rick A. Kittles, Jianfeng Xu, Mariana C. Stern, Anand P. Chokkalingam, Luc Multigner, Marie-Elise Parent, Florence Menegaux, Geraldine Cancel-Tassin, Adam S. Kibel, Eric A. Klein, Phyllis J. Goodman, Janet L. Stanford, Bettina F. Drake, Jennifer J. Hu, Peter E. Clark, Pascal Blanchet, Graham Casey, Anselm J. M. Hennis, Alexander Lubwama, Ian M. Thompson, Robin J. Leach, Susan M. Gundell, Loreall Pooler, James L. Mohler, Elizabeth T. H. Fontham, Gary J. Smith, Jack A. Taylor, Laurent Brureau, William J. Blot, Richard Biritwum, Evelyn Tay, Ann Truelove, Shelley Niwa, Yao Tettey, Rohit Varma, Roberta McKean-Cowdin, Mina Torres, Mohamed Jalloh, Serigne Magueye Gueye, Lamine Niang, Olufemi Ogunbiyi, Michael Oladimeji Idowu, Olufemi Popoola, Akindele O. Adebiyi, Oseremen Aisuodionoe-Shadrach, Maxwell Nwegbu, Ben Adusei, Sunny Mante, Afua Darkwa-Abrahams, Edward D. Yeboah, James E. Mensah, Andrew Anthony Adjei, Halimatou Diop, Michael B. Cook, Stephen J. Chanock, Stephen Watya, Rosalind A. Eeles, Charleston W. K. Chiang, Joseph Lachance, Timothy R. Rebbeck, David Conti, Christopher A. Haiman
Summary: A specific germline deletion variant in HOXB13 (X285K) was found to be associated with an increased risk of prostate cancer in men of West African ancestry. This variant was more strongly associated with aggressive and advanced disease. Understanding who carries this variant can inform prostate cancer screening in men of West African ancestry.
Article
Evolutionary Biology
Muhammad Basil Ali, Dayna L. Dreger, Reuben M. Buckley, Shahid Mansoor, Qaiser M. Khan, Elaine A. Ostrander
Summary: This study conducted a detailed population analysis on the Mackenzie River Husky and the Chinook, two breeds of Arctic sled dogs. The results showed contributions from Alaskan Malamutes, modern Greenland sled dogs, German Shepherd dogs, and Collies to both populations. Several genomic regions with provocative genes and signatures of selection were identified.
JOURNAL OF HEREDITY
(2022)
Article
Endocrinology & Metabolism
Kelsie Raspin, Dannielle E. O'Malley, James R. Marthick, Shaun Donovan, Roslyn C. Malley, Annette Banks, Frank Redwig, Marketa Skala, Joanne L. Dickinson, Liesel M. FitzGerald
Summary: Gene fusions are prevalent in prostate cancer, especially in a large family. Known and novel gene fusions were found in tumors. Patients with gene fusions were more likely to have lower-grade disease compared to those without gene fusions.
Article
Multidisciplinary Sciences
Georgea R. Foley, C. Leigh Blizzard, Brian Stokes, Marketa Skala, Frank Redwig, Joanne L. Dickinson, Liesel M. FitzGerald
Summary: There are disparities in prostate cancer diagnosis, clinical characteristics, and treatment among men living in regional and remote areas, particularly in Tasmania, Australia. Men from outer regional/remote areas are more likely to reside in lower socio-economic areas, be diagnosed at a later age, and exhibit more clinically aggressive features. However, there are no overall differences in diagnostic or treatment methods, although men from outer regional/remote areas experience delays in initiating active treatment and have to travel further for treatment.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Liudmilla Rubbi, Haoxuan Zhang, Junxi Feng, Christopher He, Patrick Kurnia, Prashansa Ratan, Aakash Tammana, Sabina House, Michael Thompson, Colin Farrell, Sagi Snir, Daniel Stahler, Elaine A. Ostrander, Bridgett M. vonHoldt, Matteo Pellegrini
Summary: This article explores the dynamic nature of DNA methylomes and develops quantitative models to measure their changes in response to various factors. The study finds strong associations between DNA methylomes and age, as well as novel associations with sex, weight, and sterilization status. Additionally, genetics influences DNA methylomes, and several factors moderate the relationship between epigenetic ages and real ages.
Article
Biochemistry & Molecular Biology
Rajya L. Gurung, Liesel M. FitzGerald, Ebony Liu, Bennet J. McComish, Georgia Kaidonis, Bronwyn Ridge, Alex W. Hewitt, Brendan J. Vote, Nitin Verma, Jamie E. Craig, Kathryn P. Burdon
Summary: This study identified genetic determinants associated with anti-VEGF treatment response in patients with DME through a genome-wide association study. Multiple genetic loci were found to predict treatment outcomes, potentially leading to personalized treatment approaches for managing DME.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Steve Horvath, Ake T. Lu, Amin Haghani, Joseph A. Zoller, Caesar Z. Li, Andrea R. Lim, Robert T. Brooke, Ken Raj, Aitor Serres-Armero, Dayna L. Dreger, Andrew N. Hogan, Jocelyn Plassais, Elaine A. Ostrander
Summary: Epigenetic clocks are reliable and highly accurate biomarkers that can be applied to 93 domestic dog breeds and potentially to humans. They are used to estimate age, lifespan, and health status, contributing to research on antiaging treatments.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Genetics & Heredity
Natasha Barrios, Cesar Gonzalez-Lagos, Dayna L. Dreger, Heidi G. Parker, Guillermo Nourdin-Galindo, Andrew N. Hogan, Marcelo A. Gomez, Elaine A. Ostrander
Summary: This article discusses the development and genetic relationship of modern dog breeds, with a focus on the Patagonian sheepdog as a rare herding breed. The study finds that Patagonian sheepdogs are closely related to modern herding breeds from the United Kingdom.
Letter
Oncology
Georgea R. Foley, James R. Marthick, Elaine A. Ostrander, Janet L. Stanford, Joanne L. Dickinson, Liesel M. FitzGerald
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Kelsie Raspin, James R. Marthick, Shaun Donovan, Leigh Blizzard, Roslyn C. Malley, Chol-hee Jung, Annette Banks, Frank Redwig, Marketa Skala, Joanne L. Dickinson, Liesel M. FitzGerald
Summary: This study found that amplification of EEF2 is predominantly present in familial prostate tumors, while deletion of EEF2 is more common in unselected tumors. Furthermore, EEF2 amplification and deletion are significantly associated with a higher Gleason score in prostate cancer.
GENES CHROMOSOMES & CANCER
(2023)
Article
Ophthalmology
Rajya L. Gurung, Liesel M. FitzGerald, Ebony Liu, Bennet J. McComish, Georgia Kaidonis, Bronwyn Ridge, Alex W. Hewitt, Brendan J. Vote, Nitin Verma, Jamie E. Craig, Kathryn P. Burdon
Summary: This study aimed to identify factors influencing the outcomes of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment for diabetic macular edema (DME) in real-world practice. The study found that higher baseline best corrected visual acuity (BCVA) and longer duration of diabetic retinopathy were negative predictors for BCVA response, while Aflibercept treatment and a positive early functional response were positive predictors. Higher baseline central macular thickness (CMT) and early anatomical response were predictors for greater reduction in CMT. Overall, the variables could only predict 23% of BCVA response and 52% of CMT response.
INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
(2023)
Meeting Abstract
Ophthalmology
Rajya L. Gurung, Liesel M. FitzGerald, Bennet J. McComish, Ebony Lui, Jamie E. Craig, Nitin Verma, Alex W. Hewitt, Brendan J. T. Vote, Kathryn P. Burdon
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Taylorlyn Stephan, Shawn M. Burgess, Hans Cheng, Charles G. Danko, Clare A. Gill, Erich D. Jarvis, Klaus-Peter Koepfli, James E. Koltes, Eric Lyons, Pamela Ronald, Oliver A. Ryder, Lynn M. Schriml, Pamela Soltis, Sue VandeWoude, Huaijun Zhou, Elaine A. Ostrander, Elinor K. Karlsson
Summary: Genomics research has primarily focused on humans and a limited number of species, resulting in a lack of understanding about the genomes of the majority of species. However, a broad view that encompasses the vast diversity of life is necessary to comprehend how genomes function and how genetic variation shapes phenotypes. Integrating comparative genomics with other fields is crucial for scientific discovery and the protection of ourselves and our world.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)