期刊
AMERICAN JOURNAL OF EPIDEMIOLOGY
卷 172, 期 1, 页码 94-106出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwq121
关键词
case-control studies; cohort studies; esophageal neoplasms; prospective studies; stomach neoplasms; vitamin D
资金
- National Institutes of Health, Division of Cancer Control and Population Sciences, National Cancer Institute (NCI) (Bethesda, Maryland)
- National Institutes of Health, Division of Cancer Epidemiology and Genetics, NCI
- NCI [R01 CA098661, R37 CA54281, P01 CA33619, R01 CA063464, N01-PC35137, R01 CA82729, R37 CA70867, N02-CP11010-66, N01-CN-25514, N01-CN-25522, N01-CN-25513, NO1-CN-25516, N01-CN25511, N01-CN-25524, N01-CN-25518, NO1-CN-75022, N01-CN-25476]
Upper gastrointestinal (GI) cancers of the stomach and esophagus have high incidence and mortality worldwide, but they are uncommon in Western countries. Little information exists on the association between vitamin D and risk of upper GI cancers. This study examined the association between circulating 25-hydroxyvitamin D (25(OH)D) and upper GI cancer risk in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Concentrations of 25(OH)D were measured from 1,065 upper GI cancer cases and 1,066 age-, sex-, race-, and season-of blood draw-matched controls from 8 prospective cohort studies. In multivariate-adjusted models, circulating 25(OH)D concentration was not significantly associated with upper GI cancer risk. Subgroup analysis by race showed that among Asians, but not Caucasians, lower concentrations of 25(OH)D (< 25 nmol/L) were associated with a statistically significant decreased risk of upper GI cancer (reference: 50-< 75 nmol/L) (odds ratio = 0.53, 95% confidence interval: 0.31, 0.91; P trend = 0.003). Never smokers with concentrations of < 25 nmol/L showed a lower risk of upper GI cancers (odds ratio = 0.55, 95% confidence interval: 0.31, 0.96). Subgroup analyses by alcohol consumption produced opposing trends. Results do not support the hypothesis that interventions aimed at increasing vitamin D status would lead to a lower risk of these highly fatal cancers.
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