Article
Multidisciplinary Sciences
Xuelian Zhu, Xiaoyan Feng, Jia Lin, Yanhong Ding
Summary: This study aimed to integrate and clarify the risk factors for delirium in paediatric intensive care unit. The results showed that developmental delay, mechanical ventilation, benzodiazepine use, anticholinergic use, age, and length of stay in the PICU were independent risk factors for delirium in children. More large-sample, multicentre studies are needed to further explore and clarify the influencing factors of delirium in children in the PICU.
Article
Multidisciplinary Sciences
Xuelian Zhu, Xiaoyan Feng, Jia Lin, Yanhong Ding
Summary: This study aimed to integrate and clarify the risk factors for delirium in children in the Pediatric Intensive Care Unit (PICU). The results showed that developmental delay, mechanical ventilation, benzodiazepine use, anticholinergic use, age, and PICU length of stay are independent risk factors for delirium in this population. However, the inclusion of only a few articles may introduce bias and affect the analytical results, emphasizing the need for further large-sample, multicenter studies to explore and confirm these independent influencing factors.
Article
Pediatrics
Keia R. Sanderson, Bradley Warady, William Carey, Veeral Tolia, Marcella H. Boynton, Daniel K. Benjamin, Wesley Jackson, Matthew Laughon, Reese H. Clark, Rachel G. Greenberg
Summary: This study aimed to identify risk factors associated with mortality for infants receiving dialysis in the neonatal intensive care unit (NICU). The results showed that infants without kidney anomalies and those with risk factors consistent with greater severity of illness were more likely to die.
JOURNAL OF PEDIATRICS
(2022)
Article
Clinical Neurology
Sophia Wang, Anthony J. Perkins, Rosalyn Chi, Brandon A. Yates, Sikandar H. Khan, Sujuan Gao, Malaz Boustani, Babar A. Khan
Summary: A secondary data analysis of ICU patients revealed that stroke and depression were identified as risk factors for post-ICU dementia, highlighting the need for interventions targeting these factors to reduce dementia incidence.
ALZHEIMERS & DEMENTIA
(2023)
Article
Endocrinology & Metabolism
Jianying Guo, Yanyan Hong, Zhiyong Wang, Yukun Li
Summary: A low concentration of plasma triiodothyronine (T3) indicates euthyroid sick syndrome (ESS), which could be associated with a poor outcome in patients in intensive care units (ICUs). This study found that the incidence of ESS in the comprehensive ICU was 38.7%, with a cut-off value of FT3 for 28-day mortality being 2.88 pmol/L.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Multidisciplinary Sciences
Kazuaki Naya, Gen Aikawa, Akira Ouchi, Mitsuki Ikeda, Ayako Fukushima, Shuhei Yamada, Megumi Kamogawa, Shun Yoshihara, Hideaki Sakuramoto
Summary: Second victim syndrome is prevalent among intensive care unit healthcare workers, with 58% experiencing this condition. Common symptoms include guilt, anxiety, self-blame, and reduced self-confidence. Approximately 20% of individuals take more than a year or do not recover at all from this syndrome.
Review
Medicine, General & Internal
Zi Yang, Xiaohui Wang, Faying Wang, Zeyu Peng, Yuying Fan
Summary: This study conducted a systematic review and meta-analysis to assess the risk factors for ICU-AW. The results indicated that female, mechanical ventilation days, age, length of ICU stay, infectious disease, renal replacement therapy, use of aminoglucoside drugs, SOFA score, and hyperglycemia are independent risk factors for ICU-AW. There was no consistent evidence found for the effects of corticosteroids, neuromuscular blockers, and sepsis on ICU-AW risk.
Article
Dermatology
Hyeon Jeong Lee, Min Young Han, Jung Hwa Hwang, Kang Ju Park, Kyung Min Shin, Eun Sil Kim, Hyea Jung Lee, Arum Lim, Eun Jin Han, Ju Yeon Park, Yeon Soo Jang
Summary: This study identified cardiac surgery, operation time, use of a mechanical ventilator, use of vasoconstrictors, use of sedative drugs, and extracorporeal membrane oxygenation treatment as significant risk factors for heel pressure injury in cardiovascular intensive care unit patients.
INTERNATIONAL WOUND JOURNAL
(2022)
Review
Medicine, General & Internal
Neng Wang, Congchen Tang, Lichun Wang
Summary: This study systematically evaluated risk factors for S. maltophilia pneumonia in ICU patients and found that APACHE-II score > 20, COPD, malignant tumor, mechanical ventilation, tracheotomy, endotracheal intubation, beta-Lactamase inhibitors, aminoglycosides, carbapenems, and quinolones were risk factors for ICU-acquired S. maltophilia pneumonia.
FRONTIERS IN MEDICINE
(2022)
Article
Nursing
Wen Dang, Yuan Liu, Qing Zhou, Yuyu Duan, Huaxiu Gan, Lin Wang, Qiongli Zhu, Chunyan Xie, Ailing Hu
Summary: This study conducted a cross-sectional study of 694 patients in 66 adult ICUs in 30 hospitals in China and found that the overall prevalence rate of MDRPI was 13.1%. Stage 1 MDRPI was the most common. CPAP or BiPAP masks were one of the main causes of MDRPI. Nurses should pay attention to lower Braden scores and skin edema as risk factors for MDRPI in adult ICU patients.
JOURNAL OF CLINICAL NURSING
(2022)
Article
Multidisciplinary Sciences
Ellen J. Thompson, Dylan M. Williams, Alex J. Walker, Ruth E. Mitchell, Claire L. Niedzwiedz, Tiffany C. Yang, Charlotte F. Huggins, Alex S. F. Kwong, Richard J. Silverwood, Giorgio Di Gessa, Ruth C. E. Bowyer, Kate Northstone, Bo Hou, Michael J. Green, Brian Dodgeon, Katie J. Doores, Emma L. Duncan, Frances M. K. Williams, Andrew Steptoe, David J. Porteous, Rosemary R. C. McEachan, Laurie Tomlinson, Ben Goldacre, Praveetha Patalay, George B. Ploubidis, Srinivasa Vittal Katikireddi, Kate Tilling, Christopher T. Rentsch, Nicholas J. Timpson, Nishi Chaturvedi, Claire J. Steves, Alex J. Walker, Brian MacKenna, Peter Inglesby, Helen J. Curtis, Caroline E. Morton, Jessica Morley, Amir Mehrkar, Seb Bacon, George Hickman, Chris Bates, Richard Croker, David Evans, Tom Ward, Jonathan Cockburn, Simon Davy, Krishnan Bhaskaran, Anna Schultze, Elizabeth J. Williamson, William J. Hulme, Simon Davy, Helen McDonald, Rohini Mathur, Rosalind M. Eggo, Kevin Wing, Angel Y. S. Wong, Harriet Forbes, John Tazare, John Parry, Frank Hester, Sam Harper, Ian J. Douglas, Stephen J. W. Evans, Liam Smeeth
Summary: The frequency and risk factors of long COVID in community-based individuals are unclear. A study analyzing data from 10 UK population-based studies and electronic health records found wide variation in the frequency of long COVID between studies, but identified some consistent risk factors.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Matthias Knefel, Elisabeth L. Zeilinger, Simone Lubowitzki, Katharina Krammer, Matthias Unseld, Rupert Bartsch, Thorsten Fuereder, Ulrich Jaeger, Barbara Kiesewetter, Maria Krauth, Markus Raderer, Philipp B. Staber, Peter Valent, Alexander Gaiger
Summary: This study examines the predictive power of biological, social, and psychological factors on overall survival in cancer patients over time. The results show that biological parameters are important throughout most of the time, while social parameters are either time-independent predictors or more important in the longer term. Of the psychological parameters, only depression is a significant predictor and loses its predictive power in the long-term.
Article
Multidisciplinary Sciences
Xiaowei Gai, Yanan Wang, Dan Gao, Jia Ma, Caijuan Zhang, Qiuyan Wang
Summary: This study analyzed the risk factors for prognosis in sepsis patients and found that low PSV is an independent risk factor and a good predictor for mortality. The results suggest the potential of ultrasound in predicting mortality in sepsis patients.
Article
Medicine, General & Internal
Ying Han, Jin Zhang, Hong-Ze Zhang, Xin-Ying Zhang, Ya-Mei Wang
Summary: This study identified major pathogens of nosocomial infection in ICUs, including Acinetobacter baumannii, Escherichia coil (E. coli), Pseudomonas aeruginosa (P. aeruginosa), Klebsiella pneumoniae (K. pneumoniae), and Staphylococcus aureus. Most of these strains showed resistance to antibiotics.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Nursing
Ruiling Nan, Yujie Su, Juhong Pei, Haixia Chen, Li He, Xinman Dou, Shuling Nan
Summary: This study aimed to understand the risk factors associated with medical device-related nasal mucosal pressure injuries in ICU patients. Through data analysis of 912 patients, it was found that high APACHE-II score, disturbance of consciousness, history of diabetes, days of gastric tube indwelling, hypoproteinemia, fever, and use of vasoconstrictive drugs were significant influencing factors of nasal mucosal pressure injuries.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Medicine, General & Internal
Alison M. Mudge, Prue McRae, Merrilyn Banks, Irene Blackberry, Sally Barrimore, John Endacott, Nicholas Graves, Theresa Green, Gill Harvey, Ruth Hubbard, Sue Kurrle, Wen Kwang Lim, Karen Lee-Steere, Phil Masel, Shaun Pandy, Adrienne Young, Adrian Barnett, Sharon K. Inouye
Summary: The study explores the implementation of an improvement program called Eat Walk Engage to consistently deliver age-friendly principles of care to older individuals in acute inpatient wards. The program was found to significantly reduce the incidence of delirium among the intervention participants. However, it did not show a reduction in the overall incidence of hospital-associated complications or length of stay.
JAMA INTERNAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Emma Shipton, Nina Meloncelli, Michael D'Emden, H. David McIntyre, Leonie Callaway, Adrian Barnett, Susan de Jersey
Summary: This qualitative study aimed to explore women's perspectives and understanding of gestational diabetes mellitus (GDM) screening and diagnosis, comparing the modified COVID-19 recommendations to the standard practices. The results showed that women preferred the modified GDM screening recommendations put in place due to the COVID-19 pandemic. They also expressed a strong need for clear communication from health professionals and the opportunity to be active participants in decision making.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Pediatrics
Richard G. McGee, Lara E. Graves, Adrian Barnett
Summary: This study examined the effects of the COVID-19 pandemic on the timing of manuscript submissions to The Journal of Paediatrics and Child Health (JPCH), and found that the pandemic had limited impact on submission timing but submission timing influenced the likelihood of a positive editorial decision.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2023)
Article
Sport Sciences
David N. Borg, Adrian G. Barnett, Aaron R. Caldwell, Nicole M. White, Ian B. Stewart
Summary: This study aimed to examine the bias for statistical significance using published confidence intervals in sport and exercise medicine research. The abstracts of 48,390 articles published in 18 sports and exercise medicine journals between 2002 and 2022 were analyzed. The results revealed a bias for statistical significance and an excess of published research with statistically significant results just below the standard significance threshold of 0.05.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2023)
Review
Cardiac & Cardiovascular Systems
Jeffrey Javidfar, Akram M. Zaaqoq, Ahmed Labib, Adrian G. Barnett, J. W. Awori Hayanga, Greg Eschun, Michael H. Yamashita, Jeffrey P. Jacobs, Silver Heinsar, Jacky Y. Suen, John F. Fraser, Gianluigi Li Bassi, Rakesh C. Arora, Giles J. Peek
Summary: Obesity is linked to a worse prognosis in COVID-19 patients with ARDS. It remains unclear how morbid obesity directly affects patients treated with V-V ECMO.
Article
Medicine, General & Internal
Yin Mo, Mathupanee Oonsivilai, Cherry Lim, Rene Niehus, Ben Cooper
Summary: This study used mathematical modeling and meta-analysis to demonstrate that reducing antibiotic treatment duration can reduce the carriage of antibiotic-resistant bacteria. The models showed that the effectiveness of shortening duration depends on the growth and decline rates of resistant bacteria under antibiotic selection pressure. The meta-analysis found that each additional day of antibiotic treatment is associated with a 7% increase in the risk of resistance carriage. These findings highlight the potential benefits and risks of shortening antibiotic treatment duration in reducing antimicrobial resistance.
Article
Medical Ethics
Adrian G. Barnett, David N. Borg, Paul Glasziou, Emma Beckett
Summary: Research Integrity Advisors in Australia provide impartial guidance to researchers and are an important part of creating a safe environment for discussing research integrity issues and resolving them. A census revealed that there are 739 advisors nationally, with an overall positive attitude towards the role. However, some advisors lack proper training and institutional support, indicating a need for improvement.
ACCOUNTABILITY IN RESEARCH-ETHICS INTEGRITY AND POLICY
(2023)
Article
Health Care Sciences & Services
Michelle J. Allen, Rachael Doran, David Brain, Elizabeth E. Powell, James O'Beirne, Patricia C. Valery, Adrian Barnett, Ruvini Hettiarachchi, Ingrid J. Hickman, Sanjeewa Kularatna
Summary: This study aimed to identify the attributes and levels for preference research on chronic liver disease screening programs to understand patient preferences.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Health Care Sciences & Services
Robin Blythe, Rex Parsons, Adrian G. Barnett, Steven M. McPhail, Nicole M. White
Summary: This study investigated the impact of repeated measures and missing data on the development of clinical deterioration prediction models using electronic medical record data from five Australian hospitals. The results showed that the variability of vital signs and patient consciousness were associated with missing data. Summary statistics and imputation methods improved model discrimination, but the clinical significance of these differences is questionable.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Medicine, General & Internal
Nina J. L. Meloncelli, Adrian G. Barnett, Cate M. Cameron, David Mcintyre, Leonie K. Callaway, Michael C. d'Emden, Susan J. de Jersey
Summary: The study aimed to determine whether excluding gestational diabetes mellitus (GDM) based on fasting venous plasma glucose (FVPG) assessment during the COVID-19 pandemic in 2020 had similar perinatal outcomes compared to excluding GDM using the standard oral glucose tolerance test (OGTT) procedure in the previous year. The results showed that the frequencies of most perinatal outcomes were similar for women without GDM in 2019 and those for whom it was excluded in 2020 based on FVPG values. However, there was an increase in the risk of caesarean delivery in 2020 compared to 2019. The probabilities of several outcomes, such as respiratory distress, neonatal intensive care or special nursery admission, and large for gestational age babies, were slightly higher for women without GDM in 2020 compared to women without GDM in 2019.
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Multidisciplinary Sciences
Ben S. Cooper, Stephanie Evans, Yalda Jafari, Thi Mui Pham, Yin Mo, Cherry Lim, Mark G. Pritchard, Diane Pople, Victoria Hall, James Stimson, David W. Eyre, Jonathan M. Read, Christl A. Donnelly, Peter Horby, Conall Watson, Sebastian Funk, Julie V. Robotham, Gwenan M. Knight
Summary: This study uses data from acute hospitals in England to quantify hospital-based transmission of SARS-CoV-2, evaluate the pathways of spread and factors associated with increased transmission risk, and explore the wider consequences. The study estimates that between June 2020 and March 2021, 95,000 to 167,000 inpatients acquired SARS-CoV-2 in hospitals, accounting for 1% to 2% of all hospital admissions during this period.
Article
Multidisciplinary Sciences
Dylan Flaws, Chelsea Allen, Stuart Baker, Adrian Barnett, Olivia Metcalf, Hamish Pollock, Mahesh Ramanan, Alexis Tabah, Tracey Varker
Summary: This study aims to evaluate the feasibility and acceptability of incorporating a psychiatric review into an existing post-ICU follow-up process. The study will run for 12 months, recruiting 30 participants at Redcliffe Hospital. Participants will be allocated to intervention or control, with the intervention group receiving psychiatric assessment and treatment. The study will assess the effectiveness of the intervention and inform future research.
Letter
Medicine, General & Internal
Adrian Barnett, Jennifer Byrne
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Review
Health Policy & Services
Sumudu A. Hewage, Rini Noviyani, David Brain, Pakhi Sharma, William Parsonage, Steven M. Mcphail, Adrian Barnett, Sanjeewa Kularatna
Summary: This study assessed the methodological quality of economic evaluations on stroke prevention strategies for atrial fibrillation patients. The results showed that LAAC is a cost-effective strategy for preventing stroke in atrial fibrillation patients. However, the study identified shortcomings in the methodological quality, which raise concerns about the reliability and validity of the results.
COST EFFECTIVENESS AND RESOURCE ALLOCATION
(2023)
Article
Multidisciplinary Sciences
Sean Cavany, Stella Nanyonga, Cathrin Hauk, Cherry Lim, Joel Tarning, Benn Sartorius, Christiane Dolecek, Celine Caillet, Paul N. Newton, Ben S. Cooper
Summary: Approximately 10% of antimicrobials used in low- and middle-income countries are substandard or falsified, which can potentially impact antimicrobial resistance levels. Our understanding of this relationship is limited, and further research is needed to understand how different drug exposures affect resistance emergence and spread, as well as the distribution of active pharmaceutical ingredients in substandard and falsified medicines.
NATURE COMMUNICATIONS
(2023)