Article
Biology
Zihao Yao, Weizhong Qi, Hongbo Zhang, Zhicheng Zhang, Liangliang Liu, Yan Shao, Hua Zeng, Jianbin Yin, Haoyan Pan, Xiongtian Guo, Anling Liu, Daozhang Cai, Xiaochun Bai, Haiyan Zhang
Summary: Obesity is a significant risk factor in the progression of osteoarthritis (OA), but the mechanism of obesity-related inflammation in OA synovitis is not fully understood. This study found that synovial macrophages infiltrated and polarized in the obesity microenvironment and identified the important role of M1 macrophages in impaired macrophage efferocytosis. The study revealed that obese OA patients and Apoe(-/-) mice showed more severe synovitis and increased macrophage infiltration, accompanied by dominant M1 macrophage polarization.
Review
Nutrition & Dietetics
Azizah Ugusman, Syarifah Amirah Syed Shahrin, Nurul Hana Azizan, Siva Balan Pillai, Khamini Krishnan, Norizam Salamt, Amilia Aminuddin, Adila A. Hamid, Jaya Kumar, Mohd Helmy Mokhtar
Summary: The study systematically reviewed the effects of honey on obesity, finding that honey showed anti-obesity effects in animal studies but had conflicting results in clinical trials. While honey supplementation did not show significant weight reduction in some trials, there was also no evidence that it increased body weight.
FRONTIERS IN NUTRITION
(2022)
Article
Multidisciplinary Sciences
Lisa Dowling, Philip Jakeman, Catherine Norton, Maeve M. Skelly, Hamid Yousuf, Miranda G. Kiernan, Margaret Toomey, Sheila Bowers, Suzanne S. Dunne, J. Calvin Coffey, Colum P. Dunne
Summary: Crohn's disease is a global inflammatory bowel condition that differs from healthy population in terms of body fat distribution, specifically showing elevated gynoid fat and reduced android fat. There is a potential rationale to refer to Crohn's disease as a fatty intestine condition, similar to fatty liver conditions, which may require further investigation in a larger patient cohort.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Qiang Zeng, Ling Wang, Shengyong Dong, Xiaojuan Zha, Limei Ran, Yongli Li, Shuang Chen, Jianbo Gao, Shaolin Li, Yong Lu, Yuqin Zhang, Xigang Xiao, Yuehua Li, Xiao Ma, Xiangyang Gong, Wei Chen, Yingying Yang, Xia Du, Bairu Chen, Yinru Lv, Yan Wu, Guobin Hong, Yaling Pan, Jun Jiao, Yan Yan, Huijuan Qi, Jian Zhai, Kai Li, Kaiping Zhao, Jing Wu, Shiwei Liu, Glen M. Blake, Haihong Fu, Xiaoxia Fu, Zhiping Guo, Isabelle Lemieux, Jean-Pierre Despres, Xiaoguang Cheng
Summary: This study investigated abdominal adiposity assessed by CT in a large-scale Chinese population, finding significant variations in the distribution of visceral and subcutaneous adiposity between sex and age groups. Visceral and subcutaneous adipose tissue areas were positively associated with BMI and waist circumference in every age group, but the proportion of visceral adipose tissue could not be predicted from BMI in a Chinese population.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Biochemistry & Molecular Biology
Xuan Song, Hongxia Wu, Wenhua Zhang, Bei Wang, Hongjun Sun
Summary: This study aimed to construct a prediction equation for estimating visceral adipose tissue (VAT) mass using anthropometric parameters and validate it with a validation group. The results showed that the prediction equations with age, sex, height, BMI, weight, TG, HDL, and grade of hepatic steatosis were strongly correlated with VAT mass. The equations could be valuable tools for predicting VAT mass when dual X-ray absorptiometry (DXA) is unavailable.
LIPIDS IN HEALTH AND DISEASE
(2022)
Review
Endocrinology & Metabolism
Alexis M. Ceasrine, Staci D. Bilbo
Summary: Poor nutrition, lack of exercise, and genetic predisposition all contribute to the epidemic of obesity, leading to chronic inflammation and negative physiological and neurological outcomes. The neuroimmune system plays a key role in regulating metabolism, with microglia being crucial in this process, especially in perinatal programming.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Nutrition & Dietetics
Cathriona Monnard, Andreas Rytz, Carmen Mirela Tudorica, Gina L. Fiore, Tram Anh Line Do, Kalpana Bhaskaran, Katherine Mace, Yasaman Shahkhalili
Summary: This study tested whether a model that used the nutrient composition of breakfast cereals to predict their glycemic index and glycemic load could accurately predict the values for complete infant cereal prototypes. The results showed that the model's predictions were strongly correlated with the measured values for infant cereals, indicating its accuracy and precision. This model could be considered a simple tool to support nutritionally responsible product development.
Article
Hematology
Eric K. Broni, Oluseye Ogunmoroti, Renato Quispe, Ty Sweeney, Bhavya Varma, Oluwaseun E. Fashanu, Pamela L. Lutsey, Matthew Allison, Moyses Szklo, Chiadi E. Ndumele, Erin D. Michos
Summary: Obesity leads to adipocyte hypertrophy and adipokine dysregulation and is an independent risk factor for venous thromboembolism (VTE). However, the association between adipokines and VTE is not well established. This study aimed to examine whether adipokines are associated with increased risk of incident VTE. The findings showed that higher resistin levels were independently associated with greater risk of incident VTE.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Agriculture, Dairy & Animal Science
J. Heijmans, E. Beijer, M. Duijster, B. Kemp, R. P. Kwakkel, W. J. J. Gerrits, H. van den Brand
Summary: Body composition and energetic efficiency in broiler breeders were evaluated using different dietary strategies. Body protein mass was linearly related to body weight, while body fat mass was exponentially related to body weight. Higher energy-to-protein ratio resulted in higher body fat mass. Sexual maturation was related to body protein mass, with each additional 100g advancing sexual maturation by 5.4 days.
Article
Geriatrics & Gerontology
N. Akazawa, M. Kishi, T. Hino, R. Tsuji, K. Tamura, A. Hioka, H. Moriyama
Summary: This study showed that older inpatients with a higher BMI have greater muscle mass and less intramuscular adipose tissue of the quadriceps.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Endocrinology & Metabolism
Georgia Colleluori, Laura Graciotti, Mauro Pesaresi, Angelica Di Vincenzo, Jessica Perugini, Eleonora Di Mercurio, Sara Caucci, Patrizia Bagnarelli, Cristina M. Zingaretti, Enzo Nisoli, Stefano Menzo, Adriano Tagliabracci, Annie Ladoux, Christian Dani, Antonio Giordano, Saverio Cinti
Summary: This study confirms the presence of lung fat embolism in COVID-19 patients and describes novel COVID-19-related features possibly contributing to the unfavorable prognosis in individuals with COVID-19 and obesity.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Multidisciplinary Sciences
Keiichiro Shimoyama, Akira Endo, Takashi Shimazui, Takashi Tagami, Kazuma Yamakawa, Mineji Hayakawa, Takayuki Ogura, Atsushi Hirayama, Hideo Yasunaga, Jun Oda
Summary: This study aimed to determine if obesity is associated with disease outcomes in critically ill COVID-19 patients requiring mechanical ventilation. The study included Japanese registry data of COVID-19 patients who required invasive mechanical ventilation and were discharged between January and September 2020. The findings showed that obesity was not significantly associated with in-hospital mortality or VV-ECMO implementation in these patients.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Nela Maksimovic, Vanja Vidovic, Tatjana Damnjanovic, Biljana Jekic, Nada Majkic Singh, Slavko Simeunovic, Dara Savic Bozovic, Stojko Vidovic, Ivana Novakovic
Summary: The study aimed to analyze the association between PRDM16 gene (rs12409277) and CtBP2 gene (rs1561589) polymorphisms with body mass index (BMI), fasting glucose level, and lipid profile in adolescents. The results showed no significant association between these two polymorphisms and BMI, glucose level, and lipid profile. However, the combined effect of rs12409277 and rs1561589 showed a significant association with lower total cholesterol and LDL cholesterol levels.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Nutrition & Dietetics
Ming Kong, Manman Xu, Ying Zhou, Nan Geng, Ning Lin, Wenyan Song, Shanshan Li, Yuetong Piao, Zuoqing Han, Rong Guo, Chao Yang, Nan Luo, Zhong Wang, Lei Ma, Quanxiao Xu, Lili Wang, Wanchun Qiu, Junfeng Li, Daimeng Shi, Eddie C. Cheung, Rongkuan Li, Yu Chen, Zhongping Duan
Summary: This study analyzed the distribution of abdominal adipose tissue in a healthy population in northern China using abdominal CT scans. The results showed significant differences in abdominal fat distribution between men and women, with a high proportion of visceral obesity even in individuals with normal BMI.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Hongrui Li, Dajun Li, Xianyun Wang, Huini Ding, Qinghua Wu, Haojun Li, Xuan Wang, Kaifeng Li, Rong Xiao, Kang Yu, Yuandi Xi
Summary: For Chinese college students, following a healthy dietary pattern or a high-quality diet, similar to the Mediterranean diet, is more likely to maintain a healthy weight and normal body composition. Fat or muscle indexes play an important role in predicting overweight and obesity, advocating for the application of BIA among Chinese college students.
Article
Nutrition & Dietetics
Tian Qiao, Yue Chen, Ruonan Duan, Mengxue Chen, Hongmei Xue, Guo Tian, Yi Liang, Jieyi Zhang, Fang He, Dagang Yang, Yunhui Gong, Rong Zhou, Guo Cheng
Summary: The study found that dietary fat intake in the year preceding pregnancy and during pregnancy does not have a direct impact on the risk of gestational diabetes mellitus among Chinese women.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Andrology
Jingyuan Xiong, Ye Tian, Aru Ling, Zhenmi Liu, Li Zhao, Guo Cheng
Summary: Genistein directly affects GnRH secretion by modulating the expression of kisspeptin receptors, SIRT1, PKC gamma, and MKRN3 in GT1-7 cells.
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2022)
Article
Nutrition & Dietetics
Yujie Xu, Jingyuan Xiong, Wanke Gao, Xiaoyu Wang, Shufang Shan, Li Zhao, Guo Cheng
Summary: The association between dietary fat and fat quality and puberty timing is inconsistent. This study found that children with higher intakes of total fat and polyunsaturated fatty acid (PUFA) were more likely to reach puberty at an earlier age, while intakes of saturated fatty acid (SFA) and monounsaturated fatty acid (MUFA) were not independently associated with puberty development.
Article
Medicine, General & Internal
Jingyuan Xiong, Yujie Xu, Xueting Liu, Xiaoyu Wang, Shufang Shan, M. James C. Crabbe, Li Zhao, He Fang, Guo Cheng
Summary: The study showed that higher childhood soy intake is associated with later puberty timing in both Chinese girls and boys, especially among individuals with a higher urinary equol level. This association is independent of prepubertal body fatness and is more pronounced in children with a high cereal fiber intake.
Article
Nutrition & Dietetics
Xue-Ting Liu, Jing-Yuan Xiong, Yu-Jie Xu, Li Zhao, Lars Libuda, Guo Cheng
Summary: The study investigated the association between parental and siblings' sugar-sweetened beverage (SSB) intake and children's SSB consumption, with a focus on potential sex differences in these associations. The results showed that parental SSB consumption was relevant to children's SSB intake, with a stronger influence in boys than girls. Fathers seemed to have a greater impact on children's SSB consumption than mothers. Additionally, children's SSB intake was prospectively associated with their older siblings' SSB consumption.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Jingyuan Xiong, Ye Tian, Guochen Ma, Aru Ling, Shufang Shan, Guo Cheng
Summary: This study investigated the effects of genistein on GT1-7 cells, focusing on its influence on the endocrine and reproductive systems. The researchers performed comparative transcriptomic analyses and constructed ceRNA networks to identify potential targets and pathways related to genistein-induced effects. They discovered that genistein interfered with cell cycle, metabolic processes, GnRH, and mitogen-activated protein kinase signaling pathways. Moreover, they predicted that specific miRNAs and lncRNAs might be involved in regulating genistein-induced GnRH secretion. These findings provide valuable insights into the endocrine-interfering effects of genistein.
MOLECULAR & CELLULAR TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xiao-Feng Ni, Chun-Song Yang, Li-Nan Zeng, Hai-Long Li, Sha Diao, De-Yuan Li, Jin Wu, Yuan-Chun Liu, Zhi-Jun Jia, Guo Cheng, Ling-Li Zhang
Summary: This cross-sectional study revealed the severity of drug-related problems (DRPs) among children with chronic diseases managed in primary health care institutions. The types of DRPs were mainly related to treatment effectiveness, and improper medication usage was one of the main causes of DRPs. The number of combined medications was an influencing factor for the frequency of DRPs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Jingyuan Xiong, Ye Tian, Guochen Ma, Xiaoyu Wang, Shufang Shan, Guo Cheng
Summary: The timing of puberty is crucial for adult well-being and can be influenced by factors such as environment, lifestyle, and diet. This study investigates the effects of genistein, a soy isoflavone, at different developmental stages on reproductive development and neuroendocrine regulations in female rats. The results show that genistein exposure during the lactational stage significantly accelerates vaginal opening time and affects the secretion of neuroendocrine factors. However, exposures during neonatal and post-weaning stages do not have significant effects.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Xiaoyu Wang, Yujie Xu, Bingbing Tan, Ruonan Duan, Shufang Shan, Linan Zeng, Kun Zou, Li Zhao, Jingyuan Xiong, Lingli Zhang, Shuang Rong, Guo Cheng
Summary: This study developed a dietary index for preschool children in China and assessed their diet quality using the index. Results showed that older age, higher household income, and urban residence were associated with better diet quality among preschoolers.
Review
Pediatrics
Zhe Chen, Siyu Li, Imti Choonara, Kun Zou, Linan Zeng, Liang Huang, Zhi-Jun Jia, Guo Cheng, Yongmu Jiang, Yong Tang, Shaoyang Zhao, Lingli Zhang
Summary: Access to essential medicines for children is challenging in China, with low availability rates and high prices. Generics are more available and affordable than original brands, especially in public hospitals. Tablets/capsules are more affordable than injections. However, some commonly used medicines for children are unaffordable. The Chinese government has implemented policies to improve accessibility, but further improvement is needed.
BMJ PAEDIATRICS OPEN
(2022)
Article
Pediatrics
Yan Liu, Hailong Li, Liang Huang, Chaomin Wan, Huiqing Wang, Xuefeng Jiao, Linan Zeng, Zhijun Jia, Guo Cheng, Lei Zhang, Wei Zhang, Lingli Zhang
Summary: This study analyzed drug signals associated with pediatric liver injury and identified 264 disproportionate drug signals. The top 10 drugs with the highest number of reports were paracetamol, methotrexate, vincristine, valproic acid, cyclophosphamide, tacrolimus, prednisone, prednisolone, etoposide, and cytarabine.
Review
Pharmacology & Pharmacy
Miao Zhang, Bingchen Lang, Hailong Li, Liang Huang, Linan Zeng, Zhi-Jun Jia, Guo Cheng, Yu Zhu, Lingli Zhang
Summary: The summary includes 69 studies with 195,894 pediatric patients. The incidence of DIKI in children is 18.2%, with risk factors including ICU admission, surgical intervention, infection, chronic kidney disease, and use of nephrotoxic drugs.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Letter
Medicine, General & Internal
Tianyi He, Xueting Liu, Ruiqi Lv, Guo Cheng
JOURNAL OF EVIDENCE BASED MEDICINE
(2023)
Letter
Medicine, General & Internal
Shufang Shan, Siquan Zhou, Guochen Ma, Xiaoyu Wang, Jingyuan Xiong, Guo Cheng
CHINESE MEDICAL JOURNAL
(2023)
Article
Environmental Sciences
Jingyuan Xiong, Minghui Wang, Ye Tian, Aru Ling, Shufang Shan, Li Zhao, Guo Cheng
Summary: This study found that (+/-)-equol has negative effects on cell viability, increases gonadotropin-releasing hormone secretion, and interferes with the expression of key neuromodulators.
TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
(2022)