Article
Biochemistry & Molecular Biology
Kim N. N. Cajachagua-Torres, Sophia M. M. Blaauwendraad, Hanan El Marroun, Hans Demmelmair, Berthold Koletzko, Romy Gaillard, Vincent W. V. Jaddoe
Summary: Fetal tobacco exposure is associated with changes in neonatal metabolite profiles, with different effects observed during different stages of maternal smoking.
Article
Veterinary Sciences
Giulia Pizzi, Silvia Michela Mazzola, Alessandro Pecile, Valerio Bronzo, Debora Groppetti
Summary: In recent years, there has been increasing attention to the detrimental effects of second-hand smoke on children and mothers. However, the risks for pets, especially dogs, have been largely overlooked. A recent study found that cotinine, a primary metabolite of nicotine, can be detected in dogs living with smoking owners, indicating the potential adverse health consequences for pets. This highlights the importance of raising awareness among pet owners about the risks of smoke exposure.
VETERINARY SCIENCES
(2023)
Article
Obstetrics & Gynecology
Sashana S. Gordon, David N. Dhanraj, C. Ganga Devaiah, Donna S. Lambers
Summary: This study investigated the effects of maternal smoking during pregnancy on female fetal testosterone levels, anogenital distance, and finger length ratio. While animal studies showed an increase in female fetal testosterone levels after nicotine exposure, this was not observed in the human study. Maternal total testosterone levels were higher in nonsmokers compared to smokers, but no significant correlation was found between maternal total testosterone and female fetal testosterone levels.
REPRODUCTIVE SCIENCES
(2022)
Article
Medical Laboratory Technology
Marcus R. Orzabal, Vishal D. Naik, Jehoon Lee, Andrew E. Hillhouse, Wesley A. Brashear, David W. Threadgill, Jayanth Ramadoss
Summary: Exposure to e-cig aerosols during pregnancy may adversely affect fetal lung development and function. Using a murine model, researchers found that prenatal e-cig exposure resulted in dysregulated gene expression, emphysematic phenotype in neonatal lungs, and increased respiratory workload in newborns.
TRANSLATIONAL RESEARCH
(2022)
Article
Biochemical Research Methods
Claire Roseren, Sylvia Binck, Francois Fays, Maria Ruiz-Castell, Hanen Samouda, Brice M. R. Appenzeller
Summary: Despite efforts to reduce tobacco consumption, smoking remains a leading cause of death for both smokers and nonsmokers exposed to environmental tobacco smoke (ETS). This study investigates the determinants of ETS in young adult students, who are considered at higher risk of exposure due to their specific lifestyle. The results highlight the widespread exposure to ETS in this population and emphasize the importance of exposure assessment and hair analysis.
DRUG TESTING AND ANALYSIS
(2023)
Article
Toxicology
Dong Zhang, Jingbo Dai, Meixing Zhang, Yilin Xie, Yong Cao, Guang He, Wangjie Xu, Lianyun Wang, Zhiguang Qiao, Zhongdong Qiao
Summary: Paternal nicotine exposure can induce hepatic fibrosis in offspring by down-regulating mmu-miR-15b expression via hyper-methylation, activating the Wnt pathway, leading to increased activation and proliferation of hepatic stellate cells. Additionally, nicotine can promote the activation of the TGF-beta pathway, cooperatively enhancing the transcription of extracellular matrix genes, ultimately contributing to liver fibrosis in offspring.
TOXICOLOGY LETTERS
(2021)
Article
Reproductive Biology
Deirdre M. McCarthy, Pradeep G. Bhide
Summary: Research has expanded our understanding of how genetic and environmental factors interact to shape behavioral phenotypes, including environment-induced epigenetic modifications and their potential association with heritable behavioral phenotypes. The molecular basis of phenotypes resulting from environment-induced epigenetic modifications is not well defined, but there is accumulating phenomenological evidence in support of it. Attention has turned to epigenetic modification of germ cells as a possible mechanism of heritability, particularly focusing on the heritable effects of environmental influences on male founders.
BIOLOGY OF REPRODUCTION
(2021)
Article
Substance Abuse
Mitzi D. Go, Wael K. Al-Delaimy, Diane Schilling, Brittany Vuylsteke, Shawn Mehess, Eliot R. Spindel, Cindy T. McEvoy
Summary: This study demonstrates that infant hair and nail nicotine levels are valid biomarkers of intrauterine tobacco smoke exposure, correlating well with maternal nicotine exposure levels.
TOBACCO INDUCED DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Kaitlyn O. Browning, Michael J. DeSarno, Danielle R. Davis, Joanna M. Streck, Cecilia L. Bergeria, Roxanne F. Harfmann, Maria A. Parker, Sarah H. Heil, Stacey C. Sigmon, Diann E. Gaalema, Jennifer W. Tidey, Dustin C. Lee, Haley J. Tetreault, Stephen T. Higgins
Summary: This study uses multivariate regression to investigate the contribution of the reinforcing value of smoking and nicotine-dependence severity to individual differences in nicotine exposure levels among vulnerable populations. The results suggest that differences in reinforcing value may underpin a considerable portion of the variance in nicotine exposure accounted for by dependence severity.
PREVENTIVE MEDICINE
(2022)
Article
Environmental Sciences
Feng-Shan Cai, Bin Tang, Jing Zheng, Xiao Yan, Wei-Keng Luo, Mian He, Xiao-Jun Luo, Ming-Zhong Ren, Yun-Jiang Yu, Bi-Xian Mai
Summary: This study investigated the levels and compositions of typical organic contaminants (OCs) in infant hair samples in Guangzhou, China. Most of the target OCs were detected and the concentrations in infant hair were higher than those in maternal samples. The study also examined the associations between maternal and infant hair for individual compounds.
ENVIRONMENTAL POLLUTION
(2023)
Article
Pediatrics
Huan Wang, Yan-Ping Ruan, Sheng Ma, Ya-Qi Wang, Xiao-Yu Wan, Yi-Hua He, Jing Li, Zhi-Yong Zou
Summary: A study on pregnant women from 1313 referral hospitals in China found that maternal ozone (O3) exposure and paternal smoking were associated with fetal congenital heart defects (CHDs), and the interaction and modification of paternal smoking on this association were significant. Effective measures are needed to reduce maternal exposure to O3 pollution and secondhand smoke for CHD prevention.
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Pathology
Kamrul M. Hasan, Alexandra Munoz, Hayk Tumoyan, Meher Parveen, Jorge Espinoza-Derout, Xuesi M. Shao, Sushil K. Mahata, Theodore C. Friedman, Amiya P. Sinha-Hikim
Summary: This study demonstrates that gestational exposure to e-cigarettes and a high-fat diet can lead to cardiomyocyte apoptosis in neonatal hearts, as well as the activation of various proteins associated with heart function. Additionally, exposure to e-cigarettes can also cause cardiomyopathy and cardiac dysfunction.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Substance Abuse
Touchanun Komonpaisarn
Summary: This study estimated the economic cost of smoking and secondhand smoke exposure at home in Thailand for the first time. The total economic cost from both types of tobacco exposure amounted to US$2.98 billion in 2017, equivalent to 17.41% of Thailand's current health expenditure or 0.65% of its gross domestic product. The findings highlight the substantial economic burden imposed by smoking in Thailand and call for prompt responses from public health agencies to implement effective tobacco control policies.
Article
Environmental Sciences
Nichole Nidey, Katherine Bowers, Lili Ding, Hong Ji, Robert T. Ammerman, Kimberly Yolton, E. Melinda Mahabee-Gittens, Alonzo T. Folger
Summary: This study investigated the effects of in-utero exposure to maternal smoking on DNA methylation of AVPR1a gene in infants. The findings suggest that infants with in-utero exposure to maternal smoking have reduced DNA methylation at AVPR1a CpG sites.
Article
Public, Environmental & Occupational Health
Andrea L. Hobkirk, Vishal Midya, Nicolle M. Krebs, Sophia I. Allen, Lisa Reinhart, Dongxiao Sun, Andrea L. Stennett, Joshua E. Muscat
Summary: The study investigated the intraindividual variability in nicotine exposure among non-daily smokers and found that menthol flavor and smoking time were related to cotinine levels, highlighting the role of smoking context in nicotine exposure.
Article
Genetics & Heredity
Young-gon Kim, Hobin Sung, Ho Seob Shin, Man Jin Kim, Jee-Soo Lee, Sung-Sup Park, Moon-Woo Seong
Summary: Rotor syndrome is caused by digenic loss-of-function variants in SLCO1B1 and SLCO1B3. The frequency of SLCO1B3 LINE-1 insertion is remarkably high in East Asian populations, especially in Southern Han Chinese, but almost absent in other populations.
JOURNAL OF HUMAN GENETICS
(2022)
Article
Medical Laboratory Technology
Boram Kim, Yongsook Park, Sung Im Cho, Man Jin Kim, Jong-Hee Chae, Ji Yeon Kim, Moon-Woo Seong, Sung Sup Park
Summary: In this study, the utility of methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) as a diagnostic tool for Prader-Willi syndrome (PWS) and Angelman syndrome (AS) was evaluated. The results showed a 100% concordance rate between MS-MLPA and MS-PCR, and MS-MLPA was found to be superior in identifying the molecular mechanisms underlying the diseases. These findings suggest that MS-MLPA has clinical utility in the diagnosis of PWS/AS.
ANNALS OF LABORATORY MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Min-Ji Sohn, Woori Chae, Jae-Sung Ko, Joo-Youn Cho, Ji-Eun Kim, Ji-Yeob Choi, Han-Byul Jang, Hye-Ja Lee, Sang-Ick Park, Kyung-Hee Park, Peter J. van der Spek, Jin-Soo Moon
Summary: This study aimed to determine the metabolomic signatures associated with weight control interventions in children with obesity. The analysis of serum metabolites before and after intervention revealed significant changes in metabolic pathways and important metabolites related to childhood obesity.
Article
Medical Laboratory Technology
Young-Gon Kim, Kiwook Jung, Seunghwan Kim, Man Jin Kim, Jee-Soo Lee, Sung-Sup Park, Moon-Woo Seong
Summary: SnackNTM is a simple and fully automated software that enables species-level identification of nontuberculous mycobacteria (NTM) from trace files. It has high performance and accuracy, and reduces the workload for NTM identification, especially in clinical laboratories processing large numbers of cases.
ANNALS OF LABORATORY MEDICINE
(2022)
Letter
Medical Laboratory Technology
Hwa Young Kim, Man Jin Kim, Moon-Woo Seong, Jung Min Ko
ANNALS OF LABORATORY MEDICINE
(2022)
Article
Medical Laboratory Technology
Kyoung Ho Roh, Ki Ho Hong, Myung-Hyun Nam, Taek Soo Kim, Moon-Woo Seong, Jin Kyung Lee, Sookyoung Bae, Hee Jae Huh, Jeong-Yeal Ahn, Jinsook Lim, Gab Jung Kim, Jae Sun Park, Hyun Yeong Kim, Cheon Kwon Yoo, Hyukmin Lee
Summary: This article provides guidelines for the operation, management, and quality control of mobile laboratories, specifically for the implementation and execution of COVID-19 molecular diagnostic testing. The guidelines cover various aspects including facility, preoperative evaluation, PCR testing, internal and external quality control, sample handling, reporting, laboratory personnel, biosafety level, and laboratory safety management. These guidelines are crucial for the maintenance and operation of mobile laboratories during normal circumstances as well as public health crises and emergencies.
ANNALS OF LABORATORY MEDICINE
(2022)
Article
Medical Laboratory Technology
Sang Mee Hwang, Beom Joon Kim, Jee-Soo Lee, Moon-Woo Seong, Soo Hyun Seo, Jin Ho Paik, Sang-A Kim, Ji Yun Lee, Jeong-Ok Lee, Yoon Hwan Chang, Soo Mee Bang
Summary: Systemic mastocytosis with associated hematological neoplasm (SM-AHN) is not uncommon in patients with acute myeloid leukemia (AML) with RUNX1::RUNX1T1. CD117 and CD25 immunohistochemical staining play an important role in screening for SM-AHN after induction chemotherapy.
ANNALS OF LABORATORY MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Woori Chae, Kyung Jae Lee, Ki Young Huh, Jin Soo Moon, Jae Sung Ko, Joo-Youn Cho
Summary: This study aimed to evaluate the metabolome profile and metabolic pathway changes associated with pediatric NAFLD, successfully developing machine learning-based diagnostic models with excellent performance. Metabolome changes in pediatric NAFLD patients' plasma are associated with disease pathophysiology and can be used for less invasive diagnosis.
Article
Endocrinology & Metabolism
Boram Kim, Han Na Jang, Kyung Shil Chae, Ho Seop Shin, Yong Hwy Kim, Su Jin Kim, Moon-Woo Seong, Jung Hee Kim
Summary: The study presented a case of a patient with Carney complex (CNC) with a novel PRKAR1A missense variant. The findings emphasize the importance of PRKAR1A genetic testing and counseling for patients with CNC and their families.
ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Medical Laboratory Technology
Ki Ho Hong, Gab Jung Kim, Kyoung Ho Roh, Hyukmin Lee, Ok Kyu Park, Taek Soo Kim, Jae-Seok Kim, Jaehyeon Lee, Moon-Woo Seong, So Yeon Kim, Jae-Sun Park, Younhee Park, Hee Jae Huh, Namhee Ryoo, Hyun Soo Kim, Heungsup Sung, Cheon Kwon Yoo
Summary: Since May 2022, there has been a rapid spread of monkeypox in non-endemic countries during the ongoing COVID-19 pandemic. Guidelines proposed by the Korean Society for Laboratory Medicine and the Korea Disease Prevention and Control Agency provide recommendations for diagnosing monkeypox in clinical laboratories in Korea. These guidelines cover various aspects such as test types, specimen selection and collection, diagnostic methods, interpretation of results, and biosafety. Molecular tests are recommended as confirmatory tests, and different specimens are recommended for testing at different stages of the disease.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Sola Lee, Nam-Joon Yi, Eui Soo Han, Su Young Hong, Jeong-Moo Lee, Suk Kyun Hong, YoungRok Choi, Hyun-Young Kim, Joong Kee Youn, Dayoung Ko, Jae Sung Ko, Jin Soo Moon, Seong Mi Yang, Kwang-Woong Lee, Kyung-Suk Suh
Summary: Pediatric acute liver failure (PALF) patients have poorer post-liver transplantation survival rates compared to patients with biliary atresia (BA). PALF patients have higher rates of renal replacement therapy (RRT) and hepatic artery complications post-transplantation. Survival outcomes in PALF patients are associated with lower body weight, hepatic artery complications, and post-transplant RRT.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Genetics & Heredity
Man Jin Kim, Sheehyun Kim, Seung Won Chae, Seungbok Lee, Jihoon G. Yoon, Boram Kim, Jee-Soo Lee, Jong Hee Chae, Moon-Woo Seong, Jangsup Moon
Summary: This study found that DRC1 exon 1-4 deletion is a common mutation in PCD patients in Korea and Japan, possibly due to a founder effect. It is suggested that genetic testing for DRC1 exon 1-4 deletion should be considered as an initial screening tool for PCD patients in Korea and Japan.
JOURNAL OF HUMAN GENETICS
(2023)
Article
Oncology
Yeseul Kim, Boram Kim, Moon-Woo Seong, Dong Soon Lee, Kyung Taek Hong, Hyoung Jin Kang, Jiwon Yun, Yoon Hwan Chang
Summary: KMT2A (11q23.3) gene rearrangements are common in acute leukemia and have a negative prognosis. The fourth most common gene fusion partner for KMT2A is MLLT10. Complex rearrangements are necessary to bring KMT2A and MLLT10 together due to their opposite transcriptional orientations. Next-generation sequencing (NGS) is a valuable option for detecting cryptic KMT2A/MLLT10 fusions, which cannot be detected by conventional methods such as FISH and chromosome analysis.
Letter
Medical Laboratory Technology
Heerah Lee, Jung Ae Lee, Hyesu Lee, Jee-Soo Lee, Jung Min Ko, Man Jin Kim, Moon-Woo Seong
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Endocrinology & Metabolism
Jaewon Choe, Jaehyun Kim, Jin Soo Moon
Summary: This study aimed to establish a standardized definition for severe obesity in children and adolescents in Korea. According to the latest national BMI growth chart for children and adolescents in Korea, a cutoff value for severe obesity of 120% of the 95th percentile is appropriate.
ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2023)